Novel designed enediynes: Molecular design, chemical synthesis, mode of cycloaromatization and guanine-specific DNA cleavage

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 1, 1996, Pages 105-113

  Toshima, Kazunobu ^a   Ohta, Kazumi ^a   Kano, Takaaki ^a   Nakamura, Takatsugu ^a   Nakata, Masaya ^a   Kinoshita, Mitsuhiro ^a   Matsumura, Shuichi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOALKENE; ZINOSTATIN CHROMOPHORE;

ARTICLE; DNA CLEAVAGE; DRUG DESIGN; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0029964457     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(95)00170-0     Document Type: Article

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93. To obtain more decisive evidence for the alkylation mechanism of DNA cleavage, we tried many attempts to isolate the alkylation products of DNA with the rearrangement product using guanine, guanosine or DNA oligomers containing guanine base. However, these attempts were unsuccessful.