DNA cleavage by an α,3-dehydrotoluene precursor conjugated to a minor groove binding element

Bioconjugate Chemistry

Volumn 7, Issue 3, 1996, Pages 322-331

  Myers, Andrew G ^a   Parrish, Cynthia A ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLENES; BINDING ELEMENTS; BIRADICALS; DNA CLEAVAGE; ENE-YNE; GROOVE-BINDING; MINOR GROOVES; SEQUENCE SELECTIVITY;

DIAGNOSTIC AGENT; DISTAMYCIN A; DITHIOTHREITOL; DNA; DRUG DERIVATIVE; FREE RADICAL; PHOSPHORUS; REACTIVE OXYGEN METABOLITE; RESTRICTION ENDONUCLEASE; TOLUENE;

ANIMAL; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CATTLE; CHEMISTRY; CYCLIZATION; DNA FOOTPRINTING; HEAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION;

ANIMALS; AUTORADIOGRAPHY; BASE SEQUENCE; BINDING SITES; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIZATION; DISTAMYCINS; DITHIOTHREITOL; DNA; DNA FOOTPRINTING; DNA RESTRICTION ENZYMES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FREE RADICALS; HEAT; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PHOSPHORUS RADIOISOTOPES; PLASMIDS; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; TOLUENE;

EID: 0030135375     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc9600170     Document Type: Article

References (15)

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2. Myers, A. G., and Dragovich, P. S. (1989) Design and Dynamics of a Chemically Triggered Reaction Cascade Leading to Biradical Formation at Subambient Temperature. J. Am. Chem. Sac. 111, 9130-9132.
3. Myers, A. G., Dragovich, P. S., and Kuo, E. Y. (1992) Studies on the Thermal Generation and Reactivity of a Class of 1,4-Biradicals. J. Am. Chem. Soc. 114, 9369-9386
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6. Dervan, P. B. (1986) Design of Sequence-Specific DNA-Binding Molecules. Science 232, 464-471.
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10. Myers, A. G., Cohen, S. B., and Kwon, B.-M. (1994) A Study of the Reaction of Calicheamicin with Glutalhione in the Presence of Double-Stranded DNA. J. Am. Chem. Soc. 116, 1255-1271.
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12. Pelton, J. G., and Wemmer, D. E. (1989) Structural characterization of a 2:1 distamycin A-d(CGCAAATTGGC) complex by two-dimensional NMR. Proc. Natl. Acad. Sci. U.SA. 86, 5723-5727.
13. 2. Determined by Two-Dimensional NMR. J. Am. Chem. Soc. 112, 1393-1399.
14. Wade, W. S., Mrksich, M., and Dervan, P. B. (1992) Design of Peptides That Bind in the Minor Groove of DNA at 5′-(A,T)G(A,T)C(A,T)-3′ Sequences by a Dimeric Side-by-Side Motif. J. Am. Chem. Soc. 114, 8783-8794.
15. Mrksich, M., Wade, W. S., Dwyer, T. J., Geierstanger, B. H., Wemmer, D. E., and Dervan, P. B. (1992) Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin. Proc. Natl. Acad. Sci. USA. 89, 7586-7590.