Thyroid hormone and "cardiac metamorphosis": Potential therapeutic implications

Pharmacology and Therapeutics

Volumn 118, Issue 2, 2008, Pages 277-294

  Pantos, Constantinos ^a   Mourouzis, Iordanis ^a   Xinaris, Christodoulos ^a   Papadopoulou Daifoti, Zoi ^a   Cokkinos, Dennis ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

Author keywords

Cardiac remodeling; Cellular signaling; Heart; Myocardial ischaemia; Thyroid hormone

Indexed keywords

ALDOSTERONE; AMIODARONE; DEETHYLAMIODARONE; DIIODOTHYROPROPIONIC ACID; G PROTEIN COUPLED RECEPTOR; HEAT SHOCK PROTEIN; LIOTHYRONINE; NORADRENALIN; PROPIONIC ACID; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROXINE;

ATHEROSCLEROSIS; BIOENERGY; CELL COMMUNICATION; CELL GROWTH; CELL STRUCTURE; DRUG MECHANISM; GENOMICS; HEART; HEART CONTRACTION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RHYTHM; HEART STROKE VOLUME; HEART VENTRICLE REMODELING; HEMODYNAMICS; HYPOTHYROIDISM; METAMORPHOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; STRESS; THYROID HORMONE METABOLISM;

ANIMALS; CORONARY CIRCULATION; HEART; HEART DISEASES; HUMANS; MYOCARDIAL ISCHEMIA; MYOCARDIUM; SIGNAL TRANSDUCTION; THYROID HORMONES; VENTRICULAR REMODELING;

EID: 43049156194     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2008.02.011     Document Type: Review

References (213)

1. Abo-Zenah H.A., Shoeb S.A., Sabry A.A., and Ismail H.A. Relating circulating thyroid hormone concentrations to serum interleukins-6 and 10 in association with non-thyroidal illnesses including chronic renal insufficiency. BMC Endocr Disord 8 (2008) 1
2. Angelin-Duclos C., Domenget C., Kolbus A., Beug H., Jurdic P., and Samarut J. Thyroid hormone T3 acting through the thyroid hormone alpha receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse. Development 132 (2005) 925-934
3. Asahi T., Shimabukuro M., Oshiro Y., Yoshida H., and Takasu N. Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats. Thyroid 11 (2001) 1009-1015
4. Baines C.P., and Molkentin J.D. STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol 38 (2005) 47-62
5. Bakker O., van Beeren H.C., and Wiersinga W.M. Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein. Endocrinology 134 (1994) 1665-1670
6. Barrett M.J., Alones V., Wang K.X., Phan L., and Swerdlow R.H. Mitochondria-derived oxidative stress induces a heat shock protein response. J Neurosci Res 78 (2004) 420-429
7. Barron A.J., Finn S.G., and Fuller S.J. Chronic activation of extracellular-signal-regulated protein kinases by phenylephrine is required to elicit a hypertrophic response in cardiac myocytes. Biochem J 371 (2003) 71-79
8. Bauab R.C., Perone D., Castro A.V., Cicogna A.C., and Nogueira C.R. Low triiodothyronine (T3) or reverse triiodothyronine (rT3) syndrome modifies gene expression in rats with congestive heart failure. Endocr Res 31 (2005) 397-405
9. Baumann C.T., Maruvada P., Hager G.L., and Yen P.M. Nuclear cytoplasmic shuttling by thyroid hormone receptors. multiple protein interactions are required for nuclear retention. J Biol Chem 276 (2001) 11237-11245
10. Belke D.D., Gloss B., Swanson E.A., and Dillmann W.H. Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy. Endocrinology 148 (2007) 2870-2877
11. Bianco A.C., and Kim B.W. Deiodinases: Implications of the local control of thyroid hormone action. J Clin Invest 116 (2006) 2571-2579
12. Bianco A.C., Salvatore D., Gereben B., Berry M.J., and Larsen P.R. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23 (2002) 38-89
13. Biondi B., and Klein I. Hypothyroidism as a risk factor for cardiovascular disease. Endocrine 24 (2004) 1-13
14. Bogoyevitch M.A., Gillespie-Brown J., Ketterman A.J., Fuller S.J., Ben-Levy R., Ashworth A., et al. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion. Circ Res 79 (1996) 162-173
15. Brar B.K., Stephanou A., Wagstaff M.J., Coffin R.S., Marber M.S., Engelmann G., et al. Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress. J Mol Cell Cardiol 31 (1999) 135-146
16. Buroker N.E., Young M.E., Wei C., Serikawa K., Ge M., Ning X.H., and Portman M.A. The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart. Am J Physiol Endocrinol Metab 292 2 (2007) E453-E460
17. Buser P.T., Wikman-Coffelt J., Wu S.T., Derugin N., Parmley W.W., and Higgins C.B. Postischemic recovery of mechanical performance and energy metabolism in the presence of left ventricular hypertrophy. A 31P-MRS study. Circ Res 66 (1990) 735-746
18. Carr A.N., and Kranias E.G. Thyroid hormone regulation of calcium cycling proteins. Thyroid 12 (2002) 453-457
19. Chassande O. Do unliganded thyroid hormone receptors have physiological functions?. J Mol Endocrinol 31 (2003) 9-20
20. Chassande O., Fraichard A., Gauthier K., Flamant F., Legrand C., Savatier P., et al. Identification of transcripts initiated from an internal promoter in the c-erbA alpha locus that encode inhibitors of retinoic acid receptor-alpha and triiodothyronine receptor activities. Mol Endocrinol 11 (1997) 1278-1290
21. Chen H., Wu X.J., Lu X.Y., Zhu L., Wang L.P., Yang H.T., et al. Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats. Acta Pharmacol Sin 26 (2005) 806-812
22. Chen Y.F., Kobayashi S., Chen J., Redetzke R.A., Said S., Liang Q., et al. Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. J Mol Cell Cardiol 44 (2008) 180-187
23. Chiellini G., Frascarelli S., Ghelardoni S., Carnicelli V., Tobias S.C., DeBarber A., et al. Cardiac effects of 3-iodothyronamine: A new aminergic system modulating cardiac function. FASEB J 21 (2007) 1597-1608
