CD25+CD4+ T cells in human cord blood: An immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene

Experimental Hematology

Volumn 32, Issue 7, 2004, Pages 622-629

  Takahata, Yasushi ^a   Nomura, Akihiko ^a   Takada, Hidetoshi ^a   Ohga, Shouichi ^a   Furuno, Kenji ^a   Hikino, Shunji ^a   Nakayama, Hideki ^a   Sakaguchi, Shimon ^b   Hara, Toshiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CELL FUNCTION; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREGULATION; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; UMBILICAL CORD BLOOD;

ANIMALS; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; DNA PRIMERS; DNA-BINDING PROTEINS; FETAL BLOOD; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GESTATIONAL AGE; HUMANS; IMMUNOPHENOTYPING; INFANT, NEWBORN; INFANT, PREMATURE; MICE; POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 3042792942     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2004.03.012     Document Type: Article

References (40)

1. Han P., Hodge G., Story C., Xu X. Phenotypic analysis of functional T-lymphocyte subtypes and natural killer cells in human cord blood: relevance to umbilical cord blood transplantation. Br J Haematol. 89:1995;733-740
2. Bikoue A., D'Ercole C., George F., Dameche L., Mutin M., Sampol J. Quantitative analysis of leukocyte membrane antigen expression on human fetal and cord blood: normal values and changes during development. Clin Immunol Immunopathol. 84:1997;56-64
3. Cohen S.B., Perez-Cruz I., Fallen P., Gluckman E., Madrigal J.A. Analysis of the cytokine production by cord and adult blood. Hum Immunol. 60:1999;331-336
4. + T cells achieve a lower magnitude of activation when compared with their adult counterparts. Immunology. 90:1997;397-401
5. Zola H., Ridings J., Elliott S., et al. Interleukin 2 receptor regulation and IL-2 function in the human infant. Hum Immunol. 59:1998;615-624
6. Bruning T., Daiminger A., Enders G. Diagnostic value of CD45RO expression on circulating T lymphocytes of fetuses and newborn infants with pre-, peri- or early post-natal infections. Clin Exp Immunol. 107:1997;306-311
7. Hodge S., Hodge G., Flower R., Han P. Surface activation markers of T lymphocytes: role in the detection of infection in neonates. Clin Exp Immunol. 113:1998;33-38
8. Byrne J.A., Stankovic A.K., Cooper M.D. A novel subpopulation of primed T cells in the human fetus. J Immunol. 152:1994;3098-3106
9. + suppressor T cells. J Exp Med. 193:2001;F41-F45
10. + suppressor T cells: more questions than answers. Nat Rev. 2:2002;389-399
11. high regulatory cells in human peripheral blood. J Immunol. 167:2001;1245-1253
12. Taams L.S., Smith J., Rustin M.H., Salmon M., Poulter L.W., Akbar A.N. Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol. 31:2001;1122-1131
13. + regulatory cells that control intestinal inflammation. J Exp Med. 192:2000;295-302
14. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 3:2002;135-142
15. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells. Nat Immunol. 4:2003;330-336
16. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor FOXP3. Science. 299:2003;1057-1061
17. Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for Scurfin in CD4(+)CD25(+) T regulatory cells. Nat Immunol. 4:2003;337-342
18. Jin C.H., Takada H., Nomura A., et al. Immunophenotypic and functional characterization of CD33(+)CD34(+) cells in human cord blood of preterm neonates. Exp Hematol. 28:2000;1174-1180
19. Nomura A., Takada H., Jin C.H., Tanaka T., Ohga S., Hara T. Functional analyses of cord blood natural killer cells and T cells: a distinctive interleukin-18 response. Exp Hematol. 29:2001;1169-1176
20. Ohga S., Nomura A., Takada H., et al. Epstein-Barr virus (EBV) load and cytokine gene expression in activated T cells of chronic active EBV infection. J Infect Dis. 183:2001;1-7
21. Ohga S., Nomura A., Ihara K., et al. Cytokine imbalance in hyper-IgE syndrome: reduced expression of transforming growth factor beta and interferon gamma genes in circulating activated T cells. Br J Haematol. 121:2003;324-331
22. Godula-Stuglik U., Mazur B., Behrendt J., Karpe J., Stojewska M., Kublin-Korzonkiewicz J. Peripheral blood cells with expression of the interleukin-2 receptor (CD25+) in severely infected full-term neonates. Acta Paediatr. 90:2001;819-820
23. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med. 193:2001;1285-1294
24. + regulatory T cells induced by an agonist self-peptide. Nat Immunol. 2:2001;301-306
25. Maloy K.J., Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol. 2:2001;816-822
26. Stockinger B. T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv Immunol. 71:1999;229-265
27. Takahashi T., Tagami T., Yamazaki S., et al. Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 192:2000;303-309
28. - T4 cell subsets. J Immunol. 142:1989;2597-2607
29. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev. 182:2001;18-32
30. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol. 168:2002;1080-1086
31. Lo Y.M.D., Lo E.S., Watson N., et al. Two-way cell traffic between mother and fetus: biologic and clinical implications. Blood. 88:1996;4390-4395
32. Scaradavou A., Carrier C., Mollen N., Stevens C., Rubinstein P. Detection of maternal DNA in placental/umbilical cord blood by locus-specific amplification of the noninherited maternal HLA gene. Blood. 88:1996;1494-1500
33. Risdon G., Gaddy J., Horie M., Broxmeyer H.E. Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells. Proc Natl Acad Sci U S A. 92:1995;2413-2417
34. Adkins B. T-cell function in newborn mice and humans. Immunol Today. 20:1999;330-335
35. + regulatory cells in acquired MHC tolerance. Immunol Rev. 182:2001;99-112
36. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 99:2002;3493-3499
37. Oldstone M.B., Tishon A., Moretta L. Active thymus derived suppressor lymphocytes in human cord blood. Nature. 269:1977;333-335
38. Hara M., Kingsley C.I., Niimi M., et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol. 166:2001;3789-3796
39. + cells: a naturally occurring population of regulatory T cells. Blood. 98:2001;2736-2744
40. + T cells in thymus, cord and adult blood. Immunology. 106:2002;190-199