Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumours

Virchows Archiv

Volumn 431, Issue 3, 1997, Pages 167-172

  Hao, Xingpei ^a   Tomlinson, Ian ^c   Ilyas, Mohammad ^a,b,d   Palazzo, Juan P ^e   Talbot, Ian C ^a,b  

^a ST MARK S HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

catenin; Adenoma carcinoma sequence; Adhesion molecules; Colorectum; Tumours

Indexed keywords

BETA CATENIN;

ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CELLULAR DISTRIBUTION; COLON ADENOMA; COLORECTAL CARCINOMA; COLORECTAL TUMOR; CONTROLLED STUDY; DYSPLASIA; GASTROINTESTINAL MUCOSA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ADENOMA; BETA CATENIN; CADHERINS; CARCINOMA; CELL MEMBRANE; CELL NUCLEUS; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; TRANS-ACTIVATORS;

EID: 0030824115     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050084     Document Type: Article

References (24)

1. McCrea P, Turck CW, Gumbiner BM (1991) A homolog of the Armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 254:1359-1361
2. Kintner C (1992) Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain. Cell 69:225-236
3. Cox RT, Kirkpatrick C, Peifer M (1996) Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J Cell Biol 134:133- 148
4. Oyama T, Kanai Y, Ochiai A, Akimoto S, Oda T, Yanagihara K, Nagafuchi A, Tsukita S, Shibamoto S, Ito F, Takeichi M, Matsuda H, Hirohashi S (1994) A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res 54:6282-6287
5. Peifer M, Wieschaus E (1990) The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 63:1167- 1178
6. Funayama N, Fagotto F, McCrea P, Gumbiner BM (1995) Embryonic axis induction by the Armadillo repeat domain of β- catenin: evidence for intracellular signalling. J Cell Biol 128:959-968
7. Rubinfeld B, Souza B, Albert I, Müller O, Chamberlain SH, Masiarz FR, Munemitsu S, Polakis P (1993) Association of the APC gene product with β-catenin. Science 262:1731-1734
8. Su LK, Vogelstein B, Kinzler KW (1993) Association of the APC tumour suppressor protein with catenins. Science 262:1734-1737
9. Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (1995) C-erbB-2 gene product directly associates with β-catenin and plakoglobin. Biochem Biophys Res Commun 208:1067-1072
10. Ochiai A, Akimoto S, Kanai Y, Shibata T, Oyama T, Hirohashi S (1994) C-erbB-2 gene product associates with catenins in human cancer cells. Biochem Biophys Res Commun 205:73- 78
11. Hoschuetzky H, Aberle H, Kemler R (1994) β-Catenin mediates the interaction of the cadherin-catenin complex with epithelial growth factor receptor. J Cell Biol 127:1375-1380
12. Shiozaki H, Kadowaki T, Doki Y, Inoue M, Tamura S, Oka H, Iwazawa T, Matsui S, Shimaya K, Takeichi M (1995) Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line. Br J Cancer 71:250-258
13. Sinicrope F, Ruan SB, Cleary KR, Stephens LC.,Lee JJ, Levin B (1995) Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 55:237-241
14. Inomata M, Ochiai A, Akimoto S, Hirohashi S (1996) Alteration of β-catenin expression in colonic cells of familial adenomatous polyposis patients. Cancer Res 56:2213-2217
15. Orsulic S, Peifer M (1996) An in vivo structure-function study of Armadillo, the β-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signaling. J Cell Biol 134:1283-1300
16. Parr BA, McMahon AP (1994) Wnt genes and vertebrate development. Curr Opin Genet Dev 4:523-528
17. Heasman J, Crawford KA, Goldstone K, Garner-Hamrick P, Gumbiner B, McCrea P, Kintner C, Noro CY, Wylie C (1994) Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 79:791-803
18. Sanson B, White P, Vincent JP (1996) Uncoupling cadherin- based adhesion from wingless signaling in Drosophila. Nature 383:627-630
19. Ilyas M, Tomlinson IPM, Rowan A, Pignatelli M, Bodmer WF (1997) The low frequency of β-catenin mutations in cell lines established from the human colorectal cancers. J Pathol (Lond) 181 (Suppl):36A
20. Hülsken J, Birchmeier W, Behrens J (1994) E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton. J Cell Biol 127:2061-2069
21. Matsuyoshi N, Hamaguchi M, Taniguchi S, Nagafuchi A, Tsukita S, Takeichi M (1992) Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J Cell Biol 118:703-714
22. Beherens J, Vakaet L, Friis R, Winterhager E, Roy F van, Mareel MM, Birchmeier W (1993) Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-src gene. J Cell Biol 120:757-766
23. Kinch MS, Clark GJ, Der CJ, Burridge K (1995) Tyrosine phosphorylation regulates the adhesions of Ras-transformed breast epithelia. J Cell Biol 130:461-471
24. Balsamo J, Leung TC, Ernst H, Zanin MKB, Hoffman S (1996) Regulated binding of a PTP1B-like phosphatase to N- cadherin: control of cadherin-mediated adhesion by dephosphorylation of β-catenin. J Cell Biol 134:801-813