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Journal of Biological Inorganic Chemistry

Volumn 11, Issue 7, 2006, Pages 903-916

Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego

(3) Dodhia, Vikash Rajnikant a,b Fantuzzi, Andrea a,b Gilardi, Gianfranco a,b,c

a IMPERIAL COLLEGE LONDON (United Kingdom)

b NanoBioDesign Ltd (United Kingdom)

c UNIVERSITY OF TURIN (Italy)

Author keywords

Drug metabolism; Electron transfer; Human cytochrome P450 fusion proteins; Molecular Lego; Protein engineering

Indexed keywords

CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DETERGENT; DICLOFENAC; ERYTHROMYCIN; HYBRID PROTEIN; OMEPRAZOLE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BACILLUS MEGATERIUM; CIRCULAR DICHROISM; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME PURIFICATION; ESCHERICHIA COLI; HUMAN; MOLECULAR HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ENGINEERING; PROTEIN FOLDING; SPECTROSCOPY;

AMINO ACID MOTIFS; ARYL HYDROCARBON HYDROXYLASES; BACTERIAL PROTEINS; CATALYSIS; CIRCULAR DICHROISM; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ERYTHROMYCIN; ESCHERICHIA COLI; HUMANS; MIXED FUNCTION OXYGENASES; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS;

BACILLUS MEGATERIUM; ESCHERICHIA COLI; MAMMALIA;

EID: 33748366369 PISSN: 09498257 EISSN: None Source Type: Journal
DOI: 10.1007/s00775-006-0144-3 Document Type: Article

Times cited : (73)

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