Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque

Infection and Immunity

Volumn 72, Issue 9, 2004, Pages 5216-5226

  Huff, Jennifer L ^b   Hansen, Lori M ^b   Solnick, Jay V ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; STRUCTURAL PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNE RESPONSE; IMMUNITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RHESUS MONKEY; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; GASTRITIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MACACA MULATTA; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; TRANSCRIPTION, GENETIC;

EID: 4544330058     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.9.5216-5226.2004     Document Type: Article

References (104)

1. Almkvist, J., and A. Karlsson. 2004. Galectins as inflammatory mediators. Glycoconj. J. 19:575-581.
2. Amieva, M. R., R. Vogelmann, A. Covacci, L. S. Tompkins, W. J. Nelson, and S. Falkow. 2003. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300:1430-1434.
3. Ando, T., R. M. Peek, Jr., Y. C. Lee, U. Krishna, K. Kusugami, and M. J. Blaser. 2002. Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan. Clin. Diagn. Lab. Immunol. 9:167-175.
4. Atherton, J. C., K. T. Tham, R. M. Peek, Jr, T. L. Cover, and M. J. Blaser. 1996. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J. Infect. Dis. 174:552-556.
5. Bach, S., A. Makristathis, M. Rotter, and A. M. Hirschl. 2002. Gene expression profiling in AGS cells stimulated with Helicobacter pylori isogenic strains (cagA positive or cagA negative). Infect. Immun. 70:988-992.
6. Bajaj-Elliott, M., P. Fedeli, G. V. Smith, P. Domizio, L. Maher, R. S. Ali, A. G. Quinn, and M. J. Farthing. 2002. Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis. Gut 51:356-361.
7. Baker, S. J., and E. P. Reddy. 1998. Modulation of life and death by the TNF receptor superfamily. Oncogene 17:3261-3270.
8. Basu, S., and P. K. Srivastava. 2000. Heat shock proteins: the fountainhead of innate and adaptive immune responses. Cell Stress Chaperones 5:443-451.
9. Bebb, J. R., D. P. Letley, R. J. Thomas, F. Aviles, H. M. Collins, S. A. Watson, N. M. Hand, A. Zaitoun, and J. C. Atherton. 2003. Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner. Gut 52:1408-1413.
10. Bergin, P. J., E. Anders, W. Sicheng, J. Erik, A. Jennie, L. Hans, M. Pierre, P. H. Qiang, and Q. J. Marianne. 2004. Increased production of matrix rnetalloproteinases in Helicobacter pylori-associated human gastritis. Helicobacter 9:201-210.
11. Bevins, C. L., E. Martin-Porter, and T. Ganz. 1999. Defensins and innate host defence of the gastrointestinal tract. Gut 45:911-915.
12. Bigger, C. B., K. M. Brasky, and R. E. Lanford. 2001. DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J. Virol. 75:7059-7066.
13. Boussioutas, A., H. Li, J. Liu, P. Waring, S. Lade, A. J. Holloway, D. Taupin, K. Gorringe, I. Haviv, P. V. Desmond, and D. D. Bowtell. 2003. Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res. 63:2569-2577.
14. Bouton, C. M., and J. Pevsner. 2002. DRAGON View: information visualization for annotated microarray data. Bioinformatics 18:323-324.
15. Byrd, J. C., and R. S. Bresalier. 2000. Alterations in gastric mucin synthesis by Helicobacter pylori. World J. Gastroenterol. 6:475-482.
16. Chattopadhyay, S., S. Datta, A. Chowdhury, S. Chowdbury, A. K. Mukhopadhyay, K. Rajendran, S. K. Bhattacharya, D. E. Berg, and G. B. Nair. 2002. Virulence genes in Helicobacter pylori strains from West Bengal residents with overt H. pylori-associated disease and healthy volunteers. J. Clin. Microbiol. 40:2622-2625.
