HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: A model for human relapsing polychondritis

Journal of Immunology

Volumn 161, Issue 9, 1998, Pages 5046-5053

  Bradley, David S ^a   Das, Pritam ^a   Griffiths, Marie M ^b,c   Luthra, Harvinder S ^a   David, Chella S ^a,d  

^a MAYO CLINIC   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; HLA DR6 ANTIGEN;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CARTILAGINOUS TISSUE; CELL INTERACTION; CELLULAR IMMUNITY; CHONDRITIS; HAPLOTYPE; IMMUNIZATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PATHOGENESIS; POLYCHONDRITIS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; ARTHRITIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; COLLAGEN; DISEASE MODELS, ANIMAL; EAR CARTILAGES; EAR DEFORMITIES, ACQUIRED; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HLA-DQ ANTIGENS; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN G; MALE; MICE; MICE, TRANSGENIC; POLYCHONDRITIS, RELAPSING; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032212253     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Jaksch-Wartenhorst, R. 1923. Polychondropathia. Wien. Arch. F. Inn. Med. 6:93.
2. Pearson, C. M., H. M. Kline, and V. D. Newcomer. 1960. Relapsing polychondritis. N. Engl. J. Med. 263:51.
3. McAdam, L. P., M. A. O'Hanlan, R. Bluestone, and C. M. Pearson. 1976. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine 55:193.
4. Luthra, H. S., C. H. McKenna, and P. I. Terasaki. 1981. Lack of association of HLA-A and B locus antigens with relapsing polychondritis. Tissue Antigens 17: 442.
5. Lang, B., A. Rothenfusser, J. S. Lanchbury, G. Rauh, F. C. Breedveld, A. Urlacher, E. D. Albert, H. H. Peter, and I. Melchers. 1993. Susceptibility to relapsing polychondritis is associated with HLA-DR4. Arthritis Rheum. 36:660.
6. Zeuner, M., R. H. Straub, G. Rauh, E. D. Albert, J. Scholmerich, and B. Lang. 1997. Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J. Rheumatol. 24:96.
7. Isaak, B. L., T. J. Liesegang, and C. J. Michet, Jr. 1986. Ocular and systemic findings in relapsing polychondritis. Ophthalmology 93:681.
8. Homma, S., T. Matsumoto, H. Abe, Y. Fukuda, M. Nagano, and M. Suzuki. 1984. Relapsing polychondritis. Pathological and immunological findings in an autopsy case. Acta Pathol. Jpn 34:1137.
9. Damiani, J. M., and H. L. Levine. 1979. Relapsing polychondritis: report of ten cases. Laryngoscope 89:929.
10. O'Hanlan, M., L. P. McAdam, R. Bluestone, and C. M. Pearson. 1976. The arthropathy of relapsing polychrondritis. Arthritis Rheum. 19:191.
11. Chang-Miller, A., M. Okamura, V. E. Torres, C. J. Michet, R. D. Wagoner, J. V. Donadio, Jr., K. P. Offord, and K. E. Holley. 1987. Renal involvement in relapsing polychondritis. Medicine 66:202.
12. Foidart, J. M., S. Abe, G. R. Martin, T. M. Zizic, E. V. Barnett, T. J. Lawley, and S. I. Katz. 1978. Antibodies to type II collagen in relapsing polychondritis. N. Engl. J. Med. 299:1203.
13. Terato, K., Y. Shimozuru, K. Katayama, Y. Takemitsu, I. Yamashita, M. Miyatsu, K. Fujii, M. Sagara, S. Kobayashi, M. Goto, et al. 1990. Specificity of antibodies to type II collagen in rheumatoid arthritis. Arthritis Rheum. 33: 1493.
14. Herman, J. H., and M. V. Dennis. 1973. Immunopathologic studies in relapsing polychondritis. J. Clin. Invest. 52:549.
15. Yang, C. L., J. Brinckmann, H. F. Rui, K. H. Vehring, H. Lehmann, J. Kekow, H. H. Wolff, W. L. Gross, and P. K. Muller. 1993. Autoantibodies to cartilage collagens in relapsing polychondritis. Arch. Dermatol. Res. 285:245.
16. Griffiths, M. M., E. J. Eichwald, J. H. Martin, C. B. Smith, and C. W. DeWitt. 1981. Immunogenetic control of experimental type II collage induced arthritis. Arthritis Rheum. 24:781.
17. Cremer, M. A., J. A. Pitcock, J. M. Stuart, A. H. Kang, and A. S. Townes. 1981. Auricular chondritis in rats: an experimental model of relapsing polychondritis induced with type II collagen. J. Exp. Med. 154:535.
18. McCune, W. J., A. L. Schiller, A. D. Dynesius-Trentham, and D. E. Trentham. 1982. Type II collagen-induced auricular chondritis. Arthritis Rheum. 25:266.
19. Bradley, D. S., G. H. Nabozny, S. Cheng, P. Zhou, M. M. Griffiths, H. S. Luthra, and C. S. David. 1997. HLA-DQB1 polymorphism determine incidence, onset, and severity of collagen-induced arthritis (CIA) in transgenic mice: implications in human rheumatoid arthritis. J. Clin. Invest. 100:2227.
