-
1
-
-
0033806822
-
Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival
-
Sze D.M., Toellner K.M., Garcia de Vinuesa C., Taylor D.R., and MacLennan I.C. Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival. J Exp Med 192 (2000) 813-821
-
(2000)
J Exp Med
, vol.192
, pp. 813-821
-
-
Sze, D.M.1
Toellner, K.M.2
Garcia de Vinuesa, C.3
Taylor, D.R.4
MacLennan, I.C.5
-
2
-
-
23444459544
-
Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
-
Turner Jr. C.A., Mack D.H., and Davis M.M. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77 (1994) 297-306
-
(1994)
Cell
, vol.77
, pp. 297-306
-
-
Turner Jr., C.A.1
Mack, D.H.2
Davis, M.M.3
-
3
-
-
0038675136
-
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response
-
Iwakoshi N.N., Lee A.H., and Glimcher L.H. The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev 194 (2003) 29-38
-
(2003)
Immunol Rev
, vol.194
, pp. 29-38
-
-
Iwakoshi, N.N.1
Lee, A.H.2
Glimcher, L.H.3
-
4
-
-
0037385313
-
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
-
This study nicely demonstrates that the expression of an XBP-1 splicing variant is linked with full plasma cells commitment but also importantly with a very unique capacity of plasma cells to handle the enormously enhanced metabolic/mitochondrial stress induced by immunoglobulin production.
-
Iwakoshi N.N., Lee A.H., Vallabhajosyula P., Otipoby K.L., Rajewsky K., and Glimcher L.H. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 4 (2003) 321-329. This study nicely demonstrates that the expression of an XBP-1 splicing variant is linked with full plasma cells commitment but also importantly with a very unique capacity of plasma cells to handle the enormously enhanced metabolic/mitochondrial stress induced by immunoglobulin production.
-
(2003)
Nat Immunol
, vol.4
, pp. 321-329
-
-
Iwakoshi, N.N.1
Lee, A.H.2
Vallabhajosyula, P.3
Otipoby, K.L.4
Rajewsky, K.5
Glimcher, L.H.6
-
5
-
-
3142658576
-
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
-
Shaffer A.L., Shapiro-Shelef M., Iwakoshi N.N., Lee A.H., Qian S.B., Zhao H., Yu X., Yang L., Tan B.K., Rosenwald A., et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21 (2004) 81-93
-
(2004)
Immunity
, vol.21
, pp. 81-93
-
-
Shaffer, A.L.1
Shapiro-Shelef, M.2
Iwakoshi, N.N.3
Lee, A.H.4
Qian, S.B.5
Zhao, H.6
Yu, X.7
Yang, L.8
Tan, B.K.9
Rosenwald, A.10
-
6
-
-
0142219442
-
Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
-
Shapiro-Shelef M., Lin K.I., McHeyzer-Williams L.J., Liao J., McHeyzer-Williams M.G., and Calame K. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19 (2003) 607-620
-
(2003)
Immunity
, vol.19
, pp. 607-620
-
-
Shapiro-Shelef, M.1
Lin, K.I.2
McHeyzer-Williams, L.J.3
Liao, J.4
McHeyzer-Williams, M.G.5
Calame, K.6
-
7
-
-
14944362858
-
Regulation of plasma-cell development
-
Shapiro-Shelef M., and Calame K. Regulation of plasma-cell development. Nat Rev Immunol 5 (2005) 230-242
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 230-242
-
-
Shapiro-Shelef, M.1
Calame, K.2
-
8
-
-
34248543774
-
Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1
-
-/- mice reconstituted with Prdm1 mutant fetal liver lack a defined plasma-cell compartment. However, detectable amounts of immunoglobulin were found. As a result, Blimp-1-independent differentiation occurs at a preplasmablast level, and early stages before Blimp-1 expression appeared to be initialized by Pax5 inhibition. These data support that plasmablast/plasma-cell subsets follow a specific differentiation path that is under control of distinct transcription factors. How this is clearly linked to phenotypic characteristics is unknown.
-
-/- mice reconstituted with Prdm1 mutant fetal liver lack a defined plasma-cell compartment. However, detectable amounts of immunoglobulin were found. As a result, Blimp-1-independent differentiation occurs at a preplasmablast level, and early stages before Blimp-1 expression appeared to be initialized by Pax5 inhibition. These data support that plasmablast/plasma-cell subsets follow a specific differentiation path that is under control of distinct transcription factors. How this is clearly linked to phenotypic characteristics is unknown.
-
(2007)
Immunity
, vol.26
, pp. 555-566
-
-
Kallies, A.1
Hasbold, J.2
Fairfax, K.3
Pridans, C.4
Emslie, D.5
McKenzie, B.S.6
Lew, A.M.7
Corcoran, L.M.8
Hodgkin, P.D.9
Tarlinton, D.M.10
-
9
-
-
33745182931
-
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
-
Klein U., Casola S., Cattoretti G., Shen Q., Lia M., Mo T., Ludwig T., Rajewsky K., and Dalla-Favera R. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol 7 (2006) 773-782
-
(2006)
Nat Immunol
, vol.7
, pp. 773-782
-
-
Klein, U.1
Casola, S.2
Cattoretti, G.3
Shen, Q.4
Lia, M.5
Mo, T.6
Ludwig, T.7
Rajewsky, K.8
Dalla-Favera, R.9
-
10
-
-
33747133955
-
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
-
Sciammas R., Shaffer A.L., Schatz J.H., Zhao H., Staudt L.M., and Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25 (2006) 225-236
-
(2006)
Immunity
, vol.25
, pp. 225-236
-
-
Sciammas, R.1
Shaffer, A.L.2
Schatz, J.H.3
Zhao, H.4
Staudt, L.M.5
Singh, H.6
-
11
-
-
33846635838
-
Imaging of germinal center selection events during affinity maturation
-
This report contains beautiful in vivo imaging of germinal center dynamics, clarifying many aspects of the cellular dynamics of this process. Also highlighted the possibly key role of the T cell B cell interaction as the mediator of selection that drives affinity maturation. That is, B cells may be competing for access to limited T cell help rather than for limiting antigen on follicular dendritic cells.
-
Allen C.D., Okada T., Tang H.L., and Cyster J.G. Imaging of germinal center selection events during affinity maturation. Science 315 (2007) 528-531. This report contains beautiful in vivo imaging of germinal center dynamics, clarifying many aspects of the cellular dynamics of this process. Also highlighted the possibly key role of the T cell B cell interaction as the mediator of selection that drives affinity maturation. That is, B cells may be competing for access to limited T cell help rather than for limiting antigen on follicular dendritic cells.
-
(2007)
Science
, vol.315
, pp. 528-531
-
-
Allen, C.D.1
Okada, T.2
Tang, H.L.3
Cyster, J.G.4
-
12
-
-
34548036949
-
Germinal-center organization and cellular dynamics
-
Allen C.D., Okada T., and Cyster J.G. Germinal-center organization and cellular dynamics. Immunity 27 (2007) 190-202
-
(2007)
Immunity
, vol.27
, pp. 190-202
-
-
Allen, C.D.1
Okada, T.2
Cyster, J.G.3
-
13
-
-
0030763072
-
Disruption of the Bcl6 gene results in an impaired germinal center formation
-
Fukuda T., Yoshida T., Okada S., Hatano M., Miki T., Ishibashi K., Okabe S., Koseki H., Hirosawa S., Taniguchi M., et al. Disruption of the Bcl6 gene results in an impaired germinal center formation. J Exp Med 186 (1997) 439-448
-
(1997)
J Exp Med
, vol.186
, pp. 439-448
-
-
Fukuda, T.1
Yoshida, T.2
Okada, S.3
Hatano, M.4
Miki, T.5
Ishibashi, K.6
Okabe, S.7
Koseki, H.8
Hirosawa, S.9
Taniguchi, M.10
-
14
-
-
34250762588
-
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
-
This paper describes the other half of Bcl6's activities in the germinal center, showing how it suppresses aspects of the DNA damage response. Interesting also in that this repression is relieved by CD40 stimulation, consistent with a cyclic reappraisal of a centroblasts progress at around the same time at which choices of differentiation may also be being made.
-
Ranuncolo S.M., Polo J.M., Dierov J., Singer M., Kuo T., Greally J., Green R., Carroll M., and Melnick A. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nat Immunol 8 (2007) 705-714. This paper describes the other half of Bcl6's activities in the germinal center, showing how it suppresses aspects of the DNA damage response. Interesting also in that this repression is relieved by CD40 stimulation, consistent with a cyclic reappraisal of a centroblasts progress at around the same time at which choices of differentiation may also be being made.
-
(2007)
Nat Immunol
, vol.8
, pp. 705-714
-
-
Ranuncolo, S.M.1
Polo, J.M.2
Dierov, J.3
Singer, M.4
Kuo, T.5
Greally, J.6
Green, R.7
Carroll, M.8
Melnick, A.9
-
15
-
-
27144462049
-
BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells
-
Phan R.T., Saito M., Basso K., Niu H., and Dalla-Favera R. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat Immunol 6 (2005) 1054-1060
-
(2005)
Nat Immunol
, vol.6
, pp. 1054-1060
-
-
Phan, R.T.1
Saito, M.2
Basso, K.3
Niu, H.4
Dalla-Favera, R.5
-
16
-
-
34548706562
-
Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells
-
Phan R.T., Saito M., Kitagawa Y., Means A.R., and Dalla-Favera R. Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. Nat Immunol 8 (2007) 1132-1139
-
(2007)
Nat Immunol
, vol.8
, pp. 1132-1139
-
-
Phan, R.T.1
Saito, M.2
Kitagawa, Y.3
Means, A.R.4
Dalla-Favera, R.5
-
17
-
-
33750839981
-
Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance
-
What should be an influential paper showing how the complex transcriptional program thought to regulate germinal center B cell differentiation can be unravelled. This paper took the approach of immunohistology to determine transcription factor expression at the single cell level that retained positional information. While many of the outcomes may have been predicted this represents an attempt at a systematic cataloguing of the location and level of the key factors regulating the production of memory and plasma cells.