17. Chiou, C. C., C. C. Chan, D. L. Sheu, K. T. Chen, Y. S. Li, and E. C. Chan. 2001. Helicobacter pylori infection induced alteration of gene expression in human gastric cells. Gut 48:598-604.
18. Chismar, J. D., T. Mondala, H. S. Fox, E. Roberts, D. Langford, E. Masliah, D. R. Salomon, and S. R. Head. 2002. Analysis of result variability from high-density oligonucleotide arrays comparing same-species and cross-species hybridizations. BioTechniques 33:516-518, 520, 522.
19. Cole, A. M., T. Ganz, A. M. Liese, M. D. Burdick, L. Liu, and R. M. Strieter. 2001. Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity. J. Immunol. 167:623-627.
20. Covacci, A., and R. Rappuoli. 2003. Helicobacter pylori: after the genomes, back to biology. J. Exp. Med. 197:807-811.
21. Cox, J. M., C. L. Clayton, T. Tomita, D. M. Wallace, P. A. Robinson, and J. E. Crabtree. 2001. cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes, Infect. Immun. 69:6970-6980.
22. Crabtree, J. E. 1998. Role of cytokines in pathogenesis of Helicobacter pylori-induced mucosal damage. Dig. Dis. Sci. 43:46S-55S.
23. Crabtree, J. E., A. Covacci, S. M. Farmery, Z. Xiang, D. S. Tompkins, S. Perry, I. J, Lindley, and R. Rappuoli. 1995. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J. Clin. Pathol. 48:41-45.
24. Crawford, H. C., U. S. Krishna, D. A. Israel, L. M. Matrisian, M. K. Washington, and R. M. Peek, Jr. 2003. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology 125:1125-1136.
25. de Hostos, E. L. 1999. The coronin family of actin-associated proteins. Trends Cell Biol. 9:345-350.
26. Drazek, E. S., A. Dubois, and R. K. Holmes. 1994. Characterization and presumptive identification of Helicobacter pylori isolates from rhesus monkeys. J. Clin. Microbiol. 32:1799-1804.
27. Dubois, A., D. E. Berg, E. T. Incecik, N. Fiala, L. M. Heman-Ackah, J. Del Valle, M. Yang, H. P. Wirth, G. I. Perez-Perez, and M. J. Blaser. 1999. Host specificity of Helicobacter pylori strains and host responses in experimentally challenged nonhuman primates. Gastroenterology 116:90-96.
28. Dubois, A., D. E. Berg, E. T. Incecik, N. Fiala, L. M. Heman-Ackah, G. I. Perez-Perez, and M. J. Blaser. 1996. Transient and persistent experimental infection of nonhuman primates with Helicobacter pylori: implications for human disease. Infect. Immun. 64:2885-2891.
29. Dubois, A., N. Fiala, L. M. Heman-Ackah, E. S. Drazek, A. Tarnawski, W. N. Fishbein, G. I. Perez-Perez, and M. J. Blaser. 1994. Natural gastric infection with Helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. Gastroenterology 106:1405-1417.
30. El-Omar, E. M., M. Carrington, W. H. Chow, K. E. McColl, J. H. Bream, H. A. Young, J. Herrera, J. Lissowska, C. C. Yuan, N. Rothman, G. Lanyon, M. Martin, J. F. Fraumeni, Jr., and C. S. Rabkin. 2000. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404:398-402.
31. Fan, X., A. Long, M. Goggins, P. W. Keeling, and D. Kelleher. 1996. Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation. Gut 38:507-512.
32. Fan, X. G., X. J. Fan, H. X. Xia, P. W. Keeling, and D. Kelleher. 1995. Up-regulation of CD44 and ICAM-1 expression on gastric epithelial cells by H. pylori. APMIS 103:744-748.
33. Friedl, A., S. P. Stoesz, P. Buckley, and M. N. Gould. 1999. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem. J. 31:433-441.
34. Gebert, B., W. Fischer, E. Weiss, R. Hoffmann, and R. Haas. 2003. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 301:1099-1102.
