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1
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0001909501
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Immune regulation in parasitic infection and disease
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Edited by Paul W. Lippincott-Raven
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Pearce EJ, Scott PA, Sher A: Immune regulation in parasitic infection and disease. In Fundamental immunology, edn 4. Edited by Paul W. Lippincott-Raven; 1999:1271-1294.
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(1999)
Fundamental Immunology, Edn 4
, pp. 1271-1294
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Pearce, E.J.1
Scott, P.A.2
Sher, A.3
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2
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0035838984
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Dendritic cells: Specialized and regulated antigen processing machines
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Mellman I., Steinman R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell. 106:2001;255-258.
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(2001)
Cell
, vol.106
, pp. 255-258
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Mellman, I.1
Steinman, R.M.2
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3
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0033178828
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The role of dendritic cells in the induction and regulation of immunity to microbial infection
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Reis e Sousa C., Sher A., Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr. Opin. Immunol. 11:1999;392-399.
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(1999)
Curr. Opin. Immunol.
, vol.11
, pp. 392-399
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Reis e Sousa, C.1
Sher, A.2
Kaye, P.3
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4
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0037261130
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The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals
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Manickasingham S.P., Edwards A.D., Schulz O., Reis e Sousa C. The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals. Eur. J. Immunol. 33:2003;101-107.
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(2003)
Eur. J. Immunol.
, vol.33
, pp. 101-107
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Manickasingham, S.P.1
Edwards, A.D.2
Schulz, O.3
Reis e Sousa, C.4
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6
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0037097795
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Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
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This study demonstrates that both DC IL-12 production in response to STAg and host resistance to T. gondii infection depend on the common TLR adaptor molecule MyD88. It thus provides some of the first evidence for a role for TLR signaling in the activation of DCs by a parasite.
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Scanga C.A., Aliberti J., Jankovic D., Tilloy F., Bennouna S., Denkers E.Y., Medzhitov R., Sher A. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J. Immunol. 168:2002;5997-6001 This study demonstrates that both DC IL-12 production in response to STAg and host resistance to T. gondii infection depend on the common TLR adaptor molecule MyD88. It thus provides some of the first evidence for a role for TLR signaling in the activation of DCs by a parasite.
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(2002)
J. Immunol.
, vol.168
, pp. 5997-6001
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Scanga, C.A.1
Aliberti, J.2
Jankovic, D.3
Tilloy, F.4
Bennouna, S.5
Denkers, E.Y.6
Medzhitov, R.7
Sher, A.8
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7
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0037087436
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Cutting edge: Identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli
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Mason N., Aliberti J., Caamano J.C., Liou H.C., Hunter C.A. Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli. J. Immunol. 168:2002;2590-2594.
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(2002)
J. Immunol.
, vol.168
, pp. 2590-2594
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Mason, N.1
Aliberti, J.2
Caamano, J.C.3
Liou, H.C.4
Hunter, C.A.5
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8
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10744227649
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Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
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Aliberti J., Valenzuela J.G., Hieny S., Andersen J., Charest H., Reis e Sousa C., Fairlamb A., Carruthers V., Ribeiro J.M., Sher A. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat. Immunol. 4:2003;485-490.
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(2003)
Nat. Immunol.
, vol.4
, pp. 485-490
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Aliberti, J.1
Valenzuela, J.G.2
Hieny, S.3
Andersen, J.4
Charest, H.5
Reis e Sousa, C.6
Fairlamb, A.7
Carruthers, V.8
Ribeiro, J.M.9
Sher, A.10
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9
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0031889474
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Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
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Gorak P.M., Engwerda C.R., Kaye P.M. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. Eur. J. Immunol. 28:1998;687-695.
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(1998)
Eur. J. Immunol.
, vol.28
, pp. 687-695
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Gorak, P.M.1
Engwerda, C.R.2
Kaye, P.M.3
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11
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0035076991
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Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes
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Bennett C.L., Misslitz A., Colledge L., Aebischer T., Blackburn C.C. Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes. Eur. J. Immunol. 31:2001;876-883.
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(2001)
Eur. J. Immunol.
