Inflammatory Gene Profiles in Gastric Mucosa during Helicobacter pylori Infection in Humans

Journal of Immunology

Volumn 172, Issue 4, 2004, Pages 2595-2606

  Wen, Sicheng ^a   Felley, Christian P ^c   Bouzourene, Hanifa ^c   Reimers, Mark ^b   Michetti, Pierre ^c   Pan Hammarström, Qiang ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; ALPHA INTEGRIN; BETA2 INTEGRIN; BETA7 INTEGRIN; CAGA PROTEIN; CELL ADHESION MOLECULE; CHEMOATTRACTANT; CHEMOKINE; COMPLEMENT RECEPTOR; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 16; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; RNA 16S; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VACUOLATING TOXIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GASTRITIS; GENE EXPRESSION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; MALE; MALIGNANT TRANSFORMATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STOMACH BIOPSY; STOMACH EPITHELIUM; STOMACH MUCOSA; UNINDEXED SEQUENCE;

HELICOBACTER PYLORI;

EID: 0842278633     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.4.2595     Document Type: Article

References (58)

1. Parsonnet, J., G. D. Friedman, D. P. Vandersteen, Y. Chang, J. H. Vogelman, N. Orentreich, and R. K. Sibley. 1991. Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 325:1127.
2. The EUROGAST Study Group. 1993. An international association between Helicobacter pylori infection and gastric cancer. Lancet 341:13-59.
3. Xiang, Z., S. Censini, P. F. Bayeli, J. L. Telford, N. Figura, R. Rappuoli, and A. Covacci. 1995. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect. Immun. 63:94.
4. van Doorn, I. J., C. Figueiredo, R. Sanna, A. Plaisier, P. Schneeberger, W. de Boer, and W. Quint. 1998. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology 115:58.
5. Ilver, D., A. Arnqvist, J. Ogren, I. M. Frick, D. Kersulyte, E. T. Incecik, D. E. Berg, A. Covacci, L. Engstrand, and T. Boren. 1998. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 279:373.
6. Prinz, C., M. Schoniger, R. Rad, I. Becker, E. Keiditsch, S. Wagenpfeil, M. Classen, T. Rosch, W. Schepp, and M. Gerhard. 2001. Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. Cancer Res. 61:1903.
7. Mahdavi, J., B. Sonden, M. Hurtig, F. O. Olfat, L. Forsberg, N. Roche, J. Angstrom, T. Larsson, S. Teneberg, K. A. Karlsson, et al. 2002. Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 297:573.
8. Perez-Perez, G. I., B. M. Dworkin, J. E. Chodos, and M. J. Blaser. 1988. Campylobacter pylori antibodies in humans. Ann. Intern. Med. 109:11.
9. Crabtree, J. E., T. M. Shallcross, J. I. Wyatt, J. D. Taylor, R. V. Heatley, B. J. Rathbone, and M. S. Losowsky. 1991. Mucosal humoral immune response to Helicobacter pylori in patients with duodenitis. Dig. Dis. Sci. 36:1266.
10. Crabtree, J. E., J. D. Taylor, J. I. Wyatt, R. V. Heatley, T. M. Shallcross, D. S. Tompkins, and B. J. Rathbone. 1991. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 338:332.
11. Tosi, M. F., and S. J. Czinn. 1990. Opsonic activity of specific human IgG against Helicobacter pylori. J. Infect. Dis. 162:156.
12. Negrini, R., L. Lisato, I. Zanella, L. Cavazzini, S. Gullini, V. Villanacci, C. Poiesi, A. Albertini, and S. Ghielmi. 1991. Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa. Gastroenterology 101:437.
13. Negrini, R., A. Savio, and B. J. Appelmelk. 1997. Autoantibodies to gastric mucosa in Helicobacter pylori infection. Helicobacter 2(Suppl. 1):S13.
14. Negrini, R., A. Savio, C. Poiesi, B. J. Appelmelk, F. Buffoli, A. Paterlini, P. Cesari, M. Graffeo, D. Vaira, and G. Franzin. 1996. Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology 111:655.
15. Bamford, K. B., X. Fan, S. E. Crowe, J. F. Leary, W. K. Gourley, G. K. Luthra, E. G. Brooks, D. Y. Graham, V. E. Reyes, and P. B. Ernst. 1998. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 114:482.
16. D'Elios, M. M., M. Manghetti, M. De Carli, F. Costa, C. T. Baldari, D. Burroni, J. L. Telford, S. Romagnani, and G. Del Prete. 1997. T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J. Immunol. 158:962.
17. + lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype. Infect. Immun. 66:5543.
18. Tomita, T., A. M. Jackson, N. Hida, M. Hayat, M. F. Dixon, T. Shimoyama, A. T. Axon, P. A. Robinson, and J. E. Crabtree. 2001. Expression of interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection. J. Infect. Dis. 183:620.
19. Wang, J., E. G. Brooks, K. B. Bamford, T. L. Denning, J. Pappo, and P. B. Ernst. 2001. Negative selection of T cells by Helicobacter pylori as a model for bacterial strain selection by immune evasion. J. Immunol. 167:926.
20. Suerbaum, S., and P. Michetti. 2002. Helicobacter pylori infection. N. Engl. J. Med. 347:1175.
21. El-Omar, E. M., M. Carrington, W. H. Chow, K. E. McColl, J. H. Bream, H. A. Young, J. Herrera, J. Lissowska, C. C. Yuan, N. Rothman, et al. 2000. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404:398.
22. Thye, T., G. D. Burchard, M. Nilius, B. Muller-Myhsok, and R. D. Horstmann. 2003. Genomewide linkage analysis identifies polymorphism in the human interferon-γ receptor affecting Helicobacter pylori infection. Am. J. Hum. Genet. 72:448.
23. Ibraghimov, A., and J. Pappo. 2000. The immune response against Helicobacter pylori - a direct linkage to the development of gastroduodenal disease. Microbes Infect. 2:1073.
24. Dixon, M. F., R. M. Genta, J. H. Yardley, and P. Correa. 1996. Classification and grading of gastritis: the updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994. Am. J. Surg. Pathol. 20:1161.
25. Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95:14863.
26. Chiou, C. C., C. C. Chan, D. L. Sheu, K. T. Chen, Y. S. Li, and E. C. Chan. 2001. Helicobacter pylori infection induced alteration of gene expression in human gastric cells. Gut 48:598.
27. Cox, J. M., C. L. Clayton, T. Tomita, D. M. Wallace, P. A. Robinson, and J. E. Crabtree. 2001. cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes. Infect. Immun. 69:6970.
28. Maeda, S., M. Otsuka, Y. Hirata, Y. Mitsuno, H. Yoshida, Y. Shiratori, Y. Masuho, M. Muramatsu, N. Seki, and M. Omata. 2001. cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells. Biochem. Biophys. Res. Commun. 284:443.
29. Bach, S., A. Makristathis, M. Rotter, and A. M. Hirschl. 2002. Gene expression profiling in AGS cells stimulated with Helicobacter pylori isogenic strains (cagA positive or cagA negative). Infect. Immun. 70:988.
30. Guillemin, K., N. R. Salama, L. S. Tompkins, and S. Falkow. 2002. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. Proc. Natl. Acad. Sci. USA 99:15136.
31. Akira, S. 2003. Mammalian Toll-like receptors. Curr. Opin. Immunol. 15:5.
32. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335.
33. Asahi, M., T. Azuma, S. Ito, Y. Ito, H. Suto, Y. Nagai, M. Tsubokawa, Y. Tohyama, S. Maeda, M. Omata, et al. 2000. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J. Exp. Med. 191:593.
34. Muotiala, A., I. M. Helander, L. Pyhala, T. U. Kosunen, and A. P. Moran. 1992. Low biological activity of Helicobacter pylori lipopolysaccharide. Infect. Immun. 60:1714.
35. Perez-Perez, G. I., V. L. Shepherd, J. D. Morrow, and M. J. Blaser. 1995. Activation of human THP-1 cells and rat bone marrow-derived macrophages by Helicobacter pylori lipopolysaccharide. Infect. Immun. 63:1183.
36. Bäckhed, F., B. Rokbi, E. Torstensson, Y. Zhao, C. Nilsson, D. Seguin, S. Normark, A. M. Buchan, and A. Richter-Dahlfors. 2003. Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4. J. Infect. Dis. 187:829.
37. Maeda, S., M. Akanuma, Y. Mitsuno, Y. Hirata, K. Ogura, H. Yoshida, Y. Shiratori, and M. Omata. 2001. Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells. J. Biol. Chem. 276:44856.
38. Aguila, A., A. G. Herrera, D. Morrison, B. Cosgrove, A. Perojo, I. Montesinos, J. Perez, G. Sierra, C. G. Gemmell, and J. H. Brock. 2001. Bacteriostatic activity of human lactoferrin against Staphylococcus aureus is a function of its iron-binding properties and is not influenced by antibiotic resistance. FEMS Immunol. Med. Microbiol. 31:145.
