Modulation of dendritic cell function by leishmania parasites

Journal of Immunology

Volumn 180, Issue 7, 2008, Pages 4355-4360

  Soong, Lynn ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LIPOPOLYSACCHARIDE;

CELL ACTIVATION; CELL FUNCTION; CELL INTERACTION; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LEISHMANIA; LEISHMANIASIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; ANIMAL; DISEASE MODEL; DOWN REGULATION; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; PARASITOLOGY;

ANIMALS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HUMANS; IMMUNOTHERAPY; LEISHMANIA; LEISHMANIASIS;

EID: 44449089588     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4355     Document Type: Review

References (71)

1. McConville, M. J., D. d. Souza, E. Saunders, V. A. Likic, and T. Naderer. 2007. Living in a phagolysosome; metabolism ofLeishmania amastigotes. Trends Parasitol. 23: 368-375
2. Cohen-Freue, G., T. R. Holzer, J. D. Forney, and W. R. McMaster. 2007. Global gene expression in Leishmania. Int. J. Parasitol. 37: 1077-1086.
3. McMahon-Pratt, D., and J. Alexander. 2004. DoestheLeishmaniamajorparadigmof pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease? Immunol. Rev. 201: 206-224.
4. Ji, J., J. Sun, and L. Soong. 2003. Impaired expression ofinflammatorycytokinesand chemokines at early stages of infection with Leishmania amazonensis. Infect. Immun. 71: 4278 -4288.
5. Jones, D. E., M. R. Ackermann, U. Wille, C. A. Hunter, and P. Scott. 2002. Early enhanced Th1 response after Leishmania amazonensis infection ofC57BL/6 interleu- kin-10-deficient mice does not lead to resolution of infection. Infect. Immun. 70:2151-2158.
6. von Stebut, E., Y. Belkaid, T. Jakob, D. L. Sacks, and M. C. Udey. 1998. Uptake of Leishmaniamajoramastigotesresultsinactivationandinterleukin12 releasefrommu- rineskin-derived dendritic cells: implicationsfortheinitiationofanti-Leishmaniaim-munity. J. Exp. Med. 188: 1547-1552.
7. + T cells. Eur. J. Immunol. 26:3163-3169.
8. Vannier-Santos, M. A., A. Martiny, and W. de Souza. 2002. Cell biologyofLeishma- nia spp.: invading and evading. Curr. Pharm. Des. 8: 297-318.
9. Kima, P. E. 2007. The amastigote forms ofLeishmania are experts at exploiting host cell processes to establish infection and persist. Int. J. Parasitol. 37: 1087-1096.
10. Sacks, D., and A. Sher. 2002. Evasion ofinnate immunitybyparasitic protozoa. Nat. Immunol. 3: 1041-1047.
11. Sher, A., E. Pearce, andP. Kaye. 2003. Shapingtheimmuneresponsetoparasites: role ofdendritic cells. Curr. Opin. Immunol. 15: 421-429.
12. Von Stebut, E. 2007. Immunology ofcutaneous leishmaniasis: the role ofmast cells, phagocytes and dendritic cells for protective immunity. Eur. J. Dermatol. 17: 115-122.
13. Ritter, U., and A. Osterloh. 2007. Anewviewon cutaneous dendritic cell subsets in experimental leishmaniasis. Med. Microbiol. Immunol. 196: 51-59.
14. Leon, B., M. Lopez-Bravo, and C. Ardavin. 2007. Monocyte-derived dendritic cells formed at the infection site control the induction ofprotective T helper 1 responses against Leishmania (see comment). Immunity 26: 519-531.
15. Silveira, F. T., J. M. Blackwell, E. A. Ishikawa, R. Braga, J. J. Shaw, R. J. Quinnell, L. Soong, P. Kima, D. McMahon-Pratt, G. F. Black, and M. A. Shaw. 1998. T cell responses to crude and defined leishmanial antigens in patients from the lower Amazon region of Brazil infected with different species of Leishmania of the subgenera Leishmania and Viannia. Parasite Immunol. 20: 19-26.
16. Silveira, F. T., R. Lainson, and C. E. Corbett. 2004. Clinical and immunopathological spectrum ofAmerican cutaneous leishmaniasis with special reference to the disease in Amazonian Brazil: a review. Mem. Inst. Oswaldo Cruz 99: 239 -251.