-
Cattoretti G., Shaknovich R., Smith P.M., Jack H.M., Murty V.V., and Alobeid B. Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance. J Immunol 177 (2006) 6930-6939. What should be an influential paper showing how the complex transcriptional program thought to regulate germinal center B cell differentiation can be unravelled. This paper took the approach of immunohistology to determine transcription factor expression at the single cell level that retained positional information. While many of the outcomes may have been predicted this represents an attempt at a systematic cataloguing of the location and level of the key factors regulating the production of memory and plasma cells.
-
(2006)
J Immunol
, vol.177
, pp. 6930-6939
-
-
Cattoretti, G.1
Shaknovich, R.2
Smith, P.M.3
Jack, H.M.4
Murty, V.V.5
Alobeid, B.6
-
18
-
-
20144369616
-
STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression
-
While mostly in vitro, this paper describes a subset of germinal center B cell in human tonsil that express active STAT5 and which have properties suggesting they may operate as a precursor for the memory cells that are eventually produced. Provides a possible link between external signals in the germinal center and the activation of Bcl6 within centrocytes.
-
Scheeren F.A., Naspetti M., Diehl S., Schotte R., Nagasawa M., Wijnands E., Gimeno R., Vyth-Dreese F.A., Blom B., and Spits H. STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat Immunol 6 (2005) 303-313. While mostly in vitro, this paper describes a subset of germinal center B cell in human tonsil that express active STAT5 and which have properties suggesting they may operate as a precursor for the memory cells that are eventually produced. Provides a possible link between external signals in the germinal center and the activation of Bcl6 within centrocytes.
-
(2005)
Nat Immunol
, vol.6
, pp. 303-313
-
-
Scheeren, F.A.1
Naspetti, M.2
Diehl, S.3
Schotte, R.4
Nagasawa, M.5
Wijnands, E.6
Gimeno, R.7
Vyth-Dreese, F.A.8
Blom, B.9
Spits, H.10
-
19
-
-
33846187999
-
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
-
Walker S.R., Nelson E.A., and Frank D.A. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene 26 (2007) 224-233
-
(2007)
Oncogene
, vol.26
, pp. 224-233
-
-
Walker, S.R.1
Nelson, E.A.2
Frank, D.A.3
-
20
-
-
33745273911
-
JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells
-
Arguni E., Arima M., Tsuruoka N., Sakamoto A., Hatano M., and Tokuhisa T. JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells. Int Immunol 18 (2006) 1079-1089
-
(2006)
Int Immunol
, vol.18
, pp. 1079-1089
-
-
Arguni, E.1
Arima, M.2
Tsuruoka, N.3
Sakamoto, A.4
Hatano, M.5
Tokuhisa, T.6
-
21
-
-
27744498868
-
Follicular B helper T cells in antibody responses and autoimmunity
-
Vinuesa C.G., Tangye S.G., Moser B., and Mackay C.R. Follicular B helper T cells in antibody responses and autoimmunity. Nat Rev Immunol 5 (2005) 853-865
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 853-865
-
-
Vinuesa, C.G.1
Tangye, S.G.2
Moser, B.3
Mackay, C.R.4
-
22
-
-
0034684672
-
Suppression of signal transducer and activator of transcription 3- dependent B lymphocyte terminal differentiation by BCL-6
-
Reljic R., Wagner S.D., Peakman L.J., and Fearon D.T. Suppression of signal transducer and activator of transcription 3- dependent B lymphocyte terminal differentiation by BCL-6. J Exp Med 192 (2000) 1841-1848
-
(2000)
J Exp Med
, vol.192
, pp. 1841-1848
-
-
Reljic, R.1
Wagner, S.D.2
Peakman, L.J.3
Fearon, D.T.4
-
23
-
-
31544474862
-
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
-
Fornek J.L., Tygrett L.T., Waldschmidt T.J., Poli V., Rickert R.C., and Kansas G.S. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood 107 (2006) 1085-1091
-
(2006)
Blood
, vol.107
, pp. 1085-1091
-
-
Fornek, J.L.1
Tygrett, L.T.2
Waldschmidt, T.J.3
Poli, V.4
Rickert, R.C.5
Kansas, G.S.6
-
24
-
-
0030984830
-
BCL-6 is phosphorylated at multiple sites in its serine- and proline-clustered region by mitogen-activated protein kinase (MAPK) in vivo
-
Moriyama M., Yamochi T., Semba K., Akiyama T., and Mori S. BCL-6 is phosphorylated at multiple sites in its serine- and proline-clustered region by mitogen-activated protein kinase (MAPK) in vivo. Oncogene 14 (1997) 2465-2474
-
(1997)
Oncogene
, vol.14
, pp. 2465-2474
-
-
Moriyama, M.1
Yamochi, T.2
Semba, K.3
Akiyama, T.4
Mori, S.5
-
25
-
-
0032128002
-
Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor
-
Niu H., Ye B.H., and Dalla-Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev 12 (1998) 1953-1961
-
(1998)
Genes Dev
, vol.12
, pp. 1953-1961
-
-
Niu, H.1
Ye, B.H.2
Dalla-Favera, R.3
-
26
-
-
34548237299
-
A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma
-
This study shows how CD40 stimulation of B cells leads to the downregulation of BCL6 through the activity of IRF4, itself activated via NFkB. Nicely joins together several of the factors critical for germinal center formation, persistence and plasma cell differentiation. Furthermore, it suggests how the extent of T cell help may influence the outcome of the T-B cell interaction.