24. Columbano A., Pibiri M., Deidda M., Cossu C., Scanlan T.S., Chiellini G., et al. The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 (2006) 3211-3218
25. Cross H.R., Murphy E., Bolli R., Ping P., and Steenbergen C. Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production. J Mol Cell Cardiol 34 (2002) 361-367
26. d'Amati G., di Gioia C.R., Mentuccia D., Pistilli D., Proietti-Pannunzi L., Miraldi F., et al. Increased expression of thyroid hormone receptor isoforms in end-stage human congestive heart failure. J Clin Endocrinol Metab 86 (2001) 2080-2084
27. Davis P.J., and Davis F.B. Nongenomic actions of thyroid hormone on the heart. Thyroid 12 (2002) 459-466
28. Davis P.J., Shih A., Lin H.Y., Martino L.J., and Davis F.B. Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR. J Biol Chem 275 (2000) 38032-38039
29. Dillmann W.H. Small heat shock proteins and protection against injury. Ann N Y Acad Sci 874 (1999) 66-68
30. Dillmann W.H. Cellular action of thyroid hormone on the heart. Thyroid 12 (2002) 447-452
31. Dorn II G.W., and Force T. Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest 115 (2005) 527-537
32. Dowell R.T., Atkins F.L., and Love S. Beta-adrenergic receptors, adenylate cyclase activation, and myofibril enzyme activity in hypothyroid rats. Am J Physiol 266 (1994) H2527-H2534
33. Dyke C.M., Yeh Jr. T., Lehman J.D., Abd-Elfattah A., Ding M., Wechsler A.S., et al. Triiodothyronine-enhanced left ventricular function after ischemic injury. Ann Thorac Surg 52 (1991) 14-19
34. Dyke C.M., Ding M., Abd-Elfattah A.S., Loesser K., Dignan R.J., Wechsler A.S., et al. Effects of triiodothyronine supplementation after myocardial ischemia. Ann Thorac Surg 56 (1993) 215-222
35. Eaton P., Fuller W., Bell J.R., and Shattock M.J. AlphaB crystallin translocation and phosphorylation: Signal transduction pathways and preconditioning in the isolated rat heart. J Mol Cell Cardiol 33 (2001) 1659-1671
36. Eber B., Schumacher M., Langsteger W., Zweiker R., Fruhwald F.M., Pokan R., et al. Changes in thyroid hormone parameters after acute myocardial infarction. Cardiology 86 (1995) 152-156
37. Esaki T., Suzuki H., Cook M., Shimoji K., Cheng S.Y., Sokoloff L., et al. Cardiac glucose utilization in mice with mutated alpha- and beta-thyroid hormone receptors. Am J Physiol Endocrinol Metab 287 (2004) E1149-E1153
38. Feingold K., Kim M.S., Shigenaga J., Moser A., and Grunfeld C. Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response. Am J Physiol Endocrinol Metab 286 (2004) E201-E207
39. Ferdinandy P., Schulz R., and Baxter G.F. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 59 (2007) 418-458
40. Fernandez V., Castillo I., Tapia G., Romanque P., Uribe-Echevarria S., Uribe M., et al. Thyroid hormone preconditioning: Protection against ischemia-reperfusion liver injury in the rat. Hepatology 45 (2007) 170-177
41. Flamant F., and Samarut J. Thyroid hormone receptors: Lessons from knockout and knock-in mutant mice. Trends Endocrinol Metab 14 (2003) 85-90
42. Flamant F., Poguet A.L., Plateroti M., Chassande O., Gauthier K., Streichenberger N., et al. Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene. Mol Endocrinol 16 (2002) 24-32
43. Forrest D., Hanebuth E., Smeyne R.J., Everds N., Stewart C.L., Wehner J.M., et al. Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: Evidence for tissue-specific modulation of receptor function. EMBO J 15 (1996) 3006-3015
44. Fox A.W., Juberg E.N., May J.M., Johnson R.D., Abel P.W., and Minneman K.P. Thyroid status and adrenergic receptor subtypes in the rat: Comparison of receptor density and responsiveness. J Pharmacol Exp Ther 235 (1985) 715-723
45. Fraichard A., Chassande O., Plateroti M., Roux J.P., Trouillas J., Dehay C., et al. The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production. EMBO J 16 (1997) 4412-4420
46. Friberg L., Werner S., Eggertsen G., and Ahnve S. Rapid down-regulation of thyroid hormones in acute myocardial infarction: Is it cardioprotective in patients with angina?. Arch Intern Med 162 (2002) 1388-1394
47. Fukuyama K., Ichiki T., Imayama I., Ohtsubo H., Ono H., Hashiguchi Y., et al. Thyroid hormone inhibits vascular remodeling through suppression of cAMP response element binding protein activity. Arterioscler Thromb Vasc Biol 26 (2006) 2049-2055
48. Gabai V.L., Meriin A.B., Yaglom J.A., Wei J.Y., Mosser D.D., and Sherman M.Y. Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation. J Biol Chem 275 (2000) 38088-38094
49. Gabai V.L., Yaglom J.A., Volloch V., Meriin A.B., Force T., Koutroumanis M., et al. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol 20 (2000) 6826-6836
50. Ganote C., and Armstrong S. Ischaemia and the myocyte cytoskeleton: Review and speculation. Cardiovasc Res 27 (1993) 1387-1403
51. Garcia-Silva S., and Aranda A. The thyroid hormone receptor is a suppressor of ras-mediated transcription, proliferation, and transformation. Mol Cell Biol 24 (2004) 7514-7523
52. Garrington T.P., and Johnson G.L. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11 (1999) 211-218
53. Gay R., Gustafson T.A., Goldman S., and Morkin E. Effects of L-thyroxine in rats with chronic heart failure after myocardial infarction. Am J Physiol 253 (1987) H341-H346
54. Gay R.G., Graham S., Aguirre M., Goldman S., and Morkin E. Effects of 10- to 12-day treatment with L-thyroxine in rats with myocardial infarction. Am J Physiol 255 (1988) H801-H806
55. Gloss B., Trost S., Bluhm W., Swanson E., Clark R., Winkfein R., et al. Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta. Endocrinology 142 (2001) 544-550
