Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production

FASEB Journal

Volumn 12, Issue 15, 1998, Pages 1651-1663

  Lizard, Gerard ^a   Gueldry, Serge ^a   Sordet, Olivier ^b   Monier, Serge ^a   Athias, Anne ^a   Miguet, Carole ^a   Bessede, Ginette ^a   Lemaire, Stephanie ^a   Solary, Eric ^b   Gambert, Philippe ^a  

^a HÔPITAL DU BOCAGE   (France)

^b INSERM   (France)

Author keywords

Low density lipoproteins; N acetylcysteine; Oxidation; Oxysterol; TUNEL

Indexed keywords

7 OXOCHOLESTEROL; ACETYLCYSTEINE; CASPASE; CASPASE 8; CYCLOHEXIMIDE; CYTOCHROME C; DNA FRAGMENT; ETOPOSIDE; FLUORESCEIN DERIVATIVE; GLUTATHIONE; OXIDIZED LOW DENSITY LIPOPROTEIN; OXYGEN RADICAL; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL COUNT; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; FATTY ACID OXIDATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IMMUNOBLOTTING; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 0031729620     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.15.1651     Document Type: Article

References (84)

1. Kannel, W. B., Castelli, W. P., Gordon, T., and MacNamara, P. M. (1971) Serum cholesterol lipoproteins, and high risk of coronary heart disease. The Framingham Study. Ann. Int. Med. 74, 1-12
2. Esterbauer, H., and Ramos, P. (1995) Chemistry and pathophysiology of oxidation of LDL. Rev. Physiol. Biochem. Pharmacol. 127, 31-64
3. Colles, S., Irwin, K., and Chisolm, G. (1996) Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7β-hydroperoxycholesterol. J. Lipid Res. 36, 2018-2028
4. Christ, M., Luu, B., Meija, J. E., Moosbrugger, I., and Bischoff, P. (1993) Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes. Immunology 78, 455-460
5. Boissonneault, G. A., Hennig, B., and Ouyang, C. M. (1991) Oxysterols, cholesterol biosynthesis, and vascular endothelial cell monolayer barrier function. Proc. Soc. Exp. Biol. Med. 196, 338-343
6. Lizard, G., Gueldiy, S., Deckert, V., Gambert, P., and Lagrost, L, (1997) Evaluation of the cytotoxic effects of some oxysterols and of cholesterol on endothelial cell growth: methodological aspects. Pathol. Biol. 45, 281-290
7. Zhou, Q., Smith, T., and Kummerov, F. A. (1993) Cytotoxicity of oxysterols on cultured smooth muscle cells from human umbilical artery. Proc. Soc. Exp. Biol. Med. 202, 75-80
8. Nishio, E., and Watanabe, Y. (1996) Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. Biochem. Biophys. Res. Commun. 226, 928-934
9. Brown, M. S., and Goldstein, J. L. (1974) Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. J. Biol. Chem. 249, 7306-7314
10. Lizard, G., Decken, V., Dubrez, L., Moisant, M., Gambert, P., and Lagrost, L. (1996) Induction of apoptosis in endothelial cells treated with cholesterol oxides. Am. J. Pathol. 148, 1625-1638
11. Lizard, G., Moisant, M., Cordelet, C., Monier, S., Gambert, P., and Lagrost, L. (1997) Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. J. Pathol. 183, 330-338
12. Harada-Shiba, M., Kinoshita, M., Kamido, H., and Shimokado, K. (1998) Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. J. Biol. Chem. 273, 9681-9687
13. Lizard, G., Lemaire, S., Monier, S., Gueldry, S., Néel, D., and Gambert, P. (1997) Induction of apoptosis and of interleukinlβ secretion by 7β-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression. FEBS Lett. 419, 276-280
14. Carpenter, K. L. H., Taylor, S. E., Ballantine, J. A., Fussell, B., Halliwell, B., and Mitchinson, M. J. (1993) Lipids and oxidised lipids in human atheroma and normal aorta. Biochim. Biophys. Acta 1167, 121-130
15. Breuer, O., Dzeletovic, S., Lund, E., and Diczfalusy, U. (1996) The oxysterols cholest-5-ene-3β, 4α-diol, cholest-5-ene-3β, 4βdiol and cholestane-3β, 5α, 6α-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques. Biochim. Biophys. Acta 1302, 145-152
16. Brown, A. J., Leong, S. L., Dean, R. T., and Jessup, W. (1997) 7hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque. J. Lipid Res. 38, 1730-1745
