Mechanical signaling through connective tissue: A mechanism for the therapeutic effect of acupuncture

FASEB Journal

Volumn 15, Issue 12, 2001, Pages 2275-2282

  Langevin, Helene M ^a   Churchill, David L ^a   Cipolla, Marilyn J ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Collagen; Mechanotransduction; Meridian

Indexed keywords

COLLAGEN;

ACUPUNCTURE; ARTICLE; CONNECTIVE TISSUE; HUMAN; MANIPULATIVE MEDICINE; NEEDLE; PRIORITY JOURNAL; ROTATION; SIGNAL TRANSDUCTION;

ACUPUNCTURE THERAPY; ANIMALS; AUTOCRINE COMMUNICATION; COLLAGEN; CONNECTIVE TISSUE; CULTURE TECHNIQUES; FIBROBLASTS; HUMANS; MECHANORECEPTORS; MODELS, BIOLOGICAL; NEEDLES; PAIN; PARACRINE COMMUNICATION; RATS; SIGNAL TRANSDUCTION; SKIN; STRESS, MECHANICAL; TORQUE;

EID: 0034816286     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0015hyp     Document Type: Article

References (65)

1. A survey of six acupuncture clinics: Demographic and satisfaction data
2. Acupuncture
3. Investigating alternative therapies in randomized controlled trials
4. The evaluation of therapeutic acupuncture: Concepts and methods
5. Acupuncture loci: A proposal for their classification according to their relationship to known neural structures
6. Electroacupuncture: Mechanisms and clinical applications
7. The neurological mechanism of needle grasp in acupuncture
8. Electron microscopical and immunohistochemical studies on the induction of 'qi' employing needling manipulation
9. Biomechanical response to acupuncture needling in humans
10. Structure and biological activity of the extracellular matrix
11. Cellular control lies in the balance of forces
12. Integrin signaling
13. Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton
14. Integrin signaling transduces shear stress-dependent vasodilatation of coronary arterioles
15. Integrins and signal transduction pathways: The road taken
16. Mechanoreception at the cellular level: The detection, interpretation and diversity of responses to mechanical signals
17. Orientation response of arterial smooth muscle cells to mechanical stimulation
18. Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation
19. Calcium ions and tyrosine phosphorylation interact coordinately with actin to regulate cytoprotective responses to stretching
20. Direct observations of the mechanical behaviors of the cytoskeleton in living fibroblasts
21. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
22. Silicone rubber substrata: A new wrinkle in the study of cell locomotion
23. Regulation of extracellular matrix gene expression by mechanical stress
24. Mechanotransduction across the cell surface and through the cytoskeleton
25. Mechanical influences on vascular smooth muscle cell function
26. Tenascin-C expression by fibroblasts is elevated in stressed collagen gels
27. Temporal gradient in shear-induced signaling pathway: Involvement of MAP kinase, c-fos and connexin43
28. Differential immediate-early gene responses to shear stress and intraluminal pressure in intact human conduit vessels
29. Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices
30. Rapid effects of stretched myocardial and vascular cells on gene expression of neonatal rat cardiomyocytes with emphasis on autocrine and paracrine mechanisms
31. Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions
32. Nitric oxide synthase expression in endothelial cells exposed to mechanical forces
33. Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro
34. Strain-responsive regions in the platelet-derived growth factor-A gene promoter
35. Mechanical stretch modulates TGFβ1 and α1 (1) collagen expression in fetal human intestinal smooth muscle cells
36. Mechanical strain increases TGFβ1 mRNA expression and matrix production by human vascular smooth muscle cells
37. Stretch-induced membrane type matrix metalloproteinase and tissue plasminogen activator in cardiac fibroblast cells
38. Stretch-induced parathyroid hormone-related peptide gene expression in the rat uterus
39. What do tissues and cells know of mechanics?
40. Mechanotransduction and the functional response of bone to mechanical strain
41. Biochemical consequences of mechanical forces generated by distention and distortion
42. Influence of mechanical forces on cells and tissues
43. Biologic mechanisms of connective tissue mutability
44. Modulation of fibroblastic cytoskeletal features during pathological situations: The role of extracellular matrix and cytokines
45. Isometric contraction by fibroblasts and endothelial cells in tissue culture: A quantitative study
46. Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations
47. Expression of stress fibers in bullfrog mesothelial cells in response to tension
48. A study on the receptive field of acupoints and the relationship between characteristics of needling sensation and groups of afferent tissues
49. Etude des recepteurs musculaires innerves par les fibres afferents du groupe III (fibres myelinisees fines) chez le chat
50. Activity, dependent neuronal plasticity following tissue injury and inflammation
51. Peptides and the primary afferent nociceptor
52. Interaction of nitric oxide with myogenic and adrenergic vasoconstrictor processes in the control of microcirculatory blood flow
53. Is acupuncture effective for the treatment of chronic pain? A systematic review
54. A trial method for assessing the adequacy of acupuncture treatments