LXRα enhances lipid synthesis in SZ95 sebocytes

Journal of Investigative Dermatology

Volumn 128, Issue 5, 2008, Pages 1266-1272

  Hong, Il ^a   Lee, Min Ho ^a   Na, Tae Young ^a   Zouboulis, Christos C ^b,c   Lee, Mi Ock ^a  

^a Seoul National University   (South Korea)

^b DESSAU MEDICAL CENTER   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL DERIVATIVE; CYCLOOXYGENASE 2; FATTY ACID SYNTHASE; LIPOPOLYSACCHARIDE; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; NITRIC OXIDE SYNTHASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; AZO COMPOUND; CELL RECEPTOR; COLORING AGENT; DNA BINDING PROTEIN; FAS ANTIGEN; FLUORINATED HYDROCARBON; LIPID; LIVER X RECEPTOR; MESSENGER RNA; OIL RED O; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; SREBF1 PROTEIN, HUMAN; SULFONAMIDE; TO-901317;

ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEBACEOUS GLAND; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; SEBUM; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; AZO COMPOUNDS; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; COLORING AGENTS; DNA-BINDING PROTEINS; GENE EXPRESSION; HUMANS; HYDROCARBONS, FLUORINATED; LIPIDS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SEBACEOUS GLANDS; SEBUM; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFONAMIDES; TRANSFECTION;

EID: 42149164866     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701134     Document Type: Article

References (44)

1. Alberti S, Steffensen KR, Gustafsson JA (2000) Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene 43:93-103
2. Alestas T, Ganceviciene R, Fimmel S, Muller-Decker K, Zouboulis CC (2006) Enzymes involved in the biosynthesis of leukotriene B(4) and prostaglandin E(2) are active in sebaceous glands. J Mol Med 84:75-87
3. Brown SK, Shalita AR (1998) Acne vulgaris. Lancet 351:1871-6
4. Chen WC, Yang CC, Sheu HM, Seltmann H, Zouboulis CC (2003) Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 121:441-7
5. Downie MM, Kealey T (1998) Lipogenesis in the human sebaceous gland: glycogen and glycerophosphate are substrates for the synthesis of sebum lipids. J Invest Dermatol 111:199-205
6. Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L et al. (2003) Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 120:246-55
7. Fritsch M, Orfanos CE, Zouboulis CC (2001) Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol 116:793-800
8. Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S et al. (2005) A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial skin infections. Infect Immunol 73:4512-21
9. Hanley K, Jiang Y, Crumrine D, Bass NM, Appel R, Elias PM et al. (1997) Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. J Clin Invest 100:705-12
10. Hanley K, Ng DC, He SS, Lau P, Min K, Elisa PM et al. (2000) Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. J Invest Dermatol 114:545-53
11. Hayden MS, Ghosh S (2004) Signaling to NF-kB. Genes Dev 18:2195-224
12. Im SS, Kang SY, Kim SY, Kim HI, Kim JW, Kim KS et al. (2005) Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes. Diabetes 54:1684-91
13. Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ et al. (1999) Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci USA 96:266-71
14. Joseph SB, Laffitte B, Patel PH, Watson MA, Matsukuma KE, Walczak R et al. (2002) Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem 77:11019-25
15. Kim MJ, Ciletti N, Michel S, Reichert U, Rosenfield RL (2000) The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J Invest Dermatol 114:349-53
16. Kim SW, Park K, Kwak E, Choi E, Lee S, Ham J et al. (2003) Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice. Mol Cell Biol 23:3583-92
17. Kligman AM (1963) The uses of sebum. Br J Dermatol 75:307-19
18. Komuves LG, Schmuth M, Fowler AJ, Elisa PM, Hanley K, Man MQ et al. (2002) Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J Invest Dermatol 118:25-34
19. Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su JL et al. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 272:3137-40
20. Lu TT, Repa JJ, Mangelsdorf DJ (2001) Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem 276:37735-8
21. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I et al. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 14:2819-30
22. Repa JJ, Mangelsdorf DJ (2000) The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 16:459-81
23. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79-82
24. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM (2000) Transcriptional regulation of adipogenesis. Genes Dev 14:1293-307
25. Rosenfield RL, Deplewski D, Greene ME (2000) Peroxisome proliferator-activated receptors and skin development. Horm Res 54:269-74
26. Rosenfield RL, Kentsis A, Deplewski D, Ciletti N (1999) Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors. J Invest Dermatol 112:226-32
27. Russell L, Harrison W, Zouboulis CC, Burrin J, Philpott MP (2006) Characterisation of liver X receptors within the pilo-sebaceous unit. Exp Dermatol 213:69 [abstract]
28. Schmuth MC, Haqq M, Cairns WJ, Holder JC, Dorsam S, Chang S et al. (2004) Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122:971-83
29. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev 14:2831-8
30. Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ et al. (2004) Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol 24:3430-44
31. Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J et al. (2002) Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol 118:94-101
32. Strauss JS, Pochi PE (1964) Effect of cyclic progestin-estrogen therapy on sebum and acne in women. JAMA 190:815-9
33. Thiboutot D, Jabara S, McAllister JM, Sivarajah A, Gilliland K, Cong Z et al. (2003) Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol 120:905-14
34. Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O'Driscoll J et al. (2003) The distribution of estrogen receptor beta is distinct to that of estrogen receptor alpha and the androgen receptor in human skin and the pilosebaceous unit. J Investig Dermatol Symp Proc 8: 100-103
35. Trivedi NR, Cong Z, Nelson AM, Albert AJ, Rosamilia LL, Sivarajah S et al. (2006) Peroxisome proliferators-activated receptors increase human sebum production. J Invest Dermatol 126:2002-9
36. Tsukada M, Schröder M, Roos TC, Chandraratna RAS, Reichert U, Merk HF et al. (2000) 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol 115:321-7
37. Wu Z, Puigserver P, Spiegelman BM (1999) Transcriptional activation of adipogenesis. Curr Opin Cell Biol 11:689-94
38. Yoo YG, Kong G, Lee MO (2006) Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J 25:1231-41
39. Zelcer N, Tontonoz P (2006) Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116:607-14
40. Zhang Q, Seltmann H, Zouboulis CC, Konger RL (2006) Involvement of PPARgamma in oxidative stress-mediated prostaglandin E2 production in SZ95 human sebaceous gland cells. J Invest Dermatol 126:42-8
41. Zouboulis CC (2004) Acne: Sebaceous gland action. Clin Dermatol 22: 360-366
42. Zouboulis CC, Eady A, Philpott M, Goldsmith LA, Orfanos C, Cunliffe WJ et al. (2005) What is the pathogenesis of acne? Exp Dermatol 14:143-52
43. Zouboulis CC, Krieter A, Gollnick H, Mischke D, Orfanos CE (1994) Progressive differentiation of human sebocytes in vitro is characterized by increased cell size and altered antigenic expression and is regulated by culture duration and retinoids. Exp Dermatol 3:151-60
44. Zouboulis CC, Seltmann H, Neitzel H, Orfanos CE (1999) Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 113:1011-20