Thyroxine pretreatment increases basal myocardial heat-shock protein 27 expression and accelerates translocation and phosphorylation of this protein upon ischaemia

European Journal of Pharmacology

Volumn 478, Issue 1, 2003, Pages 53-60

  Pantos, Constantinos ^a   Malliopoulou, Vassiliki ^a   Mourouzis, Iordanis ^a   Karamanoli, Evangelia ^a   Moraitis, Panagiotis ^a   Tzeis, Stylianos ^a   Paizis, Ioannis ^a   Cokkinos, Alexandros D ^a   Carageorgiou, Hariclia ^a   Varonos, Dennis D ^a   Cokkinos, Dennis V ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

Author keywords

(Rat); Heart; HSP27 (heat shock protein 27); Ischaemia reperfusion; Thyroxine

Indexed keywords

HEAT SHOCK PROTEIN 27; LEVOTHYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; ISOLATED HEART; MALE; NONHUMAN; PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PHOSPHORYLATION; PROTEIN TRANSPORT; RATS; RATS, WISTAR; THYROXINE;

EID: 12144286195     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2003.08.030     Document Type: Article

References (39)

1. Arrigo A.P., Landry J. Expression and function of the low molecular-weight heat-shock proteins. Morimoto R.I., Tissieres A., Georgopoulos C. The Biology of Heat-shock Proteins and Molecular Chaperones. 1994;335-373 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
2. Barbato R., Menabo R., Dainese P., Carafoli E., Schiaffino S., DiLisa F. Binding of cytosolic proteins to myofibrils in ischemic rat hearts. Circ. Res. 78:1996;821-828.
3. Benndorf R., Hayess K., Ryazantsev S., Wieske M., Behlke J., Lutseh G. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J. Biol. Chem. 269:1994;20780-20784.
4. Coss R.A., Sedar A.W., Sistrun S.S., Storck C.W., Wang P.H., Wachasberger P.R. HSP27 protects the cytoskeleton and nucleus from the effects of 42 degrees C at Ph 6.7 in CHO cells adapted to growth at pH6.7. Int. J. Hypertherm. 18:2002;216-232.
5. Eaton P., Fuller W., Bell J.R., Shattock M.J. αB crystallin translocation and phosphorylation: signal transduction pathways and preconditioning in the isolated rat heart. J. Mol. Cell. Cardiol. 33:2001;1659-1671.
6. Fortin A., Raybaud-Diogene H., Tetu B., Huot J., Landry J., Deschenes R. Overexpression of the 27 kDa heat-shock protein is associated with thermoresistance and chemoresistance but not with radioresistance. Int. J. Radiat. Oncol. Biol. Phys. 46:2000;1259-1266.
7. Gabai V.L., Kabakov A.E. Tumor cell resistance to energy deprivation and hyperthermia can be determined by the actin skeleton stability. Cancer Lett. 70:1993;25-31.
8. Ganote C., Armstrong S. Ischemia and the myocyte cytoskeleton - review and speculation. Cardiovasc. Res. 27:1993;1387-1403.
9. Geum D., Son G.H., Kim K. Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells. J. Biol. Chem. 277:2002;19913-19921.
10. Golenhofen N., Htun P., Ness W., Koob R., Schaper W., Drenckhahn D. Binding of the stress protein alpha B crystalline to cardiac myofibrils correlates with the degree of myocardial damage during ischaemia reperfusion in vivo. J. Mol. Cell. Cardiol. 31:1999;569-580.
11. Guay J., Lambert H., Gingras-Breton G., Lavoie J.N., Hout J., Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J. Cell Sci. 110:1997;357-368.
12. Huot J., Houle F., Spitz D.R., Landry J. HSP 27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Res. 56:1996;273-279.
13. James M., Crabbe C., Hepburne-Scott H.W. Small heat shock proteins (sHSPs) as potential drug targets. Curr. Pharm. Biotechnol. 2:2001;77-111.
14. Knowlton A.A., Sun L. Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. Am. J. Physiol. 280:2001;H455-H464.
15. Lambert H., Charette S.J., Bernier A.F., Guimond A., Landry J. HSP27 multimerization mediated by phosphorylation sensitive intermolecular interactions at the amino terminus. J. Biol. Chem. 274:1999;9378-9385.
16. Landry J., Chretien P., Lambert H., Hickey E., Weber L.A. Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. J. Cell Biol. 109:1989;7-15.
17. Lavoie J.N., Gingras-Breton G., Tanguay R.M., Landry J. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. J. Biol. Chem. 268:1993;3420-3429.
18. Lavoie J.N., Hickey E., Weber L.A., Landry J. Modulation of actin filament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J. Biol. Chem. 268:1993;24210-24214.
19. Lavoie J.N., Lambert H., Hickey E., Weber L.A., Landry J. Modulation of cellular thermotolerance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol. Cell. Biol. 15:1995;505-516.
