Depletion of focal adhesion kinase by antisense depresses contractile activation of smooth muscle

American Journal of Physiology - Cell Physiology

Volumn 280, Issue 4 49-4, 2001, Pages

  Tang, Dale D ^a   Gunst, Susan J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytoskeleton; Intracellular calcium; Myosin light chain phosphorylation; Paxillin; Smooth muscle contraction

Indexed keywords

ACETYLCHOLINE; ANTISENSE OLIGODEOXYNUCLEOTIDE; CALCIUM; FOCAL ADHESION KINASE; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; VINCULIN;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSKELETON; DOG; MUSCLE FORCE; NONHUMAN; NUCLEIC ACID PROBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; TRACHEA MUSCLE;

ANIMALIA; CANIS FAMILIARIS;

EID: 0034998560     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.280.4.c874     Document Type: Article

References (13)

1. Abedi H and Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272: 15442-15451, 1997.
2. Barry ST, Flinn HM, Humphries MJ, Critchley DR, and Ridley AJ. Requirement for Rho in integrin signalling. Cell Adhes Commun 4: 387-398, 1997.
3. Bellis SL, Miller JT, and Turner CE. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem 270: 17437-17441, 1995.
4. Burridge K and Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol 12: 463-518, 1996.
5. Burridge K, Fath K, Kelly T, Nuckolls G, and Turner C. Focal adhesions: transmembrane junctions between the extra-cellular matrix and the cytoskeleton. Annu Rev Cell Biol 4: 487-525, 1988.
6. FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol 119: 893-903, 1992.
7. Chrzanowska-Wodnicka M and Burridge K. Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. J Cell Sci 107: 3643-3654, 1994.
8. 2+]; induced by RGD-containing peptide. Am J Physiol Heart Circ Physiol 272: H2065-H2070, 1997.
9. Di Salvo J, Nelson SR, and Kaplan N. Protein tyrosine phosphorylation in smooth muscle: a potential coupling mechanism between receptor activation and intracellular calcium. Proc Soc Exp Biol Med 214: 285-301, 1997.
10. 125I vinculin overlay, immunoblotting and immunocytochemistry. Eur J Cell Biol 46: 513-522, 1988.
11. Earley JJ, Su X, and Morcland RS. Caldesmon inhibits active crossbridges in unstimulated vascular smooth muscle: an anti-sense oligodeoxynucleotide approach. Circ Res 83: 661-667, 1998.
12. Fabiato A and Fabiato F. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol (Paris) 75: 463-505, 1979.
13. rho. Biochem J 327: 461-472, 1997.