Involvement of PPARγ in oxidative stress-mediated prostaglandin E2 production in SZ95 human sebaceous gland cells

Journal of Investigative Dermatology

Volumn 126, Issue 1, 2006, Pages 42-48

  Zhang, Qiwei ^a   Seltmann, Holger ^b   Zouboulis, Christos C ^b   Konger, Raymond L ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CYCLOOXYGENASE 2; OXIDIZING AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PROSTAGLANDIN E2; TERT BUTYL HYDROPEROXIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; CIGLITAZONE; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; DRUG SPECIFICITY; EXAMINATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN STABILITY; REPORTER GENE; SEBACEOUS GLAND; ULTRAVIOLET B RADIATION; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EPIDERMIS; GENETICS; METABOLISM; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

ANILIDES; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; EPIDERMIS; HUMANS; OXIDANTS; OXIDATIVE STRESS; PPAR GAMMA; RNA, MESSENGER; SEBACEOUS GLANDS; TERT-BUTYLHYDROPEROXIDE; THIAZOLIDINEDIONES; ULTRAVIOLET RAYS;

EID: 33644772497     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700028     Document Type: Article

References (41)

1. 2 are active in sebaceous glands. J Mol Med (in press)
2. Athar M, Lloyd JR, Bickers DR, Mukhtar H (1989) Malignant conversion of UV radiation and chemically induced mouse skin benign tumors by free-radical-generating compounds. Carcinogenesis 10:1841-5
3. Babich H, Zuckerbraun HL, Wurzburger BJ, Rubin YL, Borenfreund E, Blau L (1996) Benzoyl peroxide cytotoxicity evaluated in vitro with the human keratinocyte cell line, RHEK-1. Toxicology 106:187-96
4. Bishop-Bailey D, Warner TD (2003) PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist. FASEB J 17:1925-7
5. Bordea C, Wojnarowska F, Millard PR, Doll H, Welsh K, Morris PJ (2004) Skin cancers in renal-transplant recipients occur more frequently than previously recognized in a temperate climate. Transplantation 77:574-9
6. Buckman SY, Gresham A, Hale P, Hruza G, Anast J, Masferrer J et al. (1998) COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis 19:723-9
7. Chen W, Yang CC, Sheu HM, Seltmann H, Zouboulis CC (2003) Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 121:441-7
8. Davies SS, Pontsler AV, Marathe GK, Harrison KA, Murphy RC, Hinshaw JC et al. (2001) Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem 276:16015-23
9. Dixon DA, Balch GC, Kedersha N, Anderson P, Zimmerman GA, Beauchamp RD et al. (2003) Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med 198:475-81
10. Dixon DA, Kaplan CD, McIntyre TM, Zimmerman GA, Prescott SM (2000) Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3′-untranslated region. J Biol Chem 275:11750-7
11. Downie MM, Sanders DA, Maier LM, Stock DM, Kealey T (2004) Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. Br J Dermatol 151:766-75
12. Fischer SM, Lo HH, Gordon GB, Seibert K, Kelloff G, Lubet RA et al. (1999) Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol Carcinogen 25:231-40
13. Gupta MA, Gupta AK (2003) Psychiatric and psychological co-morbidity in patients with dermatologic disorders: epidemiology and management. Am J Clin Dermatol 4:833-42
14. Harper JC, Thiboutot DM (2003) Pathogenesis of acne: recent research advances. Adv Dermatol 19:1-10
15. Hinz B, Brune K, Pahl A (2003) 15-Deoxy-delta(12, 14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. Biochem Biophys Res Commun 302:415-20
16. Holland DB, Jeremy AH, Roberts SG, Seukeran DC, Layton AM, Cunliffe WJ (2004) Inflammation in acne scarring: a comparison of the responses in lesions from patients prone and not prone to scar. Br J Dermatol 150:72-81
17. 12,14 -prostaglandin J2 production. J Invest Dermatol 125:865-72
18. Kim MJ, Deplewski D, Ciletti N, Michel S, Reichert U, Rosenfield RL (2001) Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development. Mol Genet Metab 74:362-9
19. Kuenzli S, Saurat JH (2003) Peroxisome proliferators-activated receptors in cutaneous biology. Br J Dermatol 149:229-36
20. Kuenzli S, Saurat JH (2004) Peroxisome proliferator-activated receptors as new molecular targets in psoriasis. Curr Drug Targets 3:205-11
21. Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG et al. (2002) Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41:6640-50
22. Liang YC, Tsai SH, Tsai DC, Lin-Shiau SY, Lin JK (2001) Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett 496:12-8
23. Mao-Qiang M, Fowler AJ, Schmuth M, Lau P, Chang S, Brown BE et al. (2004) Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 123:305-12
24. Matsuura H, Sakaue M, Subbaramaiah K, Kamitani H, Eling TE, Dannenberg AJ et al. (1999) Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. J Biol Chem 274:29138-48
25. Meade EA, McIntyre TM, Zimmerman GA, Prescott SM (1999) Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. J Biol Chem 274:8328-34
26. Mendez M, LaPointe MC (2003) PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes. Hypertension 42:844-50
27. Muller-Decker K, Neufang G, Berger I, Neumann M, Marks F, Furstenberger G (2002) Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc Natl Acad Sci USA 99:12483-8
28. Neufang G, Furstenberger G, Heidt M, Marks F, Muller-Decker K (2001) Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc Natl Acad Sci USA 98:7629-34
29. Nijsten T, Colpaert CG, Vermeulen PB, Harris AL, Van Marck E, Lambert J (2004) Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. Br J Dermatol 151:837-45
30. Omura NE, Collison DW, Perry AE, Myers LM (2002) Sebaceous carcinoma in children. J Am Acad Dermatol 47:950-3
31. Ota S, Bamba H, Kato A, Kawamoto C, Yoshida Y, Fujiwara K (2002) Review article: COX-2, prostanoids and colon cancer. Aliment Pharmacol Therap 16(Suppl 2):102-6
32. Pentland AP, Schoggins JW, Scott GA, Khan KN, Han R (1999) Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis 20:1939-44
33. Pontsler AV, St Hilaire A, Marathe GK, Zimmerman GA, McIntyre TM (2002) Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. J Biol Chem 277:13029-36
34. Rosenfield RL, Deplewski D, Greene ME (2000) Peroxisome proliferator-activated receptors and skin development. Hormone Res 54:269-74
35. Rosenfield RL, Deplewski D, Kentsis A, Ciletti N (1998) Mechanisms of androgen induction of sebocyte differentiation. Dermatology 196:43-6
36. Sabichi AL, Subbarayan V, Llansa N, Lippman SM, Menter DG (2004) Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. Cancer Epidemiol Biomarkers Prev 13:1704-9
37. Yang WL, Frucht H (2001) Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. Carcinogenesis 22:1379-83
38. Yazici K, Baz K, Yazici AE, Kokturk A, Tot S, Demirseren D et al. (2004) Disease-specific quality of life is associated with anxiety and depression in patients with acne. J Eur Acad Dermatol Venereol 18:435-9
39. Zhang Q, Southall MD, Mezsick SM, Johnson C, Murphy RC, Konger RL et al. (2005) Epidermal peroxisome proliferator-activated receptor gamma as a target for ultraviolet B radiation. J Biol Chem 280:73-9
40. Zouboulis CC, Eady A, Philpott M, Goldsmith LA, Orfanos C, Cunliffe WC et al. (2005) What is the pathogenesis of acne? Exp Dermatol 14:143-52
41. Zouboulis CC, Seltmann H, Neitzel H, Orfanos CE (1999) Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 113:1011-20