Two waves of antigen-containing dendritic cells in vivo in experimental Leishmania major infection

European Journal of Immunology

Volumn 34, Issue 3, 2004, Pages 715-725

  Misslitz, Ana Clara ^a   Bonhagen, Kerstin ^b   Harbecke, Dorothee ^c   Lippuner, Christoph ^a   Kamradt, Thomas ^b   Aebischer, Toni ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^c MAX PLANCK INST FÜR BIOLOGIE   (Germany)

Author keywords

Dendritic cell turnover; Green fluorescent protein; Transgenic parasites

Indexed keywords

INTERLEUKIN 12; PARASITE ANTIGEN; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; GREEN FLUORESCENT PROTEIN; PHOTOPROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DATA ANALYSIS; DENDRITIC CELL; EXPERIMENTAL INFECTION; GENETIC DIFFERENCE; IN VIVO STUDY; LEISHMANIA MAJOR; LEISHMANIASIS; LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; IMMUNOLOGY; KINETICS; MOUSE; PARASITOLOGY; SKIN LEISHMANIASIS;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, PROTOZOAN; CELLS, CULTURED; DENDRITIC CELLS; GREEN FLUORESCENT PROTEINS; INDICATORS AND REAGENTS; INTERLEUKIN-12; KINETICS; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LUMINESCENT PROTEINS; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TH2 CELLS;

EID: 1642303398     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324391     Document Type: Article

References (38)

