Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts

American Journal of Physiology - Endocrinology and Metabolism

Volumn 275, Issue 3 38-3, 1998, Pages

  Liu, Que ^a   Clanachan, Alexander S ^a   Lopaschuk, Gary D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Fatty acid oxidation; Glucose oxidation; Glycolysis; Hydrogen production

Indexed keywords

FATTY ACID; GLUCOSE; HYDROGEN; LIOTHYRONINE; PALMITIC ACID; PYRUVATE DEHYDROGENASE; TRICARBOXYLIC ACID;

ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE REPERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031668174     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.275.3.e392     Document Type: Article

References (40)

1. Brand, M. D., L. F. Chien, G. K. Ainscon, D. F. S. Rolfe, and R. K. Porter. The cause and function of mitochondrial proton leak. Biochim. Biophys. Acta 1187: 132-139, 1994.
2. Broderick, T. L., H. A. Quinney, C. C. Barker, and G. D. Lopaschuk. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation 87: 972-981, 1993.
3. Burns, A. H., and W. J. Reddy. Direct effects of thyroid hormones on glucose oxidation by isolated rat cardiac myocytes. J. Mol. Cell. Cardiol. 7: 553-561, 1975.
4. Clarke, B., M. Spedding, L. Patmore, and J. G. McCormack. Protective effects of ranolazine in guinea-pig hearts during low-flow ischemia and their association with increases in active pyruvate dehydrogenase. Br. J. Pharmacol. 109: 748-750, 1993.
5. Collins-Nakai, R. L., D. Noseworthy, and G. D. Lopaschuk. Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1862-H1871, 1994.
6. Constantin-Teodosiu, D., G. Cederblad, and E. Hultman. A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue. Anal. Biochem. 198: 347-351, 1991.
7. Constantin-Teodosiu, D., G. Cederblad, and E. Hultman. PDC activity and acetyl group accumulation in skeletal muscle during prolonged exercise. J. Appl. Physiol. 73: 2403-2407, 1992.
8. Davis, P. J., and F. B. Davis. Acute cellular actions of thyroid hormone and myocardial function. Ann. Thorac. Surg. 56: S16-S23, 1993.
9. Dennis, S. C., W. Gevers, and L. H. Opie. Protons in ischemia: where do they come from; where do they go to? J. Mol. Cell. Cardiol. 23: 1077-1086, 1991.
10. Finegan, B. A., G. D. Lopaschuk, S. C. Coulson, and A. S. Clanachan. Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts. Circulation 87: 900-908, 1993.
11. Hamilton, M. A. Prevalence and clinical implication of abnormal thyroid hormone metabolism in advanced heart failure. Ann. Thorac. Surg. 56: S48-S53, 1993.
12. Hardy, D. L., and J. Mowbray. Direct thyroid hormone signalling via ADP-ribosylation controls mitochondrial nucleotide transport and membrane leakiness by changing the conformation of the adenine nucleotide transporter. FEBS Lett. 394: 61-65, 1996.
13. Kadletz, M., P. G. Mullen, M. Ding, L. G. Wolf, and A. S. Wechsler. Effect of triiodothyronine on postischemic myocardial function in the isolated heart. Ann. Thorac. Surg. 57: 657-662 1994.
14. + exchange in cardiac ischemia and reperfusion injury by the pH paradox Cardiovasc. Res. 27: 915-924, 1993.
15. Klein, I. Thyroid hormone and the cardiovascular system Am. J. Med. 88: 631-637, 1990.
16. Klemperer, J. D., K. Ojamaa, and I. Klein. Thyroid hormone therapy in cardiovascular disease. Prog. Cardiovasc. Dis. 4: 329-336, 1996.
17. Klemperer, J. D., J. Zelano, R. E. Helm, K. Berman, K. Ojamaa, I. Klein, O. W. Isom, and K. Krieger. Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia. J. Thorac. Cardiovasc. Surg. 109: 457-465, 1995.
18. Kobayashi, K., and J. R. Neely. Effects of ischemia and reperfusion on pyruvate dehydrogenase activity in isolated rat hearts. J. Mol. Cell. Cardiol 15: 359-367, 1983.
