Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 8, 2008, Pages 2594-2598

  Kamal, Ahmed ^a   Praveen Kumar, P ^a   Sreekanth, K ^a   Seshadri, B N ^a   Ramulu, P ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Benzimidazoles; DNA binding affinity; In vitro cytotoxicity; Pyrrolobenzodiazepine

Indexed keywords

BENZIMIDAZOLE; BENZODIAZEPINE DERIVATIVE; DNA; PYRROLO[2,1 C][1,4]BENZODIAZEPINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO SELECTION; STRUCTURE ANALYSIS;

ANIMALS; BENZIMIDAZOLES; BENZODIAZEPINES; CATTLE; CELL LINE, TUMOR; CELL SURVIVAL; DNA; HUMANS; MOLECULAR STRUCTURE; NUCLEIC ACID DENATURATION; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 41849101471     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.039     Document Type: Article

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