, vol.31
, pp. 876-883
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Bennett, C.L.1
Misslitz, A.2
Colledge, L.3
Aebischer, T.4
Blackburn, C.C.5
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12
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0036081566
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Hierarchy of susceptibility of dendritic cell subsets to infection by Leishmania major: Inverse relationship to interleukin-12 production
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Henri S., Curtis J., Hochrein H., Vremec D., Shortman K., Handman E. Hierarchy of susceptibility of dendritic cell subsets to infection by Leishmania major: inverse relationship to interleukin-12 production. Infect Immun. 70:2002;3874-3880.
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(2002)
Infect Immun.
, vol.70
, pp. 3874-3880
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Henri, S.1
Curtis, J.2
Hochrein, H.3
Vremec, D.4
Shortman, K.5
Handman, E.6
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13
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0036073280
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Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent
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The literature on Leishmania infections is complex and often attempts have been made to amalgamate data derived from various in vitro or in vivo studies that have used different species of this parasite. This paper clearly shows that the outcome of the interaction of Leishmania with DCs is very species-dependent and argues therefore that both initial and subsequent responses to these various parasites may be quite dissimilar.
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McDowell M.A., Marovich M., Lira R., Braun M., Sacks D. Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent. Infect. Immun. 70:2002;3994-4001 The literature on Leishmania infections is complex and often attempts have been made to amalgamate data derived from various in vitro or in vivo studies that have used different species of this parasite. This paper clearly shows that the outcome of the interaction of Leishmania with DCs is very species-dependent and argues therefore that both initial and subsequent responses to these various parasites may be quite dissimilar.
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(2002)
Infect. Immun.
, vol.70
, pp. 3994-4001
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McDowell, M.A.1
Marovich, M.2
Lira, R.3
Braun, M.4
Sacks, D.5
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14
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0035003815
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Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species
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Turco S.J., Spath G.F., Beverley S.M. Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species. Trends Parasitol. 17:2001;223-226.
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(2001)
Trends Parasitol.
, vol.17
, pp. 223-226
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Turco, S.J.1
Spath, G.F.2
Beverley, S.M.3
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15
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0034661692
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A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity
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Belkaid Y., Mendez S., Lira R., Kadambi N., Milon G., Sacks D. A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity. J. Immunol. 165:2000;969-977.
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(2000)
J. Immunol.
, vol.165
, pp. 969-977
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Belkaid, Y.1
Mendez, S.2
Lira, R.3
Kadambi, N.4
Milon, G.5
Sacks, D.6
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16
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0037183983
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Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes
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DC-SIGN has received much recent attention, not just as a mediator of DC-T cell interactions, but as a pathogen binding receptor. In this paper, the authors describe the first interaction between a protozoan parasite and DC mediated by DC-SIGN. Whether DC-SIGN or structurally related molecules are involved in the pathogenesis of leishmaniasis, however, remains to be determined.
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Colmenares M., Puig-Kroger A., Pello O.M., Corbi A.L., Rivas L. Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes. J. Biol. Chem. 277:2002;36766-36769 DC-SIGN has received much recent attention, not just as a mediator of DC-T cell interactions, but as a pathogen binding receptor. In this paper, the authors describe the first interaction between a protozoan parasite and DC mediated by DC-SIGN. Whether DC-SIGN or structurally related molecules are involved in the pathogenesis of leishmaniasis, however, remains to be determined.
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(2002)
J. Biol. Chem.
, vol.277
, pp. 36766-36769
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Colmenares, M.1
Puig-Kroger, A.2
Pello, O.M.3
Corbi, A.L.4
Rivas, L.5
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18
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0037087471
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DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-β, and anti-inflammatory agents
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Relloso M., Puig-Kroger A., Pello O.M., Rodriguez-Fernandez J.L., de la Rosa G., Longo N., Navarro J., Munoz-Fernandez M.A., Sanchez-Mateos P., Corbi A.L. DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-β, and anti-inflammatory agents. J. Immunol. 168:2002;2634-2643.
