Early enhanced Th1 response after Leishmania amazonensis infection of C57BL/6 interleukin-10-deficient mice does not lead to resolution of infection

Infection and Immunity

Volumn 70, Issue 4, 2002, Pages 2151-2158

  Jones, Douglas E ^a   Ackermann, Mark R ^a   Wille, Ulrike ^a   Hunter, Christopher A ^a   Scott, Phillip ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G2A; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BACTERIAL INFECTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DISEASE PREDISPOSITION; DOWN REGULATION; EFFECTOR CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; LEISHMANIA; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, PROTOZOAN; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; TH1 CELLS;

EID: 0036130639     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.4.2151-2158.2002     Document Type: Article

References (49)

1. + T-cell response
2. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis
3. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10
4. H-2M molecules, like MHC class 11 molecules, are targeted to parasitophorous vacuoles of Leishmania-infected macrophages and internalized by amastigotes of L. amazonensis and L. mexicana
5. Late metastatic leishmaniasis in the mouse. A model for mucocutaneous disease
6. Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis
7. Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
8. Experimental Leishmania major infection in mice: Role of IL-10
9. Inbred mice as model hosts for cutaneous leishmaniasis. I. Resistance and susceptibility to infection with Leishmania braziliensis. L. mexicana, and L. aethiopica
10. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/ IL-12 synthesis in accessory cells
11. Analysis of the immune responses of mice to infection with Leishmania braziliensis
12. Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells
13. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity, of monocytes via downregulation of class II major histocompatibility complex expression
14. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
15. IL-10 inhibits cytokine production by activated macrophages
16. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
17. + T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
18. A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells
19. Altered immune responses in interleukin 10 transgenic mice
20. IL-10 and the dangers of immune polarization: Excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis
21. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages
22. IL-10 is required to prevent immune hyperactivity, during infection with Trypanosoma cruzi
23. IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection
24. The role of IL-10 in promoting disease progression in leishmaniasis
25. Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis
26. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
27. IL-4-deficient Balb/c mice resist infection with Leishmania major
28. IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity
29. Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production
30. Interleukin-10
31. Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii
32. Susceptibility to Leishmania major infection in interleukin-4-deficient mice
33. IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
34. Secreted proteophosphoglycan of Leishmania mexicana amastigotes activates complement by triggering the mannan binding lectin pathway
35. Cytokine patterns in the pathogenesis of human leishmaniasis
36. IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-lbeta synthesis and rescue from apoptosis
37. T helper cell differentiation in immune response
38. Visualizing the generation of memory CD4 T cells in the whole body
39. Genetic analysis of Leishmania mexicana infection in mice: Single gene (Scl-2) controlled predisposition to cutaneous lesion development
40. Down-regulation of Th1 type of response in early human American cutaneous leishmaniasis
41. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis
42. Regulation of immunity to parasites by T cells and T cell-derived cytokines
43. Cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis in Amazonian Brazil, and the significance of a negative Montenegro skin-test in human infections
44. + T cells in pathogenesis associated with Leishmania amazonensis infection
45. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
46. Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis
47. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase
48. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii
49. IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease