Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 13, Issue 2, 2008, Pages 130-140

  Tang, Dale D ^a   Anfinogenova, Yana ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Actin cytoskeleton; Contraction; Vascular smooth muscle

Indexed keywords

ABELSON KINASE; ACTIN RELATED PROTEIN 2-3 COMPLEX; CARBACHOL; CRK ASSOCIATED SUBSTRATE PROTEIN; ENDOTHELIN 1; FOCAL ADHESION KINASE; FORSKOLIN; GUANOSINE TRIPHOSPHATE; IMATINIB; ISOPRENALINE; LATRUNCULIN A; MITOGEN ACTIVATED PROTEIN KINASE; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROFILIN; PROTEIN TYROSINE KINASE; RHO FACTOR; SMOOTH MUSCLE ACTIN;

ACTIN FILAMENT; ACTIN MYOSIN INTERACTION; ACTIN POLYMERIZATION; ARTERY MUSCLE; CELL ADHESION; DRUG MECHANISM; EXTRACELLULAR MATRIX; FOCAL ADHESION; MECHANICAL STIMULATION; MUSCLE CONTRACTILITY; MUSCLE EXCITATION; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; STRESS FIBER; VASCULAR SMOOTH MUSCLE;

ACTINS; ANIMALS; CYTOSKELETON; HEAT-SHOCK PROTEINS; HUMANS; INTEGRINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PROTEIN KINASES; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 43949104415     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1177/1074248407313737     Document Type: Review

References (134)

1. Gunst SJ, Tang DD The contractile apparatus and mechanical properties of airway smooth muscle. Eur Respir J. 2000 ; 15 (3). 600-616.
2. Small JV Structure-function relationships in smooth muscle: the missing links. Bioessays. 1995 ; 17 (9). 785-792.
3. Small JV, Gimona M. The cytoskeleton of the vertebrate smooth muscle cell. Acta Physiol Scand. 1998 ; 164 (4). 341-348.
4. Gerthoffer WT, Gunst SJ Invited review: focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J Appl Physiol. 2001 ; 91 (2). 963-972.
5. Gerthoffer WT Actin cytoskeletal dynamics in smooth muscle contraction. Can J Physiol Pharmacol. 2005 ; 83 (10). 851-856.
6. Tang DD, Tan J. Downregulation of profilin with antisense oligodeoxynucleotides inhibits force development during stimulation of smooth muscle. Am J Physiol Heart Circ Physiol. 2003 ; 285: H1528 - H1536.
7. Tang DD, Tan J. Role of Crk-associated substrate in the regulation of vascular smooth muscle contraction. Hypertension. 2003 ; 42: 858-863.
8. Mehta D., Gunst SJ Actin polymerization stimulated by contractile activation regulates force development in canine tracheal smooth muscle. J Physiol. 1999 ; 519 (Pt 3). 829-840.
9. Tang DD, Turner CE, Gunst SJ Expression of nonphosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development. J Physiol. 2003 ; 553 (1). 21-35.
10. Tang DD, Zhang W., Gunst SJ The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. J Biol Chem. 2005 ; 280 (24). 23380-23389.
11. Tang DD, Wu MF, Opazo Saez AM, Gunst SJ The focal adhesion protein paxillin regulates contraction in canine tracheal smooth muscle. J Physiol. 2002 ; 542 (Pt 2). 501-513.
12. Tang DD, Gunst SJ The small GTPase Cdc42 regulates actin polymerization and tension development during contractile stimulation of smooth muscle. J Biol Chem. 2004 ; 279 (50). 51722-51728.
13. Zhang W., Wu Y., Du L., Tang DD, Gunst SJ Activation of the Arp2/3 complex by N-WASp is required for actin polymerization and contraction in smooth muscle. Am J Physiol Cell Physiol. 2005 ; 288 (5). C1145 - C1160.
14. Chen X., Pavlish K., Zhang HY, Benoit JN Effects of chronic portal hypertension on agonist-induced actin polymerization in small mesenteric arteries. Am J Physiol Heart Circ Physiol. 2006 ; 290 (5). H1915 - H1921.
15. Meeks MK, Ripley ML, Jin Z., Rembold CM Heat shock protein 20-mediated force suppression in forskolinrelaxed swine carotid artery. Am J Physiol Cell Physiol. 2005 ; 288 (3). C633 - C639.
16. Rembold CM, Tejani AD, Ripley ML, Han S. Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction. Am J Physiol Cell Physiol. 2007 ; 293 (3). C993 - C1002.
17. Hirshman CA, Emala CW Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho. Am J Physiol. 1999 ; 277 (3 Pt 1). L653 - L661.
18. Hirshman CA, Zhu D., Panettieri RA, Emala CW Actin depolymerization via the beta-adrenoceptor in airway smooth muscle cells: a novel PKA-independent pathway. Am J Physiol Cell Physiol. 2001 ; 281 (5). C1468 - C1476.
19. Barany M., Barron JT, Gu L., Barany K. Exchange of the actin-bound nucleotide in intact arterial smooth muscle. J Biol Chem. 2001 ; 276 (51). 48398-48403.
20. Bursac P., Fabry B., Trepat X., et al. Cytoskeleton dynamics: fluctuations within the network. Biochem Biophys Res Commun. 2007 ; 355 (2). 324-330.
21. Trepat X., Deng L., An SS, et al. Universal physical responses to stretch in the living cell. Nature. 2007 ; 447 (7144). 592-595.
22. Tang D., Mehta D., Gunst SJ Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle. Am J Physiol. 1999 ; 276 (1 Pt 1). C250 - C258.
23. Tang DD, Gunst SJ Selected contribution: roles of focal adhesion kinase and paxillin in the mechanosensitive regulation of myosin phosphorylation in smooth muscle. J Appl Physiol. 2001 ; 91 (3). 1452-1459.
24. Deng L., Fairbank NJ, Fabry B., Smith PG, Maksym GN Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells. Am J Physiol Cell Physiol. 2004 ; 287 (2). C440 - C448.
25. Anfinogenova Y., Wang R., Li QF, Spinelli AM, Tang DD Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. Circ Res. 2007 ; 101 (4). 420-428.
26. Mehta D., Tang DD, Wu MF, Atkinson S., Gunst SJ Role of Rho in Ca(2+)-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle. Am J Physiol. 2000 ; 279 (2). C308 - C318.
27. Pollard TD Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct. 2007 ; 36: 451-477.
28. Jones KA, Perkins WJ, Lorenz RR, Prakash YS, Sieck GC, Warner DO F-actin stabilization increases tension cost during contraction of permeabilized airway smooth muscle in dogs. J Physiol. 1999 ; 519 (Pt 2). 527-538.
29. Small JV, Rottner K., Kaverina I. Functional design in the actin cytoskeleton. Curr Opin Cell Biol. 1999 ; 11 (1). 54-60.
30. Adler KB, Krill J., Alberghini TV, Evans JN Effect of cytochalasin D on smooth muscle contraction. Cell Motility. 1983 ; 3 (5-6). 545-551.
31. Cipolla MJ, Gokina NI, Osol G. Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behavior. FASEB J. 2002 ; 16 (1). 72-76.
32. Obara K., Yabu H. Effect of cytochalasin B on intestinal smooth muscle cells. Eur J Pharmacol. 1994 ; 255 (1-3). 139-147.
33. Coue M., Brenner SL, Spector I., Korn ED Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987 ; 213 (2). 316-318.
34. Cooper JA Effects of cytochalasin and phalloidin on actin. J Cell Biol. 1987 ; 105 (4). 1473-1478.
35. Gunst SJ, Tang DD, Opazo SA Cytoskeletal remodeling of the airway smooth muscle cell: a mechanism for adaptation to mechanical forces in the lung. Respir Physiol Neurobiol. 2003 ; 137 (2-3). 151-168.
36. Burridge K., Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol. 1996 ; 12: 463-518.
37. Rohatgi R., Ma L., Miki H., et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 1999 ; 97 (2). 221-231.
38. Blanchoin L., Pollard TD, Mullins RD Interactions of ADF/cofilin, Arp2/3 complex, capping protein, and profilin in remodeling of branched actin filament networks. Curr Biol. 2000 ; 10 (20). 1273-1282.
