Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent

Infection and Immunity

Volumn 70, Issue 8, 2002, Pages 3994-4001

  McDowell, Mary Ann ^a   Marovich, Mary ^a   Lira, Rosalia ^a   Braun, Michael ^a   Sacks, David ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; INTERLEUKIN 12;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; IMMUNITY; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LEISHMANIA TROPICA; LEISHMANIASIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; SKIN DISEASE; SPECIES DIFFERENCE; STRAIN DIFFERENCE; T LYMPHOCYTE; TH1 CELL;

ANIMALS; ANTIGENS, CD40; CD40 LIGAND; DENDRITIC CELLS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LEISHMANIA TROPICA; SPECIES SPECIFICITY; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036073280     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.8.3994-4001.2002     Document Type: Article

References (57)

1. Differential role for p38 mitogen-activated protein kinase in regulating CD40-induced gene expression in dendritic cells and B cells
2. Immunobiology of dendritic cells
3. A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity
4. Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes
5. Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major
6. CD40 ligand is required for protective cell-mediated immunity to Leishmania major
7. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice
8. Interleukin-12 production by human polymorphonuclear leukocytes
9. Activation of human dendritic cells through CD40 cross-linking
10. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
11. Vaccination against the intracellular pathogens Leishmania major and L. amazonensis by directing CD40 ligand to macrophages
12. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
13. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
14. Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes
15. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge
16. Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells
17. Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
18. Underproduction of interleukin-12 in susceptible mice during progressive leishmaniasis is due to decreased CD40 activity
19. Recombinant interleukin 12 cures mice infected with Leishmania major
20. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells
21. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype
22. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
23. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction
24. Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses
25. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
26. Murine dendritic cells internalize Leishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferation in vitro
27. Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani
28. Regulation of protective immunity against Leishmania major in mice
29. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
30. Visceral infection caused by Leishmania tropica in veterans of Operation Desert Storm
31. IL-12p70 production by Leishmania major-harboring human dendritic cells is a CD40/CD40 ligand-dependent process
32. Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors
33. Visceral leishmaniasis unresponsive to pentostam caused by Leishmania tropica in Kenya
34. Dendritic cells induce immunity to cutaneous leishmaniasis in mice
35. Clinical picture of cutaneous leishmaniasis in Isfahan, Iran
36. Treatment of recurrent cutaneous Leishmaniasis
37. A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment
38. Cutaneous leishmaniasis - A case with persistent organisms after treatment in presence of normal immune response
39. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection
40. Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes
41. Indian kala-azar caused by Leishmania tropica
42. Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells
43. The biochemical and serological taxonomy of visceralizing leishmania
44. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
45. The role of IL-12 in regulation of T helper cell subsets in vivo. Lessons from experimental cutaneous leishmaniasis
46. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction
47. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
48. High-level IL-12 production by human dendritic cells requires two signals
49. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
50. An LPG-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation
51. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
52. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective T helper type 1 immune response
53. Immunobiology of interleukin-12
54. Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species
55. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: Implications for the initiation of anti-Leishmania immunity
56. Leishmania major-infected murine langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis
57. Characterization of the A2-A2rel gene cluster in Leishmania donovani: Involvement of A2 in visceralization during infection