-
Saito M., Gao J., Basso K., Kitagawa Y., Smith P.M., Bhagat G., Pernis A., Pasqualucci L., and Dalla-Favera R. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 12 (2007) 280-292. This study shows how CD40 stimulation of B cells leads to the downregulation of BCL6 through the activity of IRF4, itself activated via NFkB. Nicely joins together several of the factors critical for germinal center formation, persistence and plasma cell differentiation. Furthermore, it suggests how the extent of T cell help may influence the outcome of the T-B cell interaction.
-
(2007)
Cancer Cell
, vol.12
, pp. 280-292
-
-
Saito, M.1
Gao, J.2
Basso, K.3
Kitagawa, Y.4
Smith, P.M.5
Bhagat, G.6
Pernis, A.7
Pasqualucci, L.8
Dalla-Favera, R.9
-
27
-
-
6344269331
-
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
-
Ozaki K., Spolski R., Ettinger R., Kim H.P., Wang G., Qi C.F., Hwu P., Shaffer D.J., Akilesh S., Roopenian D.C., et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 173 (2004) 5361-5371
-
(2004)
J Immunol
, vol.173
, pp. 5361-5371
-
-
Ozaki, K.1
Spolski, R.2
Ettinger, R.3
Kim, H.P.4
Wang, G.5
Qi, C.F.6
Hwu, P.7
Shaffer, D.J.8
Akilesh, S.9
Roopenian, D.C.10
-
28
-
-
0037159687
-
A critical role for IL-21 in regulating immunoglobulin production
-
Ozaki K., Spolski R., Feng C.G., Qi C.F., Cheng J., Sher A., Morse III H.C., Liu C., Schwartzberg P.L., and Leonard W.J. A critical role for IL-21 in regulating immunoglobulin production. Science 298 (2002) 1630-1634
-
(2002)
Science
, vol.298
, pp. 1630-1634
-
-
Ozaki, K.1
Spolski, R.2
Feng, C.G.3
Qi, C.F.4
Cheng, J.5
Sher, A.6
Morse III, H.C.7
Liu, C.8
Schwartzberg, P.L.9
Leonard, W.J.10
-
29
-
-
29144519767
-
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
-
Ettinger R., Sims G.P., Fairhurst A.M., Robbins R., da Silva Y.S., Spolski R., Leonard W.J., and Lipsky P.E. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 175 (2005) 7867-7879
-
(2005)
J Immunol
, vol.175
, pp. 7867-7879
-
-
Ettinger, R.1
Sims, G.P.2
Fairhurst, A.M.3
Robbins, R.4
da Silva, Y.S.5
Spolski, R.6
Leonard, W.J.7
Lipsky, P.E.8
-
30
-
-
33749531054
-
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
-
Good K.L., Bryant V.L., and Tangye S.G. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol 177 (2006) 5236-5247
-
(2006)
J Immunol
, vol.177
, pp. 5236-5247
-
-
Good, K.L.1
Bryant, V.L.2
Tangye, S.G.3
-
31
-
-
19344368745
-
Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
-
Cattoretti G., Pasqualucci L., Ballon G., Tam W., Nandula S.V., Shen Q., Mo T., Murty V.V., and Dalla-Favera R. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 7 (2005) 445-455
-
(2005)
Cancer Cell
, vol.7
, pp. 445-455
-
-
Cattoretti, G.1
Pasqualucci, L.2
Ballon, G.3
Tam, W.4
Nandula, S.V.5
Shen, Q.6
Mo, T.7
Murty, V.V.8
Dalla-Favera, R.9
-
32
-
-
34548393739
-
The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation
-
Jaye D.L., Iqbal J., Fujita N., Geigerman C.M., Li S., Karanam S., Fu K., Weisenburger D.D., Chan W.C., Moreno C.S., et al. The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. J Pathol 213 (2007) 106-115
-
(2007)
J Pathol
, vol.213
, pp. 106-115
-
-
Jaye, D.L.1
Iqbal, J.2
Fujita, N.3
Geigerman, C.M.4
Li, S.5
Karanam, S.6
Fu, K.7
Weisenburger, D.D.8
Chan, W.C.9
Moreno, C.S.10
-
33
-
-
5344280456
-
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation
-
Fujita N., Jaye D.L., Geigerman C., Akyildiz A., Mooney M.R., Boss J.M., and Wade P.A. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 119 (2004) 75-86
-
(2004)
Cell
, vol.119
, pp. 75-86
-
-
Fujita, N.1
Jaye, D.L.2
Geigerman, C.3
Akyildiz, A.4
Mooney, M.R.5
Boss, J.M.6
Wade, P.A.7