20. Nabozny, G. H., J. M. Baisch, S Cheng, D. Cosgrove, M. M. Griffiths, H. S. Luthra, and C. S. David. 1996. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J. Exp. Med. 183:27.
21. Giles, R. C., G. Nunez, C. K. Hurley, A. Nunez-Roldan, R. Winchester, P. Stastny, and J. D. Capra. 1983. Structural analysis of a human I-A homologue using a monoclonal antibody that recognizes an MB3-like specificity. J. Exp. Med. 157:1461.
22. Lampson, L. A., and R. Levy. 1980. Two populations of Ia-like molecules on a human B cell line. J. Immunol. 125:293.
23. Beck, B. N., J. M. Buerstedde, C. J. Krco, A. E. Nilson, C. G. Chase, and D. J. McKean. 1986. Characterization of cell lines expressing mutant I-Ab and I-Ak molecules allows the definition of distinct serologic epitopes on Aα and Aβ polypeptides. J. Immunol. 136:2953.
24. Lerner, E. A., L. A. Matis, C. A. Janeway, Jr., P. P. Jones, R. H. Schwartz, and D. B. Murphy. 1980. Monoclonal antibody against an Ir gene product? J. Exp. Med. 152:1085.
25. Wooley, P. H., H. S. Luthra, J. M. Stuart, and C. S. David. 1981. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J. Exp. Med. 154:688.
26. Griffiths, M. M., G. H. Nabozny, J. Hanson, D. S. Harper, S. McCall, K. G. Moder, G. W. Cannon, H. S. Luthra, and C. S. David. 1994. Collagen-induced arthritis and TCRs in SWR and B10. Q mice expressing an Ekα transgene. J. Immunol. 153:2758.
27. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
28. Portoles, P., J. Rojo, A. Golby, M. Bonneville, S. Gromkowski, L. Greenbaum. C. A. Janeway, Jr., D. B. Murphy, and K. Bottomly. 1989. Monoclonal antibodies to murine CD3 ⊗ define distinct epitopes, one of which may interact with CD4 during T cell activation. J. Immunol. 142:4169.
29. +) subsets among anti-Ia cytolytic T cell clones. J. Immunol. 132:2775.
30. Pont, S., A. Regnier-Vigouroux, S. Marchetto, and M. Pierres. 1987. Accessory molecules and T cell activation. II. Antibody binding to L3T4a inhibits Ia-independent mouse T cell proliferation. Eur. J. Immunol. 17:429.
31. Ledbetter, J. A., R. V. Rouse, H. S. Micklem, and L. A. Herzenberg. 1980. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens: two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J. Exp. Med. 152:280.
32. + lymphokine-activated killer subset. J. Immunol. 150:17.
33. Springer, T., G. Galfre, D. S. Secher, and C. Milstein. 1979. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur. J. Immunol. 9:301.
34. Holmberg, L. A., T. A. Springer, and K. A. Ault. 1981. Natural killer activity in the peritoneal exudales of mice infected with Listeria monocytogenes: characterization of the natural killer cells by using a monoclonal rat anti-murine macrophage antibody (M1/70). J. Immunol. 127:1792.
35. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
36. 1 mice detected by T cell clones. J. Immunol. 150:4777.
37. Nygard, N. R., D. M. McCarthy, J. Schiffenbauer, and B. D. Schwartz. 1993. Mixed haplotypes and autoimmunity. Immunol. Today 14:53.
38. Sollid, L. M., G. Markussen, J. Ek, H. Gjerde, F. Vartdal, and E. Thorsby. 1989. Evidence for a primary association of celiac disease to a particular HLA-DQ a_b heterodimer. J. Exp. Med. 169:345.
39. Cavan, D. A., K. H. Jacobs, M. A. Penny, M. A. Kelly, C. Mijovic, D. Jenkins, J. A. Fletcher, and A. H. Barnett. 1993. Both DQA1 and DQB1 genes are implicated in HLA-associated protection from type 1 (insulin-dependent) diabetes mellitus in a British Caucasian population. Diabetologia 36:252.
40. Tosi, G., S. Brunelli, G. Mantero, A. R. Magalini, M. Soffiati, L. Pinelli, G. Tridente, and R. S. Accolla. 1994. The complex interplay of the DQB1 and DQA1 loci in the generation of the susceptible and protective phenotype for insulin-dependent diabetes mellitus. Mol. Immunol. 31:429.
41. Tosi, G., A. Facchin, L. Pinelli, and R. S. Accolla. 1994. Assessment of the DQB1-DQA1 complete genotype allows best prediction for IDDM. Diabetes Care 17:1045.
42. Alsalameh, S., J. Mollenhauer, F. Scheuplein, H. Stoss, J. R. Kalden, H. Burkhardt, and G. R. Burmester. 1993. Preferential cellular and humoral immune reactivities to native and denatured collagen types IX and XI in a patient with fatal relapsing polychondritis. J. Rheumatol. 20:1419.
43. Wei, B. Y., J. Martin, S. Savarirayan, R. Little, and C. S. David. 1990. In Transgenic Mice and Mutants in MHC Research. I. K. Egorov and C. S. David, eds. Springer-Verlag, Berlin, p. 237.