39. Guillen, C., I. B. McInnes, D. M. Vaughan, S. Kommajosyula, P. H. Van Berkel, B. P. Leung, A. Aguila, and J. H. Brock. 2002. Enhanced Th1 response to Staphylococcus aureus infection in human lactoferrin-transgenic mice. J. Immunol. 168:3950.
40. Weinberg, E. D. 2001. Human lactoferrin: a novel therapeutic with broad spectrum potential. J. Pharm. Pharmacol. 53:1303.
41. Shimoyama, T., S. M. Everett, M. F. Dixon, A. T. Axon, and J. E. Crabtree. 1998. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J. Clin. Pathol. 51:765.
42. Mazzucchelli, L., A. Blaser, A. Kappeler, P. Scharli, J. A. Laissue, M. Baggiolini, and M. Uguccioni. 1999. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J. Clin. Invest. 104:R49.
43. Innocenti, M., A. M. Svennerholm, and M. Quiding-Jarbrink. 2001. Helicobacter pylori lipopolysaccharides preferentially induce CXC chemokine production in human monocytes. Infect. Immun. 69:3800.
44. Adema, G. J., F. Hartgers, R. Verstraten, E. de Vries, G. Marland, S. Menon, J. Foster, Y. Xu, P. Nooyen, T. McClanahan, et al. 1997. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 387:713.
45. Liao, F., R. L. Rabin, C. S. Smith, G. Sharma, T. B. Nutman, and J. M. Farber. 1999. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3α. J. Immunol. 162:186.
46. Kwon, J. H., S. Keates, L. Bassani, L. F. Mayer, and A. C. Keates. 2002. Colonic epithelial cells are a major site of macrophage inflammatory protein 3α (MIP-3α) production in normal colon and inflammatory bowel disease. Gut 51:818.
47. Hatanaka, K., R. Hokari, K. Matsuzaki, S. Kato, A. Kawaguchi, S. Nagao, H. Suzuki, K. Miyazaki, E. Sekizuka, H. Nagata, et al. 2002. Increased expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and lymphocyte recruitment in murine gastritis induced by Helicobacter pylori. Clin. Exp. Immunol. 130:183.
48. Petalidis, L., S. Bhattacharyya, G. A. Morris, V. P. Collins, T. C. Freeman, and P. A. Lyons. 2003. Global amplification of mRNA by template-switching PCR: linearity and application to microarray analysis. Nucleic Acids Res. 31:E142.
49. Liang, L., and W. C. Sha. 2002. The right place at the right time: novel B7 family members regulate effector T cell responses. Curr. Opin. Immunol. 14:384.
50. Okazaki, T., Y. Iwai, and T. Honjo. 2002. New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 14:779.
51. Porter, L. A., I. H. Cukier, and J. M. Lee. 2003. Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis. Blood 101:1928.
52. Banerjee, S. K., A. P. Weston, M. N. Zoubine, D. R. Campbell, and R. Cherian. 2000. Expression of cdc2 and cyclin B1 in Helicobacter pylori-associated gastric MALT and MALT lymphoma: relationship to cell death, proliferation, and transformation. Am. J. Pathol. 156:217.
53. Brinckerhoff, C. E., and L. M. Matrisian. 2002. Matrix metalloproteinases: a tail of a frog that became a prince. Nat. Rev. Mol. Cell. Biol. 3:207.
54. Menges, M., C. C. Chan, M. Zeitz, and A. Stallmach. 2000. Higher concentration of matrix-metalloproteinase 1 (interstitial collagenase) in H. pylori-compared to NSAID-induced gastric ulcers. Z. Gastroenterol. 38:887.
55. Yokoyama, T., Y. Otani, N. Kurihara, Y. Sakurai, K. Kameyama, H. Suzuki, N. Igarashi, M. Kimata, N. Wada, T. Kubota, et al. 2000. Matrix metalloproteinase expression in cultured human gastric wall fibroblasts-interactions with Helicobacter pylori isolated from patients with ulcers. Aliment. Pharmacol. Ther. 14(Suppl. 1):193.
56. Bass, R., A. M. Fernandez, and V. Ellis. 2002. Maspin inhibits cell migration in the absence of protease inhibitory activity. J. Biol. Chem. 277:46845.
57. Son, H. J., T. S. Sohn, S. Y. Song, J. H. Lee, and J. C. Rhee. 2002. Maspin expression in human gastric adenocarcinoma. Pathol. Int. 52:508.
58. Atherton, J. C., P. Cao, R. M. Peek, Jr., M. K. Tummuru, M. J. Blaser, and T. L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 270:17771.