35. Gendler, S. J. 2001. MUC1, the renaissance molecule. J. Mammary Gland Biol. Neoplasia 6:339-353.
36. George, M. D., S. Sankaran, E. Reay, A. C. Gelli, and S. Dandekar. 2003. High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection. Virology 312:84-94.
37. Gewirtz, A., Y. Yu, U. Krishna, D. Israel, S. Lyons, and R. Peek, Jr. 2003. Mechanisms through which Helicobacter pylori evades recognition by the host innate immune response. Int. J. Med. Microbiol. 293:118.
38. Gooz, M., M. Shaker, P. Gooz, and A. J. Smolka. 2003. Interleukin 1β induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection. Gut 52:1250-1256.
39. Guaita, S., I. Puig, C. Franci, M. Garrido, D. Dominguez, E. Batlle, E. Sancho, S. Dedhar, A. G. De Herreros, and J. Baulida. 2002. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J. Biol. Chem, 277:39209-39216.
40. Guillemin, K., N. R. Salama, L. S. Tompkins, and S. Falkow. 2002. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. Proc. Natl. Acad. Sci. USA 99:15136-15141.
41. Hamanaka, Y., M. Nakashima, A. Wada, M. Ito, H. Kurazono, H. Hojo, Y. Nakahara, S. Kohno, T. Hirayama, and I. Sekine. 2001. Expression of human beta-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: antibacterial effect of hBD-2 against Helicobacter pylori. Gut 49:481-487.
42. Hartl, F. U., and M. Hayer-Hartl. 2002. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295:1852-1858.
43. Houghton, J., J. G. Fox, and T. C. Wang. 2002. Gastric cancer: laboratory bench to clinic. J. Gastroenterol. Hepatol. 17:495-502.
44. Hynes, S. O., S. Teneberg, N. Roche, and T. Wadstrom. 2003. Glycoconjugate binding of gastric and enterohepatic Helicobacter spp. Infect. Immun. 71:2976-2980.
45. John, C. M., G. A. Jarvis, K. V. Swanson, H. Leffler, M. D. Cooper, M. E. Huflejt, and J. M. Griffiss. 2002. Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell. Microbiol. 4:649-662.
46. Jones, N. L., A. S. Day, H. A. Jennings, and P. M. Sherman. 1999. Helicobacter pylori induces gastric epithelial cell apoptosis in association with increased Fas receptor expression. Infect. Immun. 67:4237-4242.
47. Kayo, T., D. B. Allison, R. Weindruch, and T. A. Prolla. 2001. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc. Natl. Acad. Sci. USA 98:5093-5098.
48. Kitadai, Y., A. Sasaki, M. Ito, S. Tanaka, N. Oue, W. Yasui, M. Aihara, K. Imagawa, K. Haruma, and K. Chayama. 2003. Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells. Biochem. Biophys. Res. Commun. 311:809-814.
49. Konturek, J. W., H. Fischer, P. C. Konturek, V. Huber, P. Boknik, H. Luess, J. Neumann, T. Brzozowski, W. Schmitz, E. G. Hahn, W. Domschke, and S. J. Konturek. 2001. Heat shock protein 70 (HSP70) in gastric adaptation to aspirin in Helicobacter pylori infection. J. Physiol. Pharmacol. 52:153-164.
50. Kregel, K. C. 2002. Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J. Appl. Physiol. 92:2177-2186.
51. Lee, J. Y., E. M. Eom, D. S. Kim, Y. M. Ha-Lee, and D. H. Lee. 2003. Analysis of gene expression profiles of gastric normal and cancer tissues by SAGE. Genomics 82:78-85.
52. Lee, S. A., D. Kang, K. N. Shim, J. W. Choe, W. S. Hong, and H. Choi. 2003. Effect of diet and Helicobacter pylori infection to the risk of early gastric cancer. J. Epidemiol. 13:162-168.
