Cytotoxicity of 2-chlorodeoxadenosine (cladribine, 2-cdA) in combination with other chemotherapy drugs against two lymphoma cell lines

Leukemia and Lymphoma

Volumn 33, Issue 1-2, 1999, Pages 141-145

  Hoffman, Mark ^a,b   Xu, Jing Chu ^a,b   Lesser, Martin ^a,b   Rai, Kanti ^a,b  

^a LONG ISLAND JEWISH MEDICAL CENTER   (United States)

^b NORTH SHORE HOSPITAL   (United States)

Author keywords

Cladribine cytotoxicity lymphoma drug combinations

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CISPLATIN; CLADRIBINE; DAUNORUBICIN; ETOPOSIDE; PACLITAXEL;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; PRIORITY JOURNAL;

EID: 0033007405     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199909093735     Document Type: Article

References (20)

1. Seto S. Carrera C. J., Kubota M, Wason D.B., and Carson D.A. (1985) Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. Journal of Clinical Investigation, 75. 377-383.
2. Zinzani P.L., Tosi P., Visani G., Martinelli G., Farabegoli P., Buzzi M., Ottaviani E., Salvucci M., Bendani M., Zaccaria A., and Tura T. (1994) Apoptosis induction with three nucleoside analogs on freshly isolated B-chronic lymphocytic leukemia cells. American Journal of Hematology, 47, 301-306.
3. Saven A. And Piro L. (1994) Newer purine analogs for the treatment of hairy-cell Leukemia. New England Journal of Medicine, 330, 691-697.
4. Hoffman M.A. (1996) Cladribine for the treatment of indolent non-Hodgkins Lymphomas. Seminars in Hematology 33, 40-44.
5. McLauglin P., Hagemeister F.B., Romaguera J.E., Sarris A.H., Pate O., Younes A., Swan F., Keating M. and Cabanillas F. (1966) Fludarabine, mitoxantrone, and dexamethasone: an effective new regimen for indolent lymphoma. Journal of Clinical Oncology 14,1262-1268.
6. Rodriguez-Monge, E.J. and Cabanillas F. (1997) Long-term follow-up of platinum based lymphoma salvage regimens -the M.D. Anderson Cancer Center experience, in Miller T.P., Grogen T.M., eds. Hematology Oncology Clinics of North America 11,937-947.
7. Younes A. Ayoub J.P., Sarris A., Hagemeister F., Norton L., Mclaughlin P., Rodriguez, M.A., Romaguera J., Kurzrock R. Preti A., Bachier C., Smith T and Cabanillas F. (1997). Paclitaxel activity for the treatment of non-Hodgkin's lymphoma: final report of a phase II trial. British Journal of Hematology 96, 328-332.
8. Kristensen J., Nygren P., Liliemark J., Fridborg H., Killander A., Simonsson B., Oberg G. And Larsson R. (1994) Interactions between cladribine (2-chlorodeoxyadenosine) and standard antileukemic drugs in primary cultures of human tumor cells from patients with acute myelocytic leukemia. Leukemia 8, 1712-1717.
9. Begleiter A., Wang H., Verburg L., Lee K., Israels L.G, Mowat M.R.A. and Johnston J.B. (1996) In vitro cytotoxicity of 2-chlorodeoxyadenosine and chlorambucil in chronic lymphocytic leukemia. Leukemia 10, 1959-1965.
10. Kaiser-McCaw Hecht B., Epstein A.L., Berger C.S., Kaplan H.S. and Hecht F. (1985) Histiocytic Lymphoma Cell Lines: Immunologic and Cytogenetic Studies. Cancer Genetics and Cytogenetics 14, 205-218.
11. Chabner BA and Collins J.M. (1990) Cancer Chemotherapy: Principles and Practice. Philadelphia: JAB. Lippincott.
12. Cole, S.P.C. (1986) Rapid chemosensitivity testing of human lung tumor cells using the MTT assay. Cancer Chemotherapy and Pharmacology 17,259-263.
13. Sondak V.K., Korn E.L. and Kern D.H. (1988) In vitro testing of chemotherapeutic combinations in a rapid thymidine incorporation Assay. International Journal of Cell Cloning 6. 378-391.
14. Yang L.Y., Li L., Keating M.J. and Plunkett W. (1995) Arabinosyl-2-fluroadenine augments cisplatin cytotoxicity and inhibits cisplatin-DNA cross-link repair. Molecular Pharmacology 47, 1072-1079
15. Nagourney R. Horlick D. And Evans S (1997) Fludarabine synergy with cisplatin and nitrogen mustard in primary culture specimens from heavily treated leukemia and lymphoma patients. Proceedings of the American Assocition for Cancer Research 38, 475 (abstract).
16. Bergman A.M., Ruiz van Haperan V.W.T., Veennan G., Kuiper C.M. and Peters G.J. (1995) Synergistic interaction between cisplatin and gemcitabine in ovarian and colon cancer cell Lines. Advances in Experimental Medicine and Biollogy, 370, 139-143.
17. Saven A., Lee T., Kosty M. And Piro L. (1996) Cladribine and mitoxantrone dose escalation in indolent non-Hodgkin's lymphoma. Journal of Clinical Oncology, 14, 2139-2144.
18. Sawinski K., Hansz J. and Koslowska-Skrzypezak M. (1995) Effect of 2-chlorodeoxyadenosine, arabinoside cytosine and doxorubicin on acute myeloid leukemia clonogenic cell proliferation. Acta Haematol Pol. 26, 279-284.
19. Gandhi V., Estey E., Keating MJ., Chucralla A. and Plunkett W. (1996) Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharamcokinetic, pharmacodynamic and molecular interactions. Blood, 87, 256-264.
20. Rai K.R., Peterson B., Kolitz J., Elias, L., Shepherd L., Hines J., Cheson B. And Schiffer C. (1995) Fludarabine induces a high complete remission rate in previously untreated patients with active chronic lymphocytic leukemia (CLL). A randomized inter-group study. Blood 86, Suppl 1. 607a (abstract).