Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway

European Journal of Biochemistry

Volumn 269, Issue 15, 2002, Pages 3697-3704

  Cheng, Ting Jen ^a   Rey, Peter G ^b   Poon, Thomas ^b   Kan, Chen Chen ^a  

^a KECK GRADUATE INSTITUTE   (United States)

^b Claremont Mc Kenna College   (United States)

Author keywords

High throughput screening; Phospholipase D; Topoisomerase I; Tyrosyl DNA phosphodiesterase

Indexed keywords

4 NITROPHENYLTHYMIDINE 3' PHOSPHATE; DNA TOPOISOMERASE; PHOSPHODIESTERASE; PHOSPHOLIPASE D; THYMIDINE DERIVATIVE; TYROSYL DNA PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ARTICLE; COLORIMETRY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PURIFICATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; COLORIMETRY; ESCHERICHIA COLI; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR SEQUENCE DATA; PHOSPHORIC DIESTER HYDROLASES; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID; THYMIDINE MONOPHOSPHATE; YEASTS;

EID: 0036373079     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03059.x     Document Type: Article

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