Innate immune functions of human γδ T cells

Immunobiology

Volumn 213, Issue 3-4, 2008, Pages 173-182

  Beetz, Susann ^a   Wesch, Daniela ^a   Marischen, Lothar ^a   Welte, Stefan ^a   Oberg, Hans Heinrich ^a   Kabelitz, Dieter ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Cytokines; Innate immunity; Polyinosinic polycytidylic (polyI:C); Toll like receptors; T Cells

Indexed keywords

CD3 ANTIGEN; CYTOKINE; GAMMA INTERFERON; ISOPRENOID; LIGAND; POLYINOSINIC POLYCYTIDYLIC ACID; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANTIGEN RECOGNITION; CYTOKINE PRODUCTION; GENE EXPRESSION; HUMAN; INFECTION; INNATE IMMUNITY; MICROARRAY ANALYSIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

EID: 41749095175     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2007.10.006     Document Type: Review

References (74)

1. Agerberth B., Charo J., Werr J., Olsson B., Idali F., Lindbom L., Kiessling R., Jörnvall H., Wigzell H., and Gudmundsson G.H. The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96 (2000) 3086-3093
2. Altincicek B., Moll J., Campos N., Foerster G., Beck E., Hoeffler J.F., Grosdemange-Billiard C., Rodriguez-Concepcion M., Rohmer M., Boron A., Eberl M., and Jomaa H. Cutting edge: human γδ T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. J. Immunol. 166 (2001) 3655-3658
3. Angelini D.F., Borsellino G., Poupot M., Diamantini A., Poupot R., Bernardi G., Poccia F., Fournié J.J., and Battistini L. FcγIIIR discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways. Blood 104 (2004) 1801-1807
4. Arden B., Clark S.P., Kabelitz D., and Mak T. Human T-cell receptor variable gene segments. Immunogenetics 42 (1995) 455-500
5. Barnes P.F., Grissco C.L., Abrams J.S., Brand H., Rea T.H., and Modlin R.L. γδ T lymphocytes in human tuberculosis. J. Infect. Dis. 165 (1992) 506-512
6. Behr C., Poupot R., Peyrat M.A., Poquet Y., Constant P., Dubois P., Bonneville M., and Fournié J.J. Plasmodium falciparum stimuli for human γδ T cells are related to phosphorylated antigens of mycobacteria. Infect. Immun. 64 (1996) 2892-2896
7. Boismenu R., and Havran W.L. Modulation of epithelial cell growth by γδ T cells. Science 266 (1994) 1253-1255
8. Bonneville M., and Scotet E. Human Vγ9Vδ2 T cells: promising new leads for immunotherapy of infections and tumors. Curr. Opin. Immunol. 18 (2006) 539-546
9. Brandes M., Willimann K., and Moser B. Professional antigen presentation function by human γδ T cells. Science 309 (2005) 264-268
10. Caron G., Duluc D., Fremaux I., Jeannin P., David C., Gascan H., and Delneste Y. Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-γ production by memory CD4+ T cells. J. Immunol. 175 (2005) 1551-1557
11. Constant P., Davodeau F., Peyrat M.A., Poquet Y., Puzo G., Bonneville M., and Fournié J.J. Stimulation of human γδ T-cells by nonpeptidic mycobacterial ligands. Science 264 (1994) 267-270
12. Cottalorda A., Verschelde C., Marcais A., Tomkowiak M., Musette P., Uematsu S., Akira S., Marvel J., and Bonnefoy-Berard N. TLR2 engagement on CD8T cells lowers the threshold for optimal antigen-induced T cell activation. Eur. J. Immunol. 36 (2006) 1648-1693
13. Das H., Wang L., Kamath A., and Bukowski J.F. Vγ2Vδ2 T-cell receptor-mediated recognition of aminobisphosphonates. Blood 98 (2001) 1616-1618
14. Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., and Bukowski J.F. MICA engagement by human Vγ2Vδ2T cells enhances their antigen-dependent effector function. Immunity 15 (2001) 83-89
15. Deetz C.O., Hebbeler A.M., Propp N.A., Cairo C., Tikhonov I., and Pauza C.D. Gamma interferon secretion by human Vγ2Vδ2T cells after stimulation with antibody against the T-cell receptor plus the Toll-like receptor 2 agonist Pam3Cys. Infect. Immun. 74 (2006) 4505-4511