39. Pollard TD, Blanchoin L., Mullins RD Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct. 2000 ; 29: 545-576.
40. Higgs HN, Pollard TD Regulation of actin filament network formation through Arp2/3 complex: activation by a diverse array of proteins. Annu Rev Biochem. 2001 ; 70: 649-676.
41. DeMali KA, Wennerberg K., Burridge K. Integrin signaling to the actin cytoskeleton. Curr Opin Cell Biol. 2003 ; 15 (5). 572-582.
42. Kiselar JG, Mahaffy R., Pollard TD, Almo SC, Chance MR Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry. Proc Natl Acad Sci U S A. 2007 ; 104 (5). 1552-1557.
43. Cipolla MJ, Osol G. Vascular smooth muscle actin cytoskeleton in cerebral artery forced dilatation. Stroke. 1998 ; 29 (6). 1223-1228.
44. Langevin HM, Churchill DL, Cipolla MJ Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture. FASEB J. 2001 ; 15 (12). 2275-2282.
45. Herrera AM, McParland BE, Bienkowska A., Tait R., Pare PD, Seow CY "Sarcomeres" of smooth muscle: functional characteristics and ultrastructural evidence. J Cell Sci. 2005 ; 118 (Pt 11). 2381-2392.
46. Herrera AM, Martinez EC, Seow CY Electron microscopic study of actin polymerization in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2004 ; 286 (6). L1161 - L1168.
47. Bai TR, Bates JH, Brusasco V., et al. On the terminology for describing the length-force relationship and its changes in airway smooth muscle. J Appl Physiol. 2004 ; 97 (6). 2029-2034.
48. Wang L., Pare PD, Seow CY Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle. J Appl Physiol. 2000 ; 88 (6). 2246-2250.
49. Gunst SJ, Wu MF Plasticity of airway smooth muscle stiffness and extensibility: role of length-adaptive mechanisms. J Appl Physiol. 2001 ; 90: 741-749.
50. Gunst SJ, Fredberg JJ The first 3 minutes: smooth muscle contraction, cytoskeletal events, and soft glasses. J Appl Physiol. 2003 ; 95 (1). 413-425.
51. An SS, Bai TR, Bates JH, et al. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J. 2007 ; 29 (5). 834-860.
52. Rembold CM, Kaufman E. Heat-induced HSP20 phosphorylation without increased cyclic nucleotide levels in swine carotid media. BMC Physiol. 2003 ; 3 (1). 3.
53. Murphy RA, Rembold CM The latch-bridge hypothesis of smooth muscle contraction. Can J Physiol Pharmacol. 2005 ; 83 (10). 857-864.
54. Rembold CM Force suppression and the crossbridge cycle in swine carotid artery. Am J Physiol Cell Physiol. 2007 ; 293 (3). C1003 - C1009.
55. Kanner SB, Reynolds AB, Wang HC, Vines RR, Parsons JT The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110. EMBO J. 1991 ; 10 (7). 1689-1698.
56. Sakai R., Iwamatsu A., Hirano N., et al. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 1994 ; 13 (16). 3748-3756.
57. Shin NY, Dise RS, Schneider-Mergener J., Ritchie MD, Kilkenny DM, Hanks SK Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. J Biol Chem. 2004 ; 279 (37). 38331-38337.
58. Takahashi T., Kawahara Y., Taniguchi T., Yokoyama M. Tyrosine phosphorylation and association of p130Cas and c-Crk II by ANG II in vascular smooth muscle cells. Am J Physiol. 1998 ; 274 (4 Pt 2). H1059 - H1065.
59. Ogden K., Thompson JM, Hickner Z., Huang T., Tang DD, Watts SW A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction. Am J Physiol Heart Circ Physiol. 2006 ; 291 (6). H2857 - H2863.
60. Ojaniemi M., Vuori K. Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton. J Biol Chem. 1997 ; 272 (41). 25993-25998.