17. Costa, D. J., C. Favali, J. Clarencio, L. Afonso, V. Conceicao, J. C. Miranda, R. G. Titus, J. Valenzuela, M. Barral-Netto, A. Barral, and C. I. Brodskyn. 2004. Lutzomyialongipalpissalivarygland homogenate impairscytokineproductionand co- stimulatory molecule expression on human monocytes and dendritic cells. Infect. Im- mun. 72: 1298 -1305.
18. Andrade, B. B., C. I. de Oliveira, C. I. Brodskyn, A. Barral, and M. Barral-Netto.
19. 2007. Role of sand fly saliva in human and experimental leishmaniasis: current insights. Scand. J. Immunol. 66: 122-127.
20. Beil, W. J., G. Meinardus-Hager, D. C. Neugebauer, and C. Sorg. 1992. Differences in the onset ofthe inflammatoryresponse to cutaneous leishmaniasisin resistant and susceptible mice. J. LeukocyteBiol. 52: 135-142.
21. Charmoy, M., R. Megnekou, C. Allenbach, C. Zweifel, C. Perez, K. Monnat, M. Breton, C. Ronet, P. Launois, and F. Tacchini-Cottier. 2007. Leishmania major induces distinct neutrophil phenotypes in mice that are resistant or susceptible to infection J. Leukocyte Biol. 82: 288 -284.
22. van Zandbergen, G., M. Klinger, A. Mueller, S. Dannenberg, A. Gebert, W. Solbach, andT. Laskay. 2004. Cuttingedge: neutrophil granulocyte serves as a vector for Leish- mania entryinto macrophages. J. Immunol. 173: 6521-6525.
23. Gueirard, P., A. Laplante, C. Rondeau, G. Milon, and M. Desjardins. 2008. Trafficking of Leishmania donovani promastigotes in non-lytic compartments in neutrophils enables the subsequent transfer of parasites to macrophages. Cell Microbiol. 10:100 -111.
24. Schleicher, U., J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J. A. Fischer, S. Weiss, U. Kalinke, S. Kunz, and C. Bogdan. 2007. NK cell activation in visceral leishmaniasisrequiresTLR9, myeloid DCs, andIL-12, butisindependent of plasma- cytoid DCs. J. Exp. Med. 204: 893-906.
25. Remer, K. A., C. Apetrei, T. Schwarz, C. Linden, and H. Moll. 2007. Vaccination with plasmacytoid dendritic cells induces protection against infection with Leishmania major in mice. Eur. J. Immunol. 37: 2463-2473.
26. Bajenoff, M., B. Breart, A. Y. C. Huang, H. Qi, J. Cazareth, V. M. Braud, R. N. Germain, and N. Glaichenhaus. 2006. Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. J. Exp. Med. 203: 619 -631.
27. Misslitz, A. C., K. Bonhagen, D. Harbecke, C. Lippuner, T. Kamradt, and T. Aebischer. 2004. Two waves ofantigen-containing dendritic cells in vivo in experimental Leishmania major infection. Eur. J. Immunol. 34: 715-725.
28. Ritter, U., A. Meissner, C. Scheidig, and H. Korner. 2004. CD8α- and Langerin- negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cellsin leishmaniasis. Eur. J. Immunol. 34: 1542-1550.
29. Moll, H., H. Fuchs, C. Blank, and M. Rollinghoff. 1993. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur. J. Immunol. 23: 1595-1601.
30. von Stebut, E., Y. Belkaid, B. V. Nguyen, M. Cushing, D. L. Sacks, and M. C. Udey. 2000. Leishmaniamajor-infected murine Langerhans cell-like dendritic cells from sus- ceptible mice release IL-12 after infection and vaccinate against experimental cutaneous leishmaniasis. Eur. J. Immunol. 30: 3498 -3506.
31. + T cells in vivo. J. Immunol. 167: 4534-4542.
32. + T cells in vitro and in vivo. Infect. Immun. 75: 5018-5026.
33. McDowell, M. A., M. Marovich, R. Lira, M. Braun, and D. Sacks. 2002. Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent. Infect. Immun. 70: 3994-4001.
