Chemoprevention by white currant is mediated by the reduction of nuclear β-catenin and NF-κB levels in Min mice adenomas

European Journal of Nutrition

Volumn 47, Issue 3, 2008, Pages 115-122

  Rajakangas, Johanna ^a   Misikangas, Marjo ^a   Päivärinta, Essi ^a   Mutanen, Marja ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

catenin; Colon cancer; Min mouse; NF B; White currant

Indexed keywords

BETA CATENIN; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BERRY; BODY WEIGHT; CHEMOPROPHYLAXIS; COLON ADENOMA; COLON CANCER; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; LIPID DIET; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; SMALL INTESTINE TUMOR; TUMOR VOLUME; WHITE CURRANT;

ADENOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BETA CATENIN; FEMALE; FRUIT; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; MALE; MICE; MICE, MUTANT STRAINS; NF-KAPPA B; RANDOM ALLOCATION; SIGNAL TRANSDUCTION;

MUS; RIBES;

EID: 43949145241     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-008-0704-0     Document Type: Article

References (50)

1. Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D (2006) Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 54:980-985
2. Albini A, Sporn MB (2007) The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 7:139-147
3. Arber N, Hibshoosh H, Moss SF, Sutter T, Zhang Y, Begg M, Wang S, Weinstein IB, Holt PR (1996) Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology 110:669-764
4. Boivin D, Blanchette M, Barrette S, Moghrabi A, Beliveau R (2007) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice. Anticancer Res 27:937-948
5. Boon EM, Keller JJ, Wormhoudt TA, Giardiello FM, Offenhaus GJ, van der Neut R, Pals ST (2004) Sulindac targets nuclear β-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. Br J Cancer 90:224-229
6. Boon EM, Keller JJ, Wormhoudt TA, Giardiello FM, Offerhaus GJ, van der Neut R, Pals ST (2004) Sulindac targets nuclear β-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. Br J Cancer 90:224-229
7. Brabletz T, Herrmann K, Jung A, Faller G, Kirchner T (2000) Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am J Pathol 156:865-870
8. Choi BT, Cheong J, Choi YH (2003) β-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-κB in human colon cancer HCT-116 cells. Anticancer Drugs 14:845-850
9. Clevers H (2006) Wnt/β-catenin signaling in development and disease. Cell 127:469-480
10. Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ, Marczylo TH (2006) Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis-relationship with tissue anthocyanin levels. Int J Cancer 119:2213-2220
11. Duthie SJ (2007) Berry phytochemicals, genomic stability and cancer: Evidence for chemoprotection at several stages in the carcinogenic process. Mol Nutr Food Res 51:665-674
12. van Es JH, Clevers H (2005) Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol Med 11:496-502
13. Ferguson PJ, Kurowska EM, Freeman DJ, Chambers AF, Koropatnick J (2006) In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract. Nutr Cancer 56:86-94
14. Fodde R, Brablez T (2007) Wnt/β-catenin signaling in cancer stemness and malignant behaviour. Curr Opin Cell Biol 19:150-158
15. Gilmore TD, Herscovitch M (2006) Inhibitors of NF-κB signalling: 785 and counting. Oncogene 25:6887-6899
16. Hao X, Tomlinson I, Ilyas M, Palazzo JP, Talbot IC (1997) Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumours. Virchows Arch 431:167-172
17. Harris GK, Gupta A, Nines RG, Kresty LA, Habib SG, Frankel WL, LaPerle K, Gallagher DD, Schwartz SJ, Stoner GD (2001) Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2′- deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer 40:125-133
18. Heinonen M (2007) Antioxidant activity and antimicrobial effect of berry phenolics - a Finnish perspective. Mol Nutr Food Res 51:684-691
19. Huang S, Ingber DE (2007) A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. Breast Dis 26:27-54
20. Hugh TJ, Dillon SA, Taylor BA, Pignatelli M, Poston GJ, Kinsella AR (1999) Cadherin-catenin expression in primary colorectal cancer: a survival analysis. Br J Cancer 80:1046-1051
21. Häkkinen S, Heinonen M, Kärenlampi S, Mykkänen H, Ruuskanen J, Törrönen R (1999) Screening of selected favonoids and phenolic acids in 19 berries. Food Res Int 32:345-353