16. Dieli F., Troye-Blomberg M., Ivanyi J., Fournié J.J., Krensky A.M., Bonneville M., Peyrat M.A., Caccamo N., Sireci G., and Salerno A. Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vγ9Vδ2 T lymphocytes. J. Infect. Dis. 184 (2001) 1082-1085
17. Ebert L.M., Meuter S., and Moser B. Homing and function of human skin γδ T cells and NK cells: relevance for tumor surveillance. J. Immunol. 176 (2006) 4331-4336
18. Eisen M.B., Spellman P.T., Brown P.O., and Botstein D. Cluster-analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95 (1998) 14863-14868
19. Espinosa E., Belmant C., Pont F., Luciani B., Poupot R., Romagné F., Brailly H., Bonneville M., and Fournié J.J. Chemical synthesis and biological activity of bromohydrin pyrophosphate, a potent stimulator of human γδ T cells. J. Biol. Chem. 276 (2001) 18337-18344
20. Garcia V.E., Sieling P.A., Gong J.H., Barnes P.F., Uyemura K., Tanaka Y., Bloom B.R., Morita C.T., and Modlin R.L. Single cell analysis of γδ T cell response to nonpeptide mycobacterial antigens. J. Immunol. 159 (1997) 1328-1335
21. Gober H.J., Kistowska M., Angman L., Jenö P., Mori L., and de Libero G. Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells. J. Exp. Med. 197 (2003) 163-168
22. González S., Groh V., and Spiess T. Immunobiology of human NKG2D and its ligands. Curr. Top. Microbiol. Immunol. 298 (2006) 121-138
23. Groh V., Steinle A., Bauer S., and Spies T. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279 (1998) 1737-1740
24. Hayday A.C. γδ T cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 11 (2000) 637-685
25. Hayday A., and Tigelaar R. Immunoregulation by γδ T cells. Nat. Rev. Immunol. 3 (2003) 233-242
26. Holtmeier W., Witthoft T., Hennemann A., Winter H.S., and Kagnoff M.F. The TCR-δ repertoire in human intestine undergoes characteristic changes during fetal to adult development. J. Immunol. 158 (1997) 5632-5641
27. Holtmeier W., Pfander M., Hennemann A., Zollner T.M., Kaufmann R., and Caspary W.F. The TCR-δ repertoire in normal human skin is restricted and distinct from the TCR-δ repertoire in the peripheral blood. J. Invest. Dermatol. 116 (2001) 275-280
28. Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5 (2004) 987-995
29. Jameson J., and Havran W.L. Skin γδ T-cell functions in homeostasis and wound healing. Immunol. Rev. 215 (2007) 114-122
30. Kabelitz D. Expression and function of Toll-like receptors in T lymphocytes. Curr. Opin. Immunol. 19 (2007) 39-45
31. Kabelitz D., and Wesch D. Features and functions of γδ T cells: focus on chemokines and their receptors. Crit. Rev. Immunol. 23 (2003) 339-370
32. Kabelitz D., Bender A., Schondelmaier S., Schoel B., and Kaufmann S.H.E. A large fraction of human peripheral blood γδ T cells is activated by Mycobacterium tuberculosis but not by its 65-kDa heat shock protein. J. Exp. Med. 171 (1990) 667-679
33. Kabelitz D., Wesch D., and Hinz T. γδ T cells, their T cell receptor usage and role in human diseases. Springer Semin. Immunopathol. 21 (1999) 55-75
34. Kabelitz D., Glatzel A., and Wesch D. Antigen recognition by human γδ T lymphocytes. Int. Arch. Allergy Immunol. 122 (2000) 1-7
35. Kabelitz D., Wesch D., Pitters E., and Zöller M. Characterization of tumor reactivity of human Vγ9Vδ2 γδ T cells in vitro and in SCID mice in vivo. J. Immunol. 173 (2004) 6767-6776
36. Kabelitz D., Marischen L., Oberg H.H., Holtmeier W., and Wesch D. Epithelial defence by γδ T cells. Int. Arch. Allergy Immunol. 137 (2005) 73-81
37. Kabelitz D., Wesch D., and He W. Perspectives of γδT cells in tumor immunology. Cancer. Res. 67 (2007) 5-8
38. Karikó K., Ni H., Capodici J., Lamphier M., and Weissman D. mRNA is an endogenous ligand for Toll-like receptor 3. J. Biol. Chem. 279 (2004) 12542-12550
39. Koizumi H., Liu C.C., Zheng L.M., Joag S.V., Bayne N.K., Holoshitz J., and Young J.D. Expression of perforin and serine esterases by human γ/δ T cells. J. Exp. Med. 173 (1991) 499-502
40. Komai-Koma M., Jones L., Ogg G.S., Xu D., and Liew F.Y. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc. Natl. Acad. Sci. USA 101 (2004) 3029-3034
41. Kroca M., Tärnvik A., and Sjöstedt A. The proportion of circulating γδ T cells increases after the first week of onset of tularaemia and remains elevated for more than a year. Clin. Exp. Immunol. 120 (2000) 280-284
42. Kunzmann V., Kretzschmar E., Herrmann T., and Wilhelm M. Polyinosinic-polycytidylic acid-mediated stimulation of human γδ T cells via CD11c+ dendritic cell-derived type I interferons. Immunology 112 (2004) 369-377
43. Lafont V., Liautard J., Sablé-Teychené M., Sainte-Marie Y., and Favero J. Isopentenyl pyrophosphate, a mycobacterial non-peptidic antigen, triggers delayed and highly sustained signaling in human γδ T lymphocytes without inducing down-modulation of T cell antigen receptor. J. Biol. Chem. 276 (2001) 15961-15967
44. Maluish A.E., Reid J.W., Crisp E.A., Overton W.R., Levy H., Foon K.A., and Herberman R.B. Immunomodulatory effects of poly(I:C)-LC in cancer patients. J. Biol. Resp. Modif. 4 (1985) 656-673
45. Marsal J., Svensson M., Ericsson A., Iranpour A.H., Carramolino L., Márquez G., and Agace W.A. Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8αα+CD3+ intraepithelial lymphocyte compartment. Eur. J. Immunol. 32 (2002) 3488-3497
46. Miyawaki T., Kasahara Y., Taga K., Yachie A., and Taniguchi N. Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-γ/δ+ lymphocytes. J. Exp. Med. 171 (1990) 1833-1838
47. Moser B., and Eberl M. γδ T cells: novel initiators of adaptive immunity. Immunol. Rev. 215 (2007) 89-102
48. Oliaro J., Dudal S., Liautard J., Andrault J.B., Liautard J.P., and Lafont V. Vγ9Vδ2 T cells use a combination of mechanisms to limit the spread of pathogenic bacteria Brucella. J. Leukocyte Biol. 77 (2005) 652-660
49. Parker C.M., Groh V., Band H., Porcelli S.A., Morita G., Fabbi M., Glass D., Strominger J.L., and Brenner M.B. Evidence for extrathymic changes in the T-cell receptor γδ repertoire. J. Exp. Med. 171 (1990) 1597-1612
50. Pasare C., and Medzhitov R. Toll-dependent control mechanisms of CD4T cell activation. Immunity 21 (2004) 733-741
51. Pechhold K., Wesch D., Schondelmaier S., and Kabelitz D. Primary activation of Vγ9-expressing γδ T cells by Mycobacterium tuberculosis: requirement for Th1-type CD4T cell help and inhibition by interleukin-10. J. Immunol. 152 (1994) 4984-4992
52. Peng G., Guo Z., Kiniwa Y., Voo K.S., Peng W., Fu T., Wang D.Y., Li Y., Wang H.Y., and Wang R.F. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309 (2005) 1380-1384
53. Perera M.K., Carter R., Goonewardene R., and Mendis K.N. Transient increase in circulating γδ T cells during Plasmodium vivax malaria. J. Exp. Med. 179 (1994) 311-315
54. Pfeffer K., Schoel B., Gulle H., Kaufmann S.H.E., and Wagner H. Primary responses of human T cells to mycobacteria: a frequent set of γδ T cells are stimulated by protease resistant ligands. Eur. J. Immunol. 20 (1990) 1175-1180
55. Porcelli S.A., Brenner M.B., and Band H. Biology of the human γδ T-cell receptor. Immunol. Rev. 120 (1991) 137-183
56. Puan K.J., Jin C., Wang H., Sarikonda G., Raker A.M., Lee H.K., Samuelson M.I., Märker-Hermann E., Pasa-Tolic L., Nieves E., Giner J.L., Kuzuyama T., and Morita C.T. Preferential recognition of a microbial metabolite by human Vγ2Vδ2 T cells. Int. Immunol. 19 (2007) 657-673