56. Goldenthal M.J., Weiss H.R., and Marin-Garcia J. Bioenergetic remodeling of heart mitochondria by thyroid hormone. Mol Cell Biochem 265 (2004) 97-106
57. Goldenthal M.J., Ananthakrishnan R., and Marin-Garcia J. Nuclear-mitochondrial cross-talk in cardiomyocyte T3 signaling: A time-course analysis. J Mol Cell Cardiol 39 (2005) 319-326
58. Grover G.J., Mellstrom K., and Malm J. Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes. Curr Vasc Pharmacol 5 (2007) 141-154
59. Gullberg H., Rudling M., Salto C., Forrest D., Angelin B., and Vennstrom B. Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice. Mol Endocrinol 16 (2002) 1767-1777
60. Hambleton M., Hahn H., Pleger S.T., Kuhn M.C., Klevitsky R., Carr A.N., et al. Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation 114 (2006) 574-582
61. Hamilton M.A., Stevenson L.W., Fonarow G.C., Steimle A., Goldhaber J.I., Child J.S., et al. Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure. Am J Cardiol 81 (1998) 443-447
62. Harvey C.B., and Williams G.R. Mechanism of thyroid hormone action. Thyroid 12 (2002) 441-446
63. Hennemann G. Notes on the history of cellular uptake and deiodination of thyroid hormone. Thyroid 15 (2005) 753-756
64. Holland II F.W., Brown Jr. P.S., Weintraub B.D., and Clark R.E. Cardiopulmonary bypass and thyroid function: A "euthyroid sick syndrome". Ann Thorac Surg 52 (1991) 46-50
65. Holland II F.W., Brown Jr. P.S., and Clark R.E. Acute severe postischemic myocardial depression reversed by triiodothyronine. Ann Thorac Surg 54 (1992) 301-305
66. Horkko T.T., Tuppurainen K., George S.M., Jernvall P., Karttunen T.J., and Makinen M.J. Thyroid hormone receptor beta1 in normal colon and colorectal cancer-association with differentiation, polypoid growth type and K-ras mutations. Int J Cancer 118 (2006) 1653-1659
67. Huang S.A., and Bianco A.C. Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab 4 3 (2008) 148-155
68. Hyyti O.M., and Portman M.A. Molecular mechanisms of cross-talk between thyroid hormone and peroxisome proliferator activated receptors: Focus on the heart. Cardiovasc Drugs Ther 20 (2006) 463-469
69. Iemitsu M., Miyauchi T., Maeda S., Tanabe T., Takanashi M., Matsuda M., et al. Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats. Am J Physiol Heart Circ Physiol 286 (2004) H1696-H1705
70. Iervasi G., Pingitore A., Landi P., Raciti M., Ripoli A., Scarlattini M., et al. Low-T3 syndrome: A strong prognostic predictor of death in patients with heart disease. Circulation 107 (2003) 708-713
71. Jones K.E., Brubaker J.H., and Chin W.W. Evidence that phosphorylation events participate in thyroid hormone action. Endocrinology 134 (1994) 543-548
72. Kadletz M., Mullen P.G., Ding M., Wolfe L.G., and Wechsler A.S. Effect of triiodothyronine on postischemic myocardial function in the isolated heart. Ann Thorac Surg 57 (1994) 657-662
73. Kaneshige M., Suzuki H., Kaneshige K., Cheng J., Wimbrow H., Barlow C., et al. A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice. Proc Natl Acad Sci U S A 98 (2001) 15095-15100
74. Katz D., Reginato M.J., and Lazar M.A. Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation. Mol Cell Biol 15 (1995) 2341-2348
75. Kenessey A., and Ojamaa K. Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. J Biol Chem 281 (2006) 20666-20672
76. Kenessey A., Sullivan E.A., and Ojamaa K. Nuclear localization of protein kinase C-alpha induces thyroid hormone receptor-alpha1 expression in the cardiomyocyte. Am J Physiol Heart Circ Physiol 290 (2006) H381-H389
77. Kim Y.K., Suarez J., Hu Y., McDonough P.M., Boer C., Dix D.J., et al. Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy. Circulation 113 (2006) 2589-2597
78. Kimura T., Kanda T., Kotajima N., Kuwabara A., Fukumura Y., and Kobayashi I. Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. Eur J Endocrinol 143 (2000) 179-184
79. Kinugawa K., Minobe W.A., Wood W.M., Ridgway E.C., Baxter J.D., Ribeiro R.C., et al. Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression. Circulation 103 (2001) 1089-1094
80. Kinugawa K., Yonekura K., Ribeiro R.C., Eto Y., Aoyagi T., Baxter J.D., et al. Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res 89 (2001) 591-598
81. Kinugawa K., Jeong M.Y., Bristow M.R., and Long C.S. Thyroid hormone induces cardiac myocyte hypertrophy in a thyroid hormone receptor alpha1-specific manner that requires TAK1 and p38 mitogen-activated protein kinase. Mol Endocrinol 19 (2005) 1618-1628
82. Kiss E., Brittsan A.G., Edes I., Grupp I.L., Grupp G., and Kranias E.G. Thyroid hormone-induced alterations in phospholamban-deficient mouse hearts. Circ Res 83 (1998) 608-613
83. Klein I. Thyroid hormone and cardiac contractility. Am J Cardiol 91 (2003) 1331-1332
84. Klein I., and Hong C. Effects of thyroid hormone on cardiac size and myosin content of the heterotopically transplanted rat heart. J Clin Invest 77 (1986) 1694-1698
85. Klein I., and Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 344 (2001) 501-509
86. Klemperer J.D., Klein I., Gomez M., Helm R.E., Ojamaa K., Thomas S.J., et al. Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med 333 (1995) 1522-1527
87. Klemperer J.D., Zelano J., Helm R.E., Berman K., Ojamaa K., Klein I., et al. Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia. J Thorac Cardiovasc Surg 109 (1995) 457-465
88. Kukreja R.C., Kontos M.C., Loesser K.E., Batra S.K., Qian Y.Z., Gbur Jr. C.J., et al. Oxidant stress increases heat shock protein 70 mRNA in isolated perfused rat heart. Am J Physiol 267 (1994) H2213-H2219
89. Kuzman J.A., Gerdes A.M., Kobayashi S., and Liang Q. Thyroid hormone activates Akt and prevents serum starvation-induced cell death in neonatal rat cardiomyocytes. J Mol Cell Cardiol 39 (2005) 841-844
90. Lahorra J.A., Torchiana D.F., Hahn C., Bashour C.A., Denenberg A.G., Titus J.S., et al. Recovery after cardioplegia in the hypertrophic rat heart. J Surg Res 88 (2000) 88-96
91. Lanni A., Moreno M., Lombardi A., de Lange P., Silvestri E., Ragni M., et al. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB J 19 (2005) 1552-1554
92. Le Bouter S., Demolombe S., Chambellan A., Bellocq C., Aimond F., Toumaniantz G., et al. Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: Relation to cellular and integrated electrophysiology. Circ Res 92 (2003) 234-242
93. Leitman D.C., Costa C.H., Graf H., Baxter J.D., and Ribeiro R.C. Thyroid hormone activation of transcription is potentiated by activators of cAMP-dependent protein kinase. J Biol Chem 271 (1996) 21950-21955
94. Lembcke A., Dushe S., Dohmen P.M., Hoffmann U., Wegner B., Kloeters C., et al. Early and late effects of passive epicardial constraint on left ventricular geometry: Ellipsoidal re-shaping confirmed by electron-beam computed tomography. J Heart Lung Transplant 25 (2006) 90-98
95. Li Q., Sachs L., Shi Y.B., and Wolffe A.P. Modification of chromatin structure by the thyroid hormone receptor. Trends Endocrinol Metab 10 (1999) 157-164
96. Li X., Misik A.J., Rieder C.V., Solaro R.J., Lowen A., and Fliegel L. Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1). J Biol Chem 277 (2002) 28656-28662
97. Li Z., Meng Z.H., Chandrasekaran R., Kuo W.L., Collins C.C., Gray J.W., et al. Biallelic inactivation of the thyroid hormone receptor beta1 gene in early stage breast cancer. Cancer Res 62 (2002) 1939-1943
98. Li G., Ali I.S., and Currie R.W. Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27. Am J Physiol Heart Circ Physiol 294 (2008) H74-H87
99. Lin H.Y., Davis F.B., Gordinier J.K., Martino L.J., and Davis P.J. Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells. Am J Physiol 276 (1999) C1014-C1024
100. Litwin S.E., Zhang D., Roberge P., and Pennock G.D. DITPA prevents the blunted contraction-frequency relationship in myocytes from infarcted hearts. Am J Physiol Heart Circ Physiol 278 (2000) H862-H870
101. Liu Q., Clanachan A.S., and Lopaschuk G.D. Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts. Am J Physiol 275 (1998) E392-E399
102. Long X., Boluyt M.O., O'Neill L., Zheng J.S., Wu G., Nitta Y.K., et al. Myocardial retinoid X receptor, thyroid hormone receptor, and myosin heavy chain gene expression in the rat during adult aging. J Gerontol A Biol Sci Med Sci 54 (1999) B23-B27
103. Mahaffey K.W., Raya T.E., Pennock G.D., Morkin E., and Goldman S. Left ventricular performance and remodeling in rabbits after myocardial infarction. Effects of a thyroid hormone analogue. Circulation 91 (1995) 794-801
104. Mai W., Janier M.F., Allioli N., Quignodon L., Chuzel T., Flamant F., et al. Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A 101 (2004) 10332-10337
105. Malik F.S., Mehra M.R., Uber P.A., Park M.H., Scott R.L., and Van Meter C.H. Intravenous thyroid hormone supplementation in heart failure with cardiogenic shock. J Card Fail 5 (1999) 31-37
106. Mancini D.M., Eisen H., Kussmaul W., Mull R., Edmunds Jr. L.H., and Wilson J.R. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 83 (1991) 778-786
107. Mansen A., Yu F., Forrest D., Larsson L., and Vennstrom B. TRs have common and isoform-specific functions in regulation of the cardiac myosin heavy chain genes. Mol Endocrinol 15 (2001) 2106-2114
108. McKenna N.J., and O'Malley B.W. Minireview: Nuclear receptor coactivators - An update. Endocrinology 143 (2002) 2461-2465
109. Minatoya Y., Ito K., Kagaya Y., Asaumi Y., Takeda M., Nakayama M., et al. Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts are ameliorated with the administration of physiological treatment dose of T3 in rats. Acta Physiol (Oxf) 189 (2007) 221-231
110. Morkin E., Pennock G.D., Spooner P.H., Bahl J.J., and Goldman S. Clinical and experimental studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analogue, in heart failure. Thyroid 12 (2002) 527-533
111. Morreale de Escobar G., Calvo R., Escobar del Rey F., and Obregon M.J. Thyroid hormones in tissues from fetal and adult rats. Endocrinology 134 (1994) 2410-2415
112. Morrish F., Buroker N.E., Ge M., Ning X.H., Lopez-Guisa J., Hockenbery D., et al. Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA. Mitochondrion 6 (2006) 143-148
113. Morte B., Manzano J., Scanlan T., Vennstrom B., and Bernal J. Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism. Proc Natl Acad Sci U S A 99 (2002) 3985-3989
114. Moruzzi P., Doria E., Agostoni P.G., Capacchione V., and Sganzerla P. Usefulness of L-thyroxine to improve cardiac and exercise performance in idiopathic dilated cardiomyopathy. Am J Cardiol 73 (1994) 374-378
115. Moruzzi P., Doria E., and Agostoni P.G. Medium-term effectiveness of L-thyroxine treatment in idiopathic dilated cardiomyopathy. Am J Med 101 (1996) 461-467
116. Mourouzis, I., Dimopoulos, A., Saranteas, T., Tsinarakis, N., Livadarou, E., Spanou, D., Kokkinos, A. D., Xinaris, C., Pantos, C., & Cokkinos, D. V. (in press). Ischemic preconditioning fails to confer additional protection against ischemia-reperfusion injury in the hypothyroid rat heart. Physiol Res.
117. Mousa S.A., O'Connor L.J., Bergh J.J., Davis F.B., Scanlan T.S., and Davis P.J. The proangiogenic action of thyroid hormone analogue GC-1 is initiated at an integrin. J Cardiovasc Pharmacol 46 (2005) 356-360
118. Naito H., Melnychenko I., Didie M., Schneiderbanger K., Schubert P., Rosenkranz S., et al. Optimizing engineered heart tissue for therapeutic applications as surrogate heart muscle. Circulation 114 (2006) I72-I78
119. Noguchi A., and Whitsett J.A. Ontogeny of alpha 1-adrenergic receptors in the rat myocardium: Effects of hypothyroidism. Eur J Pharmacol 86 (1982) 43-50
120. Novitzky D., Cooper D.K., and Swanepoel A. Inotropic effect of triiodothyronine (T3) in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: An initial experience in patients undergoing open heart surgery. Eur J Cardiothorac Surg 3 (1989) 140-145
121. Novitzky D., Matthews N., Shawley D., Cooper D.K., and Zuhdi N. Triiodothyronine in the recovery of stunned myocardium in dogs. Ann Thorac Surg 51 (1991) 10-16 discussion 16-17
122. Novitzky D., Fontanet H., Snyder M., Coblio N., Smith D., and Parsonnet V. Impact of triiodothyronine on the survival of high-risk patients undergoing open heart surgery. Cardiology 87 (1996) 509-515
123. Novotny J., Bourova L., Malkova O., Svoboda P., and Kolar F. G proteins, beta-adrenoreceptors and beta-adrenergic responsiveness in immature and adult rat ventricular myocardium: Influence of neonatal hypo- and hyperthyroidism. J Mol Cell Cardiol 31 (1999) 761-772
124. O'Neill J.O., Young J.B., Pothier C.E., and Lauer M.S. Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers. Circulation 111 (2005) 2313-2318
125. Ocasio C.A., and Scanlan T.S. Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist. ACS Chem Biol 1 (2006) 585-593
126. Ojamaa K., and Klein I. In vivo regulation of recombinant cardiac myosin heavy chain gene expression by thyroid hormone. Endocrinology 132 (1993) 1002-1006
127. Ojamaa K., Kenessey A., and Klein I. Thyroid hormone regulation of phospholamban phosphorylation in the rat heart. Endocrinology 141 (2000) 2139-2144
128. Ojamaa K., Kenessey A., Shenoy R., and Klein I. Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat. Am J Physiol Endocrinol Metab 279 (2000) E1319-E1324
129. Ojamaa K., Klein I., Sabet A., and Steinberg S.F. Changes in adenylyl cyclase isoforms as a mechanism for thyroid hormone modulation of cardiac beta-adrenergic receptor responsiveness. Metabolism 49 (2000) 275-279
130. Olivares E.L., Marassi M.P., Fortunato R.S., da Silva A.C., Costa-e-Sousa R.H., Araujo I.G., et al. Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study. Endocrinology 148 (2007) 4786-4792
131. Pantos C. Thyroid hormone at physiological doses restores depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts. Acta Physiol (Oxf) 189 (2007) 219
132. Pantos C.I., Cokkinos D.D., Tzeis S.M., Malliopoulou V., Mourouzis I.S., Carageorgiou H.C., et al. Hyperthyroidism is associated with preserved preconditioning capacity but intensified and accelerated ischaemic contracture in rat heart. Basic Res Cardiol 94 (1999) 254-260
133. Pantos C.I., Mourouzis I.S., Tzeis S.M., Malliopoulou V., Cokkinos D.D., Asimacopoulos P., et al. Propranolol diminishes cardiac hypertrophy but does not abolish acceleration of the ischemic contracture in hyperthyroid hearts. J Cardiovasc Pharmacol 36 (2000) 384-389
134. Pantos C.I., Malliopoulou V.A., Mourouzis I.S., Karamanoli E.P., Tzeis S.M., Carageorgiou H.C., et al. Long-term thyroxine administration increases heat stress protein-70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia. J Endocrinol 170 (2001) 207-215
135. Pantos C.I., Tzilalis V., Giannakakis S., Cokkinos D.D., Tzeis S.M., Malliopoulou V., et al. Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. Int Angiol 20 (2001) 181-186
136. Pantos C.I., Malliopoulou V.A., Mourouzis I.S., Karamanoli E.P., Paizis I.A., Steimberg N., et al. Long-term thyroxine administration protects the heart in a pattern similar to ischemic preconditioning. Thyroid 12 (2002) 325-329
137. Pantos C., Malliopoulou V., Mourouzis I., Karamanoli E., Moraitis P., Tzeis S., et al. Thyroxine pretreatment increases basal myocardial heat-shock protein 27 expression and accelerates translocation and phosphorylation of this protein upon ischaemia. Eur J Pharmacol 478 (2003) 53-60