34. Quinones, M., S. K. Ahuja, P. C. Melby, L. Pate, R. L. Reddick, and S. S. Ahuja. 2000. Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source ofbioactive IL-12 that is mobilized within minutes ofcontact with an intracellular parasite. J. Exp. Med. 192: 507-516.
35. Favali, C., N. Tavares, J. Clarencio, A. Barral, M. Barral-Netto, and C. Brodskyn. 2007. Leishmania amazonensis infection impairs differentiation and function ofhu- man dendritic cells. J. Leukocyte Biol. 82: 1401-1406.
36. + Th1 cells induced by dendritic cell-based immunotherapy in mice chronically infected with Leishmania amazonensis do not promote healing. Infect. Immun. 72: 4455-4463.
37. Naderer, T., J. E. Vince, and M. J. McConville. 2004. Surface determinants ofLeish- mania parasites and their role in infectivity in the mammalian host. CurrMol. Med. 4: 649 -665.
38. Brandonisio, O., R. Spinelli, and M. Pepe. 2004. Dendritic cellsin Leishmania infection. Microbes Infect. 6: 1402-1409.
39. Turco, S. J., G. F. Spath, and S. M. Beverley. 2001. Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species. Trends Parasitol. 17: 223-226.
40. Trinchieri, G., and A. Sher. 2007. Cooperation ofToll-like receptorsignalsin innate immune defence. Nat. Rev. Immunol. 7: 179 -190.
41. Kropf, P., M. A. Freudenberg, M. Modolell, H. P. Price, S. Herath, S. Antoniazi, C. Galanos, D. F. Smith, and I. Muller. 2004. Toll-like receptor 4 contributes to efficient control ofinfection with the protozoan parasite Leishmania major. Infect. Immun. 72: 1920-1928.
42. Flandin, J. F., F. Chano, and A. Descoteaux. 2006. RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by inter- feron-γ-primed macrophages. Eur. J. Immunol. 36: 411-420.
43. Liese, J., U. Schleicher, and C. Bogdan. 2007. TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis. Eur. J. Immunol. 37:3424-3434.
44. Colmenares, M., A. L. Corbi, S. J. Turco, and L. Rivas. 2004. The dendritic cell receptor DC-SIGN discriminates among species and life cycle forms of Leishmania. J. Immunol. 172: 1186-1190.
45. Caparros, E., D. Serrano, A. Puig-Kroger, L. Riol, F. Lasala, I. Martinez, F. Vidal-Vanaclocha, R. Delgado, J. L. Rodriguez-Fernandez, L. Rivas, et al. 2005. RoleoftheC-typelectinsDC-SIGNand L-SIGNinLeishmaniainteractionwith host phagocytes. Immunobiology210: 185-193.
46. Garg, R., N. Trudel, andM. J. Tremblay. 2007. Consequences of the natural propen- sity of Leishmania and HIV-1 to target dendritic cells. Trends Parasitology 23:317-324.
47. Woelbing, F., S. L. Kostka, K. Moelle, Y. Belkaid, C. Sunderkoetter, S. Verbeek,
48. A. Waisman, A. P. Nigg, J. Knop, M. C. Udey, and E. von Stebut. 2006. Uptake of Leishmania major by dendritic cells is mediated by Fc-γ receptors and facilitates acquisition ofprotective immunity. J. Exp. Med. 203: 177-188.
49. Wanasen, N., L. Xin, and L. Soong. Pathogenic role ofB cellsand antibodiesin mu- rine Leishmania amazonensis infection. Int. J. Parasitol. In press.
50. Prina, E., S. Z. Abdi, M. Lebastard, E. Perret, N. Winter, and J. C. Antoine. 2004. Dendritic cells as host cells for the promastigote and amastigote stages of Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation. J. Cell Sci. 117: 315-325.
51. Yang, Z., D. M. Mosser, and X. Zhang. 2007. Activation ofthe MAPK, ERK, following Leishmania amazonensis infection of macrophages. J. Immunol. 178:1077-1085.
52. + T cells from healthy donors and patients with Kala-Azar. J. Infect. Dis. 194: 294-301.
53. Nigg, A. P., S. Zahn, D. Ruckerl, C. Holscher, T. Yoshimoto, J. M. Ehrchen, F. Wolbing, M. C. Udey, and E. von Stebut. 2007. Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice. J. Immunol. 178: 7251-7258.
