T to C substitution at -175 or -173 of the γ-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice

Journal of Biological Chemistry

Volumn 280, Issue 9, 2005, Pages 7452-7459

  Liu, Li Ren ^a   Du, Zhan Wen ^a   Zhao, Hua Lu ^a   Liu, Xiao Ling ^a   Huang, Xiao Dong ^a   Shen, Jie ^b   Ju, Li Mei ^b   Fang, Fu De ^a   Zhang, Jun Wu ^a,c  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOCHEMISTRY; HEMOGLOBIN; LIVING SYSTEMS STUDIES; PROTEINS;

GENE EXPRESSION; HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN (HPFH); MUTATION; PROTEIN BINDING;

GENES;

BETA GLOBIN; GAMMA GLOBIN; HEMOGLOBIN F; OCTAMER TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR GATA 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA FOOTPRINTING; ERYTHROCYTE; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; HEMOGLOBIN DETERMINATION; HEREDITY; IN VITRO STUDY; KARYOTYPE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN STRUCTURE; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; COSMIDS; DNA; DNA-BINDING PROTEINS; ERYTHROCYTES; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GATA1 TRANSCRIPTION FACTOR; GENE DELETION; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLOBINS; HELA CELLS; HUMANS; K562 CELLS; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; OCTAMER TRANSCRIPTION FACTOR-1; PHENOTYPE; PLASMIDS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN CONFORMATION; RNA; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 14844307629     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411407200     Document Type: Article

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