138. Pantos C., Malliopoulou V., Mourouzis I., Moraitis P., Tzeis S., Thempeyioti A., et al. Involvement of p38 MAPK and JNK in heat stress-induced cardioprotection. Basic Res Cardiol 98 (2003) 158-164
139. Pantos C., Malliopoulou V., Mourouzis I., Sfakianoudis K., Tzeis S., Doumba P., et al. Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart to ischaemia-reperfusion. J Endocrinol 178 (2003) 427-435
140. Pantos C., Malliopoulou V., Paizis I., Moraitis P., Mourouzis I., Tzeis S., et al. Thyroid hormone and cardioprotection: study of p38 MAPK and JNKs during ischaemia and at reperfusion in isolated rat heart. Mol Cell Biochem 242 (2003) 173-180
141. Pantos C., Mourouzis I., Tzeis S., Moraitis P., Malliopoulou V., Cokkinos D.D., et al. Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: An effect reversed by thyroxine pretreatment. Eur J Pharmacol 460 (2003) 155-161
142. Pantos C., Malliopoulou V., Varonos D.D., and Cokkinos D.V. Thyroid hormone and phenotypes of cardioprotection. Basic Res Cardiol 99 (2004) 101-120
143. Pantos C., Mourouzis I., Malliopoulou V., Paizis I., Tzeis S., Moraitis P., et al. Dronedarone administration prevents body weight gain and increases tolerance of the heart to ischemic stress: A possible involvement of thyroid hormone receptor alpha1. Thyroid 15 (2005) 16-23
144. Pantos C., Mourouzis I., Saranteas T., Paizis I., Xinaris C., Malliopoulou V., et al. Thyroid hormone receptors alpha1 and beta1 are downregulated in the post-infarcted rat heart: Consequences on the response to ischaemia-reperfusion. Basic Res Cardiol 100 (2005) 422-432
145. Pantos C., Paizis I., Mourouzis I., Moraitis P., Tzeis S., Karamanoli E., et al. Blockade of angiotensin II type 1 receptor diminishes cardiac hypertrophy, but does not abolish thyroxin-induced preconditioning. Horm Metab Res 37 (2005) 500-504
146. Pantos C., Malliopoulou V., Mourouzis I., Thempeyioti A., Paizis I., Dimopoulos A., et al. Hyperthyroid hearts display a phenotype of cardioprotection against ischemic stress: A possible involvement of heat shock protein 70. Horm Metab Res 38 (2006) 308-313
147. Pantos C., Mourouzis C., Katramadou M., Saranteas T., Mourouzis I., Karageorgiou H., et al. Decreased vascular reactivity to alpha1 adrenergic stimulation in the presence of hypothyroid state: A part of an adaptive response?. Int Angiol 25 (2006) 216-220
148. Pantos C., Mourouzis I., and Cokkinos D.V. Myocardial ischemia: Basic concepts. In: Cokkinos D.V., Pantos C., Heusch G., and Taegtmeyer H. (Eds). Myocardial Ischemia: From Mechanisms to Theurapeutic Potentials (2006), Springer, New York 11-77
149. Pantos C., Dritsas A., Mourouzis I., Dimopoulos A., Karatasakis G., Athanassopoulos G., et al. Thyroid hormone is a critical determinant of myocardial performance in patients with heart failure: potential therapeutic implications. Eur J Endocrinol 157 (2007) 515-520
150. Pantos C., Mourouzis I., Dimopoulos A., Markakis K., Panagiotou M., Xinaris C., et al. Enhanced tolerance of the rat myocardium to ischemia and reperfusion injury early after acute myocardial infarction. Basic Res Cardiol 102 (2007) 327-333
151. Pantos C., Mourouzis I., Markakis K., Dimopoulos A., Xinaris C., Kokkinos A.D., et al. Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats. Eur J Cardiothorac Surg 32 (2007) 333-339
152. Pantos C., Mourouzis I., Paizis I., Malliopoulou V., Xinaris C., Moraitis P., et al. Pharmacological inhibition of TRalpha1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight. Diabetes Obes Metab 9 (2007) 136-138
153. Pantos C., Mourouzis I., Xinaris C., Kokkinos A.D., Markakis K., Dimopoulos A., et al. Time-dependent changes in the expression of thyroid hormone receptor {alpha}1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. Eur J Endocrinol 156 (2007) 415-424
154. Pantos C., Xinaris C., Mourouzis I., Malliopoulou V., Kardami E., and Cokkinos D.V. Thyroid hormone changes cardiomyocyte shape and geometry via ERK signaling pathway: Potential therapeutic implications in reversing cardiac remodeling?. Mol Cell Biochem 297 (2007) 65-72
155. Pantos, C., Xinaris, C., Mourouzis, I., Perimenis, P., Spanou, D., & Cokkinos, D. V. (in press). Possible involvement of thyroid hormone receptor α1 in phenylephrine-induced fetal-like changes in neonatal cardiomyocytes. J Physiol Pharmacol.