-
34
-
-
34548256410
-
BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms
-
Parekh S., Polo J.M., Shaknovich R., Juszczynski P., Lev P., Ranuncolo S.M., Yin Y., Klein U., Cattoretti G., Dalla Favera R., et al. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood 110 (2007) 2067-2074
-
(2007)
Blood
, vol.110
, pp. 2067-2074
-
-
Parekh, S.1
Polo, J.M.2
Shaknovich, R.3
Juszczynski, P.4
Lev, P.5
Ranuncolo, S.M.6
Yin, Y.7
Klein, U.8
Cattoretti, G.9
Dalla Favera, R.10
-
35
-
-
0038142387
-
A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
-
Bernasconi N.L., Onai N., and Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101 (2003) 4500-4504
-
(2003)
Blood
, vol.101
, pp. 4500-4504
-
-
Bernasconi, N.L.1
Onai, N.2
Lanzavecchia, A.3
-
36
-
-
0016811399
-
B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes
-
Kearney J.F., and Lawton A.R. B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes. J Immunol 115 (1975) 671-676
-
(1975)
J Immunol
, vol.115
, pp. 671-676
-
-
Kearney, J.F.1
Lawton, A.R.2
-
37
-
-
33947644970
-
Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene
-
Fairfax K.A., Corcoran L.M., Pridans C., Huntington N.D., Kallies A., Nutt S.L., and Tarlinton D.M. Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene. J Immunol 178 (2007) 4104-4111
-
(2007)
J Immunol
, vol.178
, pp. 4104-4111
-
-
Fairfax, K.A.1
Corcoran, L.M.2
Pridans, C.3
Huntington, N.D.4
Kallies, A.5
Nutt, S.L.6
Tarlinton, D.M.7
-
38
-
-
34250192856
-
TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
-
Genestier L., Taillardet M., Mondiere P., Gheit H., Bella C., and Defrance T. TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J Immunol 178 (2007) 7779-7786
-
(2007)
J Immunol
, vol.178
, pp. 7779-7786
-
-
Genestier, L.1
Taillardet, M.2
Mondiere, P.3
Gheit, H.4
Bella, C.5
Defrance, T.6
-
39
-
-
0026584291
-
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
-
Rousset F., Garcia E., Defrance T., Peronne C., Vezzio N., Hsu D.H., Kastelein R., Moore K.W., and Banchereau J. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89 (1992) 1890-1893
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 1890-1893
-
-
Rousset, F.1
Garcia, E.2
Defrance, T.3
Peronne, C.4
Vezzio, N.5
Hsu, D.H.6
Kastelein, R.7
Moore, K.W.8
Banchereau, J.9
-
40
-
-
4644219817
-
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
-
Allen C.D., Ansel K.M., Low C., Lesley R., Tamamura H., Fujii N., and Cyster J.G. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol 5 (2004) 943-952
-
(2004)
Nat Immunol
, vol.5
, pp. 943-952
-
-
Allen, C.D.1
Ansel, K.M.2
Low, C.3
Lesley, R.4
Tamamura, H.5
Fujii, N.6
Cyster, J.G.7
-
41
-
-
2342575532
-
Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow
-
Ellyard J.I., Avery D.T., Phan T.G., Hare N.J., Hodgkin P.D., and Tangye S.G. Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow. Blood 103 (2004) 3805-3812
-
(2004)
Blood
, vol.103
, pp. 3805-3812
-
-
Ellyard, J.I.1
Avery, D.T.2
Phan, T.G.3
Hare, N.J.4
Hodgkin, P.D.5
Tangye, S.G.6
-
42
-
-
0035796411
-
A coordinated change in chemokine responsiveness guides plasma cell movements
-
Hargreaves D.C., Hyman P.L., Lu T.T., Ngo V.N., Bidgol A., Suzuki G., Zou Y.R., Littman D.R., and Cyster J.G. A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med 194 (2001) 45-56
-
(2001)
J Exp Med
, vol.194
, pp. 45-56
-
-
Hargreaves, D.C.1
Hyman, P.L.2
Lu, T.T.3
Ngo, V.N.4
Bidgol, A.5
Suzuki, G.6
Zou, Y.R.7
Littman, D.R.8
Cyster, J.G.9
-
43
-
-
0035108664
-
Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes
-