61. Petch LA, Bockholt SM, Bouton A., Parsons JT, Burridge K. Adhesion-induced tyrosine phosphorylation of the p130 src substrate. J Cell Sci. 1995 ; 108 (Pt 4). 1371-1379.
62. Rohatgi R., Nollau P., Ho HY, Kirschner MW, Mayer BJ Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J Biol Chem. 2001 ; 276 (28). 26448-26452.
63. Yang C., Huang M., DeBiasio J., et al. Profilin enhances Cdc42-induced nucleation of actin polymerization. J Cell Biol. 2000 ; 150 (5). 1001-1012.
64. Zigmond SH Actin cytoskeleton: the Arp2/3 complex gets to the point. Curr Biol. 1998 ; 8(18). R654 - R657.
65. Mayer BJ, Hirai H., Sakai R. Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr Biol. 1995 ; 5 (3). 296-305.
66. Ushio-Fukai M., Zuo L., Ikeda S., Tojo T., Patrushev NA, Alexander RW cAbl tyrosine kinase mediates reactive oxygen species- and caveolin-dependent AT1 receptor signaling in vascular smooth muscle: role in vascular hypertrophy. Circ Res. 2005 ; 97 (8). 829-836.
67. Hoeper MM, Rubin LJ Update in pulmonary hypertension 2005. Am J Respir Crit Care Med. 2006 ; 173 (5). 499-505.
68. Ghofrani HA, Seeger W., Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med. 2005 ; 353 (13). 1412-1413.
69. Tang DD, Gunst SJ Depletion of focal adhesion kinase by antisense depresses contractile activation of smooth muscle. Am J Physiol Cell Physiol. 2001 ; 280 (4). C874 - C883.
70. Abedi H., Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem. 1997 ; 272 (24). 15442-15451.
71. Baron V., Calleja V., Ferrari P., Alengrin F., Van Obberghen E. p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors. J Biol Chem. 1998 ; 273 (12). 7162-7168.
72. Guan JL Focal adhesion kinase in integrin signaling. Matrix Biol. 1997 ; 16 (4). 195-200.
73. Parsons JT Focal adhesion kinase: the first 10 years. J Cell Sci. 2003 ; 116 (Pt 8). 1409-1416.
74. Tapia JA, Camello C., Jensen RT, Garcia LJ EGF stimulates tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on phosphatidylinositol 3-kinase, the small GTP-binding protein, p21rho, and the integrity of the actin cytoskeleton. Biochimica et Biophysica Acta. 1999 ; 1448 (3). 486-99.
75. Azar ZM, Mehdi MZ, Srivastava AK Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells. Can J Physiol Pharmacol. 2006 ; 84 (7). 777-786.
76. Angelucci A., Bologna M. Targeting vascular cell migration as a strategy for blocking angiogenesis: the central role of focal adhesion protein tyrosine kinase family. Curr Pharm Des. 2007 ; 13 (21). 2129-2145.
77. Gunst SJ Does airway inflation stretch the bronchial mucosal membrane ? J Appl Physiol. 2005 ; 99 (6). 2059-2060.
78. Berk BC, Corson MA. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res. 1997 ; 80 (5). 607-616.
79. Hirshman CA, Zhu D., Pertel T., Panettieri RA, Emala CW Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS. Am J Physiol Lung Cell Mol Physiol. 2005 ; 288 (5). L924 - L931.
80. Ishida T., Ishida M., Suero J., Takahashi M., Berk BC Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. J Clin Invest. 1999 ; 103 (6). 789-797.
81. Brown MC, Turner CE Paxillin: adapting to change. Physiol Rev. 2004 ; 84 (4). 1315-1339.
82. Bellis SL, Miller JT, Turner CE Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem. 1995 ; 270 (29). 17437-17441.
83. Brown MC, Perrotta JA, Turner CE Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol. 1996 ; 135 (4). 1109-1123.
84. Roy S., Ruest PJ, Hanks SK. FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation. J Cell Biochem. 2002 ; 84 (2). 377-388.