156. Pantos, C., Mourouzis, I., Markakis, K., Tsagoulis, N., Panagiotou, M., & Cokkinos, D. V. (in press). Long-term thyroid hormone administration re-shapes left ventricular chamber and improves cardiac function after myocardial infarction in rats. Basic Res Cardiol. doi:10.1007/s00395-008-0697-0
157. Pennock G.D., Spooner P.H., Summers C.E., and Litwin S.E. Prevention of abnormal sarcoplasmic reticulum calcium transport and protein expression in post-infarction heart failure using 3, 5-diiodothyropropionic acid (DITPA). J Mol Cell Cardiol 32 (2000) 1939-1953
158. Pingitore A., Landi P., Taddei M.C., Ripoli A., L'Abbate A., and Iervasi G. Triiodothyronine levels for risk stratification of patients with chronic heart failure. Am J Med 118 (2005) 132-136
159. Pingitore A., Iervasi G., Barison A., Prontera C., Pratali L., Emdin M., et al. Early activation of an altered thyroid hormone profile in asymptomatic or mildly symptomatic idiopathic left ventricular dysfunction. J Card Fail 12 (2006) 520-526
160. Pingitore A., Galli E., Barison A., Iervasi A., Scarlattini M., Nucci D., L'abbate A., Mariotti R., and Iervasi G. Acute effects of triiodothyronine (t3) replacement therapy in patients with chronic heart failure and low-t3 syndrome: a randomized, placebo-controlled study. J Clin Endocrinol Metab 93 4 (2008) 1351-1358
161. Pipkin W., Johnson J.A., Creazzo T.L., Burch J., Komalavilas P., and Brophy C. Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart. Circulation 107 (2003) 469-476
162. Ranasinghe A.M., Quinn D.W., Pagano D., Edwards N., Faroqui M., Graham T.R., et al. Glucose-insulin-potassium and tri-iodothyronine individually improve hemodynamic performance and are associated with reduced troponin I release after on-pump coronary artery bypass grafting. Circulation 114 (2006) I245-I250
163. Redonnet A., Groubet R., Noel-Suberville C., Bonilla S., Martinez A., and Higueret P. Exposure to an obesity-inducing diet early affects the pattern of expression of peroxisome proliferator, retinoic acid, and triiodothyronine nuclear receptors in the rat. Metabolism 50 (2001) 1161-1167
164. Rodríguez-Gómez I., Cruz A., Moreno J.M., Soler A., Osuna A., and Vargas F. Clofibrate prevents and reverses the hemodynamic manifestations of hyperthyroidism in rats. Am J Hypertens 21 3 (2008) 341-347
165. Ronald A., and Dunning J. Does perioperative thyroxine have a role during adult cardiac surgery?. Interact Cardiovasc Thorac Surg 5 (2006) 166-178
166. Rybin V., and Steinberg S.F. Thyroid hormone represses protein kinase C isoform expression and activity in rat cardiac myocytes. Circ Res 79 (1996) 388-398
167. Sakamoto K., Urushidani T., and Nagao T. Translocation of HSP27 to sarcomere induced by ischemic preconditioning in isolated rat hearts. Biochem Biophys Res Commun 269 (2000) 137-142
168. Santalucia T., Moreno H., Palacin M., Yacoub M.H., Brand N.J., and Zorzano A. A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription. J Mol Biol 314 (2001) 195-204
169. Saurin A.T., Martin J.L., Heads R.J., Foley C., Mockridge J.W., Wright M.J., et al. The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. FASEB J 14 (2000) 2237-2246
170. Sawin C.T. Subclinical hyperthyroidism and atrial fibrillation. Thyroid 12 (2002) 501-503
171. Scanlan T.S., Suchland K.L., Hart M.E., Chiellini G., Huang Y., Kruzich P.J., et al. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med 10 (2004) 638-642
172. Schmidt B.M., Martin N., Georgens A.C., Tillmann H.C., Feuring M., Christ M., et al. Nongenomic cardiovascular effects of triiodothyronine in euthyroid male volunteers. J Clin Endocrinol Metab 87 (2002) 1681-1686
173. Scruggs S.B., Walker L.A., Lyu T., Geenen D.L., Solaro R.J., Buttrick P.M., et al. Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol 40 (2006) 465-473
174. Shahrara S., Tidholm A., Drvota V., Haggstom J., and Sylven C. Upregulation of thyroid hormone receptor beta 1 and beta 2 messenger RNA in the myocardium of dogs with dilated cardiomyopathy or chronic valvular disease. Am J Vet Res 60 (1999) 848-852
175. Shih A., Lin H.Y., Davis F.B., and Davis P.J. Thyroid hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase. Biochemistry 40 (2001) 2870-2878
176. Spinale F.G. Cellular and molecular therapeutic targets for treatment of contractile dysfunction after cardioplegic arrest. Ann Thorac Surg 68 (1999) 1934-1941
177. Spooner P.H., Thai H.M., Goldman S., and Gaballa M.A. Thyroid hormone analog, DITPA, improves endothelial nitric oxide and beta-adrenergic mediated vasorelaxation after myocardial infarction. J Cardiovasc Pharmacol 44 (2004) 453-459
178. Storey N.M., O'Bryan J.P., and Armstrong D.L. Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr Biol 12 (2002) 27-33
179. Sussman M.A. Cellular indigestion: Chaperones head to the cytoskeleton. J Mol Cell Cardiol 34 (2002) 83-85
180. Sylven C., Jansson E., Sotonyi P., Waagstein F., Barkhem T., and Bronnegard M. Cardiac nuclear hormone receptor mRNA in heart failure in man. Life Sci 59 (1996) 1917-1922
181. Taguchi T., Iwasaki Y., Asaba K., Takao T., and Hashimoto K. Myxedema coma and cardiac ischemia in relation to thyroid hormone replacement therapy in a 38-year-old Japanese woman. Clin Ther 29 (2007) 2710-2714
182. Tavi P., Sjogren M., Lunde P.K., Zhang S.J., Abbate F., Vennstrom B., et al. Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha1. J Mol Cell Cardiol 38 (2005) 655-663
183. Ting Y.T., Bhat M.K., Wong R., and Cheng S. Tissue-specific stabilization of the thyroid hormone beta1 nuclear receptor by phosphorylation. J Biol Chem 272 (1997) 4129-4134
