메뉴 건너뛰기




Volumn 15, Issue 6, 1998, Pages 856-862

Jejunal absorption and metabolism of R/S-verapamil in humans

Author keywords

Absorption; CYP3A4; Intestinal permeability; Intestinal secretion; Metabolism; P glycoprotein; Verapamil

Indexed keywords

GLYCOPROTEIN P; NORVERAPAMIL; VERAPAMIL;

EID: 0031780252     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011916329863     Document Type: Article
Times cited : (96)

References (35)
  • 1
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • T. Tsuruo, H. Iida, S. Tsukagoshi, and Y. Sakurai. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res. 41:1967-72 (1981).
    • (1981) Cancer Res. , vol.41 , pp. 1967-1972
    • Tsuruo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 2
    • 0030966409 scopus 로고    scopus 로고
    • Kinetics of the multidrug transporter (P-glycoprotein) and its reversal
    • W.D. Stein. Kinetics of the multidrug transporter (P-glycoprotein) and its reversal. Physiol Rev. 77:545-90 (1997).
    • (1997) Physiol Rev. , vol.77 , pp. 545-590
    • Stein, W.D.1
  • 3
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • M. M. Gottesman and I. Pastan. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427 (1993).
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 7
    • 0028229150 scopus 로고
    • Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • A. H. Schinkel et al. Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs, Cell 77:491-502 (1994).
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1
  • 8
    • 0029892497 scopus 로고    scopus 로고
    • P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    • A. H. Schinkel, E. Wagenaar, C. A. Mol, and D. L. van. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 97:2517-24 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 2517-2524
    • Schinkel, A.H.1    Wagenaar, E.2    Mol, C.A.3    Van, D.L.4
  • 9
    • 12644278301 scopus 로고    scopus 로고
    • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
    • A. Sparreboom et al. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc. Natl. Acad. Sci USA 94:2031-5 (1997).
    • (1997) Proc. Natl. Acad. Sci USA , vol.94 , pp. 2031-2035
    • Sparreboom, A.1
  • 10
    • 0028820208 scopus 로고
    • Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine
    • C. Y. Wu, L. Z. Benet, M. F. Hebert, S. K. Gupta, M. Rowland, D. Y. Gomez, and V. J. Wacher. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clin. Pharmacol. Ther. 58:492-7 (1995).
    • (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 492-497
    • Wu, C.Y.1    Benet, L.Z.2    Hebert, M.F.3    Gupta, S.K.4    Rowland, M.5    Gomez, D.Y.6    Wacher, V.J.7
  • 11
    • 0029786432 scopus 로고    scopus 로고
    • Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin
    • M. F Fromm, D. Busse, H. K. Kroemer, and M. Eichelbaum. Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin. Hepatology 24:796-801 (1996).
    • (1996) Hepatology , vol.24 , pp. 796-801
    • Fromm, M.F.1    Busse, D.2    Kroemer, H.K.3    Eichelbaum, M.4
  • 12
    • 0023588109 scopus 로고
    • Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
    • P. B. Watkins, S. A. Wrighton, E. G. Schuetz, D. T. Molowa, and P. S. Guzelian. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J. Clin. Invest. 80:1029-36 (1987).
    • (1987) J. Clin. Invest. , vol.80 , pp. 1029-1036
    • Watkins, P.B.1    Wrighton, S.A.2    Schuetz, E.G.3    Molowa, D.T.4    Guzelian, P.S.5
  • 15
    • 0029999340 scopus 로고    scopus 로고
    • Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans
    • T. Gramatte, R. Oertel, B. Terhaag, and W. Kirch. Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans. Clin. Pharmacol. Ther. 59:541-9 (1996).
    • (1996) Clin. Pharmacol. Ther. , vol.59 , pp. 541-549
    • Gramatte, T.1    Oertel, R.2    Terhaag, B.3    Kirch, W.4
  • 16
    • 0029986922 scopus 로고    scopus 로고
    • Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: Concentration- And dose-dependent absorption in vitro and in vivo
    • U. Wetterich, L. H. Spahn, E. Mutschler, B. Terhaag, W. Rosch, and P. Langguth. Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration-and dose-dependent absorption in vitro and in vivo. Pharm Res. 13:514-22 (1996).
    • (1996) Pharm Res. , vol.13 , pp. 514-522
    • Wetterich, U.1    Spahn, L.H.2    Mutschler, E.3    Terhaag, B.4    Rosch, W.5    Langguth, P.6
  • 18
    • 0029855969 scopus 로고    scopus 로고
    • Comperison between permeability coefficients in rat and human jejunum
    • U. Fagerholm, M. Johansson, and H. Lennernäs. Comperison between permeability coefficients in rat and human jejunum. Pharm. Res. 13:1336-42 (1996).
    • (1996) Pharm. Res. , vol.13 , pp. 1336-1342
    • Fagerholm, U.1    Johansson, M.2    Lennernäs, H.3
  • 19
    • 0024378474 scopus 로고
    • A new technique for segmental jejunal perfusion in man
    • L. Knutson, B. Odlind, and R. Hallgren. A new technique for segmental jejunal perfusion in man. Am. J. Gastroenterol. 84: 1278-84 (1989).
    • (1989) Am. J. Gastroenterol. , vol.84 , pp. 1278-1284
    • Knutson, L.1    Odlind, B.2    Hallgren, R.3
  • 20
    • 0026795241 scopus 로고
    • Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man