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(2002)
J. Immunol.
, vol.168
, pp. 2634-2643
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Relloso, M.1
Puig-Kroger, A.2
Pello, O.M.3
Rodriguez-Fernandez, J.L.4
De la Rosa, G.5
Longo, N.6
Navarro, J.7
Munoz-Fernandez, M.A.8
Sanchez-Mateos, P.9
Corbi, A.L.10
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19
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0035399862
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Activation of Toll-like-receptor 2 by glycosylphosphatidylinositol anchors from a protozoan parasite
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Campos M.A., Almeida I.C., Takeuchi O., Akira S., Valente E.P., Procopio D.O., Travassos L.R., Smith J.A., Golenbock D.T., Gazzinelli R.T. Activation of Toll-like-receptor 2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J. Immunol. 167:2001;416-423.
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(2001)
J. Immunol.
, vol.167
, pp. 416-423
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Campos, M.A.1
Almeida, I.C.2
Takeuchi, O.3
Akira, S.4
Valente, E.P.5
Procopio, D.O.6
Travassos, L.R.7
Smith, J.A.8
Golenbock, D.T.9
Gazzinelli, R.T.10
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20
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0037097776
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The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection
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In this study the authors identify a new class of molecules that trigger DC maturation and show that TLR-2 is not sufficient for cellular binding. The latter observation is important in that it provides a framework for cooperation between many cellular receptors involved in pathogen recognition and subsequent TLR-mediated signaling.
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Ouaissi A., Guilvard E., Delneste Y., Caron G., Magistrelli G., Herbault N., Thieblemont N., Jeannin P. The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection. J. Immunol. 168:2002;6366-6374 In this study the authors identify a new class of molecules that trigger DC maturation and show that TLR-2 is not sufficient for cellular binding. The latter observation is important in that it provides a framework for cooperation between many cellular receptors involved in pathogen recognition and subsequent TLR-mediated signaling.
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(2002)
J. Immunol.
, vol.168
, pp. 6366-6374
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Ouaissi, A.1
Guilvard, E.2
Delneste, Y.3
Caron, G.4
Magistrelli, G.5
Herbault, N.6
Thieblemont, N.7
Jeannin, P.8
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21
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0035989335
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Trypanosoma cruzi heat-shock-protein 70 kDa, alone or fused to the parasite KMP11 antigen, induces functional maturation of murine dendritic cells
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Planelles L., Thomas M., Pulgar M., Maranon C., Grabbe S., Lopez M.C. Trypanosoma cruzi heat-shock-protein 70 kDa, alone or fused to the parasite KMP11 antigen, induces functional maturation of murine dendritic cells. Immunol. Cell Biol. 80:2002;241-247.
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(2002)
Immunol. Cell Biol.
, vol.80
, pp. 241-247
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Planelles, L.1
Thomas, M.2
Pulgar, M.3
Maranon, C.4
Grabbe, S.5
Lopez, M.C.6
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22
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0036199625
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-/- setting
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Is Th2 induction by helminths simply the result of the absence of IL-12 production? This study provides evidence against this hypothesis while demonstrating a critical role for MyD88 in the dominant Th1 response induced by T. gondii.
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-/- setting. Immunity. 16:2002;429-439 Is Th2 induction by helminths simply the result of the absence of IL-12 production? This study provides evidence against this hypothesis while demonstrating a critical role for MyD88 in the dominant Th1 response induced by T. gondii.
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(2002)
Immunity
, vol.16
, pp. 429-439
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Jankovic, D.1
Kullberg, M.C.2
Hieny, S.3
Caspar, P.4
Collazo, C.M.5
Sher, A.6
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23
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0036533626
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Cutting edge: Polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells
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-/- mice, this paper shows categorically that the induction of Th2 responses against helminth antigens can occur independently of the production of IL-4 by DC. The paper makes the additional point that Th1 responses to bacterial antigens can be initiated by DC that cannot make IL-12.
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-/- mice, this paper shows categorically that the induction of Th2 responses against helminth antigens can occur independently of the production of IL-4 by DC. The paper makes the additional point that Th1 responses to bacterial antigens can be initiated by DC that cannot make IL-12.
