An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase

Journal of Biological Chemistry

Volumn 272, Issue 2, 1997, Pages 1127-1135

  Graham Lorence, Sandra ^a   Truant, Gilles ^a   Peterson, Julian A ^a   Falck, John R ^b   Wei, Shouzuo ^c   Helvig, Christian ^c   Capdevila, Jorge H ^c,d  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE LIPOXYGENASE; ARACHIDONIC ACID; ARGININE; CYTOCHROME P450; FATTY ACID; HEME; ICOSAPENTAENOIC ACID; PHENYLALANINE; PROSTAGLANDIN SYNTHASE;

AMINO ACID SUBSTITUTION; ARACHIDONIC ACID METABOLISM; ARTICLE; BINDING AFFINITY; ENZYME SUBSTRATE; EPOXIDATION; FATTY ACID OXIDATION; PRIORITY JOURNAL;

ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NADP; OXYGENASES; PHENYLALANINE; STEREOISOMERISM; VALINE;

EID: 0031021585     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.2.1127     Document Type: Article

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