17. Carpenter, K. L. H., Taylor, S. E., van der Veen, C., Williamson, B. H., Ballantine, J. A., and Mitchinson, M. J. (1995) Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. Biochim. Biophys. Acta 1256, 141-150
18. Anderson, T. J., Meredith, I. T., Yeung, A. C., Frei, B., Selwyn, A. P., and Ganz, P. (1995) The effect of cholesterol-lowering and antioxiclant therapy on endothelium-dependent coronary vasomotion. N. Engl. J. Med. 332, 488-493
19. Levine, G. N., Frei, B., Kouloukis, S. N., Gerhard, M. O., Keaney, J. F. J., and Vita, J. A. (1996) Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 93, 1107-1113
20. Freyschuss, A., Xiu, R. J., Zhang, J., Ying, X., Diczfalusy, U., Jogestrand, T., Henriksson, P., and Björkhem, I. (1997) Vitamin C reduces cholesterol-induced microcirculatory changes in rabbits. Arterioscler. Thromb. Vase. Biol. 17, 1178-1184
21. Buttke, T. M., and Sandstrom, P. A. (1994) Oxidative stress as a mediator of apoptosis. Immunol. Today 15, 7-10
22. Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L., and Korsmeyer, S. J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251
23. Busciglio, J., and Yankner, B. A. (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature (London) 378, 776-779
24. Zamzami, N., Marchetti, P., Castedo, M., Hirsch, T., Susin, S. A., Masse, B., and Kroemer, G. (1996) Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Lett. 384, 53-57
25. Slater, A. F. G., Nobel, S.I., Maellaro, E., Bustamante J., Kimland, J., and Orrenius, S. (1995) Nitrone spin trap and nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem. T. 306, 771-778
26. Marchetti, P., Castedo, M., Susin, S. A., Zamzami, N., Hirsch, T., Macho, A., Haeffner, A., Hirsch, F., Geuskens, M., and Kroemer, G. (1996) Mitochondrial permeability transition is a central co-ordinating event of apoptosis. J. Exp. Med. 184, 1155-1160
27. Briehl, M. M., Cotgreave, I. A., and Powis, G. (1995) Down-regulation of the antioxidant defence during glucocorticoid-mediated apoptosis. Cell Death Differ. 2, 41-46
28. Briehl, M. M., and Baker, A. F. (1996) Modulation of the antioxidant defence as a factor in apoptosis. Cell Death Differ. 3, 63-70
29. Mohr, S., Zech, B., Lapetina, E. G., and Brüne, B. (1997) Inhibition of caspase-3 by S-nitrosilation and oxidation caused by nitric oxide. Biochem. Biophys. Res. Commun. 238, 387-391
30. Szabo, C., Saunders, C., O'Connor, M., and Salzman, A. L. (1997) Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells. Am. J. Respir. Cell. Mol. Biol. 16, 105-109
31. Nicholson, D. W., and Thornberry, N. A. (1997) Caspases: killer proteases. Trends Biol. Sci. 22, 299-306
32. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, C. G., Salvesen, G. S., and Dixit, V. M. (1995) Yama/CPP32β, a mammalian homolog of CED-3, is a Crma-inhibitable protease that cleaves the death substrate poly (ADP-ribose)polymerase. Cell 81, 801-809
33. Dimmeler, S., Haendeler.J., Nehls, M., and Zeiher, A. M. (1997) Suppression of apoptosis by nitric oxide via inhibition of inter-leukin-lβ-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J. Exp. Med. 185, 601-607
34. Aupeix, K, Weltin, D., Mejia, J. E., Christ, M., Marchal, J., Freyssinet, J. M., and Bischoff, P. (1995) Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiol. 194, 415-428
35. Meister, A., and Anderson, M. E. (1983) Glutathione. Annu. Rev. Biochem. 52, 711-760
36. Berliner, J. A., and Heinecke, J. W. (1992) The role of oxidized lipoproteins in atherogenesis. Free Rad. Biol. Med. 13, 341-390
37. Ghibelli, L., Coppola, S., Rotilio, G., Lafavia, E., Maresca, V., and Ciriolo, M. R. (1995) Non-oxidative loss of glutathione in apoptosis via GSH extrusion. Biochem. Biophys. Res. Commun. 216, 313-320
38. Ghibelli, L., Fanelli, C., Rotilio, G., Lafavia, E., Coppola, S., Colussi, C., Civitareale, P., and Ciriolo, M. R. (1998) Rescue of cells from apoptosis by inhibition of active GSH extrusion. FASEB J. 12, 479-486
39. Zamzami, N., Susin, S. A., Marchetti, P., Hirsch, T., Gomez-Monterrey, I., Castedo, M., and Kroemer, G. (1996) Mitochondnal control of nuclear apoptosis. J. Exp. Med. 183, 1533-1544
40. Liu, X.,Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. (1996) Induction of apoptotic program in cell free extracts: requirements of dATP and cytochrome c. Cell 86, 147-157
41. Yang, J., Liu, X., Bhalla, K., Kirn, C. N., Ibrado, A. M., Cai, J., Peng, T. I., Jones, D. P., and Wang, X. (1997) Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science 275, 1129-1132
42. Kluck, R. M., Bossey-Wetzel, E., Green, D. R., and Newmeyer, D. D. (1997) The release of cytochrome c from mitochondria: a primary site for bcl-2 regulation of apoptosis. Science 275, 1132-1136
43. Liu, B., Andrieu-Abadie, N., Levade, T., Zhang, P., Obeid, I.., and Hannun, Y. A. (1998) Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death. J. Biol. Chem. 273, 11313-11320
44. Augé, N., Andrieu, N., Négre-Salvayre, A., Thiers, J. C., Levade, T., and Salvayre, R. (1996) The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. J. Biol. Chem. 271, 19251-19255
45. Yeh, C. G., Hsi, B., and Faulk, W. P. (1981) Propidium iodide as a nuclear marker in immunofluorescence. II. Use with cellular identification and viability studies. J. Immunol. Methods 43, 269-275
46. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell. Biol. 119, 493-501
47. Lizard, G., Fournel, S., Genestier, L., Dhedin, N., Chaput, C., Flacher, M., Mutin, M., Panaye, G., and Revillard, J. P. (1995) Kinetics of plasma membrane and mitochondrial alterations in cells undergoing apoptosis. Cytometry 21, 275-283
48. Skulachev, V. P. (1998) Cytochrome c in the apoptotic and antioxidant cascades. FEBS Lett, 423, 275-280
49. Kidd, J. (1998) Proteolyic activities that mediate apoptosis. Annu. Rev. Physiol. 60, 533-573
50. Villa, P., Kaufman, S. H., and Earnshaw, W. C. (1997) Caspases and caspase inhibitors. Trends Biol. Sci. 22, 388-393
51. Shrieve, D. C., Bump, E. A., and Rice, G. C. (1988) Heterogeneity of cellular glutathione among cells derived from a murine fibro-sarcoma or a human renal cell carcinoma detected by flow cytometric analysis. J. Biol. Chem. 263, 14107-14114
52. Hedley, D. W., and Chow, S. (1994) Evaluation of methods for measuring cellular glutathione content using flow cytometry. Cytometry 15, 349-358
53. Bass, D. A., Parce,J. W., Dechatelet, L. R., Szejda, P., Seeds, M. C., and Thomas, M. (1983) Flow cytometric studies of oxidative prodvict formation by neutrophils: a graded response to membrane stimulation. J. Immunol. 130, 1910-1917
54. Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509
55. Carro-Campi, G., Hunt, P. G., Turner, C. J., and Wells, P. G. (1988) A high-performance liquid chromatographie assay for reduced and oxidised glutathione in embryonic, neonatal, and adult tissues using a porous graphite electrochemical detector. J. Pharmacol. Methods 19, 75-83
56. Harvey, P., Ilson, R. G., and Strasberg, S. M. (1989) The simultaneous determination of oxidized and reduced glutathione in liver tissue by ion pairing reverse phase high performance liquid chromatography with a colorimetric electrochemical detector. Clin. Chem. Acta 180, 203-212
57. Miller, S. A., Dykes, D. D., and Polesky, H. F. (1988) A simple salting out procedure for extracting DNA for human nucleated cells. Nucleic Acids Res. 16, 1215
58. Smith, P. K., Krohn, R. I, Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goekc, N. M., Olson, B. J., and Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85
59. Park, S. W., and Addis, P. B. (1985) Capillary column gas-liquid Chromatographic resolution of oxidized cholesterol derivatives. Anal, Biochem. 149, 275-283
60. Deckert, V., Perségol, L., Viens, L., Lizard, G., Athias, A., Lallemant, C., Gambert, P., and Lagrost, L. (1997) Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Gholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. Circulation 95, 723-731
61. Lotem, J., and Sachs, I. (1992) Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor βl and cancer chemotherapy compounds in myeloid leukemic cells. Blood 80, 1750-1757
62. Dubrez, L., Savoy, I., Hamman, A., and Solary, E. (1996) Pivotal role of DEVD-sensitive step in etoposide-induccd and Fas-mediated apoptotic pathway. EMBO J. 15, 5504-5512
63. Lennon, S. V., Martin, S. J., and Cotter, T. G. (1991) Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif. 24, 203-214
64. Ramakrishnan, N., and Catravas, G. N. (1992) N-(2-mercaptoethyl)-1, 3-propanediamene (WR-1065) protects thymocytes from programmed cell death. J. Immunol. 148, 1817-1821
65. Brüne, B., Götz, C., Messmer, U.K., Sandau, K., Hirvonen, M. R., and Lapetina, E. G. (1997) Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis. J. Biol. Chem. 272, 7253-7258
66. Zhong, L. T., Saranan, T., Kane, D. J., Charles, A. C., Mah, S. P., Edwards, R. H., and Bredesen, D. E. (1993) Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl. Acad. Sci. USA 90, 4533-4537
67. Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J. L., Petit, P. X., and Kroemer, G. (1995) Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181, 1661-1672
68. Reed,J. C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell. Biol. 124, 1-6
69. Jacobson, M. D., and Raff, M. C. (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature (London) 374, 814-816
70. Shimizu, S., Eguchi, Y., Kosaka, H., Kamiike, W., Matsuda, H., and Tsujimoto, Y. (1995) Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature (London) 374, 811-813
71. Kroemer, G., Petit, P., Zamzami, N., Vayssière, J. L., and Mignotte, B. (1995) The biochemistry of programmed cell death. FASEBJ. 9, 1277-1287
72. Reed, D.J. (1990) Glutathione: lexicological implications. Annu. Rev. Pharmacol. Toxicol. 30, 603-631
73. Macho, A., Hirsch, T., Marzo, I., Marchetti, P., Dallaporta, B., Susin, S. A., Zamzami, N., and Kroemer, G. (1997) Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J. Immunol. 158, 4612-4619
74. Zhao, Z., Francis, C. E., Welch, G., Loscalzo, J., and Ravid, K. (1997) Reduced glutathione prevents nitric oxide-induced apoptosis in vascular smooth muscle cells. Biochim. Biophys. Acta 1359, 143-152
75. Cossarizza, A., Franceschi, C., Monti, D., Salvioli, S., Bellesia, E., Rivabene, R., Biondo, L., Rainaldi, G., Tinari, A., and Malorni, W. (1995) Protective effect of N-acetylcysteine in tumor necrosis factor-α-induced apoptosis in U937 cells: the role of mitochondria. Exp. Cell. Res. 220, 232-240
76. Lafon, G., Mathieu, G., Guerrin, M., Pierre, O., Vidal, S., and Valette, A. (1996) Transforming growth factor βl-induced apoptosis in human ovarian carcinoma cells: protection by the antioxidant N-acetylcysteine and bcl-2. Cell Growth Differ. 7, 1095-1104
77. Kane, D. J., Sarafian, T. A., and Anto, R. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262, 1274-1277
78. Woo, M., Hakem, R., Soengas, M. S., Duncan, G. S., Shahinian, A., Kägi, D., Hakem, A., McCurrach, M., Khoo, W., Kaufman, S. A., Senaldi, G., Howard, T., Löwe, S. W., and Mak, T. W. (1998) Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes & Dev. 12, 806-819
79. Nishio, E., Arimura, S., and Watanabe, Y. (1996) Oxidized LDL induces apoptosis in cultured smooth muscle cells: a possible role for 7-ketocholesterol. Biochem. Biophys. Res. Commun. 223, 413-418
80. Stennicke, H. R., and Salvesen, G. S. (1997) Biochemical characteristics of caspases-3, -6,-7, and-8. J. Biol. Chem. 272, 25719-25723
81. Halliwell, B., and Gutteridge,J. M. C. (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 186, 1-85
82. Zamzami, N., Hirsch, T., Dallaporta, B., Petit, P. X., and Kroemer, G. (1997) Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J. Bioenergetics Biomembranes 29, 185-193
83. Chauchan, D., Pandey, P., Ogata, A., Teoh, G., Krett, N., Halgren, R., Rosen, S., Kufe, D., Kharbanda, S., and Anderson, K. (1997) Cytochrome c-dependent and-independent induction of apoptosis in multiple myeloma cells. J. Biol. Chem. 272, 29995-29997
84. Hodis, H. N., Grawford, D. W., and Sevanian, A. (1991) Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis. Atherosclerosis 89, 117-126