Probenecid interferes with renal oxidative metabolism: A potential pitfall in its use as an inhibitor of drug transport

British Journal of Pharmacology

Volumn 131, Issue 1, 2000, Pages 57-62

  Masereeuw, Rosalinde ^a   Van Pelt, Ard P ^a   Van Os, Sandra H G ^a   Willems, Peter H G M ^a   Smits, Paul ^a   Russel, Frans G M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Drug interaction; Membrane potential; Renal drug handling; Respiratory control; Uncoupling oxidative phosphorylation

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALCOHOL DERIVATIVE; ANION; CATION; FLUORESCENT DYE; ORGANIC COMPOUND; PROBENECID;

ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; CATION TRANSPORT; CELL MEMBRANE DEPOLARIZATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RETENTION; DRUG TRANSPORT; KIDNEY CORTEX; KIDNEY METABOLISM; KIDNEY PROXIMAL TUBULE; LIPOPHILICITY; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL;

EID: 0033812041     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703541     Document Type: Article

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