β-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy

PLoS Genetics

Volumn 4, Issue 4, 2008, Pages

  Buzina, Alla ^a   Lo, Mandy Y M ^a,b   Moffett, Angela ^a,b   Hotta, Akitsu ^a   Fussner, Eden ^b,c   Bharadwaj, Rikki R ^a   Pasceri, Peter ^a   Garcia Martinez, J Victor ^d   Bazett Jones, David P ^b,c   Ellis, James ^a,b  

^a Developmental and Stem Cell Biology Program   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Program in Genetics and Genomic Biology   (Canada)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; LENTIVIRUS VECTOR; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 1; PROTEIN; GLOBIN; POU2F1 PROTEIN, MOUSE; PRIMER DNA; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL NUCLEUS; CELL ULTRASTRUCTURE; CHROMATIN; CONTROLLED STUDY; DNA HYBRIDIZATION; ENHANCER REGION; ERYTHROID CELL; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CASSETTE; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; GENE THERAPY; GENOME; HETEROCHROMATIN; IN VITRO GENE TRANSFER; INTRON; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REGULATOR GENE; SPECTROSCOPY; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; ANIMAL; CELL LINE; GENE VECTOR; GENETIC COMPLEMENTATION; GENETICS; MALE; METABOLISM; METHODOLOGY; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SICKLE CELL ANEMIA;

LENTIVIRUS; MUS MUSCULUS;

ANEMIA, SICKLE CELL; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA PRIMERS; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC COMPLEMENTATION TEST; GENETIC VECTORS; GLOBINS; INTRONS; LOCUS CONTROL REGION; MALE; MICE; MICE, TRANSGENIC; OCTAMER TRANSCRIPTION FACTOR-1; PREGNANCY; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 43249100766     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000051     Document Type: Article

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