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(2002)
J. Immunol.
, vol.168
, pp. 3127-3130
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MacDonald, A.S.1
Pearce, E.J.2
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24
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0037083298
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Microbial compounds selectively induce Th1-cell-promoting or Th2-cell-promoting dendritic cells in vitro with diverse Th-cell-polarizing signals
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This study explores the diversity of microbe-induced DC signals involved in Th polarization and establishes a role for enhanced OX40 expression in Th2 induction by schistosome antigens.
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de Jong E.C., Vieira P.L., Kalinski P., Schuitemaker J.H., Tanaka Y., Wierenga E.A., Yazdanbakhsh M., Kapsenberg M.L. Microbial compounds selectively induce Th1-cell-promoting or Th2-cell-promoting dendritic cells in vitro with diverse Th-cell-polarizing signals. J. Immunol. 168:2002;1704-1709 This study explores the diversity of microbe-induced DC signals involved in Th polarization and establishes a role for enhanced OX40 expression in Th2 induction by schistosome antigens.
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(2002)
J. Immunol.
, vol.168
, pp. 1704-1709
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De Jong, E.C.1
Vieira, P.L.2
Kalinski, P.3
Schuitemaker, J.H.4
Tanaka, Y.5
Wierenga, E.A.6
Yazdanbakhsh, M.7
Kapsenberg, M.L.8
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25
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0037100266
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Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice
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Th2 response induction by DC pulsed with helminth antigens was shown to require CD1d. This report returns attention to NK T cells as a possible source of IL-4, which is important in Th2 response development.
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Faveeuw C., Angeli V., Fontaine J., Maliszewski C., Capron A., Van Kaer L., Moser M., Capron M., Trottein F. Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice. J. Immunol. 169:2002;906-912 Th2 response induction by DC pulsed with helminth antigens was shown to require CD1d. This report returns attention to NK T cells as a possible source of IL-4, which is important in Th2 response development.
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(2002)
J. Immunol.
, vol.169
, pp. 906-912
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Faveeuw, C.1
Angeli, V.2
Fontaine, J.3
Maliszewski, C.4
Capron, A.5
Van Kaer, L.6
Moser, M.7
Capron, M.8
Trottein, F.9
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26
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0037080199
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Cutting edge: Th2-response induction by dendritic cells: A role for CD40
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Helminth antigens do not appear to induce DC maturation. This report suggests that, nevertheless, an immune-system-intrinsic maturation signal, in the form of ligation of CD40 on DC by CD40L, is necessary to allow DC pulsed with helminth antigen to induce Th2 responses.
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MacDonald A.S., Straw A.D., Dalton N.M., Pearce E.J. Cutting edge: Th2-response induction by dendritic cells: a role for CD40. J. Immunol. 168:2002;537-540 Helminth antigens do not appear to induce DC maturation. This report suggests that, nevertheless, an immune-system-intrinsic maturation signal, in the form of ligation of CD40 on DC by CD40L, is necessary to allow DC pulsed with helminth antigen to induce Th2 responses.
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(2002)
J. Immunol.
, vol.168
, pp. 537-540
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MacDonald, A.S.1
Straw, A.D.2
Dalton, N.M.3
Pearce, E.J.4
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27
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0034658107
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Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T-helper cell immunity in vitro and in vivo
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d'Ostiani C.F., Del Sero G., Bacci A., Montagnoli C., Spreca A., Mencacci A., Ricciardi-Castagnoli P., Romani L. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T-helper cell immunity in vitro and in vivo. J. Exp. Med. 191:2000;1661-1674.
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(2000)
J. Exp. Med.
, vol.191
, pp. 1661-1674
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D'Ostiani, C.F.1
Del Sero, G.2
Bacci, A.3
Montagnoli, C.4
Spreca, A.5
Mencacci, A.6
Ricciardi-Castagnoli, P.7
Romani, L.8
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28
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0035882012
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- dendritic cell activation status plays an integral role in influencing Th2 response development
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- dendritic cell activation status plays an integral role in influencing Th2 response development. J. Immunol. 167:2001;1982-1988.