53. Li, C., and W. H. Wong. 2001. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. USA 98:31-36.
54. Lim, J. W., H. Kim, and K. H. Kim. 2003. Cell adhesion-related gene expression by Helicobacter pylori in gastric epithelial AGS cells. Int. J. Biochem. Cell Biol, 35:1284-1296.
55. Lindsberg, P. J., J. Launes, L. Tian, H. Valimaa, V. Subramanian, J. Siren, L. Hokkanen, T. Hyypia, O. Carpen, and C. G. Gahmberg. 2002. Release of soluble ICAM-5, a neuronal adhesion molecule, in acute encephalitis. Neurology 58:446-451.
56. Logdberg, L., and L. Wester. 2000. Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses. Biochim. Biophys. Acta 1482:284-297.
57. Maeda, S., M. Otsuka, Y. Hirata, Y. Mitsuno, H. Yoshida, Y. Shiratori, Y. Masuho, M. Muramatsu, N. Seki, and M. Omata. 2001. cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells. Biochem. Biophys. Res. Commun. 284:443-449.
58. Maeda, S., H. Yoshida, Y. Mitsuno, Y. Hirata, K. Ogura, Y. Shiratori, and M. Omata. 2002. Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori. Mol. Pathol. 55:286-293.
59. Matsuzwa, M., H. Ota, M. Hayama, M. X. Zhang, K. Sano, T. Honda, I. Ueno, T. Akamatsu, and J. Nakayama. 2003. Helicobacter pylori infection up-regulates gland mucous cell-type mucins in gastric pyloric mucosa. Helicobacter 8:594-600.
60. Milani, V., E. Noessner, S. Ghose, M. Kuppner, B. Ahrens, A. Scharner, R. Gastpar, and R. D. Issels. 2002. Heat shock protein 70: role in antigen presentation and immune stimulation. Int. J. Hyperthermia 18:563-575.
61. Miyazaki, J., R. Hokari, S. Kato, Y. Tsuzaki, A. Kawagachi, S. Nagao, K. Itoh, and S. Miura. 2002. Increased expression of galectin-3 in primary gastric cancer and the metastatic lymph nodes. Oncol. Rep. 9:1307-1312.
62. Moran, A. P. 1999. Helicobacter pylori lipopolysaccharide-mediated gastric and extragastric pathology. J. Physiol. Pharmacol. 50:787-805.
63. Mori, N., H. Sato, T. Hayashibara, M. Senba, R. Geleziunas, A. Wada, T. Hirayama, and N. Yamamoto. 2003. Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor κB. Gastroenterology 124:983-992.
64. Murray, E., W. Khamri, M. M. Walker, P. Eggleton, A. P. Moran, J. A. Ferris, S. Knapp, Q. N. Karim, M. Worku, P. Strong, K. B. Reid, and M. R. Thursz. 2002. Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection. Infect. Immun. 70:1481-1487.
65. Nagasako, T., T. Sugiyama, T. Mizushima, Y, Miura, M. Kato, and M. Asaka. 2003. Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. J. Biol. Chem. 278:4821-4825.
66. Nedrud, J. G. 1999. Animal models for gastric Helicobacter immunology and vaccine studies. FEMS Immunol. Med. Microbiol. 24:243-250.
67. Nisht, N., H. Shoji, M. Seki, A. Itoh, H. Miyanaka, K. Yuube, M. Hirashima, and T. Nakamura. 2003. Galectin-8 modulates neutrophil function via interaction with integrin αM. Glycobiology 13:755-763.
68. Parsonnet, J., G. D. Friedman, D. P. Vandersteen, Y. Chang, J. H. Vogelman, N. Orentreich, and R. K. Sibley. 1991. Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 325:1127-1131.
69. Passaro, D. J., E. J. Chosy, and J. Parsonnet. 2002. Helicobacter pylori: consensus and controversy. Clin. Infect. Dis. 35:298-304.
70. Peek, R. M., Jr. 2002. Helicobacter pylori strain-specific modulation of gastric mucosal cellular turnover: implications for carcinogenesis. J. Gastroenterol. 37(Suppl. 13):10-16.
71. Peek, R. M., Jr. 2001. Helicobacter pylori strain-specific activation of signal transduction cascades related to gastric inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G525-G530.
72. + Helicobacter pylori strains. Lab. Investig. 73:760-770.
73. + strains and dissociation of gastric epithelial cell proliferation from apoptosis. J. Natl. Cancer Inst. 89:863-868.
74. Pelletier, I., T. Hashidata, T. Urashima, N. Nishi, T. Nakamura, M. Futai, Y. Arata, K. I. Kasai, M. Hirashima, J. Hirabayashi, and S. Sato. 2003. Specific recognition of Leishmania major poly-beta-galactosyl epitopes by galectin-9: possible implication of galectin-9 in interaction between L. major and host cells. J. Biol. Chem. 278:22223-22230.
75. Philpott, D. J., D. Belaid, P. Troubadour, J. M. Thiberge, J. Tankovic, A. Labigne, and R. L. Ferrero. 2002. Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylori isolates. Cell. Microbiol. 4:285-296.
76. Piacentini, M., C. Evangelisti, P. G. Mastroberardino, R. Nardacci, and G. Kroemer. 2003. Does prothymosin-alpha act as molecular switch between apoptosis and autophagy? Cell Death Differ. 10:937-939.
77. Rachmilewitz, J., G. J, Riely, and M. L. Tykocinski. 1999. Placental protein 14 functions as a direct T-cell inhibitor. Cell. Immunol. 191:26-33.
78. Sallenave, J. M. 2002. Antimicrobial activity of antiproteinases. Biochem. Soc. Trans. 30:111-115.
79. Segal, E. D., J. Cha, J. Lo, S. Falkow, and L. S. Tompkins. 1999. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc. Natl. Acad. Sci. USA 96:14559-14564.
80. Segal, E. D., S. Falkow, and L. S. Tompkins. 1996. Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins. Proc. Natl. Acad. Sci. USA 93:1259-1264.
81. Sepulveda, A. R., H. Tao, E. Carloni, J. Sepulveda, D. Y. Graham, and L. E. Peterson. 2002. Screening of gene expression profiles in gastric epithelial cells induced by Helicobacter pylori using microarray analysis. Aliment. Pharmacol. Ther. 16(Suppl. 2):145-157.
82. Shimoyama, T., S. Fukuda, M. Tanaka, T. Mikami, A. Munakata, and J. E. Crabtree. 1998. CagA seropositivity associated with development of gastric cancer in a Japanese population. J. Clin. Pathol. 51:225-228.
83. Slomiany, B. L., and A. Slomiany. 2001. Role of ERK and p38 mitogen-activated protein kinase cascades in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. IUBMB Life 51:315-320.
84. Solnick, J, V., L. M. Hansen, N. K. Salama, J. K. Boonjakuakul, and M. Syvanen. 2004. Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Proc. Natl. Acad. Sci. USA 101:2106-2111.
85. Solnick, J. V., D. R. Canfield, S. Vang, and J. Personnel. 1999. Rhesus monkey (Macaca mulatto) model of Helicobacter pylori: noninvasive detection and derivation of specific-pathogen-free monkeys. Lab. Anim. Sci. 49:197-201.
86. Solnick, J. V., L. M. Hansen, D. R. Canfield, and J. Parsonnet. 2001. Determination of the infectious dose of Helicobacter pylori during primary and secondary infection in rhesus monkeys (Macaca mulatto). Infect. Immun. 69:6887-6892.
87. Song, H. H., and J. Filmus. 2002. The role of glypicans in mammalian development. Biochim. Biophys. Acta 1573:241-246.
