B cell immunosenescence in the elderly and in centenarians

Rejuvenation Research

Volumn 11, Issue 2, 2008, Pages 433-439

  Colonna Romano, Giuseppina ^a   Bulati, Matteo ^a   Aquino, Alessandra ^a   Vitello, Salvatore ^b   Lio, Domenico ^a   Candore, Giuseppina ^a   Caruso, Calogero ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Asl 6 Dipartimento Cure Primarie Servizio Dipartimentale Anziani e ADI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD 27; CELL MARKER; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ARTICLE; B LYMPHOCYTE; CELL AGING; CELL COUNT; CELL DIFFERENTIATION; CELL LOSS; CELL PROLIFERATION; HUMAN; LIFESPAN; MEMORY CELL; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; T LYMPHOCYTE;

AGED; AGED, 80 AND OVER; B-LYMPHOCYTES; CELL AGING; HUMANS;

EID: 42649110681     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2008.0664     Document Type: Article

References (49)

1. Globerson A, Effros RB. Ageing of lymphocytes and lymphocytes in the aged. Immunol Today 2000;21:515-521.
2. Vasto S, Caruso C. Immunity & Ageing: a new journal looking at ageing from an immunological point of view. Immun Ageing 2004 Oct 29;1:1.
3. Cossarizza A, Ortolani C, Monti D, Franceschi C. Cytometric analysis of immunosenescence. Cytometry 1997;27:297-313.
4. Franceschi C, Monti D, Sansoni P, Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995;16:12-16.
5. Ginaldi L, Loreto MF, Corsi MP, Modesti M, De Martinis M. Immunosenescence and infectious diseases. Microbes Infect 2001;3:851-857.
6. Pawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C, Franceschi C, Fulop T, Gupta S, Mariani E, Mocchegiani E, Solana R. T cells and aging. Front Biosci 2002;7:1056-1183.
7. Pawelec G, Ouyang Q, Colonna-Romano G, Candore G, Lio D, Caruso C. Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'. Trends Immunol 2002;23:330-332.
8. Franceschi C, Bonafe M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000;18:1717-1720.
9. Fagnoni FF, Vescovini R, Passeri G, Bologna G, Pedrazzoni M, Lavagetto G, Casti A, Franceschi C, Passeri M, Sansoni P. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 2000;95:2860-2868.
10. Pawelec G, Akbar A, Caruso C, Effros R, Grübeck-Loebenstein B, Wikby A. Is immunosenescence infectious? Contribution of persistent Herpes viruses to immunosenescence and influence on human longevity. Trends Immunol 2004;25:406-410.
11. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A. Human immunosenescence: Is it infectious? Immunol Rev 2005;205:257.
12. Weksler ME. Changes in the B-cell repertoire with age. Vaccine 2000;18:1624-1628.
13. Miller RA. The aging immune system: primer and prospectus. Science 1996;273:70-74.
14. Weksler ME, Szabo P. The effect of age on the B-cell repertoire. J Clin Immunol 2000;20:240-249.
15. Caruso C, Candore G, Cigna D, Di Lorenzo G, Sireci G, Dieli F, Salerno A. Cytokine production pathway in the elderly. Immunol Res 1996;15:84-90.
16. Listì F, Candore G, Modica MA, Russo MA, Di Lorenzo G, Esposito-Pellitteri M, Colonna-Romano G, Aquino A, Bulati M, Lio D, Franceschi C, Caruso C. A study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence. Ann NY Acad Sci 2006;1089:487-495.
17. Lio D, D'Anna C, Gervasi F, Scola L, Potestio M, Di Lorenzo G, Listì F, Colombo A, Candore G, Caruso C. Interleukin-12 release by mitogen-stimulated mononuclear cells in the elderly. Mech Ageing Dev 1998;102:211-219.
18. Agematsu K, Hokibara S, Nagumo H, Komiyama A. CD27: a memory B-cell marker. Immunol Today 2000;21:204-206.
19. Colonna-Romano G, Bulati M, Aquino A, Scialabba G, Candore G, Lio D, Motta M, Malaguarnera M, Caruso C. B cells in the aged: CD27, CD5, and CD40 expression. Mech Ageing Dev 2003;124:389-393.
20. Colonna Romano G, Cossarizza A, Aquino A, Scialabba G, Bulati M, Lio D, Candore G, Di Lorenzo G, Fradà G, Caruso C. Age- and gender-related values of lymphocyte subsets in subjects from northern and southern Italy. Arch Gerontol Geriatr 2002(Suppl);8:99-107.
21. Wikby A, Johansson B, Ferguson FG, Olsson J. Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study. Exp Gerontol 1994;5:531-541.
22. Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev 1997;160:63-77.