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(2001)
J. Immunol.
, vol.167
, pp. 1982-1988
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MacDonald, A.S.1
Straw, A.D.2
Bauman, B.3
Pearce, E.J.4
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29
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0034660408
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A filarial-nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells
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Whelan M., Harnett M.M., Houston K.M., Patel V., Harnett W., Rigley K.P. A filarial-nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J. Immunol. 164:2000;6453-6460.
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(2000)
J. Immunol.
, vol.164
, pp. 6453-6460
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Whelan, M.1
Harnett, M.M.2
Houston, K.M.3
Patel, V.4
Harnett, W.5
Rigley, K.P.6
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30
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0036604930
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Control of adaptive immune responses by Toll-like receptors
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Barton G.M., Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Curr. Opin. Immunol. 14:2002;380-383.
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(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 380-383
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Barton, G.M.1
Medzhitov, R.2
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31
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0035399579
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Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response
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Okano M., Satoskar A.R., Nishizaki K., Harn D.A. Jr. Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. J. Immunol. 167:2001;442-450.
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(2001)
J. Immunol.
, vol.167
, pp. 442-450
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Okano, M.1
Satoskar, A.R.2
Nishizaki, K.3
Harn D.A., Jr.4
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32
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0034877815
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Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
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Mohrs M., Shinkai K., Mohrs K., Locksley R.M. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 15:2001;303-311.
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(2001)
Immunity
, vol.15
, pp. 303-311
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Mohrs, M.1
Shinkai, K.2
Mohrs, K.3
Locksley, R.M.4
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33
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0029959243
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+ T cells are not essential for T helper cell 2 immune responses
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+ T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184:1996;1295-1304.
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(1996)
J. Exp. Med.
, vol.184
, pp. 1295-1304
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Brown, D.R.1
Fowell, D.J.2
Corry, D.B.3
Wynn, T.A.4
Moskowitz, N.H.5
Cheever, A.W.6
Locksley, R.M.7
Reiner, S.L.8
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34
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0036569444
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Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction
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MacDonald A.S., Patton E.A., La Flamme A.C., Araujo M.I., Huxtable C.R., Bauman B., Pearce E.J. Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. J. Immunol. 168:2002;4643-4649.
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(2002)
J. Immunol.
, vol.168
, pp. 4643-4649
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MacDonald, A.S.1
Patton, E.A.2
La Flamme, A.C.3
Araujo, M.I.4
Huxtable, C.R.5
Bauman, B.6
Pearce, E.J.7
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35
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0037438643
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CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses
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Straw A.D., MacDonald A.S., Denkers E.Y., Pearce E.J. CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. J. Immunol. 170:2003;727-734.
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(2003)
J. Immunol.
, vol.170
, pp. 727-734
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Straw, A.D.1
MacDonald, A.S.2
Denkers, E.Y.3
Pearce, E.J.4
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36
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2242487380
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A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization
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Little is currently known about the role of DCs in initiating regulatory T-cell responses. This study shows that a lipid from a parasitic helminth is able to condition DC, via TLR2, to promote this type of response.
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van der Kleij D., Latz E., Brouwers J.F., Kruize Y.C., Schmitz M., Kurt-Jones E.A., Spevik T., de Jong E.C., Kapsenberg M.L., Golenbock D.T.et al. A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J. Biol. Chem. 277:2002;48122-48129 Little is currently known about the role of DCs in initiating regulatory T-cell responses. This study shows that a lipid from a parasitic helminth is able to condition DC, via TLR2, to promote this type of response.
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(2002)
J. Biol. Chem.
, vol.277
, pp. 48122-48129
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Van der Kleij, D.1
Latz, E.2
Brouwers, J.F.3
Kruize, Y.C.4
Schmitz, M.5
Kurt-Jones, E.A.6
Spevik, T.7
De Jong, E.C.8
Kapsenberg, M.L.9
Golenbock, D.T.10
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37
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0035927185
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Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection
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+ T-cell priming during a parasitic infection. The technique described may have general use in determining the role of DCs in immune responses in vivo.
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