Helicases as prospective targets for anti-cancer therapy

Anti-Cancer Agents in Medicinal Chemistry

Volumn 8, Issue 4, 2008, Pages 390-401

  Gupta, Rigu ^a   Brosh Jr , Robert M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Anti cancer drug; Cancer; Chemotherapy; DNA repair; Fanconi anemia; Genomic instability; Helicase; RecQ; Werner syndrome

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; ATR PROTEIN; BLEOMYCIN; BLOOM SYNDROME HELICASE; BRCA1 PROTEIN; BRCA2 PROTEIN; CAMPTOTHECIN; CHLORMETHINE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETHYLNITROSOUREA; ETOPOSIDE; FANCONI ANEMIA PROTEIN; HELICASE; IRINOTECAN; METHOXSALEN; MITOMYCIN C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PLATINUM DERIVATIVE; PROTEIN P53; RECQ HELICASE; RETROVIRUS VECTOR; SMALL INTERFERING RNA; TELOMESTATIN; UNINDEXED DRUG; WERNER SYNDROME PROTEIN;

ANTINEOPLASTIC ACTIVITY; BLOOM SYNDROME; BREAST CANCER; CANCER CELL; CANCER RADIOTHERAPY; CELL CYCLE REGULATION; CHROMOSOMAL INSTABILITY; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA CROSS LINKING; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; DOWN REGULATION; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION; GENE SILENCING; GENETIC STABILITY; HIGH THROUGHPUT SCREENING; HUMAN; INHIBITION KINETICS; MALIGNANT NEOPLASTIC DISEASE; OVARY CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REVIEW; RNA INTERFERENCE; ROTHMUND THOMSON SYNDROME; WERNER SYNDROME;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA DAMAGE; DNA HELICASES; DNA REPAIR; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS;

EID: 44449156516     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152008784220339     Document Type: Review

References (112)

1. Boule, J.B.; Zakian, V.A. Nucleic Acid Res., 2006, 34, 4147.
2. Heller, R.C.; Marians, K.J. Nat. Rev. Mol. Cell Biol., 2006, 7, 932.
3. Matson, S.W.; Bean, D.W.; George, J.W. Bioessays, 1994, 16, 13.
4. Sharma. S., Doherty, K.M.; Brosh, R.M. Jr. Biochem. J., 2006, 398, 319.
5. Tuteja, N.; Tuteja, R. Eur. J. Biochem., 2004, 271, 1835.
6. Wu, L.; Hickson, I.D. Annu. Rev. Genet., 2006, 40, 279.
7. Belzile, J.P.; Choudhury, S.A.; Cournoyer, D.; Chow, T.Y. Curr. Gene Ther., 2006, 6, 111.
8. Ding, J.; Miao, Z.H.; Meng, L.H.; Geng, M.Y. Trends Pharmacol. Sci., 2006, 27, 338.
9. Madhusudan, S.; Hickson, I.D. Trends Mol. Med., 2005, 11, 503.
10. Madhusudan, S.; Middleton, M.R. Cancer Treat. Rev., 2005, 31, 603.
11. Bryant, H.E.; Schultz, N.; Thomas, H.D.; Parker, K.M.; Flower, D.; Lopez, E.; Kyle, S.; Meuth, M.; Curtin, N.J.; Helleday, T. Nature, 2005, 434, 913.
12. Farmer, H.; McCabe, N.; Lord, C.J.; Tutt, A.N; Johnson, D.A.; Richardson, T.B.; Santarosa, M.; Dillon, K.J.; Hickson, I.; Knights, C.; Martin, N.M.; Jackson, S.P.; Smith, G.C.; Ashworth, A. Nature, 2005, 434, 917.
13. Noll, D.M.; Mason, T.M.; Miller, P.S. Chem. Rev., 2006, 106, 277.
14. Lyakhovich, A.; Surralles, J. Cancer Lett., 2006, 232, 99.
15. Gupta, R.; Brosh, R.M.Jr. Frontiers in Drug Design and Discovery, Ed. By Bentham Science Publishers, Ltd., 2007; Vol. 3, pp 293-316.
16. Sommers, J.A.; Sharma, S.; Doherty, K.M.; Karmakar, P.; Yang, Q.; Kenny, M.K.; Harris, C.C.; Brosh, R.M., Jr. Cancer Res., 2005, 65, 1223.
