Regulation of antioxidant metabolism by translation initiation factor 2α

Journal of Cell Biology

Volumn 152, Issue 5, 2001, Pages 997-1006

  Tan, Shirlee ^a   Somia, Nikunj ^a   Maher, Pamela ^b   Schubert, David ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

eIF2 ; Glutamate; Glutathione; Oxidative stress; Resistance

Indexed keywords

ANTIOXIDANT; GLUTAMATE CYSTEINE LIGASE; GLUTAMIC ACID; INITIATION FACTOR; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CELL SPECIFICITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME SYNTHESIS; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; GENE INSERTION; GENETIC RESISTANCE; GENETIC TRANSFECTION; GLUTATHIONE METABOLISM; METABOLIC REGULATION; MOLECULAR CLONING; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PEROXIDATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STRESS; TRANSLATION INITIATION; WILD TYPE;

ANTIOXIDANTS; APOPTOSIS; CALCIUM; CELL DIVISION; CELL LINE; CYTOTOXINS; DNA, ANTISENSE; DOWN-REGULATION; ENZYME INDUCTION; EUKARYOTIC INITIATION FACTOR-2; GLUTAMATE-CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; HUMANS; KINETICS; MUTATION; NEURONS; OXIDATIVE STRESS; PEROXIDES; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; REACTIVE OXYGEN SPECIES; TRANSFECTION;

ANIMALIA; INSERTION SEQUENCES;

EID: 0035809930     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.5.997     Document Type: Article

References (42)

1. Transport interaction of L-cysteine and L-glutamate in human diploid fibrolasts in culture
2. The intraischemic and early reperfusion changes of protein synthesis in the rat brain. eIF-2α kinase activity and role of initiation factors eIF-2α and eIF-4E
3. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 α
4. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
5. Cloning and sequencing of complementary DNAs encoding the α-sub-unit of translation factor eIF-2
6. Cloning and nucleotide sequence of a full-length cDNA for human liver γ-glutamylcysteine synthetase
7. Isolation of genetic suppressor elements (GSEs) from fragment cDNA libraries in retroviral vectors
8. Regulated translation initiation controls stress-induced gene expression in mammalian cells
9. Translational control in mammalian cells
10. Oxidative stress and the pathogenesis of Parkinson's disease
11. The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs
12. Requirement for cGMP in nerve cell death caused by glutathione depletion
13. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion
14. Signaling by reactive oxygen species in the nervous system
15. Use of retroviral vectors for gene transfer and expression
16. Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line
17. Histochemical detection of apoptosis in Parkinson's disease
18. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
19. Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents
20. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
21. Vulnerability of oligodendroglia to glutamate: Pharmacology, mechanisms, and prevention
22. Initiation of protein synthesis in eukaryotic cells
23. Structure of the beta subunit of translational initiation factor eIF-2
24. Parkinson's disease: A disorder due to nigral glutathione deficiency?
25. Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticular calcium stores
26. Regulation of protein synthesis in ventricular myocytes by vasopressin. The role of sarcoplasmic/endoplasmic reticulum
27. The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress
28. The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans
29. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins
30. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2α
31. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
32. Oxidative stress in neurodegenerative diseases
33. Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease
34. LFG: An anti-apoptotic gene that provides protection from Fas-mediated cell death
35. Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
36. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis
37. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase
38. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells
39. The regulation of reactive oxygen species production during programmed cell death
40. Glutamate neurotoxicity and the inhibition of protein synthesis in the hippocampal slice
41. eIF-2 kinases: Regulators of general and gene-specific translation initiation
42. Mechanisms of neuronal degeneration in Alzheimer's disease