    • H. Lennernas, O. Ahrenstedt, R. Hallgren, L. Knutson, M. Ryde, and L. K. Paalzow. Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man. Pharm. Res. 9: 1243-51 (1992).
    • (1992) Pharm. Res. , vol.9 , pp. 1243-1251
    • Lennernas, H.1    Ahrenstedt, O.2    Hallgren, R.3    Knutson, L.4    Ryde, M.5    Paalzow, L.K.6
  • 21
    • 15644367348 scopus 로고    scopus 로고
    • Enantioselective analysis of verapamil and norverapamil in intestinal perfusate and plasma
    • R. Sandström, A. Karlsson, and H. Lennernäs. Enantioselective analysis of verapamil and norverapamil in intestinal perfusate and plasma (Submitted). J. Chromatogr. (1998).
    • (1998) J. Chromatogr.
    • Sandström, R.1    Karlsson, A.2    Lennernäs, H.3
  • 22
    • 0028925908 scopus 로고
    • Regional rectal perfusion: A new in vivo approach to study rectal drug absorption in man
    • H. Lennernas, U. Fagerholm, Y. Raab, B. Gerdin, and R. Hallgren. Regional rectal perfusion: a new in vivo approach to study rectal drug absorption in man. Pharm. Res. 12:426-32 (1995).
    • (1995) Pharm. Res. , vol.12 , pp. 426-432
    • Lennernas, H.1    Fagerholm, U.2    Raab, Y.3    Gerdin, B.4    Hallgren, R.5
  • 23
    • 0030790029 scopus 로고    scopus 로고
    • A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I- Gut: In-vivo permeability estimation
    • H. Lennernas, I. D. Lee, U. Fagerholm, and G. L. Amidon. A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: in-vivo permeability estimation. J. Pharm. Pharmacol. 49:682-6 (1997).
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 682-686
    • Lennernas, H.1    Lee, I.D.2    Fagerholm, U.3    Amidon, G.L.4
  • 25
    • 0028307188 scopus 로고
    • Intestinal drug absorption during induced net waler absorption in man: A mechanistic study using antipyrine, atenolol and enalaprilat
    • H. Lennernas, O. Ahrenstedt, and A. L. Ungell. Intestinal drug absorption during induced net waler absorption in man: a mechanistic study using antipyrine, atenolol and enalaprilat. Br. J. Clin. Pharmacol. 37:589-96 (1994).
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 589-596
    • Lennernas, H.1    Ahrenstedt, O.2    Ungell, A.L.3
  • 26
    • 0030797273 scopus 로고    scopus 로고
    • Human jejunal effective permeability and its correlation with preclinical drug absorption models
    • H. Lennernas. Human jejunal effective permeability and its correlation with preclinical drug absorption models [In Process Citation]. J. Pharm. Pharmacol. 49:627-38 (1997).
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 627-638
    • Lennernas, H.1
  • 28
    • 0031870979 scopus 로고    scopus 로고
    • The lack of stereo-selective P-glycoprotein mediated transport of R/S-verapamil across the rat jejunum
    • R. Sandström, A. Karlsson, and H. Lennernäs. The lack of stereo-selective P-glycoprotein mediated transport of R/S-verapamil across the rat jejunum (Submitted). J. Pharm. Pharmacol. (1998).
    • (1998) J. Pharm. Pharmacol.
    • Sandström, R.1    Karlsson, A.2    Lennernäs, H.3
  • 29
    • 0026012803 scopus 로고
    • Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines
    • K. Haussermann, B. Benz, V. Gekeler, K. Schumacher, and M. Eichelbaum. Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines. Eur. J. Clin. Pharmacol. 40:53-9 (1991).
    • (1991) Eur. J. Clin. Pharmacol. , vol.40 , pp. 53-59
    • Haussermann, K.1    Benz, B.2    Gekeler, V.3    Schumacher, K.4    Eichelbaum, M.5
  • 30
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • G. L. Amidon, H. Lennernas, V. P. Shah, and J. R. Crison. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12:413-20 (1995).
    • (1995) Pharm. Res. , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 31
    • 0028818676 scopus 로고
    • The lack of effect of induced net fluid absorption on the in vivo permeability of terbutaline in the human jejunum
    • U. Fagerholm, L. Borgstrom, O. Ahrenstedt, and H. Lennernas. The lack of effect of induced net fluid absorption on the in vivo permeability of terbutaline in the human jejunum. J. Drug. Target. 3:191-200 (1995).
    • (1995) J. Drug. Target. , vol.3 , pp. 191-200
    • Fagerholm, U.1    Borgstrom, L.2    Ahrenstedt, O.3    Lennernas, H.4
  • 33
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
    • E. G. Schuetz, A. H. Schinkel, M. V. Relling, and J. D. Schuetz. P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc. Natl. Acad. Sci. U S A. 93:4001-5 (1996).
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 34
    • 12644272784 scopus 로고    scopus 로고
    • Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
    • K. S. Lown et al. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin. Pharmacol. Ther. 62:248-60 (1997).
    • (1997) Clin. Pharmacol. Ther. , vol.62 , pp. 248-260
    • Lown, K.S.1
  • 35
    • 0026778218 scopus 로고
    • Predictability of the in vivo metabolism of verapamil from in vitro data: Contribution of individual metabolic pathways and stereoselective aspects
    • H. K. Kroemer, H. Echizen, H. Heidemann, and M. Eichelbaum. Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects. J. Pharmacol Exp. Ther. 260:1052-7 (1992).
    • (1992) J. Pharmacol Exp. Ther. , vol.260 , pp. 1052-1057
    • Kroemer, H.K.1    Echizen, H.2    Heidemann, H.3    Eichelbaum, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.