Engineered resistance to camptothecin and antifolates by retroviral coexpression of tyrosyl DNA phosphodiesterase-I and thymidylate synthase

Cancer Chemotherapy and Pharmacology

Volumn 53, Issue 2, 2004, Pages 107-115

  Nivens, Michael C ^c   Felder, Takita ^a   Galloway, Amanda H ^a   Pena, Maria Marjorette O ^a   Pouliot, Jeffery J ^b   Spencer, H Trent ^c  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antifolates; Camptothecin; Drug resistance; Thymidylate synthase; Tyrosyl DNA phosphodiesterase

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; CAMPTOTHECIN; DNA FRAGMENT; ENZYME; FOLIC ACID ANTAGONIST; RETROVIRUS VECTOR; THYMIDYLATE SYNTHASE; TYROSYL DEOXYRIBONUCLEIC ACID PHOSPHODIESTERASE 1; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CELL PROTECTION; CHINESE HAMSTER; COMET ASSAY; CONTROLLED STUDY; DNA TRANSFECTION; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ESCHERICHIA COLI; FIBROBLAST; GENETIC ENGINEERING; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS RECOMBINANT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BONE MARROW CELLS; CAMPTOTHECIN; CELL LINE; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; DNA FRAGMENTATION; DNA, COMPLEMENTARY; DRUG RESISTANCE, NEOPLASM; FOLIC ACID ANTAGONISTS; GENETIC ENGINEERING; HUMANS; PHOSPHORIC DIESTER HYDROLASES; RETROVIRIDAE; THYMIDYLATE SYNTHASE; TRANSFECTION; TUMOR STEM CELL ASSAY;

EID: 0442298041     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0717-6     Document Type: Article

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