Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: Implications for the initiation of anti-Leishmania immunity

Journal of Experimental Medicine

Volumn 188, Issue 8, 1998, Pages 1547-1552

  Von Stebut, Esther ^a   Belkaid, Yasmine ^b   Jakob, Thilo ^a   Sacks, David L ^b   Udey, Mark C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Dendritic cell; Interleukin 12; Langerhans cell; Leishmania major; T helper cell type 1 T helper cell type 2 immune response

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

AMASTIGOTE; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; FETUS; HELPER CELL; INTERNALIZATION; LANGERHANS CELL; LEISHMANIA MAJOR; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTOZOAL INFECTION; SKIN CELL;

ANIMALS; DENDRITIC CELLS; INTERLEUKIN-12; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MACROPHAGE ACTIVATION; MICE; MICE, INBRED C57BL; SKIN;

EID: 0032547859     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.8.1547     Document Type: Article

References (30)

1. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
2. Banchereau, J., and R.M. Steinman. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252.
3. Jakob, T., A. Saitoh, and M.C. Udey. 1997. E-cadherin-mediated adhesion involving Langerhans cell-like dendritic cells expanded from murine fetal skin. J. Immunol 159:2693-2701.
4. Jakob, T., and M.C. Udey. 1998. Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo. J. Immunol. 160:4067-4073.
5. Jakob, T., P. Walker, A. Krieg, M. Udey, and J. Vogel. 1998. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides. A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. In press.
6. Reiner, S.L., and R.M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
7. Will, A., C. Blank, M. Rollinghoff, and H. Moll. 1992. Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis. Eur. J. Immunol. 22:1341-1347.
8. Moll, H., H. Fuchs, C. Blank, and M. Rollinghoff. 1993. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur. J. Immunol. 23:1595-1601.
9. Moll, H. 1995. The Immune Functions of Epidermal Langerhans Cells. R.G. Landes Company, Austin, TX. 190 pp.
10. Launois, P., J. Louis, and G. Milon. 1997. The fate and persistence of Leishmania major in mice of different generic backgrounds: an example of exploitation of the immune system by intracellular parasites. Parasitology. 115:S25-S32.
11. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 8: 275-283.
12. Gorham, J.D., M.L. Gueler, and K.M. Murphy. 1997. Genetic control of interleukin 12 responsiveness: implications for disease pathogenesis. J. Mol. Med. 75:502-511.
13. Belkaid, Y., B. Butcher, and D.L. Sacks. 1998. Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells. Eur. J. Immunol. 28:1389-1400.
14. Tang, A., M. Amagai, L.G. Granger, J.R. Stanley, and M.C. Udey. 1993. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature. 361:82-85.
15. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741-746.
16. Carrera, L., R.T. Gazzinelli, R. Badolato, S. Henry, W. Muller, R. Kuhn, and D.L. Sacks. 1996. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 183:515-526.
17. Sartori, A., M. Oliveira, P. Scott, and G. Trinchieri. 1997. Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells. J. Immunol. 159:2849-2857.
18. Bogdan, C., and M. Rollinghoff. 1998. The immune response to Leishmania: mechanisms of parasite control and evasion. Int. J. Parasitol. 28:121-134.
19. Locksley, R.M., F.P. Heinzel, J.E. Fankhauser, C.S. Nelson, and M.D. Sadick. 1988. Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote. Infect. Immun. 56:336-342.
20. Blank, C., H. Fuchs, K. Rappersberger, M. Rollinghoff, and H. Moll. 1993. Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major. J. Infect. Dis. 167:418-425.
21. Flohe, S., T. Lang, and H. Moll. 1997. Synthesis, stability, and subcellular distribution of major histocompatibility complex class II molecules in Langerhans cells infected with Leishmania major. Infect. Immun. 65:3444-3450.
22. Schwarzenberger, K., and M.C. Udey. 1996. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. J. Investig. Dermatol. 106:553-558.
23. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
24. Reis e Sousa, C., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R.N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819-1829.
25. Gorak, P.M.A., C.R. Engwerda, and P.M. Kaye. 1998. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. Eur. J. Immunol. 28: 687-695.
26. Moll, H., S. Flohe, and M. Rollinghoff. 1995. Dendritic cells in Leishmania major-immune mice harbor persistent parasites and mediate an antigen-specific T cell immune response. Eur. J. Immunol. 25:693-699.
27. Melby, P.C. 1991. Experimental leishmaniasis in humans: review. Rev. Infect. Dis. 13:1009-1017.
28. Racoosin, E., and S. Beverley. 1997. Leishmania major: promastigotes induce expression of a subset of chemokine genes in murine macrophages. Exp. Parasitol. 85:283-295.
29. Gazzinelli, R.T., S. Hieny, T.A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA. 90:6115-6119.
30. Tripp, C.S., S.F. Wolf, and E.R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA. 90:3725-3729.