17. Bouchet, B.P., de Fromentel, C.C.; Puisieux, A.; Galmarini, C.M. Crit Rev. Oncol. Hematol., 2006, 58, 190.
18. Vassilev, L.T.; Vu, B.T.; Graves, B.; Carvajal, D.; Podlaski, F.; Filipo-vic, Z.; Kong, N.; Kammlott, U.; Lukacs, C.; Klein, C.; Fotouhi, N.; Liu, E.A. Science, 2004, 303, 844.
19. Yun, J.; Zhong, Q.; Kwak, J.Y.; Lee, W.H. Oncogene, 2005, 24, 4009.
20. Schwartz, G.K.; Shah, M.A. J. Clin. Oncol., 2005, 23, 9408.
21. Forsburg, S.L. Microbiol. Mol. Biol. Rev., 2004, 68, 109.
22. Lei, M. Curr. Cancer Drug Targets, 2005, 5, 365.
23. Byun, T.S.; Pacek, M.; Yee, M.C.; Walter, J.C.; Cimprich, K.A. Genes Dev., 2005, 19, 1040.
24. Cobb, J.A.; Bjergbaek, L. Nucleic Acids Res., 2006, 34, 4106.
25. Davies, S.L.; North, P.S.; Dart, A., Lakin, N.D.; Hickson, I.D. Mol. Cell Biol., 2004, 24, 1279.
26. Gupta, R.; Sharma, S.; Brosh, R.M.Jr. Curr. Genom., 2006, 7, 387.
27. Bumcrot, D.; Manoharan, M.; Koteliansky, V.; Sah, D.W. Nat. Chem. Biol., 2006, 2, 711.
28. Werner, S.R.; Prahalad, A.K.; Yang, J.; Hock, J.M. Biochem. Biophys. Res. Commun., 2006, 345, 403.
29. Lehmann, A.R. Biochimie, 2003, 85, 1101.
30. Troelstra, C.; van Gool, A.; de Wit J.; Vermeulen, W.; Bootsma, D.; Hoeijmakers, J.H. Cell, 1992, 71, 939.
31. Citterio, E.; Van, D.B.; V, Schnitzler, G.; Kanaar, R.; Bonte, E.; Kingston, R.E.; Hoeijmakers, J.H.; Vermeulen, W. Mol. Cell Biol., 2000, 20, 7643.
32. Levitus, M.; Waisfisz, Q.; Godthelp, B.C.; de Vries, Y.; Hussain, S.; Wiegant, W.W.; Elghalbzouri-Maghrani, E.; Steltenpool, J.; Rooimans, M.A.; Pals, G.; Arwert, F.; Mathew, C.G.; Zdzienicka, M.Z.; Hiom, K.; De Winter, J.P.; Joenje, H. Nat. Genet., 2005, 37, 934.
33. Levran, O.; Attwooll, C.; Henry, R.T.; Milton, K.L.; Neveling, K.; Rio, P.; Batish, S.D.; Kalb, R.; Velleuer, E.; Barral, S.; Ott, J.; Petrini, J.; Schindler, D.; Hanenberg, H.; Auerbach, A.D. Nat. Genet., 2005, 37, 931.
34. Litman, R.; Peng, M.; Jin, Z.; Zhang, F.; Zhang, J.; Powell, S.; Andreassen, P.R.; Cantor, S.B. Cancer Cell, 2005, 8, 255.
35. Meetei, A.R.; Medhurst, A.L.; Ling, C.; Xue, Y.; Singh, T.R.; Bier, P.; Steltenpool, J.; Stone, S., Dokal, I.; Mathew, C.G.; Hoatlin, M.; Joenje, H.; De Winter, J.P.; Wang, W. Nat. Genet., 2005, 37, 958.
36. Cho, K.S.; Elizondo, L.I.; Boerkoel, C.F. Curr. Opin. Genet. Dev., 2004, 14, 308.
37. Gibbons, R.J.; Higgs, D.R. Am. J. Med. Genet., 2000, 97, 204.
38. Tang, J.; Wu, S.; Liu, H.; Stratt, R.; Barak, O.G.; Shiekhattar, R.; Picketts, D.J., Yang, X. J. Biol. Chem., 2004, 279, 20369.
39. Collis, S.J.; Swartz, M.J.; Nelson, W.G.; DeWeese, T.L. Cancer Res., 2003, 63, 1550.
40. Yu, X.; Chini, C.C.; He, M.; Mer, G.; Chen, J. Science, 2003, 302, 639.
41. Bridge, W.L.; Vandenberg, C.J.; Franklin, R.J.; Hiom, K. Nat. Genet., 2005, 37, 953.
42. Skibbens, R.V. Genetics, 2004, 166, 33.
43. Parish, J.L.; Rosa, J.; Wang, X.; Lahti, J.M.; Doxsey, S.J.; Androphy, E.J. J. Cell Sci., 2006, 119, 4857.
44. So, S.; Nomura, Y.; Adachi, N.; Kobayashi, Y.; Hori, T.; Kurihara, Y.; Koyama, H. Genes Cells, 2006, 11, 363.
45. Grandori, C.; Wu, K.J.; Fernandez, P.; Ngouenet, C.; Grim, J.; Clurman, B.E.; Moser, M.J.; Oshima, J.; Russell, D.W.; Swisshelm, K.; Frank, S.; Amati, B.; Dalla-Favera, R., Monnat, R.J., Jr. Genes Dev., 2003, 17, 1569.
46. Grandori, C.; Robinson, K.L.; Galloway, D.A.; Swisshelm, K. Cell Cycle, 2004, 3, 22.
47. Harrigan, J.A.; Wilson, D.M., III; Prasad, R.; Opresko, P.L.; Beck, G.; May, A.; Wilson, S.H.; Bohr, V.A. Nucleic Acids Res., 2006, 34, 745.
48. Szekely, A.M.; Bleichert, F.; Numann, A.; Van Komen, S.; Manasanch, E.; Ben Nasr, A.; Canaan, A.; Weissman, S.M. Mol. Cell Biol., 2005, 25, 10492.
49. Von, K.C.; May, A.; Grandori, C.; Bohr, V.A. FASEB J., 2004, 1 8, 1970.
50. Poot M.; Yom, J.S.; Whang, S.H.; Kato, J.T.; Gollahon, K.A.; Rabinovitch, P.S. FASEB J., 2001, 15, 1224.
51. Cheng, W.H.; Kusumoto, R.; Opresko, P.L.; Sui, X.; Huang, S.; Nicolette, M.L.; Paull, T.T.; Campisi, J.; Seidman, M.; Bohr, V.A. Nucleic Acids Res., 2006, 34, 2751.
52. Zhang, N.; Kaur, R.; Lu, X.; Shen, X.; Li, L.; Legerski, R.J. J. Biol. Chem., 2005, 280, 40559.
53. Eller, M.S.; Liao, X.; Liu, S.; Hanna, K.; Backvall, H.; Opresko, P.L.; Bohr, V.A.; Gilchrest, B.A. Proc. Natl. Acad. Sci. U. S. A., 2006, 103, 15073.
54. Chang, S.; Multani, A.S.; Cabrera, N.G.; Naylor, M.L.; Laud, P.; Lombard, D.; Pathak, S.; Guarente, L.; DePinho, R.A. Nat. Genet., 2004, 36, 877.
55. Chang, S. Int. J. Biochem Cell Biol., 2005, 37, 991.
56. Du, X.; Shen, J.; Kugan, N.; Furth, E.E.; Lombard, D.B.; Cheung, C.; Pak, S.; Luo, G.; Pignolo, R.J.; DePinho, R.A.; Guarente, L.; Johnson, F.B. Mol. Cell Biol., 2004, 24, 8437.
57. Laud, P.R.; Multani, A.S.; Bailey, S.M.; Wu, L.; Ma, J.; Kingsley, C.; Lebel, M.; Pathak, S.; DePinho, R.A.; Chang, S. Genes Dev., 2005, 19, 2560.
58. Opresko, P.L.; Otterlei, M.; Graakjaer, J.; Bruheim, P.; Dawut, L.; Kolvraa, S.; May, A.; Seidman, M.M.; Bohr, V.A. Mol. Cell, 2004, 14, 763.
59. Stavropoulos, D.J.; Bradshaw, P.S.; Li, X.; Pasic, I.; Truong, K.; Ikura, M.; Ungrin, M.; Meyn, M.S. Hum. Mol. Genet., 2002, 11, 3135.
60. Sharma, S.; Doherty, K.M.; Brosh, R.M., Jr. Curr. Med. Chem. Anti. -Canc. Agents, 2005, 5, 183.
61. Dhillon, K.K.; Sidorova, J.; Saintigny, Y.; Poot, M.; Gollahon, K.; Rabinovitch, P.S.; Monnat R.J., Jr. Aging Cell, 2007, 6, 53.
62. Petkovic, M.; Dietschy, T.; Freire, R.; Jiao, R.; Stagljar, I. J. Cell Sci., 2005, 118, 4261.
63. LeRoy, G.; Carroll, R.; Kyin, S.; Seki, M.; Cole, M.D. Nucleic Acids Res., 2005, 33, 6251.
64. Sharma, S.; Stumpo, D.J., Balajee, A.S.; Bock, C.B.; Lansdorp, P.M.; Brosh, R.M., Jr.; Blackshear, P.J. Mol. Cell Biol., 2007, 27, 1784.
65. Sharma, S.; Sommers, J.A.; Choudhary, S.; Faulkner, J.K.; Cui, S.; Andreoli, L.; Muzzolini, L.; Vindigni, A.; Brosh, R.M., Jr. J. Biol. Chem., 2005, 280, 28072.
66. Kawabe, T.; Tsuyama, N.; Kitao, S.; Nishikawa, K.; Shimamoto, A.; Shiratori, M.; Matsumoto, T.; Anno, K.; Sato, T.; Mitsui, Y.; Seki, M.; Enomoto, T.; Goto, M.; Ellis, N.A.; Ide, T.; Furuichi, Y.; Sugimoto, M. Oncogene, 2000, 19, 4764.
67. Turley, H.; Wu, L.; Canamero, M.; Gatter, K.C.; Hickson, I.D. Br. J. Cancer, 2001, 85, 261.
68. Agrelo, R.; Cheng, W.H.; Setien, F.; Ropero, S.; Espada, J.; Fraga, M.F.; Herranz, M.; Paz, M.F. Sanchez-Cespedes, M.; Artiga, M.J.; Guerrero, D.; Castells, A.; von Kobbe, C.; Bohr, V.A.; Esteller, M. Proc. Natl. Acad. Sci. U. S. A., 2006, 103, 8822.
69. Li, D.; Frazier, M.; Evans, D.B.; Hess, K.R.; Crane, CH.; Jiao, L.; Abbruzzese, J.L. J. Clin. Oncol., 2006, 24, 1720.
70. Li, D.; Liu, H.; Jiao, L.; Chang, D.Z.; Beinart, G.; Wolff, R.A., Evans, D.B.; Hassan, M.M.; Abbruzzese, J.L. Cancer Res., 2006, 66, 3323.
71. Zhang, P.; Zhang, Z.; Zhou, X.; Qiu, W.; Chen, F.; Chen, W. BMC. Cancer, 2006, 6, 224.
72. Quintela-Fandino, M.; Hitt, R.; Medina, P.P.; Gamarra, S.; Manso, L.; Cortes-Funes, H.; Sanchez-Cespedes, M. J. Clin. Oncol., 2006, 24, 4333.
73. Collins, I.; Workman, P. Nat.:Chem., Biol., 2006, 2, 689.
74. Koonin, E.V. Nucleic Acids Res., 1993, 21, 2541.
75. Fry, D.C.; Kuby, S.A.; Mildvan, A.S. Proc. Natl. Acad Sci. U. S. A., 1986, 83, 907.
76. Pause, A.; Sonenberg, N. EMBO J., 1992, 11, 2643.
77. George, J.W.; Brosh, R.M., Jr.; Matson, S.W. J. Mol. Biol., 1994, 235, 424.
78. Hall, M.C.; Matson, S.W. Mol. Microbiol., 1999, 34, 867.
79. Brosh, R.M. Jr.; Orren, D.K.; Nehlin, J.O.; Ravn, P.H.; Kenny, M.K.; Machwe, A.; Bohr, V.A. J. Biol. Chem., 1999, 274, 18341.
80. Neff, N.F.; Ellis, N.A.; Ye, T.Z.; Noonan, J.; Huang, K.; Sanz, M.; Proytcheva, M. Mol. Biol. Cell, 1999, 10, 665.
81. Linder, P.; Lasko, P.F.; Ashburner, M.; Leroy, P.; Nielsen, P.J.; Nishi, K.; Schnier, J.; Slonimski, P.P. Nature, 1989, 337, 121.