Wehrli N., Legler D.F., Finke D., Toellner K.M., Loetscher P., Baggiolini M., MacLennan I.C., and Acha-Orbea H. Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes. Eur J Immunol 31 (2001) 609-616
-
(2001)
Eur J Immunol
, vol.31
, pp. 609-616
-
-
Wehrli, N.1
Legler, D.F.2
Finke, D.3
Toellner, K.M.4
Loetscher, P.5
Baggiolini, M.6
MacLennan, I.C.7
Acha-Orbea, H.8
-
44
-
-
0032499260
-
Chemokines and leukocyte traffic
-
Baggiolini M. Chemokines and leukocyte traffic. Nature 392 (1998) 565-568
-
(1998)
Nature
, vol.392
, pp. 565-568
-
-
Baggiolini, M.1
-
46
-
-
20844450563
-
Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells
-
Muehlinghaus G., Cigliano L., Huehn S., Peddinghaus A., Leyendeckers H., Hauser A.E., Hiepe F., Radbruch A., Arce S., and Manz R.A. Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Blood 105 (2005) 3965-3971
-
(2005)
Blood
, vol.105
, pp. 3965-3971
-
-
Muehlinghaus, G.1
Cigliano, L.2
Huehn, S.3
Peddinghaus, A.4
Leyendeckers, H.5
Hauser, A.E.6
Hiepe, F.7
Radbruch, A.8
Arce, S.9
Manz, R.A.10
-
47
-
-
0031754923
-
Survival of long-lived plasma cells is independent of antigen
-
Manz R.A., Lohning M., Cassese G., Thiel A., and Radbruch A. Survival of long-lived plasma cells is independent of antigen. Int Immunol 10 (1998) 1703-1711
-
(1998)
Int Immunol
, vol.10
, pp. 1703-1711
-
-
Manz, R.A.1
Lohning, M.2
Cassese, G.3
Thiel, A.4
Radbruch, A.5
-
48
-
-
33745062526
-
Adaptation of humoral memory
-
Höfer T., Muehlinghaus G., Moser K., Yoshida T., Mei H.E., Hebel K., Hauser A., Hoyer B., Luger E.O., Dörner T., et al. Adaptation of humoral memory. Immunol Rev 211 (2006) 295-302
-
(2006)
Immunol Rev
, vol.211
, pp. 295-302
-
-
Höfer, T.1
Muehlinghaus, G.2
Moser, K.3
Yoshida, T.4
Mei, H.E.5
Hebel, K.6
Hauser, A.7
Hoyer, B.8
Luger, E.O.9
Dörner, T.10
-
49
-
-
0037073930
-
Maintenance of serological memory by polyclonal activation of human memory B cells
-
Bernasconi N.L., Traggiai E., and Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298 (2002) 2199-2202
-
(2002)
Science
, vol.298
, pp. 2199-2202
-
-
Bernasconi, N.L.1
Traggiai, E.2
Lanzavecchia, A.3
-
50
-
-
13544251387
-
Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response
-
Odendahl M., Mei H., Hoyer B.F., Jacobi A.M., Hansen A., Muehlinghaus G., Berek C., Hiepe F., Manz R., Radbruch A., et al. Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood 105 (2005) 1614-1621
-
(2005)
Blood
, vol.105
, pp. 1614-1621
-
-
Odendahl, M.1
Mei, H.2
Hoyer, B.F.3
Jacobi, A.M.4
Hansen, A.5
Muehlinghaus, G.6
Berek, C.7
Hiepe, F.8
Manz, R.9
Radbruch, A.10
-
51
-
-
0036681815
-
Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response
-
Hauser A.E., Debes G.F., Arce S., Cassese G., Hamann A., Radbruch A., and Manz R.A. Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J Immunol 169 (2002) 1277-1282
-
(2002)
J Immunol
, vol.169
, pp. 1277-1282
-
-
Hauser, A.E.1
Debes, G.F.2
Arce, S.3
Cassese, G.4
Hamann, A.5
Radbruch, A.6
Manz, R.A.7
-
52
-
-
33749018225
-
Competence and competition: the challenge of becoming a long-lived plasma cell
-
Radbruch A., Muehlinghaus G., Luger E.O., Inamine A., Smith K.G., Dorner T., and Hiepe F. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol 6 (2006) 741-750
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 741-750
-
-
Radbruch, A.1
Muehlinghaus, G.2
Luger, E.O.3
Inamine, A.4
Smith, K.G.5
Dorner, T.6
Hiepe, F.7
-
54
-
-
0042591464
-
Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals
-
In mice, a number of plasma cell survival factors, such as IL-6, TGF, TNF, GM-CSF and CXCL12 have been identified and characterized which likely contribute to the potential survival niche in the bone marrow but also at other anatomic sites during inflammation.
