Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls

Neuroscience Letters

Volumn 351, Issue 2, 2003, Pages 111-114

  Shimizu, Eiji ^a   Hashimoto, Kenji ^a   Watanabe, Hiroyuki ^a   Komatsu, Naoya ^a   Okamura, Naoe ^a   Koike, Kaori ^a   Shinoda, Naoyuki ^a   Nakazato, Michiko ^a   Kumakiri, Chikara ^a   Okada, Sin Ichi ^a   Iyo, Masaomi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Antipsychotics; Brain derived neurotrophic factor; Neurotrophic factor; Peripheral marker; Schizophrenia; Serum

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CHLORPROMAZINE; CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; RISPERIDONE;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DOSAGE FORM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENERAL ASPECTS OF DISEASE; HUMAN; MAJOR DEPRESSION; MALE; MEASUREMENT; ONSET AGE; PRIORITY JOURNAL; RATING SCALE; SCHIZOPHRENIA; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

EID: 10744224325     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.08.004     Document Type: Article

References (20)

1. Angelucci F., Mathe A.A., Aloe L. Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. J. Neurosci. Res. 60:2000;783-794.
2. Diagnostic and Statistical Manual of Mental Disorders. 4th Edition :1994;American Psychiatric Press, Washington, DC.
3. Durany N., Michel T., Zochling R., Boissl K.W., Cruz-Sanchez F.F., Riederer P., Thome J. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr. Res. 52:2001;79-86.
4. Guillin O., Diaz J., Carroll P., Griffon N., Schwartz J.C., Sokoloff P. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature. 411:2001;86-89.
5. Hyman C., Hofer M., Brade Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., Lindsay R.M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. 350:1991;230-232.
6. Karege F., Schwald M., Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci. Lett. 328:2002;261-264.
7. Lindsay R.M., Wiegand S.J., Altar C.A., DiStefano P.S. Neurotrophic factors: from molecule to man. Trends Neurosci. 17:1994;182-190.
8. Lindvall O., Kokaia Z., Bngzon J., Elmer E., Kokaia M. Neurotrophins and brain insults. Trends Neurosci. 17:1994;490-496.
9. Lipska B.K., Khaing Z.Z., Weickert C.S., Weinberger D.R. BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs. Eur. J. Neurosci. 14:2001;135-144.
10. Overall J.E., Gorham D.R. The Brief Psychiatric Rating Scale. Psychol. Rep. 10:1962;799-812.
11. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 37:1998;1553-1561.
12. Radka S.F., Holst P.A., Fritsche M., Atlar C.A. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res. 709:1996;122-130.
13. Seroogy K.B., Lundgren K.H., Tran T.M., Guthrie K.M., Isackson P.J., Gall C.M. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. J. Comp. Neurol. 342:1994;321-334.
14. Shimizu E., Hashimoto K., Okamura N., Koike K., Komatsu N., Kumakiri C., Nakazato M., Watanabe H., Shinoda N., Okada S., Iyo M. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients without or with antidepressants. Biol. Psychiatry. 54:2003;70-75.
15. Snider W.D. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell. 77:1994;627-638.
16. Takahashi M., Shirakawa O., Toyooka K., Kitamura N., Hashimoto T., Maeda K., Koizumi S., Wakabayashi K., Takahashi H., Someya T., Nawa H. Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients. Mol. Psychiatry. 5:2000;293-300.
17. Thoenen H. Neurotrophins and neuronal plasticity. Science. 270:1995;593-598.
18. Toyooka K., Asama K., Watanabe Y., Muratake T., Takahashi M., Someya T., Nawa H. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry Res. 110:2002;249-257.
19. Weickert C.S., Hyde T.M., Lipska B.K., Herman M.M., Weinberger D.R., Kleinman J.E. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol. Psychiatry. 2003;592-610.
20. Yamamoto H., Gurney M.E. Human platelets contain brain-derived neurotrophic factor. J. Neurosci. 10:1990;3469-3478.