1. Herwaldt, B. L., Leishmaniasis. Lancet 1999. 354: 1191-1199.
2. Belkaid, Y., Kamhawi, S., Modi, G., Valenzuela, J., Noben-Trauth, N., Rowton, E., Ribeiro, J. and Sacks, D. L., Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J. Exp. Med. 1998. 188: 1941-1953.
3. Bretscher, P. A., Wei, G., Menon, J. N. and Bielefeldt-Ohmann, H., Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 1992. 257: 539-542.
4. Himmelrich, H., Launois, P., Maillard, I., Biedermann, T., Tacchini-Cottier, F., Locksley, R. M., Rocken, M. and Louis, J. A., In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. J. Immunol. 2000. 164: 4819-4825.
5. + T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 1997. 6: 541-549.
6. Reiner, S. L. and Locksley, R. M., The regulation of immunity to Leishmania major Annu. Rev. Immunol. 1995. 13: 151-177.
7. Mattner, F., Magram, J., Ferrante, J., Launois, P., Dipadova, K., Behin, R., Gately, M. K., Louis, J. A. and Alber, G., Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 1996. 26: 1553-1559.
8. Menon, J. N. and Bretscher, P. A., Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low-doses of L. major and resulting in resistance to a normally pathogenic challenge. Eur. J. Immunol. 1996. 26: 243-249.
9. Belkaid, Y., Mendez, S., Lira, R., Kadambi, N., Milon, G. and Sacks, D., A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity. J. Immunol. 2000. 165: 969-977.
10. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
11. Kelsall, B. L., Stuber, E., Neurath, M. and Strober, W., Interleukin-112 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T cell responses. Ann. N. Y. Acad. Sci. 1996. 795: 116-126.
12. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
13. Pulendran, B., Smith, J. L., Caspary, G., Brasel, K., Pettit, D., Maraskovsky, E. and Maliszewski, C. R., Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc. Natl. Acad. Sci. USA 1999. 96: 1036-1041.
14. Moll, H., Experimental cutaneous leishmaniasis: Langerhans cells internalize Leishmania major and induce an antigen-specific T cell response. Adv. Exp. Med. Biol. 1993. 329: 587-592.
15. -. Eur. J. Immunol. 1995. 25: 3298-3307.
16. Sacks, D. and Sher, A., Evasion of innate immunity by parasitic protozoa. Nat. Immunol. 2002. 3: 1041-1047.
17. + cells correlate with resolution of lesions in murine cutaneous leishmaniasis. J. Immunol. 1992. 149: 2715-2721.
18. Misslitz, A. C, Mottram, J. C., Overath, P. and Aebischer, T., Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes. Mol. Biochem. Parasitol. 2000. 107: 251-261.
19. Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E. and Gately, M. K., Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 1993. 177: 1505-1509.
20. Kamath, A. T., Henri, S., Battye, F., Tough, D. F. and Shortman, K., Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood 2002. 100: 1734-1741.
21. von Stebut, E., Belkaid, Y., Nguyen, B. V., Cushing, M., Sacks, D. L. and Udey, M. C., Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous leishmaniasis. Eur. J. Immunol. 2000. 30: 3498-3506.
22. von Stebut, E., Ehrchen, J. M., Belkaid, Y., Kostka, S. L., Molle, K., Knop, J., Sunderkotter, C. and Udey, M. C., Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice. J. Exp. Med. 2003. 198: 191-199.
23. + T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells. J. Exp. Med. 2003. 198: 201-209.
24. Laskay, T., Diefenbach, A., Rollinghoff, M. and Solbach, W., Early parasite containment is decisive for resistance to Leishmania major infection. Eur. J. Immunol. 1995. 25: 2220-2227.
25. Stetson, D., Mohrs, M., Mallet-Designe, V., Teyton, L. and Locksley, R., Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity. 2002. 17: 191-200.
26. Prina, E., Lang, T., Glaichenhaus, N. and Antoine, J. C., Presentation of the protective parasite antigen LACK by Leishmania-infected macrophages. J. Immunol. 1996. 156: 4318-4327.
27. Flohe, S. B., Bauer, C., Flohe, S. and Moll, H., Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major. Eur. J. Immunol. 1998. 28: 3800-3811.
28. + T cells during initiation of infection. J. Exp. Med. 1994. 179: 447-456.
29. Oliveira, M. A., Santiago, H. C., Lisboa, C. R., Ceravollo, I. P., Trinchieri, G., Gazzinelli, R. T. and Vieira, L. Q., Leishmania sp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-gamma synthesis. Exp. Parasitol. 2000. 95: 96-105.
30. Schartonkersten, T., Afonso, L. C. C., Wysocka, M., Trinchieri, G. and Scott, P., IL-12 is required for natural-killer-cell activation and subsequent T-helper-1 cell-development in experimental leishmaniasis. J. Immunol. 1995. 154: 5320-5330.
31. Vieira, L. Q., Hondowicz, B. D., Afonso, L. C., Wysocka, M., Trinchieri, G. and Scott, P., Infection with Leishmania major induces interleukin-12 production in vivo. Immunol. Lett. 1994. 40: 157-161.
32. Trinchieri, G., Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003. 3: 133-146.
33. Shimoda, K., Tsutsui, H., Aoki, K., Kato, K., Matsuda, T., Numata, A., Takase, K., Yamamoto, T., Nukina, H., Hoshino, T., Asano, Y., Gondo, H., Okamura, T., Okamura, S., Nakayama, K., Nakanishi, K., Niho, Y. and Harada, M., Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice. Blood 2002. 99: 2094-2099.
34. Sugimoto, N., Nakahira, M., Ahn, H. J., Micallef, M., Hamaoka, T., Kurimoto, M. and Fujiwara, H., Differential requirements for Jak2 and Tyk2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18. Eur. J. Immunol. 2003. 33: 243-251.
35. Diefenbach, A., Schindler, H., Rollinghoff, M., Yokoyama, W. M. and Bogdan, C., Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science 1999. 284: 951-955.
36. Ingulli, E., Mondino, A., Khoruts, A. and Jenkins, M. K., In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J. Exp. Med. 1997. 185: 2133-2141.
37. Itano, A. A., McSorley, S. J., Reinhardt, R. L., Ehst, B. D., Ingulli, E., Rudensky, A. Y. and Jenkins, M. K., Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity. 2003. 19: 47-57.
38. Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L. and Shortman, K., The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J. Exp. Med. 1992. 176: 47-58.