23. Kline GH, Hayden TA, Klinman NR. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J Immunol 1999;162:3342-3349.
24. Hao Z, Rajewsky K. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J Exp Med 2001;194:1151-1164.
25. Kaml M, Weiskirchner I, Keller M, Luft T, Hoster E, Hasford J, Young L, Bartlett B, Neuner C, Fischer KH, Neuman B, Wurzner R, Grubeck-Loebenstein B. Booster vaccination in the elderly: Their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titers. Vaccine 2006;24:6808-6811.
26. Manz RA, Lohning M, Cassese G, Thiel A, Radbruch A. Survival of long-lived plasma cells is independent of antigen. Int Immunol 1998;10:1703-1711.
27. Maruyama M, Lam KP, Rajewsky K. Memory B-cell persistence is independent of persisting immunizing antigen. Nature 2000;407:636-642.
28. Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002;298:2199-2202.
29. Colonna-Romano G, Aquino A, Bulati M, Di Lorenzo G, Listì F, Vitello S, Lio D, Candore G, Clesi G, Caruso C. Memory B cell subpopulations in the aged. Rejuvenation Res 2006;9:149-152.
30. Aydar Y, Balogh P, Tew JG, Szakal AK. Age related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation. Eur J Immunol 2002;32:2817-2826.
31. Shi Y, Agematsu K, Ochs HD, Sugane K. Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM. Clin Immunol 2003;108:128-137.
32. Shi Y, Yamazaki T, Okubo Y, Uehara Y, Sugane K, Agematzu K. Regulation of aged immune defense against Pneumococcal bacteria by IgM memory B cell. J Immunol 2005;175:3262-3267.
33. Klein U, Rajewsky K, Küppers R. Human immunoglobulin IgM+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998;188:1679-1689.
34. - (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances. Int Immunol 2005;17:383-390.
35. Anolik JH, Barnard J, Cappione A, Pugh-Bernard AE, Felgar RE, Looney RJ, Sanz I. Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus. Arthritis Rheumatism 2004;50:3580-3590.
36. Colucci AT, Di Lorenzo G, Ingrassia A, Crescimanno G, Modica MA, Candore G, Caruso C. Blood antiphospholipid antibody levels are influenced by age, sex and HLA-B8,DR3 phenotype. Exp Clin Immunogenet 1992;9:72-79.
37. Candore G, Di Lorenzo G, Mansueto P, Melluso M, Frada G, Li Vecchi M, Esposito-Pellitteri M, Drago A, Di Salvo A, Caruso C. Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians. Mech Ageing Dev 1997;94:183-190.
38. Mariotti S, Sansoni P, Barbesino G, Caturegli P, Monti D, Cossarizza A, Giacomelli T, Passeri G, Fagiolo U, Pinchera A. Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 1992;339:1506-1508.
39. Meroni PL, Mari D, Monti D, Coppola R, Capri M, Salvioli S, Tincani A, Gerli R, Franceschi C. Anti-beta 2 glycoprotein I antibodies in centenarians. Exp Gerontol 2004;39:1459-1465.
40. Frasca D, Riley RL, Blomberg BB. Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans. Semin Immunol 2005;17:378-384.
41. Frasca D, Riley RL, Blomberg BB. Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF. Exp Gerontol 2007;42:192-203.
42. Han S, Yang K, Ozen Z, Peng W, Marinova E, Kelsoe G, Zheng B. Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. J Immunol 2003;70:1267-1273.
43. Cassese G, Arce S, Hauser AE, Lehnert K, Moewes B, Mostarac M, Muehlinghaus G, Szyska M, Radbruch A, Manz RA. Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J Immunol 2003;171:1684-1690.
44. Cassese G, Lindenau S, de Boer B, Arce S, Hauser A, Riemekasten G, Berek C, Hiepe F, Krenn V, Radbruch A, Manz RA. Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. Eur J Immunol 2001;31:2726-2732.
45. Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottavini E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000;908:244-254.
46. Candore G, Colonna-Romano G, Balistreri CR, Di Carlo D, Grimaldi MP, Listi F, Nuzzo D, Vasto S, Lio D, Caruso C. Biology of longevity: role of the innate immune system. Rejuvenation Res 2006;9:143-148.
47. Vasto S, Candore G, Balistreri CR, Caruso M, Colonna-Romano G, Grimaldi MP, Listì F, Nuzzo D, Lio D, Caruso C. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 2007;128:83-91.
48. Rodríguez-Pinto D. B cells as antigen presenting cells. Cell Immunol 2005;238:67-75.
49. Hon H, Oran A, Brocker T, Jacob J. B lymphocytes participate in cross presentation of antigen following gene gun vaccination. J Immunol 2005;174:5233-5242.