85. Turner CE Paxillin interactions. J Cell Sci. 2000 ; 113 Pt 23: 4139-4140.
86. Wade R., Bohl J., Vande PS Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Oncogene. 2002 ; 21 (1). 96-107.
87. Yano H., Uchida H., Iwasaki T., et al. Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation. Proc Natl Acad Sci U S A. 2000 ; 97 (16). 9076-9081.
88. Vuori K., Hirai H., Aizawa S., Ruoslahti E. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol. 1996 ; 16 (6). 2606-2613.
89. Nakamura I., Jimi E., Duong LT, et al. Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts. J Biol Chem. 1998 ; 273 (18). 11144-11149.
90. Hu XQ, Singh N., Mukhopadhyay D., Akbarali HI Modulation of voltage-dependent Ca2+ channels in rabbit colonic smooth muscle cells by c-Src and focal adhesion kinase. J Biol Chem. 1998 ; 273 (9). 5337-5342.
91. Schlaepfer DD, Broome MA, Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 1997 ; 17 (3). 1702-1713.
92. Schlaepfer DD, Hanks SK, Hunter T., van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994 ; 372 (6508). 786-791.
93. Eliceiri BP, Puente XS, Hood JD, et al. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 ; 157 (1). 149-160.
94. Totani L., Piccoli A., Manarini S., et al. Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem J. 2006 ; 396 (1). 89-98.
95. Guignandon A., Boutahar N., Rattner A., Vico L., Lafage-Proust MH Cyclic strain promotes shuttling of PYK2/ Hic-5 complex from focal contacts in osteoblast-like cells. Biochem Biophys Res Commun. 2006 ; 343 (2). 407-414.
96. Schoenwaelder SM, Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Curr Opin Cell Biol. 1999 ; 11 (2). 274-286.
97. Wu X., Davis GE, Meininger GA, Wilson E., Davis MJ Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins. J Biol Chem. 2001 ; 276 (32). 30285-30292.
98. Astier A., Avraham H., Manie SN, et al. The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. J Biol Chem. 1997 ; 272 (1). 228-232.
99. Keogh RJ, Houliston RA, Wheeler-Jones CP Human endothelial Pyk2 is expressed in 2 isoforms and associates with paxillin and p130Cas. Biochem Biophys Res Commun. 2002 ; 290 (5). 1470-1477.
100. Li X., Earp HS Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells. J Biol Chem. 1997 ; 272 (22). 14341-14348.
101. D'Angelo G., Mogford JE, Davis GE, Davis MJ, Meininger GA Integrin-mediated reduction in vascular smooth muscle [Ca2+]-induced by RGD-containing peptide. Am J Physiol. 1997 ; 272 (4 Pt 2). H2065 - H2070.
102. D'Angelo G., Davis MJ, Meininger GA Calcium and mechanotransduction of the myogenic response. Am J Physiol. 1997 ; 273 (1 Pt 2). H175 - H182.
103. Hirshman CA, Togashi H., Shao D., Emala CW Galphai-2 is required for carbachol-induced stress fiber formation in human airway smooth muscle cells. Am J Physiol. 1998 ; 275 (5 Pt 1). L911 - L916.
104. Kuhn TB, Meberg PJ, Brown MD, et al. Regulating actin dynamics in neuronal growth cones by ADF/cofilin and Rho family GTPases. J Neurobiol. 2000 ; 44 (2). 126-144.
105. Lee S., Helfman DM Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J Biol Chem. 2004 ; 279 (3). 1885-1891.
106. Maekawa M., Ishizaki T., Boku S., et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science. 1999 ; 285 (5429). 895-898.
107. Ohashi K., Nagata K., Maekawa M., Ishizaki T., Narumiya S., Mizuno K. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem. 2000 ; 275 (5). 3577-3582.
108. Kaunas R., Nguyen P., Usami S., Chien S. Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci U S A. 2005 ; 102 (44). 15895-15900.
109. Lammers M., Rose R., Scrima A., Wittinghofer A. The regulation of mDia1 by autoinhibition and its release by Rho*GTP. EMBO J. 2005 ; 24 (23). 4176-4187.
110. Gupton SL, Eisenmann K., Alberts AS, Waterman-Storer CM mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration. J Cell Sci. 2007 ; 120 (Pt 19). 3475-3487.