22. Kang SY, Seeram NP, Nair MG, Bourquin LD (2003) Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. Cancer Lett 194:13-19
23. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiqtination: the control of NF-κB activity. Annu Rev Immunol 18:621-623
24. Karin M, Greten FR (2005) NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5:749-759
25. Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-κB system: a treasure trove for drug development. Nat Rev Drug Disc 3:17-26
26. Katsube N, Iwashita K, Tsushida T, Yamaki K, Kobori M (2003) Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. J Agric Food Chem 51:68-75
27. Koponen JM, Happonen AM, Mattila PH, Törrönen AR (2007) Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J Agric Food Chem 55:1612-1619
28. Kundu JK, Choi KY, Surh YJ (2006) β-Catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances. Biochim Biophys Acta 1765:14-24
29. Lala G, Malik M, Zhao C, He J, Kwon Y, Giusti MM, Magnuson BA (2006) Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutr Cancer 54:84-93
30. Luu HH, Zhang R, Haydon RC, Rayburn E, Kang Q, Si W, Park JK, Wang H, Peng Y, Jiang W, He TC (2004) Wnt/β-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets 4:653-671
31. Misikangas M, Pajari AM, Päivärinta E, Mutanen M (2005) Promotion of adenoma growth by dietary inulin is associated with increase in cyclin D1 and decrease in adhesion proteins in Min/+ mice mucosa. J Nutr Biochem 16:402-409
32. Misikangas M, Pajari AM, Päivärinta E, Oikarinen SI, Rajakangas J, Marttinen M, Tanayama H, Törrönen R, Mutanen M (2007) Three Nordic berries inhibit intestinal tumorigenesis in Min/+ mice by modulating β-catenin signaling in the tumor and transcription in the mucosa. J Nutr (in press)
33. Moser AR, Pitot HC, Dove WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247:322-324
34. Määttä-Riihinen KR, Kamal-Eldin A, Mattila PH, Gonzalez-Paramas AM, Törrönen AR (2004) Distribution and contents of phenolic compounds in eighteen Scandinavian berry spieces. J Agric Food Chem 52:4477-4486
35. Määttä K, Kamal-Eldin A, Törrönen R (2001) Phenolic compounds in berries of black, red, green, and white currants (Ribes sp.). Antioxid Redox Signal 3:981-993
36. Narayanan BA, Narayanan NKD, Desai D, Pittman B, Reddy BS (2004) Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and β-catenin pathways in colon cancer cells. Carcinogenesis 25:2443-2449
37. Pahl HL (1999) Activators and target genes of Rel/ NF-κB trancription factors. Oncogene 18:6853-6866
38. Päivärinta E, Pajari AM, Törrönen R, Mutanen M (2006) Ellagic acid and natural sources of ellagitannins as possible chemopreventive agents against intestinal tumorigenesis in the Min mouse. Nutr Cancer 54:79-83
39. Reeves PG, Nielsen FH, Fahey GB (1993) AIN-93 purified diets for laboratory rodents: final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939-1951
40. Seeram NP, Adams LS, Hardy ML, Heber D (2004) Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem 52:2512-2517
41. Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, Gould KA, Dove WF (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256:668-670
42. Takayama T, Shiozaki H, Shibamoto S, Oka H, Kimura Y, Tamura S, Inoue M, Monden T, Ito F, Monden M (1996) β-catenin expression in human cancers. Am J Pathol 148:39-46
43. Thangapazham RL, Sharma A, Maheshwari RK (2006) Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J 8:E443-E449
44. Valizadeh A, Karayiannakis AJ, el-Hariry I, Kmiot W, Pignatelli M (1997) Expression of E-cadherin-associated molecules (α-, β-, and γ-catenins and p120) in colorectal polyps. Am J Pathol 150:1977-1984
45. Williams JL, Nath N, Chen J, Hundley TR, Gao J, Kopelovich L, Kashfi K, Rigas B (2003) Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention. Cancer Res 63:7613-7618
46. World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AIRC, Washington DC
47. Yamamoto Y, Yin MJ, Lin KM, Gaynor RB (1999) Sulindac inhibits activation of the NF-κB pathway. Biol Chem 274:27307-27314
48. Yi W, Fischer J, Krewer G, Akoh CC (2005) Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53:7320-7329
49. Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396:77-80
50. Zhao C, Giusti MM, Malik M, Moyer MP, Magnuson BA (2004) Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J Agric Food Chem 52:6122-6128