-
Cassese G., Arce S., Hauser A.E., Lehnert K., Moewes B., Mostarac M., Muehlinghaus G., Szyska M., Radbruch A., and Manz R.A. Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J Immunol 171 (2003) 1684-1690. In mice, a number of plasma cell survival factors, such as IL-6, TGF, TNF, GM-CSF and CXCL12 have been identified and characterized which likely contribute to the potential survival niche in the bone marrow but also at other anatomic sites during inflammation.
-
(2003)
J Immunol
, vol.171
, pp. 1684-1690
-
-
Cassese, G.1
Arce, S.2
Hauser, A.E.3
Lehnert, K.4
Moewes, B.5
Mostarac, M.6
Muehlinghaus, G.7
Szyska, M.8
Radbruch, A.9
Manz, R.A.10
-
55
-
-
14244257818
-
Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization
-
This study characterizes the timely role of the BCR affinity during an immune response having a central and apparently regulatory feedback role on plasma cell differentiation during an evolving immune response.
-
Blink E.J., Light A., Kallies A., Nutt S.L., Hodgkin P.D., and Tarlinton D.M. Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med 201 (2005) 545-554. This study characterizes the timely role of the BCR affinity during an immune response having a central and apparently regulatory feedback role on plasma cell differentiation during an evolving immune response.
-
(2005)
J Exp Med
, vol.201
, pp. 545-554
-
-
Blink, E.J.1
Light, A.2
Kallies, A.3
Nutt, S.L.4
Hodgkin, P.D.5
Tarlinton, D.M.6
-
56
-
-
0034700081
-
Protective long-term antibody memory by antigen-driven and T help- dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs
-
Ochsenbein A.F., Pinschewer D.D., Sierro S., Horvath E., Hengartner H., and Zinkernagel R.M. Protective long-term antibody memory by antigen-driven and T help- dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs. Proc Natl Acad Sci U S A 97 (2000) 13263-13268
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 13263-13268
-
-
Ochsenbein, A.F.1
Pinschewer, D.D.2
Sierro, S.3
Horvath, E.4
Hengartner, H.5
Zinkernagel, R.M.6
-
57
-
-
0030925491
-
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
-
Smith K.G., Light A., Nossal G.J., and Tarlinton D.M. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J 16 (1997) 2996-3006
-
(1997)
EMBO J
, vol.16
, pp. 2996-3006
-
-
Smith, K.G.1
Light, A.2
Nossal, G.J.3
Tarlinton, D.M.4
-
58
-
-
0034614896
-
bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
-
Smith K.G., Light A., O'Reilly L.A., Ang S.M., Strasser A., and Tarlinton D. bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J Exp Med 191 (2000) 475-484
-
(2000)
J Exp Med
, vol.191
, pp. 475-484
-
-
Smith, K.G.1
Light, A.2
O'Reilly, L.A.3
Ang, S.M.4
Strasser, A.5
Tarlinton, D.6
-
59
-
-
33750964016
-
B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles
-
Cambridge G., Leandro M.J., Teodorescu M., Manson J., Rahman A., Isenberg D.A., and Edwards J.C. B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles. Arthritis Rheum 54 (2006) 3612-3622
-
(2006)
Arthritis Rheum
, vol.54
, pp. 3612-3622
-
-
Cambridge, G.1
Leandro, M.J.2
Teodorescu, M.3
Manson, J.4
Rahman, A.5
Isenberg, D.A.6
Edwards, J.C.7
-
60
-
-
33845869839
-
Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE
-
Vallerskog T., Gunnarsson I., Widhe M., Risselada A., Klareskog L., van Vollenhoven R., Malmstrom V., and Trollmo C. Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE. Clin Immunol 122 (2007) 62-74
-
(2007)
Clin Immunol
, vol.122
, pp. 62-74
-
-
Vallerskog, T.1
Gunnarsson, I.2
Widhe, M.3
Risselada, A.4
Klareskog, L.5
van Vollenhoven, R.6
Malmstrom, V.7
Trollmo, C.8
-
61
-
-
0141796316
-
Duration of antiviral immunity after smallpox vaccination
-
Hammarlund E., Lewis M.W., Hansen S.G., Strelow L.I., Nelson J.A., Sexton G.J., Hanifin J.M., and Slifka M.K. Duration of antiviral immunity after smallpox vaccination. Nat Med 9 (2003) 1131-1137
-
(2003)
Nat Med
, vol.9
, pp. 1131-1137
-
-
