Reduced tyrosine kinase receptor C mRNA levels in the frontal cortex of patients with schizophrenia

Neuroscience Letters

Volumn 257, Issue 2, 1998, Pages 65-68

  Schramm, Maja ^a   Falkai, Peter ^a   Feldmann, Nicole ^a   Knable, Michael B ^b   Bayer, Thomas A ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Stanley Medical Research Institute   (United States)

Author keywords

Bipolar disorder; Competitive RT PCR; Post mortem; RNA; Schizophrenia; Trk C; Unipolar depression

Indexed keywords

MESSENGER RNA; TYROSINE KINASE RECEPTOR;

ADULT; AGED; ARTICLE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVITY; FEMALE; FRONTAL CORTEX; GENE ACTIVITY; HUMAN; MALE; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; TEMPORAL CORTEX;

ADULT; AGED; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; CEREBELLUM; DEPRESSIVE DISORDER; FEMALE; FLUPHENAZINE; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKC; RECEPTORS, NERVE GROWTH FACTOR; REFERENCE VALUES; RNA, MESSENGER; SCHIZOPHRENIA; TEMPORAL LOBE;

EID: 0032573442     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00807-6     Document Type: Article

References (22)

1. Barbacid M. The Trk family of neurotrophin receptors. J. Neurobiol. 25:1994;1386-1403.
2. Bayer T.A., Falkai P. Schizophrenia a subtle defect in neurotrophic gene function? Neurol. Psychiatr. Brain Res. 5:1997;151-156.
3. Boissiere F., Faucheux B., Ruberg M., Agid Y., Hirsch E.C. Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease. Exp. Neurol. 145:1997;245-252.
4. De Kant E., Rochlitz C.F., Herrmann R. Gene expression analysis by a competitive and differential PCR with antisense competitors. Biotechniques. 17:1994;934-942.
5. Ferencz I., Kokaia M., Keep M., Elmer E., Metsis M., Kokaia Z., Lindvall O. Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling. Neuroscience. 80:1997;389-399.
6. Ghosh A., Greenberg M.E. Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron. 15:1995;89-103.
7. Goldman R.P., Selemon L.D. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr. Bull. 23:1997;437-458.
8. Ichinose H., Ohye T., Fujita K., Pantucek F., Lange K., Riederer P., Nagatsu T. Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia. J. Neural Transm. Park. Dis. Dement. Sect. 8:1994;149-158.
9. Johnson H., Hokfelt T., Ulfhake B. Decreased expression of TrkB and TrkC mRNAs in spinal motoneurons of aged rats. Eur. J. Neurosci. 8:1996;494-499.
10. Katsetos C.D., Hyde T.M., Herman M.M. Neuropathology of the cerebellum in schizophrenia, an update: 1996 and future directions. Biol. Psychiatr. 42:1997;213-224.
11. Kleiner D.E., Emmert-Buck M.R., Liotta L.A. Necropsy as a research method in the age of molecular pathology. Lancet. 346:1995;945-948.
12. Kozbor D., Hyjek E., Wiaderkiewicz R., Wang Z., Wang M., Loh E. Competitor mRNA fragments for quantitation of cytokine specific transcripts in cell lysates. Mol. Immunol. 30:1993;1-7.
13. Lamballe F., Klein R., Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell. 66:1991;967-979.
14. Leonard S., Logel J., Luthman D., Casanova M., Kirch D., Freedman R. Biological stability of mRNA isolated from human postmortem brain collections. Biol. Psychiatry. 33:1993;456-466.
15. A receptor in human alcoholic brain. Brain Res. 751:1997;102-112.
16. McGregor L.M., Baylin S.B., Griffin C.A., Hawkins A.L., Nelkin B.D. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. Genomics. 22:1994;267-272.
17. Meakin S.O., Shooter E.M. The nerve growth factor family of receptors. Trends Neurosci. 15:1992;323-331.
18. Perrett C.W., Whatley S.A., Ferrier I.N., Marchbanks R.M. Changes in brain gene expression in schizophrenic and depressed patients. Schizophr. Res. 6:1992;193-200.
19. Ross C.A., Pearlson G.D. Schizophrenia, the heteromodal association neocortex and development: potential for a neurogenetic approach. Trends Neurosci. 19:1996;171-176.
20. Schramm, M., Falkai, P., Tepest, R., Schneider-Axmann, T., Przkora, R., Waha, A., Pietsch, T., Bonte, W. and Bayer, T.A., Stability of RNA transcripts in post-mortem brains, J. Neural Transm. (1998) in press.
21. Snider W.D. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell. 77:1994;627-638.
22. Yamamoto M., Sobue G., Yamamoto K., Terao S., Mitsuma T. Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and non-neural tissues. Neurochem. Res. 21:1996;929-938.