The thalamus as a site of action of antipsychotic drugs

American Journal of Psychiatry

Volumn 153, Issue 1, 1996, Pages 104-106

  Cohen, Bruce M ^a   Wan, Weihua ^b  

^a MCLEAN HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DRUG MECHANISM; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; THALAMUS;

EID: 0030045135     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.153.1.104     Document Type: Article

References (10)

1. Lesch A, Bogerts B: The diencephalon in schizophrenia: evidence for reduced thickness of the periventricular grey matter. Eur Arch Psychiatry Neurol Sci 1984; 234:212-219
2. Andreasen NC, Arndt S, Swayze V II, Cizadlo T, Flaum M, O'Leary D, Ehrhardt JC, Yuh WTC: Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 1994; 266:294-298
3. Bogerts B: Recent advances in the neuropathology of schizophrenia. Schizophr Bull 1993; 19:431-445
4. Morgan JI, Curran T: Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes. Annu Rev Neurosci 1991; 14:421-451
5. Wan W, Ennulat DJ, Cohen BM: Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain. Brain Res 1995; 688:95-104
6. Su H-S, Bentivoglio M: Thalamic midline cell populations projecting to the nucleus accumbens, amygdala, and hippocampus in the rat. J Comp Neurol 1990; 297:582-593
7. Groenewegen HJ: Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography. Neuroscience 1988; 24:379-431
8. Young KA, Wilcox RE: Characterization of D2 receptors and dopamine levels in the thalamus of the rat. Life Sci 1991; 48: 1845-1852
9. Otake K, Ruggiero DA: Monoamines and nitric oxide are employed by afferents engaged in midline thalamic regulation. J Neurosci 1995; 14:1891-1911
10. Pakkenberg B: Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry 1990; 47:1023-1028