Morphometric studies of the entorhinal cortex in neuropsychiatric patients and controls: Clusters of heterotopically displaced lamina II neurons are not indicative of schizophrenia

Schizophrenia Research

Volumn 33, Issue 3, 1998, Pages 125-132

  Bernstein, H G ^a   Krell, D ^a   Baumann, B ^a   Danos, P ^a   Falkai, P ^b   Diekmann, S ^a   Henning, H ^a   Bogerts, B ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Depression; Heterotopias; Human entorhinalcortex; Morphometry; Schizophrenia

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; ENTORHINAL CORTEX; FEMALE; HETEROTOPIA; HUMAN; HUMAN TISSUE; MALE; MORPHOMETRICS; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; AGED; BIOLOGICAL MARKERS; CHORISTOMA; DEMENTIA; DEPRESSIVE DISORDER; DIAGNOSIS, DIFFERENTIAL; DOMINANCE, CEREBRAL; ENTORHINAL CORTEX; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURONS; REFERENCE VALUES; RISK FACTORS; SCHIZOPHRENIA;

EID: 0032500560     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(98)00071-1     Document Type: Article

References (34)

1. Akil, M., Lewis, D.A., 1997. Cytoarchitecture of the entorhinal cortex in schizophrenia. Am. J. Psychiatry. 154, 1010-1012.
2. Arnold, S.E., Hyman, B.T., Hoesen, G.W.V., Damasio, A.R., 1991. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch. Gen. Psychiatry 48, 625-632.
3. Arnold, S.E., Ruscheinsky, D.D., Han, L.-Y., 1997. Further evidence of abnormal cytoarchitecture of the entorhinal cortex in schizophrenia using spatial point pattern analyses. Biol. Psychiatry 42, 639-647.
4. Barth, P.G., 1987. Disorders of neuronal migration. Can. J. Neurol. Sci. 14, 1-16.
5. Beall, M.J., Lewis, D.A., 1992. Heterogeneity of layer II neurons in human entorhinal cortex. J. Comp. Neurol. 321, 241-266.
6. Beckmann, H., Jakob, H., 1991. Prenatal disturbances of nerve cell migration in the entorhinal region: A common vulnerability factor in functional psychoses? J. Neural Transm. 84, 155-164.
7. Bernstein, H.-G., Krell, D., Danos, P., Baumann, B., Bogerts, B., 1996. Semiquantitative cytoarchtitektonische Untersuchungen an cortico-limbischen Strukturen von Schizophrenen. Fortschr. Neurol. Psychiatr. 64 (Suppl. 1), 53
8. Bernstein, H.-G., Stanarius, A., Baumann, B., Henning, H., Krell, D., Danos, P., Falkai, P., Bogerts, B., 1998. Nitric oxide synthase containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 83, 867-875.
9. Bogerts, B., Meertz, E., Schönfeldt-Bausch, R., 1985. Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Arch. Gen. Psychiatry 42, 784-791.
10. Bogerts, B., 1997. The temporolimbic system theory of positive schizophrenic symptoms. Schizophr. Bull. 23, 423-435.
11. Braak, H., 1980. Architectonics of the Human Telencephalic Cortex. Springer, Berlin.
12. Brunstrom, J.E., Gray-Swain, M.R., Osborne, P.A., Pearlman, A.L., 1997. Neuronal heterotopias in the developing cerebral cortex produced by neurotrophin-4. Neuron 18, 505-517.
13. Bruton, C.J., Crow, T.J., Frith, C.D., Johnstone, E.C., Owens, D.G.C., Roberts, G.W., 1990. Schizophrenia and the brain: A prospective clinico-neuropathological study. Psychol. Med. 20, 285-304.
14. Danos, P., Baumann, B., Bernstein, H.-G., Franz, M., Stauch, R., Northoff, G., Krell, D., Falkai, P., Bogerts, B., 1998. Schizophrenia and anteroventral thalamic nucleus: selective decrease of parvalbumin-immunoreactive thalamo-cortical projection neurons. Psychiatr. Res. Neuroimaging. 82, 1-10.
15. Dwork, A.J., 1997. Postmortem studies of the hippocampal formation in schizophrenia. Schizophr. Bull. 23, 385-402.
16. Falkai, P., Bogerts, B., Rozumek, M., 1988. Cell loss and volume reduction in the entorhinal cortex of schizophrenics. Biol. Psychiatry 24, 515-521.
17. Heinsen, H., Henn, R., Eisenmenger, W., Götz, M., Bohl, J., Bethke, B., Lockemann, U., Püschel, K., 1994. Quantitative investigations on the human human entorhinal area: Left-right asymmetry and age-related changes. Anat. Embryol. 190, 181-184.
18. Heinsen, H., Gößmann, E., Bauer, M., Ulmar, G., Rüb, U., Böcker, F., Schüler, M., Bethke, B., 1995. Neurodevelopmental disturbances in the entorhinal region of schizophrenics: misinterpretation of the rostral entorhinal transitional areas. Clin. Neuropathol. 14, 262
19. Heinsen, H., Gößmann, E., Rüb, U., Eisenmenger, W., Bauer, M., Ulmar, G., Bethke, B., Schüler, M., Schmitt, H.-P., Götz, M., Lockemann, U., Püschel, K., 1996. Variability in the human entorhinal region may confound neuropsychiatric diagnoses. Acta Anat. 157, 226-237.
20. Insausti, R., Tunon, T., Sobreviela, T., Insausti, A.M., Gonzalo, L.M., 1995. The human entorhinal cortex: a cytoarchitectural analysis. J. Comp. Neurol. 355, 171-198.
21. Jakob, H., Beckmann, H., 1986. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J. Neural Transm. 98, 83-106.
22. Jakob, H., Beckmann, H., 1989. Gross and histological citeria for developmental disorders in brains of schizophrenics. J. Royal Soc. Med. 82, 466-469.
23. Krimer, L.S., Herman, M.M., Saunders, R.C., Boyd, J.C., Kleinman, J.E., Hyde, T.M., Weinberger, D.R., 1995. Qualitative and quantitative analysis of the entorhinal cortex: cytoarcitectural organization in schizophrenia. Soc. Neurosci. Abstr. 21, 239
24. Krimer, L.S., Hyde, T.M., Herman, M.M., Saunders, R.C., 1997a. The entorhinal cortex: an examination of cyto-and myeloarchitectonic organization in humans. Cerebral Cortex 7, 722-731.
25. Krimer, L.S., Herman, M.M., Saunders, R.C., Boyd, J.C., Hyde, T.M., Carter, J.M., Kleinman, J.E., Weinberger, D.R., 1997b. A qualitative and quantitative analysis of the entorhinal cortex in schizophrenics. Cerebral Cortex 7, 732-739.
26. Meencke, H.J., Veith, G., 1992. Migration disturbances in epilepsy. Mol. Neurobiol. Epilepsy (Epilepsy Res. Suppl.) 9, 31-40.
27. Olney, J.W., Farber, N.B., 1997. Discussion of Bogerts' temporolimbic system theory of paranoid schizophrenia. Schizophr. Bull. 23, 533-535.
28. Stevens, J.R., 1988. Review article: Epilepsy, psychosis and schizophrenia. Schizophr. Res. 1, 79-89.
29. Suddath, R.L., Christison, G.W., Torrey, E.F., Casanova, M.F., Weinberger, D.R., 1990. Abnormalities in the brains of monozygotic twins discordant for schizophrenia. New Engl. J. Med. 322, 789-794.
30. Torrey, E.F., Peterson, M.R., 1974. Schizophrenia and the limbic system. Lancet 1, 942-946.
31. Weinberger, D.R., 1997. On localizing schizophrenic neuropathology. Schizophr. Bull. 23, 537-540.
32. West, M.J., Slomianka, L., 1998. Total number of neurons in the layers of the human entorhinal cortex. Hippocampus 8, 69-82.
33. Yamaguchi, K., Ogawa, Y., Handa, T., 1996. Brain displasia associated with Larsen-like syndrome. Pediatr. Neurol. 14, 75-79.
34. Zech, M., Roberts, G.W., Bogerts, B., Crow, T.J., Polak, J.M., 1986. Neuropeptides in the amygdala of controls, schizophrenics and patients suffering from Huntington's chorea: an immunohistochemical study. Acta Neuropathol. 71, 259-266.