De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 168, Issue 8, 2002, Pages 4173-4183

  Tompkins, Stephen Mark ^a   Padilla, Josette ^a   Dal Canto, Mauro C ^a   Ting, Jenny P Y ^a   Van Kaer, Luc ^a   Miller, Stephen D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEIN H 2M; PROTEOLIPID PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL TRANSFER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL;

EID: 0037090253     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.8.4173     Document Type: Article

References (64)

1. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells
2. Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: Diverse Vβ gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor Vβb and T cell receptor Vβa H-2b mice
3. Animal models
4. Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse
5. Genetic and molecular aspects of demyelination
6. Immunopathogenesis of multiple sclerosis
7. Monoclonal anti-la Ab therapy in animal models of autoimmune disease
8. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain
9. Degradation of mouse invariant chain: Roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism
10. Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM
11. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading
12. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
13. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
14. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
15. Mice lacking H2-M complexes. Enigmatic elements of the MHC class II peptide-loading pathway
16. + T cell selection in mice lacking invariant chain expression
17. Mice lacking the MHC class II-associated invariant chain
18. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes
19. Class II transactivator regulates the expression of multiple genes involved in antigen presentation
20. Reduced IL-4-, lipopolysaccharide-, and IFN-γ-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain
21. Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA
22. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
23. Mice lacking the transcription factor CIITA - A second look
24. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
25. Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells
26. In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitis
27. Transfer of experimental allergic encephalomyelitis to bone marrow chimeras: Endothelial cells are not a restricting element
28. Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-γ-activated SJL/J astrocytes
29. Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice
30. Unexpected reactivities of T cells selected by a single MHC-peptide ligand
31. The influence of invariant chain on the positive selection of single T cell receptor specificities
32. + T cells in H-2Ma0/0 mice
33. + T cells in mice lacking invariant chain
34. MHC class II expression in double mutant mice lacking invariant chain and DM functions
35. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo
36. Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain
37. DM determines the cryptic and immunodominant fate of T cell epitopes
38. Effect of the bm12 class II mutation on proliferative and cytokine responses of encephalitogenic T cells in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis
39. Experimental autoimmune encephalomyelitis induced in B6.C-H-2bm12 mice by myelin oligodendrocyte glycoprotein: Effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells
40. Induction of class II major histocompatibility complex antigens on a population of astrocytes from a mouse strain (BALB/c) resistant to experimental allergic encephalomyelitis
41. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions
42. Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation
43. Microglia present myelin antigens to T cells after phagocytosis of oligodendrocytes
44. + T lymphocytes in the central nervous system
45. + T cells compared
46. The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-γ, tumor necrosis factor α, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation
47. Microglia: Intrinsic immuneffector cell of the brain
48. Microglia are the major cell type expressing MHC class II in human white matter
49. Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat
50. Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions
51. Interferon-γ activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells
52. Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1
53. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: Studies using NOD/CIITA-deficient mice
54. + T cells in a model for multiple sclerosis
55. + T cells are encephalitogenic and produce severe disease in C57BL/6 mice
56. Antigen presentation and T cell development in H2-M-deficient mice
57. Requirement for invariant chain in B cell maturation and function
58. B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide
59. T lymphocyte entry into the central nervous system
60. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal Ab specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex
61. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones
62. + subset in mice
63. + T cells for the development of experimental autoimmune encephalomyelitis (EAE)
64. Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity