Expression of E-cadherin-associated molecules (α-, β-, and γ-catenins and p120) in colorectal polyps

American Journal of Pathology

Volumn 150, Issue 6, 1997, Pages 1977-1984

  Valizadeh, Ali ^a   Karayiannakis, Anastasios J ^a   El Hariry, Iman ^a   Kmiot, Witold ^a   Pignatelli, Massimo ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; BETA CATENIN; CYTOPLASM PROTEIN; PLAKOGLOBIN; PROTEIN P120; UNCLASSIFIED DRUG; UVOMORULIN;

ADENOMATOUS POLYP; ARTICLE; COLON POLYP; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECTUM POLYP;

ADENOMATOUS POLYPS; ALPHA CATENIN; BETA CATENIN; CADHERINS; CELL ADHESION MOLECULES; COLONIC POLYPS; CYTOSKELETAL PROTEINS; DESMOPLAKINS; GAMMA CATENIN; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; PHOSPHOPROTEINS; TRANS-ACTIVATORS;

EID: 0030945616     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Takeichi M: Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991, 251:1451-1455
2. Gumbiner BM, McCrea PD: Catenins as mediators of the cytoplasmic functions of cadherins. J Cell Sci 1993, 17:155-158
3. Ozawa M, Ringwald M, Kemler R: Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci USA 1990, 87:4246-4250
4. Fujimori T, Takeichi M: Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated non-functional N-adherin. Mol Biol Cell 1993, 4:37-47
5. Hirano S, Kimoto N, Shimoyama Y, Hirohashi S, Takeichi M: Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization. Cell 1992, 70:293-301
6. Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N, Niitsu Y: Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line, HSC-39. Mol Cell Biol 1995, 15:1175-1181
7. Pignatelli M, Liu D, Nasim MM, Stamp GWH, Hirano S, Takeichi M: Morphoregulatory activities of E-cadherin and β-1 integrins in colorectal tumour cells. Br J Cancer 1992, 66:629-634
8. Reynolds AB, Herbert L, Cleveland JL, Berg ST, Gaut JR: p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors β-catenin, plakoglobin, and armadillo. Oncogene 1992, 7:2439-2445
9. Daniel JM, Reynolds AB: The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or α-catenin. Mol Cell Biol 1995, 15:4819-4824
10. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M, Ito F: Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol 1995, 128:949-957
11. Hoschuetzky H, Aberle H, Kemler R: β-Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 1994, 127:1375-1380
12. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Oku N, Miyazawa K, Kitamura N, Takeichi M, Ito F: Tyrosine phosphorylation of β-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes Commun 1994, 1:295-305
13. Rubinfeld B, Souza B, Albert I, Müller O, Chamberlain SH, Masiarz FR, Munemitsu S, Polakis P: Association of the ARC gene product with β-catenin. Science 1993, 262:1731-1734
14. Su L-K, Vogelstein B, Kinzler KW: Association of the ARC tumor suppressor protein with catenins. Science 1993, 262:1734-1737
15. Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P: The ARC protein and E-cadherin form similar but independent complexes with α-catenin, β-catenin, and plakoglobin. J Biol Chem 1995, 270:5549-5555
16. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW: ARC mutations occur early during colorectal tumorigenesis. Nature 1992, 359:235-237
17. McCrea PD, Turck CW, Gumbiner B: A homolog of the armadillo protein in Drosophila (piakoglobin) associated with E-cadherin. Science 1991, 254:1359-1361
18. Van der Wurff AAM, Ten Kate J, Van der Linden EPM, Dinjens WNM, Arends J-W, Bosman FT: L-CAM expression in normal, premalignant, and malignant colon mucosa. J Pathol 1992, 168:287-291
19. Dorudi S, Sheffield JP, Poulsom R, Northover JMA, Hart IR: E-cadherin expression in colorectal cancer: an immunocytochemical and in situ hybridization study. Am J Pathol 1993, 142:981-986
20. Kinsella AR, Green B, Lepts GC, Hill CL, Bowie G, Taylor BA: The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis. Br J Cancer 1993, 67:904-909
21. Nigam AK, Savage FJ, Boulos PB, Stamp GWH, Liu D, Pignatelli M: Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. Br J Cancer 1993, 68:507-514
22. Gagliardi G, Kandemir O, Liu D, Guida M, Benvestito S, Ruers TGM, Benjamin IS, Northover JMA, Stamp GWH, Talbot IC, Pignatelli M: Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Arch 1995, 426:149-154
23. Takayama T, Shiozaki H, Shibamoto S, Oka H, Kimura Y, Tamura S, Inoue M, Monden T, Ito F, Monden M: β-catenin expression in human cancers. Am J Pathol 1996, 148:39-46
24. Shiozaki H, Iihara K, Oka H, Kadowaki T, Matsui S, Gofuku J, Inoue M, Nagafuchi A, Tsukita S, Mori T: Immunohistochemical detection of α-catenin expression in human cancers. Am J Pathol 1994, 144:667-674
25. Utsunomiya J: The concept of hereditary colorectal cancer and the implications of its study. Hereditary Colorectal Cancer. Edited by J Utsunomiya, HT Lynch, Berlin, Springer-Verlag, 1990, pp 3-16
26. Jawhari A, Jordan S, Poole S, Browne P, Pignatelli M, Farthing MJG: Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: relationship with patient survival. Gastroenterology 1997, 112:46-54
27. Wilding J, Vousden KH, Soutter PW, McCrea PD, Del Buono R, Pignatelli M: E-cadherin transfection down-regulates the epithelial growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes. Cancer Res 1996, 56:5285-5292
28. Behrens J, Mareel MM, Van Roy FM, Birchmeier W: Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989, 108:2435-2447
29. Vleminckx K, Vakaet L Jr, Mareel M, Fiers W, Van Roy F: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991, 66:107-119
30. Breen E, Steele G Jr, Mercurio AM: Role of the E-cadherin/α-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells, Ann Surg Oncol 1995, 2:378-385
31. Hermiston ML, Gordon JI: Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 1995, 270:1203-1207
32. Hermiston ML, Wong MH, Gordon JI: Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes Dev 1996, 10:985-996
33. Hermiston ML, Gordon JI: In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol 1995, 129:489-506
34. Inomata M, Ochiai A, Akimoto S, Kitano S, Hirohashi S: Alteration of β-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res 1996, 56:2213-2217
35. Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P: Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 1995, 92:3046-3050
36. Peifer M, Sweeton D, Casey M, Wieschaus E: Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of armadillo. Development 1994, 120:369-380
37. Van Leeuwen F, Samos CH, Nusse R: Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature 1994, 368:342-344
38. Funayama N, Fagotto F, McCrea P, Gumbiner BM: Embryonic axis induction by the armadillo repeat domain of β-catenin: evidence for intracellular signaling. J Cell Biol 1995, 128:959-968
39. Bradley RS, Cowin P, Brown AMC: Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. J Cell Biol 1993, 123:1857-1865
40. Hinck L, Näthke IS, Papkoff J, Nelson WJ: Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol 1994, 125:1327-1340
41. Polakis P: Mutations in the APC gene and their implications for protein structure and function. Curr Opin Genet Dev 1995, 5:66-71