2-Alkynyl-N-propargyl pyridinium salts: Pyridinium-based heterocyclic skipped aza-enediynes that cleave DNA by deoxyribosyl hydrogen-atom abstraction and guanine oxidation

Biochemistry

Volumn 45, Issue 23, 2006, Pages 7265-7276

  Tuesuwan, Bodin ^a   Kerwin, Sean M ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DNA; ISOMERIZATION; OXIDATION; REACTION KINETICS;

2-ALKYNYL-N-PROPARGYL PYRIDINIUM SALTS; ANTITUMOR AGENTS; AZA-ENEDIYNES; CLEAVAGE; CYCLIZATIONS;

ORGANIC COMPOUNDS;

ALKYNE DERIVATIVE; DNA; HYDROGEN; PYRIDINIUM DERIVATIVE;

ARTICLE; CYCLIZATION; DNA CLEAVAGE; ISOMERIZATION; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SYNTHESIS;

BASE SEQUENCE; DNA; DNA PRIMERS; GUANINE; HETEROCYCLIC COMPOUNDS; HYDROGEN; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MORPHINANS; OXIDATION-REDUCTION; PYRIDINIUM COMPOUNDS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 33745049226     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052519j     Document Type: Article

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60. 6 cyclization of 1-hepta-1,2-dienyl-2-(2-phenyl) ethynyl-benzene has been noted (see ref 9).