54. Miles, S. A., S. M. Conrad, R. G. Alves, S. M. Jeronimo, and D. M. Mosser. 2005. A role for IgG immune complexes during infection with the intracellular pathogen Leishmania. J. Exp. Med. 201: 747-754.
55. Besteiro, S., R. A. Williams, G. H. Coombs, and J. C. Mottram. 2007. Protein turnover and differentiation in Leishmania. Int. J. Parasitol. 37: 1063-1075.
56. Ueda-Nakamura, T., M. Attias, and W. de Souza. 2007. Comparative analysis ofme- gasomes in members of the Leishmania mexicana complex. Res. Microbiol. 158: 456-462.
57. de Matos Guedes, H. L., M. P. D. Carneiro, D. C. de Oliveira Gomes, B. Rossi-Bergmann, and S. G. de Simone. 2007. Oligopeptidase B from L. amazonen- sis: molecular cloning, gene expression analysis and molecular model. Parasitol. Res. 101: 866 -875.
58. Cameron, P., A. McGachy, M. Anderson, A. Paul, G. H. Coombs, J. C. Mottram, J. Alexander, and R. Plevin. 2004. Inhibition of lipopolysaccharide- induced macro- phageIL-12 production by Leishmania mexicana amastigotes: the role of cysteinepep- tidases and the NF-κB signaling pathway. J. Immunol. 173: 3297-3304.
59. Saravia, N. G., B. Escorcia, Y. Osorio, L. Valderrama, D. Brooks, L. Arteaga, G. Coombs, J. Mottram, and B. L. Travi. 2006. Pathogenicity and protective immu- nogenicity ofcysteine proteinase-deficient mutants ofLeishmania mexicana in non- murine models. Vaccine 24: 4247-4259.
60. Ato, M., S. Stager, C. R. Engwerda, and P. M. Kaye. 2002. Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nat. Immunol. 3: 1185-1191.
61. Steigerwald, M., and H. Moll. 2005. Leishmania major modulates chemokine and chemokine receptor expression by dendritic cells and affects their migratory capacity. Infect. Immun. 73: 2564-2567.
62. Berberich, C., J. R. Ramirez-Pineda, C. Hambrecht, G. Alber, Y. A. Skeiky, and H. Moll. 2003. Dendritic Cell (DC)-based protection against an intracellularpatho- gen isdependent upon DC-derived IL-12 and can be induced bymolecularlydefined antigens. J. Immunol. 170: 3171-3179.
63. Ramirez-Pineda, J. R., A. Frohlich, C. Berberich, and H. Moll. 2004. Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC. J. Immunol. 172: 6281 6289.
64. Carrion, J., A. Nieto, M. Soto, and C. Alonso. 2007. Adoptive transfer ofdendritic cells pulsed with Leishmania infantum nucleosomal histones confers protection against cutaneous leishmaniosis in BALB/c mice. Microbes Infect. 9: 735-743.
65. Fajardo-Moser, M., S. Berzel, and H. Moll. 2008. Mechanisms of dendritic cell-based vaccination against infection. Int. J. Med. Microbiol. 298: 11-20.
66. Ji, J., J. Sun, H. Qi, and L. Soong. 2002. Analysis of T helper cell responses during infection with Leishmania amazonensis. Am. J. Trop. Med. Hyg. 66: 338 -345.
67. Svensson, M., and P. M. Kaye. 2006. Stromal-cell regulation ofdendritic-cell differentiation and function. Trends Immunol. 27: 580 -587.
68. Zubairi, S., S. L. Sanos, S. Hill, and P. M. Kaye. 2004. Immunotherapy with OX40L-Fc or anti-CTLA-4 enhances local tissue responses and killing of Leishmania donovani. Eur. J. Immunol. 34: 1433-1440.
69. Field, A. E., S. Wagage, S. M. Conrad, and D. M. Mosser. 2007. Reduced pathology following infection with transgenic Leishmania major expressing murine CD40 li- gand. Infect. Immun. 75: 3140-3149.
70. Robinson, K. A., S. Goyard, and S. M. Beverley. 2004. In vitro shuttle mutagenesis using engineered mariner transposons. Methods Mol. Biol. 270: 299-318.
71. Dutta, S., D. Ray, B. K. Kolli, and K. P. Chang. 2005. Photodynamic sensitization of Leishmania amazonensis in both extracellular and intracellular stages with aluminum phthalocyanine chloride for photolysis in vitro. Antimicrob. Agents Chemother. 49: 4474-4484.