184. Tinnikov A., Nordstrom K., Thoren P., Kindblom J.M., Malin S., Rozell B., et al. Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1. EMBO J 21 (2002) 5079-5087
185. Tomanek R.J., Doty M.K., and Sandra A. Early coronary angiogenesis in response to thyroxine: Growth characteristics and upregulation of basic fibroblast growth factor. Circ Res 82 (1998) 587-593
186. Tomanek R.J., Zimmerman M.B., Suvarna P.R., Morkin E., Pennock G.D., and Goldman S. A thyroid hormone analog stimulates angiogenesis in the post-infarcted rat heart. J Mol Cell Cardiol 30 (1998) 923-932
187. Torchia J., Glass C., and Rosenfeld M.G. Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol 10 (1998) 373-383
188. Torre-Amione G. Immune activation in chronic heart failure. Am J Cardiol 95 (2005) 3C-8C discussion 38C-40C
189. Trivieri M.G., Oudit G.Y., Sah R., Kerfant B.G., Sun H., Gramolini A.O., et al. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proc Natl Acad Sci U S A 103 (2006) 6043-6048
190. Trost S.U., Swanson E., Gloss B., Wang-Iverson D.B., Zhang H., Volodarsky T., et al. The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology 141 (2000) 3057-3064
191. van Beeren H.C., Bakker O., and Wiersinga W.M. Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the beta 1-thyroid hormone receptor. FEBS Lett 481 (2000) 213-216
192. Van Beeren H.C., Jong W.M., Kaptein E., Visser T.J., Bakker O., and Wiersinga W.M. Dronerarone acts as a selective inhibitor of 3,5,3′-triiodothyronine binding to thyroid hormone receptor-alpha1: In vitro and in vivo evidence. Endocrinology 144 (2003) 552-558
193. Venditti P., Masullo P., Agnisola C., and Di Meo S. Effect of vitamin E on the response to ischemia-reperfusion of Langendorff heart preparations from hyperthyroid rats. Life Sci 66 (2000) 697-708
194. Venero C., Guadano-Ferraz A., Herrero A.I., Nordstrom K., Manzano J., de Escobar G.M., et al. Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment. Genes Dev 19 (2005) 2152-2163
195. Walker J.D., Crawford Jr. F.A., and Spinale F.G. 3,5,3' Triiodo-L-thyronine pretreatment with cardioplegic arrest and chronic left ventricular dysfunction. Ann Thorac Surg 60 (1995) 292-299
196. Wang B., Ouyang J., and Xia Z. Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: Reversal of increased beta-myosin heavy chain gene expression. Can J Physiol Pharm 84 (2006) 935-941
197. Wassen F.W., Schiel A.E., Kuiper G.G., Kaptein E., Bakker O., Visser T.J., et al. Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure. Endocrinology 143 (2002) 2812-2815
198. Weber K.T., Kinasewitz G.T., Janicki J.S., and Fishman A.P. Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure. Circulation 65 (1982) 1213-1223
199. White P., Burton K.A., Fowden A.L., and Dauncey M.J. Developmental expression analysis of thyroid hormone receptor isoforms reveals new insights into their essential functions in cardiac and skeletal muscles. FASEB J 15 (2001) 1367-1376
200. Wikstrom L., Johansson C., Salto C., Barlow C., Campos Barros A., Baas F., et al. Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1. EMBO J 17 (1998) 455-461
201. Wong K., Boheler K.R., Petrou M., and Yacoub M.H. Pharmacological modulation of pressure-overload cardiac hypertrophy: Changes in ventricular function, extracellular matrix, and gene expression. Circulation 96 (1997) 2239-2246
202. Wong S.P., French J.K., Lydon A.M., Manda S.O., Gao W., Ashton N.G., et al. Relation of left ventricular sphericity to 10-year survival after acute myocardial infarction. Am J Cardiol 94 (2004) 1270-1275
203. Xiao L., Pimental D.R., Amin J.K., Singh K., Sawyer D.B., and Colucci W.S. MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J Mol Cell Cardiol 33 (2001) 779-787
204. Xinaris C., Mourouzis I., Carageorgiou H., Pantos C., and Cokkinos D.V. Differential activation of stress kinase signaling by phenylephrine and thyroid hormone in neonatal cardiomyocytes. J Mol Cell Cardiol 40 (2006) 999
205. Xinaris C., Mourouzis I., Pantos C., and Cokkinos D.V. Thyroid hormone promotes cardiac myocyte plasticity via activation of stress kinase signalling. J Mol Cell Cardiol 40 (2006) 218 (Abstract)
206. Xinaris C., Mourouzis I., Livadarou E., Perimenis P., Spanou D., Pantos C., et al. Negative regulation of TRβ1 receptor by TNF-α administration in neonatal cardiac cells: An effect reversed by T3. J Mol Cell Cardiol 42 (2007) S32 (Abstract)
207. Yao J., and Eghbali M. Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro. Circ Res 71 (1992) 831-839
208. Yen P.M. Physiological and molecular basis of thyroid hormone action. Physiol Rev 81 (2001) 1097-1142
209. Yue T.L., Gu J.L., Wang C., Reith A.D., Lee J.C., Mirabile R.C., et al. Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy. J Biol Chem 275 (2000) 37895-37901
210. Zhang J., and Lazar M.A. The mechanism of action of thyroid hormones. Annu Rev Physiol 62 (2000) 439-466
211. Zheng W., Weiss R.M., Wang X., Zhou R., Arlen A.M., Lei L., et al. DITPA stimulates arteriolar growth and modifies myocardial postinfarction remodeling. Am J Physiol Heart Circ Physiol 286 (2004) H1994-H2000
212. Ziegelhoffer-Mihalovicova B., Briest W., Baba H.A., Rassler B., and Zimmer H.G. The expression of mRNA of cytokines and of extracellular matrix proteins in triiodothyronine-treated rat hearts. Mol Cell Biochem 247 (2003) 61-68
213. Zinman T., Shneyvays V., Tribulova N., Manoach M., and Shainberg A. Acute, nongenomic effect of thyroid hormones in preventing calcium overload in newborn rat cardiocytes. J Cell Physiol 207 (2006) 220-231