82. Brosh, R.M., Jr.; Matson, S.W. J. Bacteriol., 1995, 177, 5612.
83. Graves-Woodward, K.L.; Gottlieb, J.; Challberg, M.D.; Weller, S.K. J. Biol. Chem., 1997, 272, 4623.
84. Dillingham, M.S.; Soultanas, P.; Wigley, D.B. Nucleic Acids Res., 1999, 27, 3310.
85. Korolev, S.; Hsieh, J.; Gauss, G.H.; Lohman, T.M.; Waksman, G. Cell, 1997, 90, 635.
86. Velankar, S.S.; Soultanas, P.; Dillingham, M.S.; Subramanya, H.S.; Wigley, D.B. Cell, 1999, 97, 75.
87. Brosh, R.M., Jr.; Matson, S.W. J. Biol. Chem., 1996, 271, 25360.
88. Zittel, M.C.; Keck, J.L. Nucleic Acids Res., 2005, 33, 6982.
89. Bernstein, D.A.; Zittel, M.C.; Keck, J.L. EMBO J., 2003, 22, 4910.
90. Subramanya, H.S.; Bird, L.E.; Brannigan, J.A.; Wigley, D.B. Nature, 1996, 384, 379.
91. Marintcheva, B.; Weller, S.K. J. Virol., 2003, 77, 2477.
92. Hall, M.C.; Matson, S.W. J. Biol. Chem., 1997, 272, 18614.
93. Graves-Woodward, K.L.; Weller, S.K. J. Biol. Chem., 1996, 271, 13629.
94. Schneider, S.; Campodonico, E.; Schwer, B. J. Biol. Chem., 2004, 279, 8617.
95. Hall, M.C.; Ozsoy, A.Z.; Matson, S.W. J. Mol. Biol., 1998, 277, 257.
96. Zhu, L.A.; Weller, S.K. J. Virol., 1992, 66, 469.
97. Hu, J.S.; Feng, H.; Zeng, W.; Lin, G.X.; Xi, X.G. Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 18379.
98. Bernstein, D.A.; Keck, J.L. Structure (Camb.), 2005, 13, 1173.
99. Perry, J.J.; Yannone, S.M.; Holden, L.G.; Hitomi, C.; Asaithamby, A.; Han, S.; Cooper, P.K.; Chen, D.J.; Tainer, J.A. Nat. Struct. Mol. Biol., 2006, 13, 414.
100. Lee, J.Y.; Yang, W. Cell, 2006, 127, 1349.
101. Hadden, M.K.; Lubbers, D.J.; Blagg, B.S. Curr. Top. Med. Chem., 2006, 6, 1173.
102. McDonald, E.; Workman, P.; Jones, K. Curr. Top. Med. Chem., 2006, 6, 1091.
103. Fan, L.; Arvai, A.S.; Cooper, P.K.; Iwai, S.; Hanaoka, F.; Tainer, J.A. Mol. Cell, 2006, 22, 27.
104. Connell, P.P.; Siddiqui, N.; Hoffman, S.; Kuang, A.; Khatipov, E.A.; Weichselbaum, R.R.; Bishop, D.K. Cancer Res., 2004, 64, 3002.
105. Doherty, K.M.; Sommers, J.A.; Gray, M.D.; Lee, J.W.; von Kobbe, C.; Thoma, N.H.; Kureekattil, R.P.; Kenny, M.K.; Brosh, R.M., Jr. J. Biol. Chem., 2005, 280, 29494.
106. von Kobbe, C.; Harrigan, J.A.; May, A.; Opresko, P.L.; Dawut, L.; Cheng, W.H.; Bohr, V.A. Mol. Cell Biol., 2003, 23, 8601.
107. Brosh, R.M. Jr.; von Kobbe, C.; Sommers, J.A.; Karmakar, P.; Opresko, P.L.; Piotrowski, J.; Dianova, I.; Dianov, G.L.; Bohr, V.A. EMBO J., 2001, 20, 5791.
108. Sharma, S.; Sommers, J.A.; Gary, R.K.; Friedrich-Heineken, E.; Hubscher, U.; Brosh, R.M., Jr. Nucleic Acids Res., 2005, 33, 6769.
109. Sharma, S.; Sommers, J.A.; Brosh, R.M., Jr. Hum. Mol. Genet., 2004, 13, 2247.
110. Simonsson, T. Biol. Chem., 2001, 382, 621.
111. Doherty, K.M.; Sharma, S.; Gupta, R.; Brosh, R.M.Jr. Recent Patents on Anti-Cancer Drug Discovery., 2006, 1, 185.
112. Allan, J.M.; Travis, L.B. Nat. Rev. Cancer, 2005, 5, 943.