20. Martin J.L., Mestril R., Hilal-Dandan R., Brunton L.L., Dillmann W.H. Small heat shock proteins and protection against ischaemic injury in cardiac myocytes. Circulation. 96:1997;4343-4348.
21. Ohga Y., Sakata S., Takenaka C., Abe T., Tsuji T., Taniguchi S., Takaki M. Cardiac dysfunction in terms of left ventricular mechanical work and energetics in hypothyroid rats. Am. J. Physiol. 283:2002;H631-H641.
22. Pantos C., Mourouzis I., Tzeis S., Malliopoulou V., Cokkinos D.D., Asimakopoulos P., Carageorgiou H., Varonos D.D., Cokkinos D.V. Propranolol diminishes cardiac hypertrophy but does not abolish acceleration of the ischemic contracture in hyperthyroid hearts. J. Cardiovasc. Pharmacol. 36:2000;384-389.
23. Pantos C., Malliopoulou V., Mourouzis I., Karamanoli E., Tzeis S.M., Carageorgiou H., Varonos D., Cokkinos D.V. Long-term thyroxine administration increases HSP70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia. J. Endocrinol. 170:2001;207-215.
24. Pantos C., Malliopoulou V., Mourouzis I., Karamanoli E., Paizis I., Steimberg N., Varonos D., Cokkinos D.V. Long-term thyroxine administration protects the heart in a similar pattern as ischaemic preconditioning. Thyroid. 12:2002;325-329.
25. Pantos C., Mourouzis I., Delbruyere M., Malliopoulou V., Tzeis S., Cokkinos D.D., Nikitas N., Carageorgiou H., Varonos D., Cokkinos D., Nisato D. Effects of dronedarone and amiodarone on plasma thyroid hormones and on the basal and postischemic performance of the isolated rat heart. Eur. J. Pharmacol. 444:2002;191-196.
26. Pantos C., Malliopoulou V., Paizis I., Moraitis P., Mourouzis I., Tzeis S., Karamanoli E., Cokkinos D.D., Carageorgiou H., Varonos D., Cokkinos D. Thyroid hormone and cardioprotection; study of p38 MAPK and JNKs during ischaemia and at reperfusion in isolated rat heart. Mol. Cell. Biochem. 242:2003;173-180.
27. Pantos C., Mourouzis I., Tzeis S., Moraitis P., Malliopoulou V., Cokkinos D.D., Carageorgiou H., Varonos D., Cokkinos D. Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts; an effect reversed by thyroxine pre-treatment. Eur. J. Pharmacol. 460:2003;155-161.
28. Pantos C., Malliopoulou V., Mourouzis I., Moraitis P., Tzeis S., Thempeyioti A., Paizis I., Cokkinos A.D., Carageorgiou H., Varonos D., Cokkinos D. Involvement of p38 MAPK and JNK in the heat stress induced cardioprotection. Basic Res. Cardiol. 98:2003;158-164.
29. Pipkin W., Johnson J.A., Creazzo T.L., Burch J., Komalavilas P., Brophy C. Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart. Circulation. 107:2003;469-476.
30. Ray P.S., Martin J.L., Swanson E.A., Otani H., Dillmann W.H., Das D.K. Transgene overexpression of αB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion. FASEB J. 15:2001;393-402.
31. Rogalla T., Ehrnsperger M., Priville X., Kotlyarov A., Lutsch G., Ducasse C., Paul C., Wieske M., Arrigo A.-P., Buchner J., Gaestel M. Regulation of HSP27 oligomerization, chaperone function and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. J. Biol. Chem. 274:1999;18947-18956S.
32. Sakamoto K., Urushidami T., Nagao T. Translocation of HSP27 to sarcomere induced by ischaemic preconditioning in isolated rat hearts. Biochem. Biophys. Res. Commun. 269:2000;137-142.
33. Schenker M., Riederer B.M., Kuntzer T., Barakat-Walter I. Thyroid hormones stimulate expression and modification of cytoskeletal protein during rat sciatic nerve regeneration. Brain Res. 957:2002;259-270.
34. Steenbergen C., Hill M.L., Jennings R.B. Cytoskeletal damage during myocardial ischemia - changes in vinculin immunofluorescence during total in vitro ischemia in canine heart. Circ. Res. 60:1987;478-486.
35. Sugden P.H., Clerk A. 'Stress-responsive' mitogen-activated protein kinases (c-jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ. Res. 83:1998;345-352.
36. Sussman M.A. Cellular indigestion: chaperones head to the cytoskeleton. J. Mol. Cell. Cardiol. 34:2002;83-85.
37. Valentim L.M., Rodnight R., Geyer A.B., Horn A.P., Tavares A., Cimarosti H., Netto C.A., Salbego C.G. Changes in heat shock protein 27 Phosphorylation and immunocontent in response to preconditioning to oxygen and glucose deprivation in organotypic hippocampal cultures. Neuroscience. 118:2003;379-386.
38. Walker J.M. Basic Protein and Peptide Protocols. 1994;Humana Press, Totowa, NJ, USA.
39. Wyttenbach A., Sauvageot O., Carmichael J., Diaz-Latoud C., Arrigo A.P., Rubinsztein D.C. Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum. Mol. Genet. 11:2002;1137-1151.