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Kabelitz D., Wesch D., Pitters E., and Zoller M. Characterization of tumor reactivity of human Vγ9Vδ2 γδ T cells in vitro and in SCID mice in vivo. J Immunol 173 (2004) 6767-6776
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Kabelitz, D.1
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Effect of human natural killer and γδ T cells on the growth of human autologous melanoma xenografts in SCID mice
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Lozupone F., Pende D., Burgio V.L., Castelli C., Spada M., Venditti M., Luciani F., Lugini L., Federici C., Ramoni C., et al. Effect of human natural killer and γδ T cells on the growth of human autologous melanoma xenografts in SCID mice. Cancer Res 64 (2004) 378-385
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In vivo immunomanipulation of Vγ9Vδ2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model
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This article demonstrates efficient in vivo expansion and activation of Vγ9Vδ2 T cells following injection of a synthetic phosphoAg and IL-2 in monkeys, as well as exhaustion of Vγ9Vδ2 T cell responses upon repeated treatments. This forms the basis of subsequent clinical trials that aim to use phosphoAg to activate Vγ9Vδ2 T cells.
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Sicard H., Ingoure S., Luciani B., Serraz C., Fournie J.J., Bonneville M., Tiollier J., and Romagne F. In vivo immunomanipulation of Vγ9Vδ2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. J Immunol 175 (2005) 5471-5480. This article demonstrates efficient in vivo expansion and activation of Vγ9Vδ2 T cells following injection of a synthetic phosphoAg and IL-2 in monkeys, as well as exhaustion of Vγ9Vδ2 T cell responses upon repeated treatments. This forms the basis of subsequent clinical trials that aim to use phosphoAg to activate Vγ9Vδ2 T cells.
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Sicard, H.1
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Fournie, J.J.5
Bonneville, M.6
Tiollier, J.7
Romagne, F.8
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45
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Drug-induced expansion and differentiation of Vγ9Vδ2 T cells in vivo: the role of exogenous IL-2
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Casetti R., Perretta G., Taglioni A., Mattei M., Colizzi V., Dieli F., D'Offizi G., Malkovsky M., and Poccia F. Drug-induced expansion and differentiation of Vγ9Vδ2 T cells in vivo: the role of exogenous IL-2. J Immunol 175 (2005) 1593-1598
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Casetti, R.1
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D'Offizi, G.7
Malkovsky, M.8
Poccia, F.9
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46
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γδ T cells for immune therapy of patients with lymphoid malignancies
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Wilhelm M., Kunzmann V., Eckstein S., Reimer P., Weissinger F., Ruediger T., and Tony H.P. γδ T cells for immune therapy of patients with lymphoid malignancies. Blood 102 (2003) 200-206
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Tony, H.P.7
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47
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Mycobacteria-reactive γδ T cells in HIV-infected individuals: lack of Vγ9 cell responsiveness is due to deficiency of antigen-specific CD4 T helper type 1 cells
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Wesch D., Kabelitz D., Friese K., and Pechhold K. Mycobacteria-reactive γδ T cells in HIV-infected individuals: lack of Vγ9 cell responsiveness is due to deficiency of antigen-specific CD4 T helper type 1 cells. Eur J Immunol 26 (1996) 557-562
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Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vγ9Vδ2 naïve, memory and effector T cell subsets
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Caccamo N., Meraviglia S., Ferlazzo V., Angelini D., Borsellino G., Poccia F., Battistini L., Dieli F., and Salerno A. Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vγ9Vδ2 naïve, memory and effector T cell subsets. Eur J Immunol 35 (2005) 1764-1772
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49
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Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
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Meresse B., Chen Z., Ciszewski C., Tretiakova M., Bhagat G., Krausz T.N., Raulet D.H., Lanier L.L., Groh V., Spies T., et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21 (2004) 357-366
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Autoreactivity by design: innate B and T lymphocytes
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Bendelac A., Bonneville M., and Kearney J.F. Autoreactivity by design: innate B and T lymphocytes. Nat Rev Immunol 1 (2001) 177-186
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