The critical distance for the cycloaromatization reactions of enediynes

Current Topics in Medicinal Chemistry

Volumn 8, Issue 6, 2008, Pages 470-486

  Capitani, Joseph F ^a   Gaffney, Shannon M ^a   Castaldo, Lyana ^a   Mitra, Abhijit ^a  

^a Division of Natural Sciences   (United States)

Author keywords

Antitumor antibiotics; Bergman cyclization; Critical distance model; Cycloaromatization; Enediynes; Hopf cyclization; Myers Saito cyclization; QSAR

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; CALICHEAMICIN; DNA; DYNEMICIN A; ENEDIYNE; ESPERAMICIN; GEMTUZUMAB OZOGAMICIN; KEDARCIDIN; MERCAPTOETHANOL; NAMENAMICIN; SHISHIJIMICIN; UNCIALAMYCIN; WATER; ZINOSTATIN; ZINOSTATIN MALEIC ACID STYRENE COPOLYMER;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIBIOTIC RESISTANCE; ANTINEOPLASTIC ACTIVITY; AROMATIZATION; CHROMATOPHORE; CYCLIZATION; CYTOTOXICITY; DNA CLEAVAGE; DRUG MECHANISM; DRUG SPECIFICITY; DRUG STRUCTURE; HUMAN; MATHEMATICAL ANALYSIS; MICHAEL ADDITION; PHARMACOPHORE; PREDICTION; REVIEW; STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

ANTIBIOTICS, ANTINEOPLASTIC; CYCLIZATION; ENEDIYNES; MODELS, THEORETICAL; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 44649133221     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802608783955719     Document Type: Review

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