Thyroid hormone and cardioprotection: Study of p38 MAPK and JNKs during ischaemia and at reperfusion in isolated rat heart

Molecular and Cellular Biochemistry

Volumn 242, Issue 1-2, 2003, Pages 173-180

  Pantos, Constantinos ^a   Malliopoulou, Vassiliki ^a   Paizis, Ioannis ^a   Moraitis, Panagiotis ^a   Mourouzis, Iordanis ^a   Tzeis, Stylianos ^a   Karamanoli, Evangelia ^a   Cokkinos, Demosthenes D ^a   Carageorgiou, Hariclia ^a   Varonos, Dennis ^a   Cokkinos, Dennis V ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

Author keywords

Ischaemic preconditioning; Ischemia; JNK; p38 MAPK; Rat heart; Thyroid hormone

Indexed keywords

LEVOTHYROXINE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; THYROID HORMONE;

ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; CONVALESCENCE; DOSE RESPONSE; ENZYME ACTIVATION; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; MEDICAL ASSESSMENT; NONHUMAN; RAT; RAT STRAIN; TIME; WESTERN BLOTTING;

ANIMALS; ENZYME ACTIVATION; HEART; ISCHEMIC PRECONDITIONING, MYOCARDIAL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL ISCHEMIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, WISTAR; REPERFUSION; THYROID HORMONES; THYROXINE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0037286899     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021162417490     Document Type: Article

References (30)

1. Nakano A, Cohen MV, Downey JM: Ischemic preconditioning: From basic mechanisms to clinical applications. Pharmacol Ther 86: 263-275, 2000
2. Pantos C, Malliopoulou V, Mourouzis I, Karamanoli E, Tzeis SM, Carageorgiou H, Varonos D, Cokkinos DV: Long-term thyroxine administration increases HSP70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia. J Endocrinol 170: 207-215, 2001
3. Pantos C, Cokkinos DD, Tzeis S, Malliopoulou V, Mourouzis I, Carageorgiou H, Limas C, Varonos D, Cokkinos D: Hyperthyroidism is associated with preserved preconditioning capacity but intensified and accelerated ischaemic contracture in rat heart. Basic Res Cardiol 94: 254-260, 1999
4. Klein I, Ojamaa K: Thyroid hormone -targeting the heart. Endocrinology 142: 11-12, 2001
5. Fryer LGD, Holness MJ, Decock JB, Sugden MC: Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: Effect of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat). J Endocrinol 158: 27-33, 1998
6. Pantos C, Malliopoulou V, Mourouzis I, Karamanoli E, Paizis I, Steimberg N, Varonos D, Cokkinos DV. Long-term thyroxine administration protects the heart in a similar pattern as ischaemic preconditioning. Thyroid 12: 325-329, 2002
7. Han J, Lee J-D, Bibbs L, Ulevitch RJ: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994
8. Bogoyevitch M, Gillespie-Brown J, Ketterman A, Fuller S, Ben-Levy R, Ashworth A, Marshall CJ, Sugden PH: Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart: p38/RK mitogen-activated protein kinases and c-jun N-Terminal kinases are activated by ischemia/reperfusion. Circ Res 79: 162-173, 1996
9. Yin T, Sandhu G, Wolfgang C, Burrier A, Randy LW, Rigel DF, Tsonwin H, Whelan J: Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney. J Biol Chem 272: 19943-19950, 1997
10. Knight RJ, Buxton DB: Stimulation of c-Jun kinase and mitogen-activated protein kinase by ischaemia and reperfusion in the perfused rat heart. Biochem Biophys Res Commun 218: 83-88, 1996
11. Chen Y-R, Wang X, Templeton D, Davis RJ, Tan T-H: The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. J Biol Chem 271: 31929-31936, 1996
12. Mackay K, Mochly-Rosen D: An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. J Biol Chem 274: 6272-6279, 1999
13. Nagarkatti D, Sha'afi R: Role of p38 MAP kinase in myocardial stress. J Mol Cell Cardiol 30: 1651-1664, 1998
14. Marais E, Genade S, Huisamen B, Strijdom JG, Moolman JA, Lochner A: Activation of p38 MAPK induced by a multicycle ischaemic preconditioning protocol is associated with attenuated p38 MAPK activity during sustained ischaemia and reperfusion. J Mol Cell Cardiol 33: 769-778, 2001
15. Ma XL, Kumar S, Gao F et al.: Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation 99:1685-1691, 1999
16. Pantos CI, Tzilalis V, Giannakakis S, Cokkinos DD, Tzeis SM, Malliopoulou V, Mourouzis I, Asimacopoulos P, Carageorgiou H, Varonos DD, Cokkinos DV. Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. Int Angiol 20: 181-186, 2001
17. Pantos C, Mourouzis I, Tzeis S, Malliopoulou V, Cokkinos DD, Asimakopoulos P, Carageorgiou H, Varonos DD, Cokkinos DV: Propranolol diminishes cardiac hypertrophy but does not abolish acceleration of the ischemic contracture in hyperthyroid hearts. J Cardiovasc Pharmacol 36: 384-389, 2000
18. Schneider S, Chen W, Hou J, Steenbergen C, Murphy E: Inhibition of p38 MAPK α/β reduces ischemic injury and does not block protective effects of preconditioning. Am J Physiol Heart Circ Physiol 280: H499-H508, 2001
19. Marais E, Genade S, Strijdom JG, Moolman JA, Lochner A: p38 MAPK activation triggers pharmacologically-induced beta-adrenergic preconditioning, but not ischaemic preconditioning. J Mol Cell Cardiol 33: 2157-2177, 2001
20. Saurin AT, Martin JL, Heads RJ, Foley C, Mockridge W, Wright MJ, Wang Y, Marber MS: The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes FASEB J 14: 2237-2246, 2000
21. Van Der Vusse GJ, Coumans WA, Ulrich M, Van Bilsen M: Thyroxine induced alteration in cardiac energy metabolism. J Moll Cell Cardiol 30: A110, 1998
22. Kolocassides KG, Galinanes M, Hearse DJ: Dichotomy of ischaemic preconditioning. Improved postischaemic contractile function despite intensification of ischaemic contracture. Circulation 93: 1725-1733, 1996
23. Asimakis GK, Conti VR: Preconditioning with dobutamine in the isolated rat heart. Life Sci 57: 177-187, 1995
24. Hearse DJ, Sutherland FJ: Catecholamines and preconditioning: Studies on contraction and function in isolated rat hearts. Am J Physiol 277: H136-H143, 1999
25. Gabai VL, Meriin AB, Yaglom JA, Wei JY, Mosser DD, Sherman MY: Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation: HSP72 alleviates the stress-induced inhibition of JNK dephosphorylation. J Biol Chem 275: 38088-38094, 2000
26. Sato M, Cordis G, Maulik N, Das DK: SAPKs regulation of ischemic preconditioning. Am J Physiol Heart Circ Physiol 279: H901-H907, 2000
27. Mackay K, Mochly-Rosen D: Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia. J Moll Cell Cardiol 32: 1585-1588, 2000
28. Kimura T, KandaT, Kotajima N, Kuwabara A, FukumuraY, Kobayashi I: Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. Eur J Endocrinol 143: 179-184, 2000
29. Friberg L, Drvota V, Bjelak AH, Eggertsen G, Ahnvc S: Association between increased levels of reverse triiodothyronine and mortality after acute myocardial infarction, Am J Med 111: 699-711, 2001
30. Ojamaa K, Kenessey A, Shenoy R, Klein I: Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat. Am J Physiol 279: E1319-E1324, 2000