A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation

Biochemistry

Volumn 36, Issue 7, 1997, Pages 1567-1572

  Oliver, Catherine F ^b,c,d   Modi, Sandeep ^b,c,d   Sutcliffe, Michael J ^c   Primrose, William U ^b,d   Lian, Lu Yun ^b,d   Roberts, Gordon C K ^a,b,c,d  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b Centre Mechanisms of Human Toxicity   (United Kingdom)

^c Department of Biochemistry ^*  (United Kingdom)

^d Biological NMR Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450;

AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS MEGATERIUM; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

BACILLUS MEGATERIUM; BACTERIAL PROTEINS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MIXED FUNCTION OXYGENASES; MUTAGENESIS; SUBSTRATE SPECIFICITY;

BACILLUS MEGATERIUM;

EID: 0031033653     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962826c     Document Type: Article

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