57. Rincon-Orozco B., Kunzmann V., Wrobel P., Kabelitz D., Steinle A., and Herrmann T. Activation of Vγ9Vδ2 T cells by NKG2D. J. Immunol. 175 (2005) 2144-2151
58. Rothenfusser S., Hornung V., Krug A., Towarowski A., Krieg A.M., Endres S., and Hartmann G. Distinct CpG oligonucleotide sequences activate human γδ T cells via interferon-α/β. Eur. J. Immunol. 31 (2001) 3525-3534
59. Ruprecht C.R., and Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur. J. Immunol. 36 (2006) 798-801
60. Russano A.M., Bassotti G., Agea E., Bistoni O., Mazzocchi A., Morelli A., Porcelli S.A., and Spinozzi F. CD1-restricted recognition of exogenous and self-lipid antigens by duodenal γδ+ T lymphocytes. J. Immunol. 178 (2007) 3620-3626
61. Scotet E., Martinez L.O., Grant E., Barbaras R., Jenö P., Guiraud M., Monsarrat B., Saulquin X., Maillet S., Estève J.P., Lopez F., Perret B., Collet X., Bonneville M., and Champagne E. Tumor recognition following Vγ9Vδ2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity 22 (2005) 71-80
62. Sharp L.L., Jameson J.M., Witherden D.A., Komori H.K., and Havran W.L. Dendritic epidermal T-cell activation. Crit. Rev. Immunol. 25 (2005) 1-18
63. Sicard H., Ingoure S., Luciani B., Serraz C., Fournié J.J., Bonneville M., Tiollier J., and Romagné F. In vivo manipulation of Vγ9Vδ2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. J. Immunol. 175 (2005) 5471-5480
64. Sobek V., Birkner N., Falk I., Würch A., Kirschning C.J., Wagner H., Wallich R., Lamers M.C., and Simon M.M. Direct Toll-like receptor 2-mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease. Arthritis Res. Ther. 6 (2004) R433-R446
65. Spinozzi F., Agea E., Bistoni O., Forenza N., Monaco A., Falini B., Bassotti G., de Benedictis F., Grignani F., and Bertotto A. Local expansion of allergen-specific CD30+ Th2-type γδ T cells in bronchial asthma. Mol. Med. 1 (1995) 821-826
66. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17 (2005) 1-14
67. Takeuchi S., and Akira S. Signaling pathways activated by microorganisms. Curr. Opin. Cell Biol. 19 (2007) 185-191
68. Uchida R., Ashihara E., Sato S., Kimura S., Kuroda J., Takeuchi M., Kawata E., Taniguchi K., Okamoto M., Shimura K., Kiyono Y., Shimazaki C., Taniwaki M., and Maekawa T. γδ T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface. Biochem. Biophys. Res. Commun. 354 (2007) 613-618
69. Wang L., Das H., Kamath A., and Bukowski J.F. Human Vγ2Vδ2 T cells produce IFN-γ and TNF-α with an on/off/on cycling pattern in response to live bacterial products. J. Immunol. 167 (2001) 6195-6201
70. Wang L., Kamath A., Das H., Li L., and Bukowski J.F. Antibacterial effect of human Vγ2Vδ2 T cells in vivo. J. Clin. Invest. 108 (2001) 1349-1357
71. Wesch D., Glatzel A., and Kabelitz D. Differentiation of resting human peripheral blood γδ T cells toward Th1- or Th2 phenotype. Cell Immunol. 212 (2001) 110-117
72. Wesch D., Beetz S., Oberg H.H., Marget M., Krengel K., and Kabelitz D. Direct costimulatory effect of TLR3 ligand poly(I:C) on human γδ T lymphocytes. J. Immunol. 176 (2006) 1348-1354
73. Workalemahu G., Foerster M., Kroegel C., and Braun R.K. Human γδ-T lymphocytes express and synthesize connective tissue growth factor: effect of IL-15 and TGF-β1 and comparison with αβ-T lymphocytes. J. Immunol. 170 (2003) 153-157
74. Wrobel P., Shojaei H., Schittek B., Gieseler F., Wollenberg B., Kalthoff H., Kabelitz D., and Wesch D. Lysis of a broad range of epithelial tumor cells by human γδ T cells: involvement of NKG2D ligands and T cell receptor-versus NKG2D-dependent recognition. Scand. J. Immunol. 66 (2007) 320-328