19. 2 during reperfusion of ischemic hearts. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H72-H80, 1996.
20. Liu, B., A. S. Clanachan, R. Schulz, and G. D. Lopaschuk. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ. Res. 79: 940-948, 1996.
21. Lopaschuk, G. D., D. D. Belke, J. Gamble, I. Itoi, and B. O. Schonekess. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim. Biophys. Acta 1213: 263-276, 1994.
22. Lopaschuk, G. D., R. B. Wambolt, and R. L. Barr. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J. Pharmacol. Exp. Ther. 264: 135-144, 1993.
23. McCormack, J. G., R. L. Barr, A. A. Wolff, and G. D. Lopaschuk. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 93: 135-142, 1996.
24. Meng, H.-P., T. G. Maddaford, and G. N. Pierce. Effect of amiloride and selected analogues on postischemic recovery of cardiac contractile function. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1831-H1835, 1993.
25. Moller, N., S. Nielsen, B. Nyholm, N. Porksen, K. G. Alberti, and J. Weeke. Glucose turnover, fuel oxidation and forearm substrate exchange in patients with thyrotoxicosis before and after medical treatment. Clin. Endocrinol. 4: 453-459, 1996.
26. Neely, J. R., and H. E. Morgan. Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu. Rev. Physiol. 36: 413-459, 1974.
27. Nelson, B. D. Thyroid hormone regulation of mitochondrial function. Comments on the mechanism of signal transduction. Biochim. Biophys. Acta 1018: 275-277, 1990.
28. Novitzky, D., P. A. Human, and D. K. C. Cooper. Inotropic effect of triiodothyronine following myocardial ischemia and cardiopulmonary bypass: an experimental study in pigs. Ann. Thorac. Surg. 45: 50-55, 1988.
29. Opie, L. H. Myocardial ischemia - metabolic pathways and implications of increased glycolysis. Cardiovasc. Drugs Ther. 4: 777-790, 1990.
30. Orfali, K. A., G. D. L. Fryer, M. J. Holness, and M. C. Sugden. Interactive effects of insulin and triiodothyronine on pyruvate dehydrogenase kinase activity in cardiac myocytes. J. Mol. Cell. Cardiol. 27: 901-908, 1995.
31. Patel, T. B., and M. S. Olson. Regulation of pyruvate dehydrogenase complex in ischemic rat heart. Am. J. Physiol. 246 (Heart Circ. Physiol. 15): H858-H864, 1984.
32. Segal, J. Acute effect of thyroid hormone on the heart: an extranuclear increase in sugar uptake. J. Mol. Cell. Cardiol. 21: 323-334, 1989.
33. Seitz, H. J., M. J. Muller, and S. Soboll. Rapid thyroid-hormone effect on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell. Biochem. J. 227: 149-153, 1985.
34. Siess, E. A., and O. H. Wieland. Regulation of pyruvate dehydrogenase interconversion in isolated hepatocytes by the mitochondria ATP/ADP ratio. FEBS Lett. 52: 226-230, 1975.
35. Sinci, V., H. Soncul, S. Gunaydin, V. Halit, L. Gokgoz, O. Tatlican, A. Yener, A. Bilgehan, and A. Ersoz. The effects of thyroid hormones on the heart following global ischemia: a clinical and experimental study. Jpn. Heart J. 35: 443-454, 1994.
36. Sterling, K. Direct thyroid hormone activation of mitochondria: identification of adenine nucleotide translocase (AdNT) as the hormone receptor. Transaction Assoc. Am. Physicians 100: 284-293, 1987.
37. 3) action by a primary mitochondrial pathway. Endocr. Res. 15: 683-715, 1989.
38. Sterling, K., and M. A. Brenner. Thyroid hormone action: effect of triiodothyronine on mitochondrial adenine nucleotide translocase in vivo and in vitro. Metabolism 44: 193-199, 1995.
39. Sugden, M. C., M. J. Holness, Y. L. Liu, D. M. Smith, L. G. Fryer, and Y. T. Krusznska. Mechanisms regulating cardiac fuel selection in hyperthyroidism. Biochem. J. 286: 513-517, 1992.
40. 3): effects on myocyte contractile function after hypothermic cardioplegic arrest and rewarming. J. Thorac. Cardiovasc. Surg. 110: 315-327, 1995.