111. Wu X., Li S., Chrostek-Grashoff A., et al. Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development. Dev Dyn. 2007 ; 236 (10). 2767-2778.
112. El-Sibai M., Nalbant P., Pang H., et al. Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci. 2007 ; 120 (Pt 19). 3465-3474.
113. Arozarena I., Aaronson DS, Matallanas D., et al. The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF. J Biol Chem. 2000 ; 275 (34). 26441-26448.
114. Cau J., Hall A. Cdc42 controls the polarity of the actin and microtubule cytoskeletons through 2 distinct signal transduction pathways. J Cell Sci. 2005 ; 118 (Pt 12). 2579-2587.
115. Zigmond SH, Joyce M., Yang C., Brown K., Huang M., Pring M. Mechanism of Cdc42-induced actin polymerization in neutrophil extracts. J Cell Biol. 1998 ; 142 (4). 1001-1012.
116. Higgs HN, Pollard TD Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J Cell Biol. 2000 ; 150 (6). 1311-1320.
117. Dechert MA, Holder JM, Gerthoffer WT p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 Mapk. Am J Physiol Cell Physiol. 2001 ; 281 (1). C123 - C132.
118. Woolfolk EA, Eguchi S., Ohtsu H., et al. Angiotensin IIinduced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2005 ; 289 (5). C1286 - C1294.
119. Li QF, Spinelli AM, Wang R., Anfinogenova Y., Singer HA, Tang DD Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling. J Biol Chem. 2006 ; 281 (45). 34716-34724.
120. Jaffer ZM, Chernoff J. p21-activated kinases: 3 more join the Pak. Int J Biochem Cell Biol. 2002 ; 34 (7). 713-717.
121. Knaus UG, Bokoch GM The p21Rac/Cdc42-activated kinases (PAKs). Int J Biochem Cell Biol. 1998 ; 30 (8). 857-862.
122. Tang DD, Bai Y., Gunst SJ Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Biochem J. 2005 ; 388 (Pt 3). 773-783.
123. Wang R., Li QF, Anfinogenova Y., Tang DD Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007 ; 292 (1). L240 - L248.
124. Larsen JK, Yamboliev IA, Weber LA, Gerthoffer WT Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle. Am J Physiol. 1997 ; 273 (5 Pt 1). L930 - L940.
125. Yamboliev IA, Chen J., Gerthoffer WT PI 3-kinases and Src kinases regulate spreading and migration of cultured VSMCs. Am J Physiol Cell Physiol. 2001 ; 281 (2). C709 - C718.
126. Shakirova Y., Bonnevier J., Albinsson S., et al. Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1. Am J Physiol Cell Physiol. 2006 ; 291 (6). C1326 - C1335.
127. Shimizu T., Nakazawa T., Cho A., et al. Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. Circ Res. 2007 ; 101 (10). 995-1000.
128. Sakurada S., Takuwa N., Sugimoto N., et al. Ca2+- dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res. 2003 ; 93 (6). 548-556.
129. Smith PG, Garcia R., Kogerman L. Strain reorganizes focal adhesions and cytoskeleton in cultured airway smooth muscle cells. Exp Cell Res. 1997 ; 232 (1). 127-136.
130. Benndorf R., Hayess K., Ryazantsev S., Wieske M., Behlke J., Lutsch G. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J Biol Chem. 1994 ; 269 (32). 20780-20784.
131. Miron T., Vancompernolle K., Vanderkerckhove J., Wilchek M., Geiger B. A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J Cell Biol. 1991 ; 114: 255-261.
132. Ibitayo AI, Sladick J., Tuteja S., et al. HSP27 in signal transduction and association with contractile proteins in smooth muscle cells. Am J Physiol. 1999 ; 277: G445 - G454.
133. Bitar KN, Kaminski MS, Hailat N., Cease KB, Strahler JR Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin. Biochem Biophys Res Commun. 1991 ; 181: 1192-1200.
134. Yamboliev IA, Hedges JC, Mutnick JL, Adam LP, Gerthoffer WT Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. Am J Physiol Heart Circ Physiol. 2000 ; 278 (6). H1899 - H1907.