MEK1/2-ERK1/2 mediates α1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes

Journal of Molecular and Cellular Cardiology

Volumn 33, Issue 4, 2001, Pages 779-787

  Xiao, Lei ^a   Pimental, David R ^a   Amin, Jay K ^a   Singh, Krishna ^a   Sawyer, Douglas B ^a   Colucci, Wilson S ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adult rat cardiac myocytes; MEK ERK MAPK PD98059; Myocardial hypertrophy; 1 Adrenergic receptor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA 1A ADRENERGIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PRAZOSIN; PROPRANOLOL;

ANIMAL CELL; ANTIBODY SPECIFICITY; CALCIUM CELL LEVEL; CELL GROWTH; CONFERENCE PAPER; ENZYME ACTIVATION; HEART AUTOMATICITY; HEART HYPERTROPHY; HEART MUSCLE CELL; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT;

EID: 0034970775     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2001.1348     Document Type: Article

References (37)

1. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response
2. Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression
3. The alpha 1A-adrenergic receptor subtype mediates biochemical molecular and morphologic features of cultured myocardial cell hypertrophy
4. G (o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism
5. Signaling in myocardial hypertrophy: Life after calcineurin?
6. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
7. Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes
8. Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes
9. The MEKK-JNK pathway is stimulated by alphal-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy
10. A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth sarcomeric organization and cardiac-specific gene expression
11. Age-dependent changes in expression of alpha 1-adrenergic receptors in rat myocardium
12. Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor
13. Neuronal regulation of the development of the alpha-adrenergic chronotropic response in the rat heart
14. Effects of adrenergic amines on electrophysiological properties and automaticity of neonatal and adult canine Purkinje fibers: Evidence for a
15. Regulation of growth in the adult cardiomyocytes
16. Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy
17. Pressure- and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and different induction of peptide growth factor mRNAs
18. Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alpha
19. Molecular cloning expression and characterization of cDNA encoding a mouse alphala-adrenoceptor
20. Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes
21. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
22. Nitric oxide atrial natriuretic peptide and cGMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts
23. p38 Mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta-adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activation
24. Regulation of cardiomyocyte apoptosis in ischemic reperfused mouse heart by glutathione peroxidase
25. The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury
26. Oxygen free radical signaling in ischemic preconditioning
27. Interaction of bradykinin with angiotensin prostacyclin and nitric oxide in myocardial preservation
28. Properties of MEKs the kinases that phosphorylate and activate the extracellular signal-regulated kinases
29. Endothelin-1 phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes
30. Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors
31. Myocardial protection with red wine extract
32. Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase in vitro
33. The stress-activated protein kinase subfamily of c-Jun kinases
34. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
35. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
36. Enhanced expression and localization of heme oxygenase-1 during recovery phase of porcine stunned myocardium
37. Targeted disruption of the mouse sod I gene makes the hearts vulnerable to ischemic reperfusion injury