88. Srivastava, P. 2002. Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2:185-194.
89. Syder, A. J., J. D. Oh, J. L. Gurnge, D. O'Donnell, M. Karlsson, J. C. Mills, B. M. Bjorkholm, and J. I. Gordon. 2003. The impact of parietal cells on Helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice. Proc. Natl. Acad. Sci. USA 100:3467-3472.
90. Telford, J. L., P. Ghiara, M. Dell'Orco, M. Comanducci, D. Burroni, M. Bugnoli, M. F. Tecce, S. Censini, A. Covacci, Z. Xiang, et al. 1994. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J. Exp. Med. 179:1653-1658.
91. Todryk, S. M., M. J. Gough, and A. G. Pockley. 2003. Facets of heat shock protein 70 show immunotherapeutic potential. Immunology 110:1-9.
92. Uehara, N., A. Yagihashi, K. Kondoh, N. Tsuji, T. Fujita, H. Haraada, and N. Watanabe, 2003. Human beta-defensin-2 induction in Helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpression. J. Med. Microbiol. 52:41-45.
93. Uemura, N., S. Okamoto, S. Yamamoto, N. Matsumura, S. Yamaguchi, M. Yamakido, K. Taniyama, N. Sasaki, and R. J. Schlemper. 2001. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345:784-789.
94. Van De Bovenkamp, J. H., J. Mahdavi, A. M. Korteland-Van Male, H. A. Buller, A. W. Einerhand, T. Boren, and J. Dekker. 2003. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. Helicobacter 8:521-532.
95. Wehkamp, J., K. Schmidt, K. R. Herrlinger, S. Baxmann, S. Behling, C. Wohlschlager, A. C. Feller, E. F. Stange, and K. Fellermann. 2003. Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status. J. Clin. Pathol. 56:352-357.
96. Wen, S., C. P. Felley, H. Bouzourene, M. Reimers, P. Michetti, and Q. Pan-Haramarstrom. 2004. Inflammatory gene profiles in gastric mucosa during Helicobacter pylori infection in humans. J. Immunol. 172:2595-2606.
97. Wright, G. W., and R. M. Simon. 2003. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19:2448-2455.
98. Yoshida, N., T. Ishikawa, E. Ichiishi, Y. Yoshida, K. Hanashiro, M. Kuchide, K. Uchiyama, S. Kokura, H. Ichikawa, Y. Naito, Y. Yamamura, T. Okanoue, and T. Yoshikawa. 2003. The effect of rebamipide on Helicobacter pylori extract-mediated changes of gene expression in gastric epithelial cells. Aliment. Pharmacol. Ther. 18(Suppl. 1):63-75.
99. Yoshimura. T., T. Tomita, M. F. Dixon, A. T. Axon, P. A. Robinson, and J. E. Crabtree. 2002. ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. J. Infect. Dis. 185:332-340.
100. Yu, Q., and I. Stamenkovic. 2000. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 14:163-176.
101. Zheng, P. Y., and N. L. Jones. 2003. Helicobacter pylori strains expressing the vacuolating cytotoxin interrupt phagosome maturation in macrophages by recruiting and retaining TACO (coronin 1) protein. Cell. Microbiol. 5:25-40.
102. Zhu, Z., H. Friess, J. Kleeff, L. Wang, M. Wirtz, A. Zimmermann, M. Korc, and M. W. Buchler. 2002. Glypican-3 expression is markedly decreased in human gastric cancer but not in esophageal cancer. Am. J. Surg. 184:78-83.
103. Zick, Y., M. Eisenstein, R. A. Goren, Y. R. Hadari, Y. Levy, and D. Ronen. 2004. Role of galectin-8 as a modulator of cell adhesion and cell growth. Glycoconj. J. 19:517-526.
104. Zou, J., S. Young, F. Zhu, F. Gheyas, S. Skeans, Y. Wan, L. Wang, W. Ding, M. Billah, T. McClanahan, R. L. Coffman, R. Egan, and S. Umland. 2002. Microarray profile of differentially expressed genes in a monkey model of allergic asthma. Genome Biol. 3:research0020.