Hammarlund, E.1
Lewis, M.W.2
Hansen, S.G.3
Strelow, L.I.4
Nelson, J.A.5
Sexton, G.J.6
Hanifin, J.M.7
Slifka, M.K.8
-
62
-
-
0347285357
-
BCMA is essential for the survival of long-lived bone marrow plasma cells
-
O'Connor B.P., Raman V.S., Erickson L.D., Cook W.J., Weaver L.K., Ahonen C., Lin L.L., Mantchev G.T., Bram R.J., and Noelle R.J. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med 199 (2004) 91-98
-
(2004)
J Exp Med
, vol.199
, pp. 91-98
-
-
O'Connor, B.P.1
Raman, V.S.2
Erickson, L.D.3
Cook, W.J.4
Weaver, L.K.5
Ahonen, C.6
Lin, L.L.7
Mantchev, G.T.8
Bram, R.J.9
Noelle, R.J.10
-
63
-
-
8644227902
-
The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity
-
Nie Y., Waite J., Brewer F., Sunshine M.J., Littman D.R., and Zou Y.R. The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med 200 (2004) 1145-1156
-
(2004)
J Exp Med
, vol.200
, pp. 1145-1156
-
-
Nie, Y.1
Waite, J.2
Brewer, F.3
Sunshine, M.J.4
Littman, D.R.5
Zou, Y.R.6
-
64
-
-
0037108354
-
The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity
-
Minges Wols H.A., Underhill G.H., Kansas G.S., and Witte P.L. The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity. J Immunol 169 (2002) 4213-4221
-
(2002)
J Immunol
, vol.169
, pp. 4213-4221
-
-
Minges Wols, H.A.1
Underhill, G.H.2
Kansas, G.S.3
Witte, P.L.4
-
65
-
-
33947575824
-
FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis
-
Xiang Z., Cutler A.J., Brownlie R.J., Fairfax K., Lawlor K.E., Severinson E., Walker E.U., Manz R.A., Tarlinton D.M., and Smith K.G. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol 8 (2007) 419-429
-
(2007)
Nat Immunol
, vol.8
, pp. 419-429
-
-
Xiang, Z.1
Cutler, A.J.2
Brownlie, R.J.3
Fairfax, K.4
Lawlor, K.E.5
Severinson, E.6
Walker, E.U.7
Manz, R.A.8
Tarlinton, D.M.9
Smith, K.G.10
-
66
-
-
28544444025
-
Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
-
Contains an elegant experiment suggesting that continuous Blimp-1 expression is required to maintain a plasma cell state. Raises interesting questions of the stability of the differentiation state, when if ever it becomes irreversible and whether the consequences of failing to maintain Blimp-1 are death or de-differentiation.
-
Shapiro-Shelef M., Lin K.I., Savitsky D., Liao J., and Calame K. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med 202 (2005) 1471-1476. Contains an elegant experiment suggesting that continuous Blimp-1 expression is required to maintain a plasma cell state. Raises interesting questions of the stability of the differentiation state, when if ever it becomes irreversible and whether the consequences of failing to maintain Blimp-1 are death or de-differentiation.
-
(2005)
J Exp Med
, vol.202
, pp. 1471-1476
-
-
Shapiro-Shelef, M.1
Lin, K.I.2
Savitsky, D.3
Liao, J.4
Calame, K.5
-
67
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., and Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415 (2002) 92-96
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
69
-
-
34147219234
-
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation
-
Naito Y., Takematsu H., Koyama S., Miyake S., Yamamoto H., Fujinawa R., Sugai M., Okuno Y., Tsujimoto G., Yamaji T., et al. Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol 27 (2007) 3008-3022
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3008-3022
-
-
Naito, Y.1
Takematsu, H.2
Koyama, S.3
Miyake, S.4
Yamamoto, H.5
Fujinawa, R.6
Sugai, M.7
Okuno, Y.8
Tsujimoto, G.9
Yamaji, T.10
-
70
-
-
0033970457
-
Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers
-
Raaphorst F.M., van Kemenade F.J., Fieret E., Hamer K.M., Satijn D.P., Otte A.P., and Meijer C.J. Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers. J Immunol 164 (2000) 1-4
-
(2000)
J Immunol
, vol.164
, pp. 1-4
-
-
Raaphorst, F.M.1
van Kemenade, F.J.2
Fieret, E.3
Hamer, K.M.4
Satijn, D.P.5
Otte, A.P.6
Meijer, C.J.7
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